YLR452C / SST2

GTPase-activating protein for Gpa1p, regulates desensitization to alpha factor pheromone; also required to prevent receptor-independent signaling of the mating pathway; member of the RGS (regulator of G-protein signaling) family

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR452C / SST2

Click on Significant Values for Screen Details ID:SGTC_65|Compound:0798-0905|FD-Score:-3.35|P-value:3.05E-4 ID:SGTC_125|Compound:0133-0007|FD-Score:3.64|P-value:9.73E-5 ID:SGTC_408|Compound:cantharidin|FD-Score:4.62|P-value:1.12E-6 ID:SGTC_441|Compound:propafenone|FD-Score:-3.37|P-value:2.81E-4 ID:SGTC_456|Compound:gingerol|FD-Score:3.10|P-value:7.61E-4 ID:SGTC_539|Compound:4859-0462|FD-Score:3.45|P-value:2.04E-4 ID:SGTC_587|Compound:k089-0003|FD-Score:-3.58|P-value:1.23E-4 ID:SGTC_653|Compound:0203-0016|FD-Score:4.32|P-value:4.83E-6 ID:SGTC_670|Compound:4204-0025|FD-Score:-3.18|P-value:5.64E-4 ID:SGTC_682|Compound:0kpi-0099|FD-Score:-5.01|P-value:1.45E-7 ID:SGTC_690|Compound:glyoxal|FD-Score:3.41|P-value:2.40E-4 ID:SGTC_757|Compound:1066-0008|FD-Score:-3.77|P-value:5.79E-5 ID:SGTC_897|Compound:1000-0139|FD-Score:-3.25|P-value:4.39E-4 ID:SGTC_991|Compound:3996-0057|FD-Score:3.81|P-value:4.84E-5 ID:SGTC_1318|Compound:1280-3875|FD-Score:-3.05|P-value:8.85E-4 ID:SGTC_1416|Compound:3966-0321|FD-Score:3.46|P-value:1.97E-4 ID:SGTC_1421|Compound:4029-0249|FD-Score:3.12|P-value:6.95E-4 ID:SGTC_1528|Compound:arabinosylhypoxanthine|FD-Score:-3.40|P-value:2.50E-4 ID:SGTC_1627|Compound:st003713|FD-Score:3.75|P-value:6.02E-5 ID:SGTC_1749|Compound:st037932|FD-Score:3.04|P-value:9.13E-4 ID:SGTC_1859|Compound:st055998|FD-Score:3.25|P-value:4.42E-4 ID:SGTC_1876|Compound:myriocin|FD-Score:-3.14|P-value:6.45E-4 ID:SGTC_1915|Compound:st067105|FD-Score:3.11|P-value:7.20E-4 ID:SGTC_1927|Compound:st060202|FD-Score:-3.58|P-value:1.22E-4 ID:SGTC_1961|Compound:st076550|FD-Score:4.00|P-value:2.07E-5 ID:SGTC_1969|Compound:st069479|FD-Score:4.00|P-value:2.09E-5 ID:SGTC_2019|Compound:4016004|FD-Score:3.03|P-value:9.69E-4 ID:SGTC_2082|Compound:5219693|FD-Score:3.18|P-value:5.61E-4 ID:SGTC_2188|Compound:6126565|FD-Score:-3.06|P-value:8.79E-4 ID:SGTC_2292|Compound:7671323|FD-Score:5.72|P-value:2.40E-9 ID:SGTC_2303|Compound:7774051|FD-Score:5.09|P-value:9.09E-8 ID:SGTC_2421|Compound:5690543|FD-Score:-3.39|P-value:2.55E-4 ID:SGTC_2429|Compound:5902844|FD-Score:3.02|P-value:9.95E-4 ID:SGTC_2433|Compound:5607874|FD-Score:4.75|P-value:5.71E-7 ID:SGTC_2435|Compound:5706476|FD-Score:6.41|P-value:2.64E-11 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:-3.35|P-value:3.00E-4 ID:SGTC_2552|Compound:juarezic acid|FD-Score:3.12|P-value:6.95E-4 ID:SGTC_2790|Compound:5423970|FD-Score:-3.05|P-value:8.96E-4 ID:SGTC_2807|Compound:7945238|FD-Score:-3.03|P-value:9.76E-4 ID:SGTC_2940|Compound:9060638|FD-Score:4.79|P-value:4.58E-7 ID:SGTC_2950|Compound:9072895|FD-Score:3.15|P-value:6.20E-4 ID:SGTC_2953|Compound:9074162|FD-Score:4.78|P-value:5.03E-7 ID:SGTC_2973|Compound:9094665|FD-Score:-3.24|P-value:4.50E-4 ID:SGTC_2997|Compound:9067075|FD-Score:6.22|P-value:9.30E-11 ID:SGTC_3093|Compound:9117344|FD-Score:3.06|P-value:8.76E-4 ID:SGTC_3311|Compound:9131146|FD-Score:-3.62|P-value:1.07E-4 ID:SGTC_3330|Compound:9141424|FD-Score:-3.21|P-value:5.08E-4 ID:SGTC_65|Compound:0798-0905|FD-Score:-3.35|P-value:3.05E-4 ID:SGTC_125|Compound:0133-0007|FD-Score:3.64|P-value:9.73E-5 ID:SGTC_408|Compound:cantharidin|FD-Score:4.62|P-value:1.12E-6 ID:SGTC_441|Compound:propafenone|FD-Score:-3.37|P-value:2.81E-4 ID:SGTC_456|Compound:gingerol|FD-Score:3.10|P-value:7.61E-4 ID:SGTC_539|Compound:4859-0462|FD-Score:3.45|P-value:2.04E-4 ID:SGTC_587|Compound:k089-0003|FD-Score:-3.58|P-value:1.23E-4 ID:SGTC_653|Compound:0203-0016|FD-Score:4.32|P-value:4.83E-6 ID:SGTC_670|Compound:4204-0025|FD-Score:-3.18|P-value:5.64E-4 ID:SGTC_682|Compound:0kpi-0099|FD-Score:-5.01|P-value:1.45E-7 ID:SGTC_690|Compound:glyoxal|FD-Score:3.41|P-value:2.40E-4 ID:SGTC_757|Compound:1066-0008|FD-Score:-3.77|P-value:5.79E-5 ID:SGTC_897|Compound:1000-0139|FD-Score:-3.25|P-value:4.39E-4 ID:SGTC_991|Compound:3996-0057|FD-Score:3.81|P-value:4.84E-5 ID:SGTC_1318|Compound:1280-3875|FD-Score:-3.05|P-value:8.85E-4 ID:SGTC_1416|Compound:3966-0321|FD-Score:3.46|P-value:1.97E-4 ID:SGTC_1421|Compound:4029-0249|FD-Score:3.12|P-value:6.95E-4 ID:SGTC_1528|Compound:arabinosylhypoxanthine|FD-Score:-3.40|P-value:2.50E-4 ID:SGTC_1627|Compound:st003713|FD-Score:3.75|P-value:6.02E-5 ID:SGTC_1749|Compound:st037932|FD-Score:3.04|P-value:9.13E-4 ID:SGTC_1859|Compound:st055998|FD-Score:3.25|P-value:4.42E-4 ID:SGTC_1876|Compound:myriocin|FD-Score:-3.14|P-value:6.45E-4 ID:SGTC_1915|Compound:st067105|FD-Score:3.11|P-value:7.20E-4 ID:SGTC_1927|Compound:st060202|FD-Score:-3.58|P-value:1.22E-4 ID:SGTC_1961|Compound:st076550|FD-Score:4.00|P-value:2.07E-5 ID:SGTC_1969|Compound:st069479|FD-Score:4.00|P-value:2.09E-5 ID:SGTC_2019|Compound:4016004|FD-Score:3.03|P-value:9.69E-4 ID:SGTC_2082|Compound:5219693|FD-Score:3.18|P-value:5.61E-4 ID:SGTC_2188|Compound:6126565|FD-Score:-3.06|P-value:8.79E-4 ID:SGTC_2292|Compound:7671323|FD-Score:5.72|P-value:2.40E-9 ID:SGTC_2303|Compound:7774051|FD-Score:5.09|P-value:9.09E-8 ID:SGTC_2421|Compound:5690543|FD-Score:-3.39|P-value:2.55E-4 ID:SGTC_2429|Compound:5902844|FD-Score:3.02|P-value:9.95E-4 ID:SGTC_2433|Compound:5607874|FD-Score:4.75|P-value:5.71E-7 ID:SGTC_2435|Compound:5706476|FD-Score:6.41|P-value:2.64E-11 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:-3.35|P-value:3.00E-4 ID:SGTC_2552|Compound:juarezic acid|FD-Score:3.12|P-value:6.95E-4 ID:SGTC_2790|Compound:5423970|FD-Score:-3.05|P-value:8.96E-4 ID:SGTC_2807|Compound:7945238|FD-Score:-3.03|P-value:9.76E-4 ID:SGTC_2940|Compound:9060638|FD-Score:4.79|P-value:4.58E-7 ID:SGTC_2950|Compound:9072895|FD-Score:3.15|P-value:6.20E-4 ID:SGTC_2953|Compound:9074162|FD-Score:4.78|P-value:5.03E-7 ID:SGTC_2973|Compound:9094665|FD-Score:-3.24|P-value:4.50E-4 ID:SGTC_2997|Compound:9067075|FD-Score:6.22|P-value:9.30E-11 ID:SGTC_3093|Compound:9117344|FD-Score:3.06|P-value:8.76E-4 ID:SGTC_3311|Compound:9131146|FD-Score:-3.62|P-value:1.07E-4 ID:SGTC_3330|Compound:9141424|FD-Score:-3.21|P-value:5.08E-4

Top fitness defect scores for YLR452C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2435 5706476 6.41 10.6 µM 2.64E-11 4 7.31E-11
2 SGTC_2997 9067075 6.22 71.4 µM 9.30E-11 unfolded protein response 16 2.44E-10
3 SGTC_2292 7671323 5.72 168.1 µM 2.40E-9 RNA processing & uracil transport 9 5.43E-9
4 SGTC_2303 7774051 5.09 200.0 µM 9.09E-8 9 1.75E-7
5 SGTC_2940 9060638 4.79 45.9 µM 4.58E-7 amide catabolism 8 8.19E-7
6 SGTC_2953 9074162 4.78 66.5 µM 5.03E-7 11 8.95E-7
7 SGTC_2433 5607874 4.75 27.8 µM 5.71E-7 8 1.01E-6
8 SGTC_408 cantharidin 4.62 100.0 µM 1.12E-6 cell wall signaling 12 1.92E-6
9 SGTC_653 0203-0016 4.32 55.2 µM 4.83E-6 8 7.77E-6
10 SGTC_1961 st076550 4.00 68.7 µM 2.07E-5 12 3.12E-5
11 SGTC_1969 st069479 4.00 40.1 µM 2.09E-5 11 3.15E-5
12 SGTC_991 3996-0057 3.81 64.7 µM 4.84E-5 22 7.04E-5
13 SGTC_1627 st003713 3.75 25.6 µM 6.02E-5 calcium & mitochondrial duress 86 8.67E-5
14 SGTC_125 0133-0007 3.64 11.8 µM 9.73E-5 DNA intercalators 17 1.37E-4
15 SGTC_1416 3966-0321 3.46 25.3 µM 1.97E-4 37 2.69E-4
16 SGTC_539 4859-0462 3.45 2.5 µM 2.04E-4 RNA pol III & RNase P/MRP 42 2.78E-4
17 SGTC_690 glyoxal 3.41 20.3 µM 2.40E-4 116 3.26E-4
18 SGTC_1859 st055998 3.25 20.0 µM 4.42E-4 48 5.83E-4
19 SGTC_2082 5219693 3.18 150.0 µM 5.61E-4 RNA processing & uracil transport 54 7.34E-4
20 SGTC_2950 9072895 3.15 21.5 µM 6.20E-4 85 8.07E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.129 7.24E-14 YHR078W_p YHR078W_p hom High osmolarity-regulated gene of unknown function
0.113 4.57E-11 YJL020C BBC1 hom Protein possibly involved in assembly of actin patches; interacts with an actin assembly factor Las17p and with the SH3 domains of Type I myosins Myo3p and Myo5p; localized predominantly to cortical actin patches
0.111 1.29E-10 YCL048W SPS22 hom Protein of unknown function; SPS22 has a paralog, SPS2, that arose from the whole genome duplication; redundant with Sps2p for the organization of the beta-glucan layer of the spore wall
0.110 1.55E-10 YBL073W_d YBL073W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the essential gene AAR2/YBL074C
0.110 1.69E-10 YNR011C PRP2 het RNA-dependent ATPase in the DEAH-box family, required for activation of the spliceosome before the first transesterification step in RNA splicing; orthologous to human protein DHX16
0.093 5.86E-8 YHR104W GRE3 hom Aldose reductase; involved in methylglyoxal, d-xylose, arabinose, and galactose metabolism; stress induced (osmotic, ionic, oxidative, heat shock, starvation and heavy metals); regulated by the HOG pathway; protein abundance increases in response to DNA replication stress
0.089 2.71E-7 YLR063W_p YLR063W_p hom Putative S-adenosylmethionine-dependent methyltransferase; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR063W is not an essential gene
0.088 3.60E-7 YDR247W VHS1 hom Cytoplasmic serine/threonine protein kinase; identified as a high-copy suppressor of the synthetic lethality of a sis2 sit4 double mutant, suggesting a role in G1/S phase progression; homolog of Sks1p
0.087 4.85E-7 YNL307C MCK1 hom Protein serine/threonine/tyrosine (dual-specificity) kinase; involved in control of chromosome segregation and in regulating entry into meiosis; interacts with Clb2p and Mih1p; inhibits Clb2p-Cdk1 activity; related to mammalian glycogen synthase kinases of the GSK-3 family
0.086 5.33E-7 YPR033C HTS1 het Cytoplasmic and mitochondrial histidine tRNA synthetase; efficient mitochondrial localization requires both a presequence and an amino-terminal sequence; mutations in human ortholog HARS2 are associated with Perrault syndrome
0.085 7.91E-7 YCR075C ERS1 hom Protein with similarity to human cystinosin, which is a H(+)-driven transporter involved in L-cystine export from lysosomes and implicated in the disease cystinosis; contains seven transmembrane domains
0.085 8.27E-7 YPL089C RLM1 hom MADS-box transcription factor; component of the protein kinase C-mediated MAP kinase pathway involved in the maintenance of cell integrity; phosphorylated and activated by the MAP-kinase Slt2p; RLM1 has a paralog, SMP1, that arose from the whole genome duplication
0.084 9.91E-7 YOL162W_p YOL162W_p hom Putative protein of unknown function; member of the Dal5p subfamily of the major facilitator family
0.083 1.50E-6 YKL112W ABF1 het DNA binding protein with possible chromatin-reorganizing activity involved in transcriptional activation, gene silencing, and DNA replication and repair
0.082 1.90E-6 YBR296C-A_p YBR296C-A_p hom Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching