Protein involved in meiotic progression; mutants are delayed in meiotic nuclear division and are defective in synaptonemal complex assembly; transcription is regulated by Ume6p and induced in response to alpha factor
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YLR445W deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Correlation | pval | ORF | Gene | Zygosity | Description |
---|---|---|---|---|---|
0.095 | 3.52E-8 | YPR013C_p | CMR3_p | hom | Putative zinc finger protein; YPR013C is not an essential gene |
0.087 | 4.26E-7 | YNL039W | BDP1 | het | Essential subunit of RNA polymerase III transcription factor (TFIIIB), which is involved in transcription of genes encoding tRNAs, 5S rRNA, U6 snRNA, and other small RNAs |
0.077 | 7.87E-6 | YDR527W | RBA50 | het | Protein involved in transcription; interacts with RNA polymerase II subunits Rpb2p, Rpb3, and Rpb11p; has similarity to human RPAP1 |
0.076 | 1.08E-5 | YBR025C | OLA1 | hom | P-loop ATPase with similarity to human OLA1 and bacterial YchF; identified as specifically interacting with the proteasome; protein abundance increases in response to hydrogen peroxide and to DNA replication stress |
0.075 | 1.51E-5 | YBR128C | ATG14 | hom | Autophagy-specific subunit of phosphatidylinositol 3-kinase complex I (with Vps34/15/30p); Atg14p targets complex I to the phagophore assembly site (PAS); required for localizing additional ATG proteins to the PAS; required for overflow degradation of misfolded proteins when ERAD is saturated; homolog of human Barkor |
0.071 | 3.65E-5 | YFL041W-A_p | YFL041W-A_p | hom | Putative protein of unknown function; identified by fungal homology and RT-PCR |
0.070 | 4.50E-5 | YIL041W | GVP36 | hom | BAR domain-containing protein that localizes to both early and late Golgi vesicles; required for adaptation to varying nutrient concentrations, fluid-phase endocytosis, polarization of the actin cytoskeleton, and vacuole biogenesis |
0.070 | 4.49E-5 | YIR017C | MET28 | hom | Basic leucine zipper (bZIP) transcriptional activator in the Cbf1p-Met4p-Met28p complex, participates in the regulation of sulfur metabolism |
0.068 | 7.58E-5 | YNR008W | LRO1 | hom | Acyltransferase that catalyzes diacylglycerol esterification; one of several acyltransferases that contribute to triglyceride synthesis; putative homolog of human lecithin cholesterol acyltransferase |
0.067 | 1.10E-4 | YCR091W | KIN82 | hom | Putative serine/threonine protein kinase implicated in the regulation of phospholipid asymmetry through the activation of phospholipid translocases (flippases) Lem3p-Dnf1p/Dnf2p; similar to Fpk1p |
0.066 | 1.43E-4 | YLR152C_p | YLR152C_p | hom | Putative protein of unknown function; YLR152C is not an essential gene |
0.065 | 1.69E-4 | YPL009C | TAE2 | hom | Protein of unknown function, involved in protein translation; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm |
0.065 | 1.83E-4 | YHR088W | RPF1 | het | Nucleolar protein involved in the assembly and export of the large ribosomal subunit; constituent of 66S pre-ribosomal particles; contains a sigma(70)-like motif, which is thought to bind RNA |
0.064 | 2.25E-4 | YJL049W_p | YJL049W_p | hom | Putative protein of unknown function; YJL049W is a non-essential gene |
0.063 | 2.43E-4 | YMR143W | RPS16A | hom | Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S16 and bacterial S9; RPS16A has a paralog, RPS16B, that arose from the whole genome duplication |