YLR445W / GMC2

Protein involved in meiotic progression; mutants are delayed in meiotic nuclear division and are defective in synaptonemal complex assembly; transcription is regulated by Ume6p and induced in response to alpha factor

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR445W / GMC2

Click on Significant Values for Screen Details ID:SGTC_78|Compound:0336-0123|FD-Score:4.39|P-value:3.15E-6 ID:SGTC_240|Compound:5hr heat shock (37°C) + Streptovitacin|FD-Score:3.93|P-value:2.60E-5 ID:SGTC_278|Compound:4092-0821|FD-Score:-3.36|P-value:2.15E-4 ID:SGTC_295|Compound:k015-0027|FD-Score:3.51|P-value:1.57E-4 ID:SGTC_317|Compound:4495-0002|FD-Score:4.60|P-value:1.07E-6 ID:SGTC_345|Compound:1362-0200|FD-Score:-3.38|P-value:2.05E-4 ID:SGTC_445|Compound:e6 berbamine|FD-Score:3.17|P-value:5.76E-4 ID:SGTC_560|Compound:2332-1943|FD-Score:4.30|P-value:4.88E-6 ID:SGTC_666|Compound:0272-0154|FD-Score:3.04|P-value:9.19E-4 ID:SGTC_835|Compound:0312-0010|FD-Score:3.82|P-value:4.25E-5 ID:SGTC_874|Compound:0599-0792|FD-Score:-4.35|P-value:2.82E-6 ID:SGTC_982|Compound:1491-0518|FD-Score:3.25|P-value:4.16E-4 ID:SGTC_1045|Compound:1348-1485|FD-Score:5.52|P-value:6.33E-9 ID:SGTC_1063|Compound:disulfiram|FD-Score:5.04|P-value:1.02E-7 ID:SGTC_1069|Compound:diphenylcyclopropenone|FD-Score:5.99|P-value:3.25E-10 ID:SGTC_1105|Compound:epirubicin|FD-Score:3.56|P-value:1.25E-4 ID:SGTC_1109|Compound:tnp00067|FD-Score:3.59|P-value:1.13E-4 ID:SGTC_1119|Compound:parthenolide|FD-Score:3.69|P-value:7.50E-5 ID:SGTC_1232|Compound:0279-0259|FD-Score:3.69|P-value:7.58E-5 ID:SGTC_1234|Compound:0326-0494|FD-Score:3.45|P-value:1.98E-4 ID:SGTC_1235|Compound:benzylparaben|FD-Score:3.12|P-value:6.77E-4 ID:SGTC_1258|Compound:0671-0043|FD-Score:4.41|P-value:2.84E-6 ID:SGTC_1457|Compound:k015-0032|FD-Score:4.56|P-value:1.34E-6 ID:SGTC_1458|Compound:k015-0034|FD-Score:3.35|P-value:2.86E-4 ID:SGTC_1511|Compound:0906-3109|FD-Score:4.19|P-value:7.97E-6 ID:SGTC_1693|Compound:xanthone|FD-Score:4.84|P-value:3.16E-7 ID:SGTC_1738|Compound:st035555|FD-Score:3.22|P-value:4.72E-4 ID:SGTC_1816|Compound:st051957|FD-Score:-3.57|P-value:9.40E-5 ID:SGTC_1824|Compound:st053723|FD-Score:3.77|P-value:5.19E-5 ID:SGTC_1871|Compound:st057448|FD-Score:-3.30|P-value:2.77E-4 ID:SGTC_2027|Compound:5150920|FD-Score:4.53|P-value:1.51E-6 ID:SGTC_2088|Compound:5278280|FD-Score:-3.80|P-value:3.50E-5 ID:SGTC_2105|Compound:5350118|FD-Score:-2.96|P-value:9.57E-4 ID:SGTC_2147|Compound:5545932|FD-Score:3.88|P-value:3.25E-5 ID:SGTC_2266|Compound:7929956|FD-Score:3.47|P-value:1.78E-4 ID:SGTC_2359|Compound:9039622|FD-Score:3.30|P-value:3.56E-4 ID:SGTC_2513|Compound:baicalein|FD-Score:-3.57|P-value:9.43E-5 ID:SGTC_2591|Compound:skatole|FD-Score:3.14|P-value:6.40E-4 ID:SGTC_2750|Compound:bromebric acid|FD-Score:-3.34|P-value:2.39E-4 ID:SGTC_2756|Compound:carbadox|FD-Score:-3.56|P-value:9.96E-5 ID:SGTC_2857|Compound:9024691|FD-Score:4.69|P-value:6.88E-7 ID:SGTC_2906|Compound:7926292|FD-Score:3.29|P-value:3.62E-4 ID:SGTC_2908|Compound:7930301|FD-Score:3.06|P-value:8.46E-4 ID:SGTC_3014|Compound:9081533|FD-Score:3.09|P-value:7.69E-4 ID:SGTC_3136|Compound:9095672|FD-Score:5.98|P-value:3.36E-10 ID:SGTC_3209|Compound:9113616|FD-Score:3.84|P-value:3.98E-5 ID:SGTC_3303|Compound:9125618|FD-Score:-3.37|P-value:2.07E-4 ID:SGTC_3312|Compound:9133330|FD-Score:3.29|P-value:3.68E-4 ID:SGTC_78|Compound:0336-0123|FD-Score:4.39|P-value:3.15E-6 ID:SGTC_240|Compound:5hr heat shock (37°C) + Streptovitacin|FD-Score:3.93|P-value:2.60E-5 ID:SGTC_278|Compound:4092-0821|FD-Score:-3.36|P-value:2.15E-4 ID:SGTC_295|Compound:k015-0027|FD-Score:3.51|P-value:1.57E-4 ID:SGTC_317|Compound:4495-0002|FD-Score:4.60|P-value:1.07E-6 ID:SGTC_345|Compound:1362-0200|FD-Score:-3.38|P-value:2.05E-4 ID:SGTC_445|Compound:e6 berbamine|FD-Score:3.17|P-value:5.76E-4 ID:SGTC_560|Compound:2332-1943|FD-Score:4.30|P-value:4.88E-6 ID:SGTC_666|Compound:0272-0154|FD-Score:3.04|P-value:9.19E-4 ID:SGTC_835|Compound:0312-0010|FD-Score:3.82|P-value:4.25E-5 ID:SGTC_874|Compound:0599-0792|FD-Score:-4.35|P-value:2.82E-6 ID:SGTC_982|Compound:1491-0518|FD-Score:3.25|P-value:4.16E-4 ID:SGTC_1045|Compound:1348-1485|FD-Score:5.52|P-value:6.33E-9 ID:SGTC_1063|Compound:disulfiram|FD-Score:5.04|P-value:1.02E-7 ID:SGTC_1069|Compound:diphenylcyclopropenone|FD-Score:5.99|P-value:3.25E-10 ID:SGTC_1105|Compound:epirubicin|FD-Score:3.56|P-value:1.25E-4 ID:SGTC_1109|Compound:tnp00067|FD-Score:3.59|P-value:1.13E-4 ID:SGTC_1119|Compound:parthenolide|FD-Score:3.69|P-value:7.50E-5 ID:SGTC_1232|Compound:0279-0259|FD-Score:3.69|P-value:7.58E-5 ID:SGTC_1234|Compound:0326-0494|FD-Score:3.45|P-value:1.98E-4 ID:SGTC_1235|Compound:benzylparaben|FD-Score:3.12|P-value:6.77E-4 ID:SGTC_1258|Compound:0671-0043|FD-Score:4.41|P-value:2.84E-6 ID:SGTC_1457|Compound:k015-0032|FD-Score:4.56|P-value:1.34E-6 ID:SGTC_1458|Compound:k015-0034|FD-Score:3.35|P-value:2.86E-4 ID:SGTC_1511|Compound:0906-3109|FD-Score:4.19|P-value:7.97E-6 ID:SGTC_1693|Compound:xanthone|FD-Score:4.84|P-value:3.16E-7 ID:SGTC_1738|Compound:st035555|FD-Score:3.22|P-value:4.72E-4 ID:SGTC_1816|Compound:st051957|FD-Score:-3.57|P-value:9.40E-5 ID:SGTC_1824|Compound:st053723|FD-Score:3.77|P-value:5.19E-5 ID:SGTC_1871|Compound:st057448|FD-Score:-3.30|P-value:2.77E-4 ID:SGTC_2027|Compound:5150920|FD-Score:4.53|P-value:1.51E-6 ID:SGTC_2088|Compound:5278280|FD-Score:-3.80|P-value:3.50E-5 ID:SGTC_2105|Compound:5350118|FD-Score:-2.96|P-value:9.57E-4 ID:SGTC_2147|Compound:5545932|FD-Score:3.88|P-value:3.25E-5 ID:SGTC_2266|Compound:7929956|FD-Score:3.47|P-value:1.78E-4 ID:SGTC_2359|Compound:9039622|FD-Score:3.30|P-value:3.56E-4 ID:SGTC_2513|Compound:baicalein|FD-Score:-3.57|P-value:9.43E-5 ID:SGTC_2591|Compound:skatole|FD-Score:3.14|P-value:6.40E-4 ID:SGTC_2750|Compound:bromebric acid|FD-Score:-3.34|P-value:2.39E-4 ID:SGTC_2756|Compound:carbadox|FD-Score:-3.56|P-value:9.96E-5 ID:SGTC_2857|Compound:9024691|FD-Score:4.69|P-value:6.88E-7 ID:SGTC_2906|Compound:7926292|FD-Score:3.29|P-value:3.62E-4 ID:SGTC_2908|Compound:7930301|FD-Score:3.06|P-value:8.46E-4 ID:SGTC_3014|Compound:9081533|FD-Score:3.09|P-value:7.69E-4 ID:SGTC_3136|Compound:9095672|FD-Score:5.98|P-value:3.36E-10 ID:SGTC_3209|Compound:9113616|FD-Score:3.84|P-value:3.98E-5 ID:SGTC_3303|Compound:9125618|FD-Score:-3.37|P-value:2.07E-4 ID:SGTC_3312|Compound:9133330|FD-Score:3.29|P-value:3.68E-4

Top fitness defect scores for YLR445W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature		Screen
Rank
Screen
P-value
1 SGTC_1069 diphenylcyclopropenone 5.99 8.5 µM 3.25E-10 7 1.05E-9
2 SGTC_3136 9095672 5.98 49.5 µM 3.36E-10 1 1.08E-9
3 SGTC_1045 1348-1485 5.52 165.0 µM 6.33E-9 7 1.70E-8
4 SGTC_1063 disulfiram 5.04 1.8 µM 1.02E-7 8 2.30E-7
5 SGTC_1693 xanthone 4.84 101.9 µM 3.16E-7 DNA damage response 6 6.63E-7
6 SGTC_2857 9024691 4.69 58.4 µM 6.88E-7 11 1.38E-6
7 SGTC_317 4495-0002 4.60 170.0 µM 1.07E-6 5 2.10E-6
8 SGTC_1457 k015-0032 4.56 57.3 µM 1.34E-6 23 2.58E-6
9 SGTC_2027 5150920 4.53 200.0 µM 1.51E-6 6 2.89E-6
10 SGTC_1258 0671-0043 4.41 57.1 µM 2.84E-6 14 5.22E-6
11 SGTC_78 0336-0123 4.39 156.8 µM 3.15E-6 15 5.75E-6
12 SGTC_560 2332-1943 4.30 155.0 µM 4.88E-6 4 8.67E-6
13 SGTC_1511 0906-3109 4.19 28.5 µM 7.97E-6 excess fatty acid 39 1.38E-5
14 SGTC_240 5hr heat shock (37°C) + Streptovitacin 3.93 300.0 µM 2.60E-5 heat shock/prefoldin 42 4.17E-5
15 SGTC_2147 5545932 3.88 89.7 µM 3.25E-5 ergosterol biosynthesis 14 5.16E-5
16 SGTC_3209 9113616 3.84 49.5 µM 3.98E-5 29 6.24E-5
17 SGTC_835 0312-0010 3.82 67.2 µM 4.25E-5 11 6.63E-5
18 SGTC_1824 st053723 3.77 68.6 µM 5.19E-5 39 8.00E-5
19 SGTC_1119 parthenolide 3.69 318.5 nM 7.50E-5 TSC3-RPN4 46 1.13E-4
20 SGTC_1232 0279-0259 3.69 161.0 µM 7.58E-5 28 1.14E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.095 3.52E-8 YPR013C_p CMR3_p hom Putative zinc finger protein; YPR013C is not an essential gene
0.087 4.26E-7 YNL039W BDP1 het Essential subunit of RNA polymerase III transcription factor (TFIIIB), which is involved in transcription of genes encoding tRNAs, 5S rRNA, U6 snRNA, and other small RNAs
0.077 7.87E-6 YDR527W RBA50 het Protein involved in transcription; interacts with RNA polymerase II subunits Rpb2p, Rpb3, and Rpb11p; has similarity to human RPAP1
0.076 1.08E-5 YBR025C OLA1 hom P-loop ATPase with similarity to human OLA1 and bacterial YchF; identified as specifically interacting with the proteasome; protein abundance increases in response to hydrogen peroxide and to DNA replication stress
0.075 1.51E-5 YBR128C ATG14 hom Autophagy-specific subunit of phosphatidylinositol 3-kinase complex I (with Vps34/15/30p); Atg14p targets complex I to the phagophore assembly site (PAS); required for localizing additional ATG proteins to the PAS; required for overflow degradation of misfolded proteins when ERAD is saturated; homolog of human Barkor
0.071 3.65E-5 YFL041W-A_p YFL041W-A_p hom Putative protein of unknown function; identified by fungal homology and RT-PCR
0.070 4.50E-5 YIL041W GVP36 hom BAR domain-containing protein that localizes to both early and late Golgi vesicles; required for adaptation to varying nutrient concentrations, fluid-phase endocytosis, polarization of the actin cytoskeleton, and vacuole biogenesis
0.070 4.49E-5 YIR017C MET28 hom Basic leucine zipper (bZIP) transcriptional activator in the Cbf1p-Met4p-Met28p complex, participates in the regulation of sulfur metabolism
0.068 7.58E-5 YNR008W LRO1 hom Acyltransferase that catalyzes diacylglycerol esterification; one of several acyltransferases that contribute to triglyceride synthesis; putative homolog of human lecithin cholesterol acyltransferase
0.067 1.10E-4 YCR091W KIN82 hom Putative serine/threonine protein kinase implicated in the regulation of phospholipid asymmetry through the activation of phospholipid translocases (flippases) Lem3p-Dnf1p/Dnf2p; similar to Fpk1p
0.066 1.43E-4 YLR152C_p YLR152C_p hom Putative protein of unknown function; YLR152C is not an essential gene
0.065 1.69E-4 YPL009C TAE2 hom Protein of unknown function, involved in protein translation; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.065 1.83E-4 YHR088W RPF1 het Nucleolar protein involved in the assembly and export of the large ribosomal subunit; constituent of 66S pre-ribosomal particles; contains a sigma(70)-like motif, which is thought to bind RNA
0.064 2.25E-4 YJL049W_p YJL049W_p hom Putative protein of unknown function; YJL049W is a non-essential gene
0.063 2.43E-4 YMR143W RPS16A hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S16 and bacterial S9; RPS16A has a paralog, RPS16B, that arose from the whole genome duplication