YLR446W_p

Putative hexokinase; transcript is upregulated during sporulation and the unfolded protein response; YLR446W is not an essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR446W / YLR446W

Click on Significant Values for Screen Details ID:SGTC_176|Compound:1486-1328|FD-Score:3.54|P-value:1.24E-4 ID:SGTC_203|Compound:k066-0004|FD-Score:5.02|P-value:1.02E-7 ID:SGTC_360|Compound:0957-0399|FD-Score:3.86|P-value:3.21E-5 ID:SGTC_452|Compound:diindolylmethane|FD-Score:3.11|P-value:6.40E-4 ID:SGTC_471|Compound:1-acyl-paf|FD-Score:4.81|P-value:3.32E-7 ID:SGTC_475|Compound:α-linolenic acid|FD-Score:3.20|P-value:4.74E-4 ID:SGTC_549|Compound:1661-1316|FD-Score:4.40|P-value:2.65E-6 ID:SGTC_552|Compound:k242-0005|FD-Score:3.20|P-value:4.61E-4 ID:SGTC_601|Compound:0986-0029|FD-Score:3.20|P-value:4.63E-4 ID:SGTC_618|Compound:k072-0232|FD-Score:3.11|P-value:6.57E-4 ID:SGTC_628|Compound:1636-0253|FD-Score:3.18|P-value:4.98E-4 ID:SGTC_687|Compound:k029-0044|FD-Score:3.30|P-value:3.26E-4 ID:SGTC_724|Compound:3910-0327|FD-Score:2.99|P-value:9.78E-4 ID:SGTC_773|Compound:4358-1457|FD-Score:3.74|P-value:5.44E-5 ID:SGTC_787|Compound:4152-0075|FD-Score:3.75|P-value:5.15E-5 ID:SGTC_790|Compound:1575-0012|FD-Score:4.42|P-value:2.39E-6 ID:SGTC_869|Compound:0564-0080|FD-Score:3.02|P-value:8.98E-4 ID:SGTC_881|Compound:0833-0569|FD-Score:5.56|P-value:4.37E-9 ID:SGTC_905|Compound:2-aminofluorene|FD-Score:3.38|P-value:2.41E-4 ID:SGTC_1013|Compound:4112-3890|FD-Score:4.16|P-value:8.32E-6 ID:SGTC_1038|Compound:k292-0204|FD-Score:3.98|P-value:1.95E-5 ID:SGTC_1171|Compound:0368-0077|FD-Score:2.99|P-value:9.94E-4 ID:SGTC_1173|Compound:0443-0020|FD-Score:3.57|P-value:1.09E-4 ID:SGTC_1191|Compound:1487-1166|FD-Score:4.73|P-value:4.91E-7 ID:SGTC_1218|Compound:1348-1416|FD-Score:3.61|P-value:9.37E-5 ID:SGTC_1229|Compound:0139-0193|FD-Score:3.50|P-value:1.45E-4 ID:SGTC_1267|Compound:0828-0272|FD-Score:3.94|P-value:2.28E-5 ID:SGTC_1470|Compound:k295-0292|FD-Score:3.93|P-value:2.38E-5 ID:SGTC_1636|Compound:st007707|FD-Score:-3.07|P-value:7.45E-4 ID:SGTC_1638|Compound:st008370|FD-Score:3.74|P-value:5.45E-5 ID:SGTC_1787|Compound:fluconazole|FD-Score:3.37|P-value:2.45E-4 ID:SGTC_1840|Compound:st055363|FD-Score:3.93|P-value:2.36E-5 ID:SGTC_1873|Compound:rapamycin|FD-Score:3.34|P-value:2.78E-4 ID:SGTC_2108|Compound:5365811|FD-Score:3.50|P-value:1.47E-4 ID:SGTC_2160|Compound:5660466|FD-Score:5.13|P-value:5.58E-8 ID:SGTC_2247|Compound:cerulenin|FD-Score:-4.09|P-value:1.12E-5 ID:SGTC_2248|Compound:tofa|FD-Score:3.28|P-value:3.44E-4 ID:SGTC_2267|Compound:7931562|FD-Score:3.44|P-value:1.85E-4 ID:SGTC_2269|Compound:7935389|FD-Score:3.89|P-value:2.88E-5 ID:SGTC_2324|Compound:6149169|FD-Score:-3.86|P-value:3.25E-5 ID:SGTC_2326|Compound:6164455|FD-Score:3.90|P-value:2.74E-5 ID:SGTC_2378|Compound:9074213|FD-Score:3.27|P-value:3.59E-4 ID:SGTC_2389|Compound:9091542|FD-Score:3.23|P-value:4.16E-4 ID:SGTC_2436|Compound:5633522|FD-Score:3.55|P-value:1.20E-4 ID:SGTC_2453|Compound:5731132|FD-Score:4.15|P-value:8.86E-6 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:3.05|P-value:8.05E-4 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:3.08|P-value:7.11E-4 ID:SGTC_2738|Compound:aclarubicin|FD-Score:3.08|P-value:7.34E-4 ID:SGTC_2750|Compound:bromebric acid|FD-Score:-3.01|P-value:9.26E-4 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:3.05|P-value:7.97E-4 ID:SGTC_2835|Compound:9006588|FD-Score:3.51|P-value:1.41E-4 ID:SGTC_2841|Compound:9004761|FD-Score:4.53|P-value:1.38E-6 ID:SGTC_2893|Compound:9048488|FD-Score:-3.10|P-value:6.73E-4 ID:SGTC_3011|Compound:9081274|FD-Score:3.11|P-value:6.51E-4 ID:SGTC_3044|Compound:9093193|FD-Score:6.73|P-value:1.62E-12 ID:SGTC_3049|Compound:9092223|FD-Score:3.39|P-value:2.27E-4 ID:SGTC_3058|Compound:9093861|FD-Score:-3.05|P-value:7.81E-4 ID:SGTC_3068|Compound:9116768|FD-Score:3.22|P-value:4.32E-4 ID:SGTC_3094|Compound:9117742|FD-Score:3.70|P-value:6.45E-5 ID:SGTC_176|Compound:1486-1328|FD-Score:3.54|P-value:1.24E-4 ID:SGTC_203|Compound:k066-0004|FD-Score:5.02|P-value:1.02E-7 ID:SGTC_360|Compound:0957-0399|FD-Score:3.86|P-value:3.21E-5 ID:SGTC_452|Compound:diindolylmethane|FD-Score:3.11|P-value:6.40E-4 ID:SGTC_471|Compound:1-acyl-paf|FD-Score:4.81|P-value:3.32E-7 ID:SGTC_475|Compound:α-linolenic acid|FD-Score:3.20|P-value:4.74E-4 ID:SGTC_549|Compound:1661-1316|FD-Score:4.40|P-value:2.65E-6 ID:SGTC_552|Compound:k242-0005|FD-Score:3.20|P-value:4.61E-4 ID:SGTC_601|Compound:0986-0029|FD-Score:3.20|P-value:4.63E-4 ID:SGTC_618|Compound:k072-0232|FD-Score:3.11|P-value:6.57E-4 ID:SGTC_628|Compound:1636-0253|FD-Score:3.18|P-value:4.98E-4 ID:SGTC_687|Compound:k029-0044|FD-Score:3.30|P-value:3.26E-4 ID:SGTC_724|Compound:3910-0327|FD-Score:2.99|P-value:9.78E-4 ID:SGTC_773|Compound:4358-1457|FD-Score:3.74|P-value:5.44E-5 ID:SGTC_787|Compound:4152-0075|FD-Score:3.75|P-value:5.15E-5 ID:SGTC_790|Compound:1575-0012|FD-Score:4.42|P-value:2.39E-6 ID:SGTC_869|Compound:0564-0080|FD-Score:3.02|P-value:8.98E-4 ID:SGTC_881|Compound:0833-0569|FD-Score:5.56|P-value:4.37E-9 ID:SGTC_905|Compound:2-aminofluorene|FD-Score:3.38|P-value:2.41E-4 ID:SGTC_1013|Compound:4112-3890|FD-Score:4.16|P-value:8.32E-6 ID:SGTC_1038|Compound:k292-0204|FD-Score:3.98|P-value:1.95E-5 ID:SGTC_1171|Compound:0368-0077|FD-Score:2.99|P-value:9.94E-4 ID:SGTC_1173|Compound:0443-0020|FD-Score:3.57|P-value:1.09E-4 ID:SGTC_1191|Compound:1487-1166|FD-Score:4.73|P-value:4.91E-7 ID:SGTC_1218|Compound:1348-1416|FD-Score:3.61|P-value:9.37E-5 ID:SGTC_1229|Compound:0139-0193|FD-Score:3.50|P-value:1.45E-4 ID:SGTC_1267|Compound:0828-0272|FD-Score:3.94|P-value:2.28E-5 ID:SGTC_1470|Compound:k295-0292|FD-Score:3.93|P-value:2.38E-5 ID:SGTC_1636|Compound:st007707|FD-Score:-3.07|P-value:7.45E-4 ID:SGTC_1638|Compound:st008370|FD-Score:3.74|P-value:5.45E-5 ID:SGTC_1787|Compound:fluconazole|FD-Score:3.37|P-value:2.45E-4 ID:SGTC_1840|Compound:st055363|FD-Score:3.93|P-value:2.36E-5 ID:SGTC_1873|Compound:rapamycin|FD-Score:3.34|P-value:2.78E-4 ID:SGTC_2108|Compound:5365811|FD-Score:3.50|P-value:1.47E-4 ID:SGTC_2160|Compound:5660466|FD-Score:5.13|P-value:5.58E-8 ID:SGTC_2247|Compound:cerulenin|FD-Score:-4.09|P-value:1.12E-5 ID:SGTC_2248|Compound:tofa|FD-Score:3.28|P-value:3.44E-4 ID:SGTC_2267|Compound:7931562|FD-Score:3.44|P-value:1.85E-4 ID:SGTC_2269|Compound:7935389|FD-Score:3.89|P-value:2.88E-5 ID:SGTC_2324|Compound:6149169|FD-Score:-3.86|P-value:3.25E-5 ID:SGTC_2326|Compound:6164455|FD-Score:3.90|P-value:2.74E-5 ID:SGTC_2378|Compound:9074213|FD-Score:3.27|P-value:3.59E-4 ID:SGTC_2389|Compound:9091542|FD-Score:3.23|P-value:4.16E-4 ID:SGTC_2436|Compound:5633522|FD-Score:3.55|P-value:1.20E-4 ID:SGTC_2453|Compound:5731132|FD-Score:4.15|P-value:8.86E-6 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:3.05|P-value:8.05E-4 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:3.08|P-value:7.11E-4 ID:SGTC_2738|Compound:aclarubicin|FD-Score:3.08|P-value:7.34E-4 ID:SGTC_2750|Compound:bromebric acid|FD-Score:-3.01|P-value:9.26E-4 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:3.05|P-value:7.97E-4 ID:SGTC_2835|Compound:9006588|FD-Score:3.51|P-value:1.41E-4 ID:SGTC_2841|Compound:9004761|FD-Score:4.53|P-value:1.38E-6 ID:SGTC_2893|Compound:9048488|FD-Score:-3.10|P-value:6.73E-4 ID:SGTC_3011|Compound:9081274|FD-Score:3.11|P-value:6.51E-4 ID:SGTC_3044|Compound:9093193|FD-Score:6.73|P-value:1.62E-12 ID:SGTC_3049|Compound:9092223|FD-Score:3.39|P-value:2.27E-4 ID:SGTC_3058|Compound:9093861|FD-Score:-3.05|P-value:7.81E-4 ID:SGTC_3068|Compound:9116768|FD-Score:3.22|P-value:4.32E-4 ID:SGTC_3094|Compound:9117742|FD-Score:3.70|P-value:6.45E-5

Top fitness defect scores for YLR446W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3044 9093193 6.73 49.5 µM 1.62E-12 1 8.26E-12
2 SGTC_881 0833-0569 5.56 170.0 µM 4.37E-9 2 1.34E-8
3 SGTC_2160 5660466 5.13 132.9 µM 5.58E-8 60S ribosome export 3 1.45E-7
4 SGTC_203 k066-0004 5.02 30.9 µM 1.02E-7 RSC & ERG11 5 2.55E-7
5 SGTC_471 1-acyl-paf 4.81 4.0 µM 3.32E-7 DNA intercalators 16 7.70E-7
6 SGTC_1191 1487-1166 4.73 10.6 µM 4.91E-7 azole & statin 21 1.11E-6
7 SGTC_2841 9004761 4.53 39.0 µM 1.38E-6 amide catabolism 13 2.93E-6
8 SGTC_790 1575-0012 4.42 79.1 µM 2.39E-6 TSC3-RPN4 17 4.90E-6
9 SGTC_549 1661-1316 4.40 519.0 µM 2.65E-6 9 5.39E-6
10 SGTC_1013 4112-3890 4.16 241.0 µM 8.32E-6 TSC3-RPN4 27 1.58E-5
11 SGTC_2453 5731132 4.15 22.2 µM 8.86E-6 15 1.67E-5
12 SGTC_1038 k292-0204 3.98 154.0 µM 1.95E-5 17 3.49E-5
13 SGTC_1267 0828-0272 3.94 9.5 µM 2.28E-5 20 4.06E-5
14 SGTC_1840 st055363 3.93 71.0 µM 2.36E-5 11 4.18E-5
15 SGTC_1470 k295-0292 3.93 231.0 µM 2.38E-5 12 4.22E-5
16 SGTC_2326 6164455 3.90 177.6 µM 2.74E-5 mitochondrial processes 24 4.80E-5
17 SGTC_2269 7935389 3.89 174.4 µM 2.88E-5 tubulin folding & SWR complex 27 5.03E-5
18 SGTC_360 0957-0399 3.86 1.0 µM 3.21E-5 cell wall 46 5.57E-5
19 SGTC_787 4152-0075 3.75 138.0 µM 5.15E-5 26 8.69E-5
20 SGTC_773 4358-1457 3.74 44.6 µM 5.44E-5 51 9.15E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.102 2.76E-9 YHL010C ETP1 hom Putative protein of unknown function that is required for growth on ethanol; contains a zinc finger region and has homology to human BRAP2, which is a cytoplasmic protein that binds nuclear localization sequences
0.095 3.78E-8 YNL203C_d YNL203C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.085 7.71E-7 YNL312W RFA2 het Subunit of heterotrimeric Replication Protein A (RPA); RPA is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombination; protein abundance increases in response to DNA replication stress
0.084 1.10E-6 YBR052C RFS1 hom Protein of unknown function; member of a flavodoxin-like fold protein family that includes Pst2p and Ycp4p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; RFS1 has a paralog, PST2, that arose from the whole genome duplication
0.076 1.04E-5 YMR016C SOK2 hom Nuclear protein that negatively regulates pseudohyphal differentiation; plays a regulatory role in the cyclic AMP (cAMP)-dependent protein kinase (PKA) signal transduction pathway; SOK2 has a paralog, PHD1, that arose from the whole genome duplication
0.075 1.26E-5 YAL043C PTA1 het Subunit of holo-CPF, a multiprotein complex and functional homolog of mammalian CPSF, required for the cleavage and polyadenylation of mRNA and snoRNA 3' ends; involved in pre-tRNA processing; binds to the phosphorylated CTD of RNAPII
0.075 1.40E-5 YJL075C_d APQ13_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 85% of ORF overlaps the verified gene NET1; null mutant is sensitive to sorbate
0.075 1.51E-5 YIL104C SHQ1 het Chaperone protein required for the assembly of box H/ACA snoRNPs and thus for pre-rRNA processing, forms a complex with Naf1p and interacts with H/ACA snoRNP components Nhp2p and Cbf5p; homology with known Hsp90p cochaperones
0.073 2.07E-5 YLR164W SHH4 hom Mitochondrial inner membrane protein of unknown function; similar to Tim18p and Sdh4p; a fraction copurifies with Sdh3p, but Shh4p is neither a stoichiometric subunit of succinate dehydrogenase nor of the TIM22 translocase; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner
0.073 2.38E-5 YMR208W ERG12 het Mevalonate kinase, acts in the biosynthesis of isoprenoids and sterols, including ergosterol, from mevalonate
0.072 3.17E-5 YHR148W IMP3 het Component of the SSU processome, which is required for pre-18S rRNA processing, essential protein that interacts with Mpp10p and mediates interactions of Imp4p and Mpp10p with U3 snoRNA
0.071 3.72E-5 YEL017W GTT3 hom Protein of unknown function with a possible role in glutathione metabolism, as suggested by computational analysis of large-scale protein-protein interaction data; GFP-fusion protein localizes to the nuclear periphery
0.069 6.35E-5 YML025C YML6 het Mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L4 ribosomal protein and human mitoribosomal MRP-L4 protein; essential for viability, unlike most other mitoribosomal proteins
0.068 8.27E-5 YNL317W PFS2 het Integral subunit of the pre-mRNA cleavage and polyadenylation factor (CPF) complex; plays an essential role in mRNA 3'-end formation by bridging different processing factors and thereby promoting the assembly of the processing complex
0.068 8.45E-5 YGL112C TAF6 het Subunit (60 kDa) of TFIID and SAGA complexes, involved in transcription initiation of RNA polymerase II and in chromatin modification, similar to histone H4