YLR449W / FPR4

Peptidyl-prolyl cis-trans isomerase (PPIase) (proline isomerase) localized to the nucleus; catalyzes isomerization of proline residues in histones H3 and H4, which affects lysine methylation of those histones

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR449W / FPR4

Click on Significant Values for Screen Details ID:SGTC_66|Compound:0109-0187|FD-Score:-3.31|P-value:5.99E-4 ID:SGTC_320|Compound:4092-0846|FD-Score:3.94|P-value:5.52E-5 ID:SGTC_523|Compound:1934-0222|FD-Score:4.89|P-value:7.93E-7 ID:SGTC_587|Compound:k089-0003|FD-Score:3.59|P-value:2.12E-4 ID:SGTC_616|Compound:4092-0450|FD-Score:4.50|P-value:4.96E-6 ID:SGTC_651|Compound:3253-0966|FD-Score:5.04|P-value:3.83E-7 ID:SGTC_818|Compound:4072-2707|FD-Score:-3.40|P-value:4.39E-4 ID:SGTC_821|Compound:1114-0266|FD-Score:5.58|P-value:2.16E-8 ID:SGTC_840|Compound:0245-0196|FD-Score:3.36|P-value:4.87E-4 ID:SGTC_866|Compound:0495-0101|FD-Score:4.34|P-value:1.00E-5 ID:SGTC_868|Compound:0527-0199|FD-Score:4.46|P-value:5.94E-6 ID:SGTC_907|Compound:3448-6986|FD-Score:3.61|P-value:1.93E-4 ID:SGTC_913|Compound:3487-1245|FD-Score:-4.68|P-value:2.23E-6 ID:SGTC_931|Compound:2812-0076|FD-Score:4.11|P-value:2.74E-5 ID:SGTC_939|Compound:1165-0479|FD-Score:-3.51|P-value:2.99E-4 ID:SGTC_1003|Compound:4049-0218|FD-Score:3.91|P-value:6.25E-5 ID:SGTC_1108|Compound:betulinic acid|FD-Score:-3.95|P-value:5.41E-5 ID:SGTC_1168|Compound:k815-0004|FD-Score:4.09|P-value:3.00E-5 ID:SGTC_1191|Compound:1487-1166|FD-Score:3.95|P-value:5.24E-5 ID:SGTC_1336|Compound:1486-0901|FD-Score:6.03|P-value:1.65E-9 ID:SGTC_1338|Compound:1486-1223|FD-Score:3.35|P-value:5.04E-4 ID:SGTC_1527|Compound:coumarin|FD-Score:3.99|P-value:4.40E-5 ID:SGTC_1599|Compound:8-chlro-1-tetrahydronorharmanone|FD-Score:5.56|P-value:2.41E-8 ID:SGTC_1827|Compound:berberine|FD-Score:3.65|P-value:1.66E-4 ID:SGTC_1838|Compound:st055369|FD-Score:4.49|P-value:5.28E-6 ID:SGTC_2166|Compound:5933061|FD-Score:4.27|P-value:1.38E-5 ID:SGTC_2259|Compound:7964009|FD-Score:3.42|P-value:3.97E-4 ID:SGTC_2309|Compound:7664088|FD-Score:4.18|P-value:2.03E-5 ID:SGTC_2362|Compound:9071156|FD-Score:4.16|P-value:2.22E-5 ID:SGTC_2363|Compound:9053361|FD-Score:12.80|P-value:9.69E-37 ID:SGTC_2366|Compound:9070441|FD-Score:3.45|P-value:3.51E-4 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:4.11|P-value:2.71E-5 ID:SGTC_2459|Compound:5811157|FD-Score:3.65|P-value:1.69E-4 ID:SGTC_2475|Compound:5812728|FD-Score:-3.40|P-value:4.28E-4 ID:SGTC_2486|Compound:5283202|FD-Score:-3.65|P-value:1.77E-4 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:-3.82|P-value:9.30E-5 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:3.37|P-value:4.69E-4 ID:SGTC_2700|Compound:st077718|FD-Score:3.32|P-value:5.61E-4 ID:SGTC_2720|Compound:fluspirilene|FD-Score:3.25|P-value:7.00E-4 ID:SGTC_2780|Compound:5215298|FD-Score:3.54|P-value:2.53E-4 ID:SGTC_2790|Compound:5423970|FD-Score:8.35|P-value:1.22E-16 ID:SGTC_2811|Compound:7967822|FD-Score:6.46|P-value:1.13E-10 ID:SGTC_2915|Compound:7971052|FD-Score:3.30|P-value:5.90E-4 ID:SGTC_2932|Compound:9016711|FD-Score:-4.20|P-value:1.98E-5 ID:SGTC_2936|Compound:9038235|FD-Score:3.81|P-value:9.08E-5 ID:SGTC_2937|Compound:9044753|FD-Score:-3.60|P-value:2.09E-4 ID:SGTC_2952|Compound:9073731|FD-Score:3.25|P-value:6.96E-4 ID:SGTC_66|Compound:0109-0187|FD-Score:-3.31|P-value:5.99E-4 ID:SGTC_320|Compound:4092-0846|FD-Score:3.94|P-value:5.52E-5 ID:SGTC_523|Compound:1934-0222|FD-Score:4.89|P-value:7.93E-7 ID:SGTC_587|Compound:k089-0003|FD-Score:3.59|P-value:2.12E-4 ID:SGTC_616|Compound:4092-0450|FD-Score:4.50|P-value:4.96E-6 ID:SGTC_651|Compound:3253-0966|FD-Score:5.04|P-value:3.83E-7 ID:SGTC_818|Compound:4072-2707|FD-Score:-3.40|P-value:4.39E-4 ID:SGTC_821|Compound:1114-0266|FD-Score:5.58|P-value:2.16E-8 ID:SGTC_840|Compound:0245-0196|FD-Score:3.36|P-value:4.87E-4 ID:SGTC_866|Compound:0495-0101|FD-Score:4.34|P-value:1.00E-5 ID:SGTC_868|Compound:0527-0199|FD-Score:4.46|P-value:5.94E-6 ID:SGTC_907|Compound:3448-6986|FD-Score:3.61|P-value:1.93E-4 ID:SGTC_913|Compound:3487-1245|FD-Score:-4.68|P-value:2.23E-6 ID:SGTC_931|Compound:2812-0076|FD-Score:4.11|P-value:2.74E-5 ID:SGTC_939|Compound:1165-0479|FD-Score:-3.51|P-value:2.99E-4 ID:SGTC_1003|Compound:4049-0218|FD-Score:3.91|P-value:6.25E-5 ID:SGTC_1108|Compound:betulinic acid|FD-Score:-3.95|P-value:5.41E-5 ID:SGTC_1168|Compound:k815-0004|FD-Score:4.09|P-value:3.00E-5 ID:SGTC_1191|Compound:1487-1166|FD-Score:3.95|P-value:5.24E-5 ID:SGTC_1336|Compound:1486-0901|FD-Score:6.03|P-value:1.65E-9 ID:SGTC_1338|Compound:1486-1223|FD-Score:3.35|P-value:5.04E-4 ID:SGTC_1527|Compound:coumarin|FD-Score:3.99|P-value:4.40E-5 ID:SGTC_1599|Compound:8-chlro-1-tetrahydronorharmanone|FD-Score:5.56|P-value:2.41E-8 ID:SGTC_1827|Compound:berberine|FD-Score:3.65|P-value:1.66E-4 ID:SGTC_1838|Compound:st055369|FD-Score:4.49|P-value:5.28E-6 ID:SGTC_2166|Compound:5933061|FD-Score:4.27|P-value:1.38E-5 ID:SGTC_2259|Compound:7964009|FD-Score:3.42|P-value:3.97E-4 ID:SGTC_2309|Compound:7664088|FD-Score:4.18|P-value:2.03E-5 ID:SGTC_2362|Compound:9071156|FD-Score:4.16|P-value:2.22E-5 ID:SGTC_2363|Compound:9053361|FD-Score:12.80|P-value:9.69E-37 ID:SGTC_2366|Compound:9070441|FD-Score:3.45|P-value:3.51E-4 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:4.11|P-value:2.71E-5 ID:SGTC_2459|Compound:5811157|FD-Score:3.65|P-value:1.69E-4 ID:SGTC_2475|Compound:5812728|FD-Score:-3.40|P-value:4.28E-4 ID:SGTC_2486|Compound:5283202|FD-Score:-3.65|P-value:1.77E-4 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:-3.82|P-value:9.30E-5 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:3.37|P-value:4.69E-4 ID:SGTC_2700|Compound:st077718|FD-Score:3.32|P-value:5.61E-4 ID:SGTC_2720|Compound:fluspirilene|FD-Score:3.25|P-value:7.00E-4 ID:SGTC_2780|Compound:5215298|FD-Score:3.54|P-value:2.53E-4 ID:SGTC_2790|Compound:5423970|FD-Score:8.35|P-value:1.22E-16 ID:SGTC_2811|Compound:7967822|FD-Score:6.46|P-value:1.13E-10 ID:SGTC_2915|Compound:7971052|FD-Score:3.30|P-value:5.90E-4 ID:SGTC_2932|Compound:9016711|FD-Score:-4.20|P-value:1.98E-5 ID:SGTC_2936|Compound:9038235|FD-Score:3.81|P-value:9.08E-5 ID:SGTC_2937|Compound:9044753|FD-Score:-3.60|P-value:2.09E-4 ID:SGTC_2952|Compound:9073731|FD-Score:3.25|P-value:6.96E-4

Top fitness defect scores for YLR449W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2363 9053361 12.80 176.0 µM 9.69E-37 Golgi 1 4.36E-38
2 SGTC_2790 5423970 8.35 71.4 µM 1.22E-16 endomembrane recycling 11 3.32E-17
3 SGTC_2811 7967822 6.46 32.5 µM 1.13E-10 3 5.16E-11
4 SGTC_1336 1486-0901 6.03 104.0 µM 1.65E-9 6 8.39E-10
5 SGTC_821 1114-0266 5.58 29.2 µM 2.16E-8 4 1.21E-8
6 SGTC_1599 8-chlro-1-tetrahydronorharmanone 5.56 90.6 µM 2.41E-8 11 1.35E-8
7 SGTC_651 3253-0966 5.04 34.4 µM 3.83E-7 calcium & mitochondrial duress 15 2.38E-7
8 SGTC_523 1934-0222 4.89 13.7 µM 7.93E-7 15 5.07E-7
9 SGTC_616 4092-0450 4.50 108.0 µM 4.96E-6 6 3.40E-6
10 SGTC_1838 st055369 4.49 84.5 µM 5.28E-6 9 3.62E-6
11 SGTC_868 0527-0199 4.46 213.0 µM 5.94E-6 fatty acid desaturase (OLE1) 19 4.09E-6
12 SGTC_866 0495-0101 4.34 262.0 µM 1.00E-5 60S ribosome export 10 7.02E-6
13 SGTC_2166 5933061 4.27 31.5 µM 1.38E-5 tubulin folding & SWR complex 27 9.77E-6
14 SGTC_2309 7664088 4.18 163.9 µM 2.03E-5 18 1.46E-5
15 SGTC_2362 9071156 4.16 126.0 µM 2.22E-5 6 1.60E-5
16 SGTC_2410 aloe-emodin-8-o-glycoside 4.11 46.3 µM 2.71E-5 mitochondrial processes 24 1.98E-5
17 SGTC_931 2812-0076 4.11 566.0 µM 2.74E-5 21 2.00E-5
18 SGTC_1168 k815-0004 4.09 80.5 µM 3.00E-5 DNA damage response 15 2.19E-5
19 SGTC_1527 coumarin 3.99 137.0 µM 4.40E-5 24 3.26E-5
20 SGTC_1191 1487-1166 3.95 10.6 µM 5.24E-5 azole & statin 32 3.91E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.175 1.96E-24 YMR285C NGL2 hom Protein involved in 5.8S rRNA processing; Ccr4p-like RNase required for correct 3'-end formation of 5.8S rRNA at site E; similar to Ngl1p; NGL2 has a paralog, NGL3, that arose from the whole genome duplication
0.146 1.67E-17 YNL007C SIS1 het Type II HSP40 co-chaperone that interacts with the HSP70 protein Ssa1p; not functionally redundant with Ydj1p due to due to substrate specificity; has similarity to bacterial DnaJ proteins; protein abundance increases in response to DNA replication stress
0.133 1.33E-14 YCL023C_d YCL023C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF KCC4
0.130 5.04E-14 YNL270C ALP1 hom Arginine transporter; expression is normally very low and it is unclear what conditions would induce significant expression; ALP1 has a paralog, CAN1, that arose from the whole genome duplication
0.126 2.13E-13 YML100W TSL1 hom Large subunit of trehalose 6-phosphate synthase/phosphatase complex; Tps1p-Tps2p complex converts uridine-5'-diphosphoglucose and glucose 6-phosphate to trehalose; mutant has aneuploidy tolerance; protein abundance increases in response to DNA replication stress; TSL1 has a paralog, TPS3, that arose from the whole genome duplication
0.119 4.28E-12 YML043C RRN11 het Component of the core factor (CF) rDNA transcription factor complex; CF is required for transcription of 35S rRNA genes by RNA polymerase I and is composed of Rrn6p, Rrn7p, and Rrn11p
0.118 8.04E-12 YPR023C EAF3 hom Esa1p-associated factor, nonessential component of the NuA4 acetyltransferase complex, homologous to Drosophila dosage compensation protein MSL3; plays a role in regulating Ty1 transposition
0.117 1.26E-11 YPL119C DBP1 hom Putative ATP-dependent RNA helicase of the DEAD-box protein family; mutants show reduced stability of the 40S ribosomal subunit scanning through 5' untranslated regions of mRNAs; protein abundance increases in response to DNA replication stress
0.112 8.25E-11 YLR334C_d YLR334C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps a stand-alone long terminal repeat sequence whose presence indicates a retrotransposition event occurred here
0.108 3.98E-10 YKR009C FOX2 hom Multifunctional enzyme of the peroxisomal fatty acid beta-oxidation pathway; has 3-hydroxyacyl-CoA dehydrogenase and enoyl-CoA hydratase activities
0.098 1.13E-8 YDL164C CDC9 het DNA ligase found in the nucleus and mitochondria, an essential enzyme that joins Okazaki fragments during DNA replication; also acts in nucleotide excision repair, base excision repair, and recombination
0.095 3.63E-8 YKL163W PIR3 hom O-glycosylated covalently-bound cell wall protein; required for cell wall stability; expression is cell cycle regulated, peaking in M/G1 and also subject to regulation by the cell integrity pathway; PIR3 has a paralog, HSP150, that arose from the whole genome duplication
0.090 1.52E-7 YFR029W PTR3 het Component of the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p), which senses external amino acid concentration and transmits intracellular signals that result in regulation of expression of amino acid permease genes
0.088 3.04E-7 YNL285W_d YNL285W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.088 3.56E-7 YIL015W BAR1 hom Aspartyl protease secreted into the periplasmic space of mating type a cells, helps cells find mating partners, cleaves and inactivates alpha factor allowing cells to recover from alpha-factor-induced cell cycle arrest