YLR444C_d

Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR444C / YLR444C

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:9.01|P-value:2.53E-22 ID:SGTC_64|Compound:000l-0018|FD-Score:-3.66|P-value:4.14E-5 ID:SGTC_65|Compound:0798-0905|FD-Score:3.34|P-value:1.76E-4 ID:SGTC_75|Compound:0159-0059|FD-Score:2.94|P-value:8.43E-4 ID:SGTC_220|Compound:paclitaxel|FD-Score:-3.63|P-value:4.74E-5 ID:SGTC_230|Compound:MPP+|FD-Score:4.43|P-value:1.09E-6 ID:SGTC_361|Compound:000s-0510|FD-Score:3.52|P-value:8.44E-5 ID:SGTC_367|Compound:0335-0881|FD-Score:3.08|P-value:4.96E-4 ID:SGTC_375|Compound:3970-0961|FD-Score:3.47|P-value:1.01E-4 ID:SGTC_405|Compound:ebelactone b|FD-Score:2.99|P-value:6.90E-4 ID:SGTC_763|Compound:3453-1109|FD-Score:3.26|P-value:2.43E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:4.01|P-value:9.02E-6 ID:SGTC_997|Compound:3996-0078|FD-Score:-3.03|P-value:5.75E-4 ID:SGTC_1011|Compound:4112-3381|FD-Score:3.17|P-value:3.52E-4 ID:SGTC_1031|Compound:k035-0009|FD-Score:3.49|P-value:9.55E-5 ID:SGTC_1052|Compound:3253-3998|FD-Score:3.13|P-value:4.07E-4 ID:SGTC_1064|Compound:honokiol|FD-Score:3.94|P-value:1.24E-5 ID:SGTC_1119|Compound:parthenolide|FD-Score:3.31|P-value:2.04E-4 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:4.33|P-value:1.82E-6 ID:SGTC_1166|Compound:k206-0078|FD-Score:3.00|P-value:6.77E-4 ID:SGTC_1346|Compound:1488-2224|FD-Score:3.17|P-value:3.55E-4 ID:SGTC_1385|Compound:3091-4834|FD-Score:3.09|P-value:4.81E-4 ID:SGTC_1389|Compound:3405-0187|FD-Score:3.05|P-value:5.49E-4 ID:SGTC_1393|Compound:3470-5649|FD-Score:3.53|P-value:7.84E-5 ID:SGTC_1395|Compound:3486-0190|FD-Score:3.18|P-value:3.32E-4 ID:SGTC_1530|Compound:rhein|FD-Score:-2.95|P-value:7.65E-4 ID:SGTC_1552|Compound:6-methylflavone|FD-Score:4.64|P-value:3.43E-7 ID:SGTC_1559|Compound:coumarin 343|FD-Score:3.46|P-value:1.09E-4 ID:SGTC_1596|Compound:piperlongumine|FD-Score:3.72|P-value:3.43E-5 ID:SGTC_1600|Compound:coumarin 106|FD-Score:2.91|P-value:9.48E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:3.12|P-value:4.22E-4 ID:SGTC_1804|Compound:st050076|FD-Score:3.30|P-value:2.13E-4 ID:SGTC_1835|Compound:st008666|FD-Score:3.16|P-value:3.71E-4 ID:SGTC_1845|Compound:st056753|FD-Score:3.37|P-value:1.57E-4 ID:SGTC_2148|Compound:5546263|FD-Score:3.45|P-value:1.11E-4 ID:SGTC_2309|Compound:7664088|FD-Score:4.53|P-value:6.29E-7 ID:SGTC_2366|Compound:9070441|FD-Score:4.00|P-value:9.54E-6 ID:SGTC_2461|Compound:5755302|FD-Score:2.96|P-value:7.69E-4 ID:SGTC_2509|Compound:methyl 7-deshydroxypyrogallin-4-carboxylate|FD-Score:3.76|P-value:2.83E-5 ID:SGTC_2585|Compound:alliin|FD-Score:3.92|P-value:1.35E-5 ID:SGTC_2619|Compound:obliquin|FD-Score:3.22|P-value:2.84E-4 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:4.43|P-value:1.06E-6 ID:SGTC_2772|Compound:vinpocetine|FD-Score:2.89|P-value:9.94E-4 ID:SGTC_2818|Compound:7996756|FD-Score:-3.71|P-value:3.35E-5 ID:SGTC_3041|Compound:9091929|FD-Score:4.64|P-value:3.42E-7 ID:SGTC_3154|Compound:9100113|FD-Score:3.41|P-value:1.33E-4 ID:SGTC_3204|Compound:9114183|FD-Score:4.06|P-value:6.92E-6 ID:SGTC_3212|Compound:9128307|FD-Score:-7.28|P-value:2.76E-15 ID:SGTC_3293|Compound:9120939|FD-Score:3.49|P-value:9.54E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:9.01|P-value:2.53E-22 ID:SGTC_64|Compound:000l-0018|FD-Score:-3.66|P-value:4.14E-5 ID:SGTC_65|Compound:0798-0905|FD-Score:3.34|P-value:1.76E-4 ID:SGTC_75|Compound:0159-0059|FD-Score:2.94|P-value:8.43E-4 ID:SGTC_220|Compound:paclitaxel|FD-Score:-3.63|P-value:4.74E-5 ID:SGTC_230|Compound:MPP+|FD-Score:4.43|P-value:1.09E-6 ID:SGTC_361|Compound:000s-0510|FD-Score:3.52|P-value:8.44E-5 ID:SGTC_367|Compound:0335-0881|FD-Score:3.08|P-value:4.96E-4 ID:SGTC_375|Compound:3970-0961|FD-Score:3.47|P-value:1.01E-4 ID:SGTC_405|Compound:ebelactone b|FD-Score:2.99|P-value:6.90E-4 ID:SGTC_763|Compound:3453-1109|FD-Score:3.26|P-value:2.43E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:4.01|P-value:9.02E-6 ID:SGTC_997|Compound:3996-0078|FD-Score:-3.03|P-value:5.75E-4 ID:SGTC_1011|Compound:4112-3381|FD-Score:3.17|P-value:3.52E-4 ID:SGTC_1031|Compound:k035-0009|FD-Score:3.49|P-value:9.55E-5 ID:SGTC_1052|Compound:3253-3998|FD-Score:3.13|P-value:4.07E-4 ID:SGTC_1064|Compound:honokiol|FD-Score:3.94|P-value:1.24E-5 ID:SGTC_1119|Compound:parthenolide|FD-Score:3.31|P-value:2.04E-4 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:4.33|P-value:1.82E-6 ID:SGTC_1166|Compound:k206-0078|FD-Score:3.00|P-value:6.77E-4 ID:SGTC_1346|Compound:1488-2224|FD-Score:3.17|P-value:3.55E-4 ID:SGTC_1385|Compound:3091-4834|FD-Score:3.09|P-value:4.81E-4 ID:SGTC_1389|Compound:3405-0187|FD-Score:3.05|P-value:5.49E-4 ID:SGTC_1393|Compound:3470-5649|FD-Score:3.53|P-value:7.84E-5 ID:SGTC_1395|Compound:3486-0190|FD-Score:3.18|P-value:3.32E-4 ID:SGTC_1530|Compound:rhein|FD-Score:-2.95|P-value:7.65E-4 ID:SGTC_1552|Compound:6-methylflavone|FD-Score:4.64|P-value:3.43E-7 ID:SGTC_1559|Compound:coumarin 343|FD-Score:3.46|P-value:1.09E-4 ID:SGTC_1596|Compound:piperlongumine|FD-Score:3.72|P-value:3.43E-5 ID:SGTC_1600|Compound:coumarin 106|FD-Score:2.91|P-value:9.48E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:3.12|P-value:4.22E-4 ID:SGTC_1804|Compound:st050076|FD-Score:3.30|P-value:2.13E-4 ID:SGTC_1835|Compound:st008666|FD-Score:3.16|P-value:3.71E-4 ID:SGTC_1845|Compound:st056753|FD-Score:3.37|P-value:1.57E-4 ID:SGTC_2148|Compound:5546263|FD-Score:3.45|P-value:1.11E-4 ID:SGTC_2309|Compound:7664088|FD-Score:4.53|P-value:6.29E-7 ID:SGTC_2366|Compound:9070441|FD-Score:4.00|P-value:9.54E-6 ID:SGTC_2461|Compound:5755302|FD-Score:2.96|P-value:7.69E-4 ID:SGTC_2509|Compound:methyl 7-deshydroxypyrogallin-4-carboxylate|FD-Score:3.76|P-value:2.83E-5 ID:SGTC_2585|Compound:alliin|FD-Score:3.92|P-value:1.35E-5 ID:SGTC_2619|Compound:obliquin|FD-Score:3.22|P-value:2.84E-4 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:4.43|P-value:1.06E-6 ID:SGTC_2772|Compound:vinpocetine|FD-Score:2.89|P-value:9.94E-4 ID:SGTC_2818|Compound:7996756|FD-Score:-3.71|P-value:3.35E-5 ID:SGTC_3041|Compound:9091929|FD-Score:4.64|P-value:3.42E-7 ID:SGTC_3154|Compound:9100113|FD-Score:3.41|P-value:1.33E-4 ID:SGTC_3204|Compound:9114183|FD-Score:4.06|P-value:6.92E-6 ID:SGTC_3212|Compound:9128307|FD-Score:-7.28|P-value:2.76E-15 ID:SGTC_3293|Compound:9120939|FD-Score:3.49|P-value:9.54E-5

Top fitness defect scores for YLR444C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_58 0957-0393 9.01 9.0 µM 2.53E-22 cell wall 96 1.04E-19
2 SGTC_3041 9091929 4.64 49.5 µM 3.42E-7 redox potentiating 12 1.73E-6
3 SGTC_1552 6-methylflavone 4.64 10.6 µM 3.43E-7 superoxide 7 1.74E-6
4 SGTC_2309 7664088 4.53 163.9 µM 6.29E-7 15 2.96E-6
5 SGTC_2634 4'-methoxyflavone 4.43 100.0 µM 1.06E-6 23 4.67E-6
6 SGTC_230 MPP+ 4.43 141.7 µM 1.09E-6 10 4.79E-6
7 SGTC_1135 dihydrocapsaicin 4.33 536.7 nM 1.82E-6 24 7.49E-6
8 SGTC_3204 9114183 4.06 49.5 µM 6.92E-6 28 2.42E-5
9 SGTC_996 3970-0799 4.01 1.8 µM 9.02E-6 82 3.05E-5
10 SGTC_2366 9070441 4.00 60.6 µM 9.54E-6 28 3.21E-5
11 SGTC_1064 honokiol 3.94 6.8 µM 1.24E-5 25 4.03E-5
12 SGTC_2585 alliin 3.92 100.0 µM 1.35E-5 26 4.35E-5
13 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 3.76 54.6 µM 2.83E-5 RPP1 & pyrimidine depletion 35 8.35E-5
14 SGTC_1596 piperlongumine 3.72 63.0 µM 3.43E-5 21 9.87E-5
15 SGTC_1393 3470-5649 3.53 58.2 µM 7.84E-5 60S ribosome export 22 2.04E-4
16 SGTC_361 000s-0510 3.52 1.4 µM 8.44E-5 48 2.18E-4
17 SGTC_3293 9120939 3.49 62.0 µM 9.54E-5 34 2.43E-4
18 SGTC_1031 k035-0009 3.49 16.0 µM 9.55E-5 47 2.43E-4
19 SGTC_375 3970-0961 3.47 9.3 µM 1.01E-4 tubulin folding & SWR complex 34 2.56E-4
20 SGTC_1559 coumarin 343 3.46 70.1 µM 1.09E-4 18 2.73E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.245 4.61E-47 YDR205W MSC2 hom Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids
0.237 4.56E-44 YGR217W CCH1 hom Voltage-gated high-affinity calcium channel involved in calcium influx in response to some environmental stresses as well as exposure to mating pheromones; interacts and co-localizes with Mid1p, suggesting Cch1p and Mid1p function together
0.229 3.94E-41 YOR231W MKK1 hom MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication
0.214 3.16E-36 YJR054W KCH1 hom Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family; potential Cdc28p substrate
0.207 1.02E-33 YGR058W PEF1 hom Penta-EF-hand protein required for polar bud growth and cell wall abscission; binds calcium and zinc with different affinity; localizes to bud site in G1, bud neck in G2; binds to Sec31p and modulates COPII coat assembly
0.201 4.70E-32 YBR120C CBP6 hom Mitochondrial protein required for translation of the COB mRNA; forms a complex with Cbp3p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.197 7.78E-31 YKL115C_d YKL115C_d hom Dubious open reading frame, unlikely to encode a protein; partially overlaps the verified gene PRR1
0.195 4.32E-30 YKL033W-A_p YKL033W-A_p hom Putative protein of unknown function; similar to uncharacterized proteins from other fungi
0.188 4.22E-28 YNL291C MID1 hom N-glycosylated integral membrane protein of the ER membrane and plasma membrane, functions as a stretch-activated Ca2+-permeable cation channel required for Ca2+ influx stimulated by pheromone; interacts with Cch1p; forms an oligomer
0.186 1.48E-27 YNL211C_p YNL211C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YNL211C is not an essential gene
0.186 1.84E-27 YAL015C NTG1 hom DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase; involved in base excision repair; acts in both nucleus and mitochondrion; creates a double-strand break at mtDNA origins that stimulates replication in response to oxidative stress; NTG1 has a paralog, NTG2, that arose from the whole genome duplication
0.184 4.67E-27 YIL160C POT1 hom 3-ketoacyl-CoA thiolase with broad chain length specificity, cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids
0.182 2.00E-26 YLR150W STM1 hom Protein required for optimal translation under nutrient stress; perturbs association of Yef3p with ribosomes; involved in TOR signaling; binds G4 quadruplex and purine motif triplex nucleic acid; helps maintain telomere structure; protein abundance increases in response to DNA replication stress; serves as a ribosome preservation factor both during quiescence and recovery
0.181 3.98E-26 YML057C-A_d YML057C-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene CMP2/YML057W
0.177 3.92E-25 YNL314W DAL82 hom Positive regulator of allophanate inducible genes; binds a dodecanucleotide sequence upstream of all genes that are induced by allophanate; contains an UISALL DNA-binding, a transcriptional activation, and a coiled-coil domain