YLR448W / RPL6B

Ribosomal 60S subunit protein L6B; binds 5.8S rRNA; homologous to mammalian ribosomal protein L6, no bacterial homolog; RPL6B has a paralog, RPL6A, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR448W / RPL6B

Click on Significant Values for Screen Details ID:SGTC_118|Compound:0083-0097|FD-Score:3.41|P-value:6.05E-4 ID:SGTC_150|Compound:3970-0969|FD-Score:3.68|P-value:2.45E-4 ID:SGTC_233|Compound:rapamycin|FD-Score:3.50|P-value:4.54E-4 ID:SGTC_246|Compound:cycloheximide|FD-Score:5.06|P-value:8.13E-7 ID:SGTC_252|Compound:miconazole|FD-Score:-4.05|P-value:6.66E-5 ID:SGTC_299|Compound:1273-0059|FD-Score:-3.70|P-value:2.45E-4 ID:SGTC_303|Compound:1348-1668|FD-Score:4.43|P-value:1.33E-5 ID:SGTC_421|Compound:streptovitacin|FD-Score:3.44|P-value:5.63E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.97|P-value:9.17E-5 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-4.03|P-value:7.27E-5 ID:SGTC_529|Compound:4076-0302|FD-Score:4.32|P-value:2.12E-5 ID:SGTC_644|Compound:1498-1197|FD-Score:3.59|P-value:3.36E-4 ID:SGTC_849|Compound:0386-0493|FD-Score:4.48|P-value:1.08E-5 ID:SGTC_894|Compound:0960-0238|FD-Score:-3.37|P-value:7.44E-4 ID:SGTC_1035|Compound:k081-0041|FD-Score:3.83|P-value:1.45E-4 ID:SGTC_1134|Compound:3477-0009|FD-Score:-3.75|P-value:2.04E-4 ID:SGTC_1153|Compound:4055-0057|FD-Score:4.16|P-value:4.07E-5 ID:SGTC_1172|Compound:0370-0043|FD-Score:-3.30|P-value:9.49E-4 ID:SGTC_1226|Compound:3909-7979|FD-Score:-3.57|P-value:3.78E-4 ID:SGTC_1272|Compound:0839-0021|FD-Score:4.16|P-value:4.09E-5 ID:SGTC_1399|Compound:3562-5772|FD-Score:3.69|P-value:2.33E-4 ID:SGTC_1536|Compound:cytidine-2',3'-monophosphoric acid;  3'-cytidylic acid|FD-Score:4.63|P-value:5.70E-6 ID:SGTC_1566|Compound:6,7-dimethoxy-4-ethylcoumarin|FD-Score:-5.00|P-value:1.22E-6 ID:SGTC_1665|Compound:st014639|FD-Score:3.57|P-value:3.60E-4 ID:SGTC_1742|Compound:st038235|FD-Score:-3.70|P-value:2.47E-4 ID:SGTC_1744|Compound:st037937|FD-Score:3.56|P-value:3.67E-4 ID:SGTC_1845|Compound:st056753|FD-Score:3.65|P-value:2.74E-4 ID:SGTC_1968|Compound:st069590|FD-Score:-3.78|P-value:1.84E-4 ID:SGTC_1974|Compound:st069448|FD-Score:-3.35|P-value:7.92E-4 ID:SGTC_1980|Compound:st071811|FD-Score:5.03|P-value:9.38E-7 ID:SGTC_2075|Compound:5212009|FD-Score:-3.51|P-value:4.76E-4 ID:SGTC_2111|Compound:5486399|FD-Score:-4.06|P-value:6.40E-5 ID:SGTC_2123|Compound:5259487|FD-Score:4.09|P-value:5.39E-5 ID:SGTC_2243|Compound:6634756|FD-Score:3.40|P-value:6.35E-4 ID:SGTC_2334|Compound:9017922|FD-Score:-3.65|P-value:2.88E-4 ID:SGTC_2335|Compound:9018011|FD-Score:6.24|P-value:1.79E-9 ID:SGTC_2405|Compound:ticlatone|FD-Score:4.81|P-value:2.59E-6 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:6.86|P-value:4.36E-11 ID:SGTC_2489|Compound:cantharidin|FD-Score:4.89|P-value:1.83E-6 ID:SGTC_2519|Compound:cryptotanshinone|FD-Score:-3.37|P-value:7.48E-4 ID:SGTC_2520|Compound:obtusaquinone|FD-Score:-3.65|P-value:2.89E-4 ID:SGTC_2625|Compound:euphol|FD-Score:3.52|P-value:4.20E-4 ID:SGTC_2683|Compound:piperine|FD-Score:3.29|P-value:9.14E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.88|P-value:1.17E-4 ID:SGTC_2806|Compound:7952793|FD-Score:4.42|P-value:1.44E-5 ID:SGTC_2865|Compound:9030313|FD-Score:-3.74|P-value:2.09E-4 ID:SGTC_2877|Compound:9040724|FD-Score:5.90|P-value:1.16E-8 ID:SGTC_2887|Compound:9044784|FD-Score:-4.18|P-value:4.02E-5 ID:SGTC_2896|Compound:9052656|FD-Score:-3.92|P-value:1.12E-4 ID:SGTC_2967|Compound:9089538|FD-Score:3.96|P-value:8.80E-5 ID:SGTC_2997|Compound:9067075|FD-Score:-5.40|P-value:1.77E-7 ID:SGTC_3033|Compound:9090887|FD-Score:3.26|P-value:9.85E-4 ID:SGTC_3073|Compound:9114972|FD-Score:-4.51|P-value:1.06E-5 ID:SGTC_3078|Compound:9116413|FD-Score:-3.95|P-value:9.89E-5 ID:SGTC_3089|Compound:9117425|FD-Score:5.44|P-value:1.29E-7 ID:SGTC_3100|Compound:9120536|FD-Score:3.34|P-value:7.83E-4 ID:SGTC_3347|Compound:9188721|FD-Score:4.26|P-value:2.69E-5 ID:SGTC_118|Compound:0083-0097|FD-Score:3.41|P-value:6.05E-4 ID:SGTC_150|Compound:3970-0969|FD-Score:3.68|P-value:2.45E-4 ID:SGTC_233|Compound:rapamycin|FD-Score:3.50|P-value:4.54E-4 ID:SGTC_246|Compound:cycloheximide|FD-Score:5.06|P-value:8.13E-7 ID:SGTC_252|Compound:miconazole|FD-Score:-4.05|P-value:6.66E-5 ID:SGTC_299|Compound:1273-0059|FD-Score:-3.70|P-value:2.45E-4 ID:SGTC_303|Compound:1348-1668|FD-Score:4.43|P-value:1.33E-5 ID:SGTC_421|Compound:streptovitacin|FD-Score:3.44|P-value:5.63E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.97|P-value:9.17E-5 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-4.03|P-value:7.27E-5 ID:SGTC_529|Compound:4076-0302|FD-Score:4.32|P-value:2.12E-5 ID:SGTC_644|Compound:1498-1197|FD-Score:3.59|P-value:3.36E-4 ID:SGTC_849|Compound:0386-0493|FD-Score:4.48|P-value:1.08E-5 ID:SGTC_894|Compound:0960-0238|FD-Score:-3.37|P-value:7.44E-4 ID:SGTC_1035|Compound:k081-0041|FD-Score:3.83|P-value:1.45E-4 ID:SGTC_1134|Compound:3477-0009|FD-Score:-3.75|P-value:2.04E-4 ID:SGTC_1153|Compound:4055-0057|FD-Score:4.16|P-value:4.07E-5 ID:SGTC_1172|Compound:0370-0043|FD-Score:-3.30|P-value:9.49E-4 ID:SGTC_1226|Compound:3909-7979|FD-Score:-3.57|P-value:3.78E-4 ID:SGTC_1272|Compound:0839-0021|FD-Score:4.16|P-value:4.09E-5 ID:SGTC_1399|Compound:3562-5772|FD-Score:3.69|P-value:2.33E-4 ID:SGTC_1536|Compound:cytidine-2',3'-monophosphoric acid;  3'-cytidylic acid|FD-Score:4.63|P-value:5.70E-6 ID:SGTC_1566|Compound:6,7-dimethoxy-4-ethylcoumarin|FD-Score:-5.00|P-value:1.22E-6 ID:SGTC_1665|Compound:st014639|FD-Score:3.57|P-value:3.60E-4 ID:SGTC_1742|Compound:st038235|FD-Score:-3.70|P-value:2.47E-4 ID:SGTC_1744|Compound:st037937|FD-Score:3.56|P-value:3.67E-4 ID:SGTC_1845|Compound:st056753|FD-Score:3.65|P-value:2.74E-4 ID:SGTC_1968|Compound:st069590|FD-Score:-3.78|P-value:1.84E-4 ID:SGTC_1974|Compound:st069448|FD-Score:-3.35|P-value:7.92E-4 ID:SGTC_1980|Compound:st071811|FD-Score:5.03|P-value:9.38E-7 ID:SGTC_2075|Compound:5212009|FD-Score:-3.51|P-value:4.76E-4 ID:SGTC_2111|Compound:5486399|FD-Score:-4.06|P-value:6.40E-5 ID:SGTC_2123|Compound:5259487|FD-Score:4.09|P-value:5.39E-5 ID:SGTC_2243|Compound:6634756|FD-Score:3.40|P-value:6.35E-4 ID:SGTC_2334|Compound:9017922|FD-Score:-3.65|P-value:2.88E-4 ID:SGTC_2335|Compound:9018011|FD-Score:6.24|P-value:1.79E-9 ID:SGTC_2405|Compound:ticlatone|FD-Score:4.81|P-value:2.59E-6 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:6.86|P-value:4.36E-11 ID:SGTC_2489|Compound:cantharidin|FD-Score:4.89|P-value:1.83E-6 ID:SGTC_2519|Compound:cryptotanshinone|FD-Score:-3.37|P-value:7.48E-4 ID:SGTC_2520|Compound:obtusaquinone|FD-Score:-3.65|P-value:2.89E-4 ID:SGTC_2625|Compound:euphol|FD-Score:3.52|P-value:4.20E-4 ID:SGTC_2683|Compound:piperine|FD-Score:3.29|P-value:9.14E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.88|P-value:1.17E-4 ID:SGTC_2806|Compound:7952793|FD-Score:4.42|P-value:1.44E-5 ID:SGTC_2865|Compound:9030313|FD-Score:-3.74|P-value:2.09E-4 ID:SGTC_2877|Compound:9040724|FD-Score:5.90|P-value:1.16E-8 ID:SGTC_2887|Compound:9044784|FD-Score:-4.18|P-value:4.02E-5 ID:SGTC_2896|Compound:9052656|FD-Score:-3.92|P-value:1.12E-4 ID:SGTC_2967|Compound:9089538|FD-Score:3.96|P-value:8.80E-5 ID:SGTC_2997|Compound:9067075|FD-Score:-5.40|P-value:1.77E-7 ID:SGTC_3033|Compound:9090887|FD-Score:3.26|P-value:9.85E-4 ID:SGTC_3073|Compound:9114972|FD-Score:-4.51|P-value:1.06E-5 ID:SGTC_3078|Compound:9116413|FD-Score:-3.95|P-value:9.89E-5 ID:SGTC_3089|Compound:9117425|FD-Score:5.44|P-value:1.29E-7 ID:SGTC_3100|Compound:9120536|FD-Score:3.34|P-value:7.83E-4 ID:SGTC_3347|Compound:9188721|FD-Score:4.26|P-value:2.69E-5

Top fitness defect scores for YLR448W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2422 chlorphenesin carbamate 6.86 384.2 µM 4.36E-11 2 3.57E-12
2 SGTC_2335 9018011 6.24 154.2 µM 1.79E-9 4 2.25E-10
3 SGTC_2877 9040724 5.90 71.4 µM 1.16E-8 1 1.81E-9
4 SGTC_3089 9117425 5.44 49.5 µM 1.29E-7 3 2.63E-8
5 SGTC_246 cycloheximide 5.06 667.0 µM 8.13E-7 7 2.05E-7
6 SGTC_1980 st071811 5.03 45.7 µM 9.38E-7 RPP1 & pyrimidine depletion 5 2.41E-7
7 SGTC_2489 cantharidin 4.89 73.4 µM 1.83E-6 cell wall signaling 22 5.06E-7
8 SGTC_2405 ticlatone 4.81 3.5 µM 2.59E-6 41 7.46E-7
9 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 4.63 61.9 µM 5.70E-6 4 1.79E-6
10 SGTC_849 0386-0493 4.48 241.0 µM 1.08E-5 8 3.67E-6
11 SGTC_303 1348-1668 4.43 34.2 µM 1.33E-5 5 4.62E-6
12 SGTC_2806 7952793 4.42 58.4 µM 1.44E-5 11 5.01E-6
13 SGTC_529 4076-0302 4.32 30.3 µM 2.12E-5 mitochondrial processes 13 7.72E-6
14 SGTC_3347 9188721 4.26 44.7 µM 2.69E-5 17 1.01E-5
15 SGTC_1153 4055-0057 4.16 267.0 µM 4.07E-5 21 1.60E-5
16 SGTC_1272 0839-0021 4.16 27.0 µM 4.09E-5 12 1.60E-5
17 SGTC_2123 5259487 4.09 200.0 µM 5.39E-5 17 2.18E-5
18 SGTC_2967 9089538 3.96 49.9 µM 8.80E-5 31 3.76E-5
19 SGTC_2688 kanamycin b 3.88 96.7 µM 1.17E-4 calcium & mitochondrial duress 381 5.14E-5
20 SGTC_1035 k081-0041 3.83 55.2 µM 1.45E-4 Golgi 26 6.53E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.163 2.26E-21 YDR101C ARX1 hom Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit biogenesis; interacts directly with Alb1; responsible for Tif6 recycling defects in absence of Rei1; associated with the ribosomal export complex
0.125 4.23E-13 YML094W GIM5 hom Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it
0.124 7.17E-13 YOR282W_d YOR282W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps essential, verified gene PLP2/YOR281C
0.119 3.81E-12 YCR047C BUD23 hom Methyltransferase, methylates residue G1575 of 18S rRNA; required for rRNA processing and nuclear export of 40S ribosomal subunits independently of methylation activity; diploid mutant displays random budding pattern
0.115 2.74E-11 YBR191W RPL21A hom Ribosomal 60S subunit protein L21A; homologous to mammalian ribosomal protein L21, no bacterial homolog; RPL21A has a paralog, RPL21B, that arose from the whole genome duplication
0.113 4.98E-11 YBR189W RPS9B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S9 and bacterial S4; RPS9B has a paralog, RPS9A, that arose from the whole genome duplication
0.112 6.92E-11 YIL110W HPM1 hom AdoMet-dependent methyltransferase involved in a novel 3-methylhistidine modification of ribosomal protein Rpl3p; seven beta-strand MTase family member; null mutant exhibits a weak vacuolar protein sorting defect and caspofungin resistance
0.111 1.35E-10 YGL188C-A_p YGL188C-A_p hom Putative protein of unknown function
0.110 1.78E-10 YML073C RPL6A hom Ribosomal 60S subunit protein L6A; N-terminally acetylated; binds 5.8S rRNA; homologous to mammalian ribosomal protein L6, no bacterial homolog; RPL6A has a paralog, RPL6B, that arose from the whole genome duplication
0.101 4.42E-9 YFL033C RIM15 hom Glucose-repressible protein kinase involved in signal transduction during cell proliferation in response to nutrients, specifically the establishment of stationary phase; identified as a regulator of IME2; substrate of Pho80p-Pho85p kinase
0.101 5.08E-9 YGR160W_d YGR160W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.100 5.95E-9 YDR417C_d YDR417C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RPL12B/YDR418W
0.100 6.88E-9 YGR085C RPL11B hom Ribosomal 60S subunit protein L11B; expressed at half the level of Rpl11Ap; involved in ribosomal assembly; depletion causes degradation of 60S proteins and RNA; homologous to mammalian ribosomal protein L11 and bacterial L5; RPL11B has a paralog, RPL11A, that arose from the whole genome duplication
0.098 1.21E-8 YHR205W SCH9 hom AGC family protein kinase; functional ortholog of mammalian S6 kinase; phosphorylated by Tor1p and required for TORC1-mediated regulation of ribosome biogenesis, translation initiation, and entry into G0 phase; involved in transactivation of osmostress-responsive genes; regulates G1 progression, cAPK activity and nitrogen activation of the FGM pathway; integrates nutrient signals and stress signals from sphingolipids to regulate lifespan
0.097 2.05E-8 YJL177W RPL17B hom Ribosomal 60S subunit protein L17B; homologous to mammalian ribosomal protein L17 and bacterial L22; RPL17B has a paralog, RPL17A, that arose from the whole genome duplication