YLR453C / RIF2

Protein that binds to the Rap1p C-terminus and acts synergistically with Rif1p to help control telomere length and establish telomeric silencing; deletion results in telomere elongation

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR453C / RIF2

Click on Significant Values for Screen Details ID:SGTC_35|Compound:0133-0054|FD-Score:3.03|P-value:8.10E-4 ID:SGTC_71|Compound:0417-1750|FD-Score:-3.12|P-value:5.66E-4 ID:SGTC_114|Compound:0364-0001|FD-Score:4.45|P-value:1.80E-6 ID:SGTC_158|Compound:k038-0087|FD-Score:5.06|P-value:6.72E-8 ID:SGTC_164|Compound:4100-3994|FD-Score:4.31|P-value:3.58E-6 ID:SGTC_183|Compound:3914-0051|FD-Score:3.42|P-value:1.86E-4 ID:SGTC_233|Compound:rapamycin|FD-Score:3.21|P-value:4.16E-4 ID:SGTC_294|Compound:k038-0071|FD-Score:2.98|P-value:9.42E-4 ID:SGTC_340|Compound:k038-0059|FD-Score:4.00|P-value:1.56E-5 ID:SGTC_358|Compound:0075-0058|FD-Score:3.13|P-value:5.51E-4 ID:SGTC_367|Compound:0335-0881|FD-Score:4.08|P-value:1.08E-5 ID:SGTC_381|Compound:3461-2219|FD-Score:3.51|P-value:1.26E-4 ID:SGTC_577|Compound:r071-0003|FD-Score:4.97|P-value:1.10E-7 ID:SGTC_586|Compound:0957-0265|FD-Score:-3.21|P-value:3.91E-4 ID:SGTC_767|Compound:0929-0023|FD-Score:3.90|P-value:2.46E-5 ID:SGTC_911|Compound:3456-4043|FD-Score:4.86|P-value:2.00E-7 ID:SGTC_912|Compound:3474-0017|FD-Score:4.49|P-value:1.45E-6 ID:SGTC_1047|Compound:2043-3044|FD-Score:3.93|P-value:2.13E-5 ID:SGTC_1136|Compound:pergolide|FD-Score:3.24|P-value:3.64E-4 ID:SGTC_1170|Compound:0310-0127|FD-Score:3.81|P-value:3.67E-5 ID:SGTC_1171|Compound:0368-0077|FD-Score:8.51|P-value:3.43E-19 ID:SGTC_1175|Compound:0741-0056|FD-Score:3.60|P-value:8.92E-5 ID:SGTC_1179|Compound:1021-1431|FD-Score:-3.34|P-value:2.38E-4 ID:SGTC_1187|Compound:1391-0724|FD-Score:4.09|P-value:1.02E-5 ID:SGTC_1274|Compound:0865-0114|FD-Score:3.03|P-value:8.05E-4 ID:SGTC_1320|Compound:1313-0481|FD-Score:4.44|P-value:1.83E-6 ID:SGTC_1436|Compound:4092-1007|FD-Score:3.84|P-value:3.10E-5 ID:SGTC_1441|Compound:4106-0040|FD-Score:4.93|P-value:1.35E-7 ID:SGTC_1445|Compound:4239-0156|FD-Score:-2.98|P-value:9.12E-4 ID:SGTC_1449|Compound:4112-4002|FD-Score:5.08|P-value:5.87E-8 ID:SGTC_1485|Compound:3909-9022|FD-Score:3.71|P-value:5.44E-5 ID:SGTC_1496|Compound:4469-0713|FD-Score:4.80|P-value:2.80E-7 ID:SGTC_1514|Compound:1189-1591|FD-Score:-3.54|P-value:1.06E-4 ID:SGTC_1578|Compound:josamycin|FD-Score:6.51|P-value:5.56E-12 ID:SGTC_1582|Compound:3',3',6'-trihydroxyflavone|FD-Score:5.86|P-value:5.08E-10 ID:SGTC_1592|Compound:4',5'-dihydroxyflavone|FD-Score:3.05|P-value:7.36E-4 ID:SGTC_1807|Compound:st050092|FD-Score:3.24|P-value:3.74E-4 ID:SGTC_1833|Compound:st055984|FD-Score:4.57|P-value:9.48E-7 ID:SGTC_1845|Compound:st056753|FD-Score:4.18|P-value:6.76E-6 ID:SGTC_1945|Compound:st075991|FD-Score:2.98|P-value:9.55E-4 ID:SGTC_2086|Compound:5274770|FD-Score:3.68|P-value:6.16E-5 ID:SGTC_2104|Compound:5389443|FD-Score:3.47|P-value:1.50E-4 ID:SGTC_2152|Compound:5568786|FD-Score:3.48|P-value:1.42E-4 ID:SGTC_2176|Compound:5809774|FD-Score:3.48|P-value:1.46E-4 ID:SGTC_2223|Compound:6903751|FD-Score:3.02|P-value:8.23E-4 ID:SGTC_2235|Compound:salicylic acid|FD-Score:3.99|P-value:1.59E-5 ID:SGTC_2307|Compound:7538926|FD-Score:3.64|P-value:7.42E-5 ID:SGTC_2364|Compound:9055074|FD-Score:4.79|P-value:3.04E-7 ID:SGTC_2396|Compound:5342950|FD-Score:3.57|P-value:1.01E-4 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:-3.18|P-value:4.41E-4 ID:SGTC_2442|Compound:5158906|FD-Score:-3.09|P-value:6.27E-4 ID:SGTC_2447|Compound:5741742|FD-Score:5.77|P-value:9.17E-10 ID:SGTC_2450|Compound:5739737|FD-Score:-3.66|P-value:6.61E-5 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:3.15|P-value:5.25E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:3.58|P-value:9.40E-5 ID:SGTC_2787|Compound:5284540|FD-Score:3.85|P-value:3.07E-5 ID:SGTC_2831|Compound:7999036|FD-Score:3.27|P-value:3.29E-4 ID:SGTC_2873|Compound:9040596|FD-Score:4.21|P-value:5.85E-6 ID:SGTC_2908|Compound:7930301|FD-Score:3.10|P-value:6.29E-4 ID:SGTC_2940|Compound:9060638|FD-Score:3.26|P-value:3.48E-4 ID:SGTC_2962|Compound:9082311|FD-Score:-3.56|P-value:9.90E-5 ID:SGTC_3047|Compound:9092122|FD-Score:3.99|P-value:1.61E-5 ID:SGTC_3136|Compound:9095672|FD-Score:3.42|P-value:1.82E-4 ID:SGTC_3180|Compound:9109287|FD-Score:4.13|P-value:8.41E-6 ID:SGTC_3217|Compound:9129673|FD-Score:5.37|P-value:1.11E-8 ID:SGTC_3339|Compound:9145883|FD-Score:4.66|P-value:5.92E-7 ID:SGTC_35|Compound:0133-0054|FD-Score:3.03|P-value:8.10E-4 ID:SGTC_71|Compound:0417-1750|FD-Score:-3.12|P-value:5.66E-4 ID:SGTC_114|Compound:0364-0001|FD-Score:4.45|P-value:1.80E-6 ID:SGTC_158|Compound:k038-0087|FD-Score:5.06|P-value:6.72E-8 ID:SGTC_164|Compound:4100-3994|FD-Score:4.31|P-value:3.58E-6 ID:SGTC_183|Compound:3914-0051|FD-Score:3.42|P-value:1.86E-4 ID:SGTC_233|Compound:rapamycin|FD-Score:3.21|P-value:4.16E-4 ID:SGTC_294|Compound:k038-0071|FD-Score:2.98|P-value:9.42E-4 ID:SGTC_340|Compound:k038-0059|FD-Score:4.00|P-value:1.56E-5 ID:SGTC_358|Compound:0075-0058|FD-Score:3.13|P-value:5.51E-4 ID:SGTC_367|Compound:0335-0881|FD-Score:4.08|P-value:1.08E-5 ID:SGTC_381|Compound:3461-2219|FD-Score:3.51|P-value:1.26E-4 ID:SGTC_577|Compound:r071-0003|FD-Score:4.97|P-value:1.10E-7 ID:SGTC_586|Compound:0957-0265|FD-Score:-3.21|P-value:3.91E-4 ID:SGTC_767|Compound:0929-0023|FD-Score:3.90|P-value:2.46E-5 ID:SGTC_911|Compound:3456-4043|FD-Score:4.86|P-value:2.00E-7 ID:SGTC_912|Compound:3474-0017|FD-Score:4.49|P-value:1.45E-6 ID:SGTC_1047|Compound:2043-3044|FD-Score:3.93|P-value:2.13E-5 ID:SGTC_1136|Compound:pergolide|FD-Score:3.24|P-value:3.64E-4 ID:SGTC_1170|Compound:0310-0127|FD-Score:3.81|P-value:3.67E-5 ID:SGTC_1171|Compound:0368-0077|FD-Score:8.51|P-value:3.43E-19 ID:SGTC_1175|Compound:0741-0056|FD-Score:3.60|P-value:8.92E-5 ID:SGTC_1179|Compound:1021-1431|FD-Score:-3.34|P-value:2.38E-4 ID:SGTC_1187|Compound:1391-0724|FD-Score:4.09|P-value:1.02E-5 ID:SGTC_1274|Compound:0865-0114|FD-Score:3.03|P-value:8.05E-4 ID:SGTC_1320|Compound:1313-0481|FD-Score:4.44|P-value:1.83E-6 ID:SGTC_1436|Compound:4092-1007|FD-Score:3.84|P-value:3.10E-5 ID:SGTC_1441|Compound:4106-0040|FD-Score:4.93|P-value:1.35E-7 ID:SGTC_1445|Compound:4239-0156|FD-Score:-2.98|P-value:9.12E-4 ID:SGTC_1449|Compound:4112-4002|FD-Score:5.08|P-value:5.87E-8 ID:SGTC_1485|Compound:3909-9022|FD-Score:3.71|P-value:5.44E-5 ID:SGTC_1496|Compound:4469-0713|FD-Score:4.80|P-value:2.80E-7 ID:SGTC_1514|Compound:1189-1591|FD-Score:-3.54|P-value:1.06E-4 ID:SGTC_1578|Compound:josamycin|FD-Score:6.51|P-value:5.56E-12 ID:SGTC_1582|Compound:3',3',6'-trihydroxyflavone|FD-Score:5.86|P-value:5.08E-10 ID:SGTC_1592|Compound:4',5'-dihydroxyflavone|FD-Score:3.05|P-value:7.36E-4 ID:SGTC_1807|Compound:st050092|FD-Score:3.24|P-value:3.74E-4 ID:SGTC_1833|Compound:st055984|FD-Score:4.57|P-value:9.48E-7 ID:SGTC_1845|Compound:st056753|FD-Score:4.18|P-value:6.76E-6 ID:SGTC_1945|Compound:st075991|FD-Score:2.98|P-value:9.55E-4 ID:SGTC_2086|Compound:5274770|FD-Score:3.68|P-value:6.16E-5 ID:SGTC_2104|Compound:5389443|FD-Score:3.47|P-value:1.50E-4 ID:SGTC_2152|Compound:5568786|FD-Score:3.48|P-value:1.42E-4 ID:SGTC_2176|Compound:5809774|FD-Score:3.48|P-value:1.46E-4 ID:SGTC_2223|Compound:6903751|FD-Score:3.02|P-value:8.23E-4 ID:SGTC_2235|Compound:salicylic acid|FD-Score:3.99|P-value:1.59E-5 ID:SGTC_2307|Compound:7538926|FD-Score:3.64|P-value:7.42E-5 ID:SGTC_2364|Compound:9055074|FD-Score:4.79|P-value:3.04E-7 ID:SGTC_2396|Compound:5342950|FD-Score:3.57|P-value:1.01E-4 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:-3.18|P-value:4.41E-4 ID:SGTC_2442|Compound:5158906|FD-Score:-3.09|P-value:6.27E-4 ID:SGTC_2447|Compound:5741742|FD-Score:5.77|P-value:9.17E-10 ID:SGTC_2450|Compound:5739737|FD-Score:-3.66|P-value:6.61E-5 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:3.15|P-value:5.25E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:3.58|P-value:9.40E-5 ID:SGTC_2787|Compound:5284540|FD-Score:3.85|P-value:3.07E-5 ID:SGTC_2831|Compound:7999036|FD-Score:3.27|P-value:3.29E-4 ID:SGTC_2873|Compound:9040596|FD-Score:4.21|P-value:5.85E-6 ID:SGTC_2908|Compound:7930301|FD-Score:3.10|P-value:6.29E-4 ID:SGTC_2940|Compound:9060638|FD-Score:3.26|P-value:3.48E-4 ID:SGTC_2962|Compound:9082311|FD-Score:-3.56|P-value:9.90E-5 ID:SGTC_3047|Compound:9092122|FD-Score:3.99|P-value:1.61E-5 ID:SGTC_3136|Compound:9095672|FD-Score:3.42|P-value:1.82E-4 ID:SGTC_3180|Compound:9109287|FD-Score:4.13|P-value:8.41E-6 ID:SGTC_3217|Compound:9129673|FD-Score:5.37|P-value:1.11E-8 ID:SGTC_3339|Compound:9145883|FD-Score:4.66|P-value:5.92E-7

Top fitness defect scores for YLR453C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1171 0368-0077 8.51 21.4 µM 3.43E-19 1 8.50E-18
2 SGTC_1578 josamycin 6.51 24.2 µM 5.56E-12 1 3.67E-11
3 SGTC_1582 3',3',6'-trihydroxyflavone 5.86 74.0 µM 5.08E-10 3 2.35E-9
4 SGTC_2447 5741742 5.77 33.8 µM 9.17E-10 5 4.04E-9
5 SGTC_3217 9129673 5.37 49.5 µM 1.11E-8 7 4.03E-8
6 SGTC_1449 4112-4002 5.08 201.0 µM 5.87E-8 RPP1 & pyrimidine depletion 9 1.87E-7
7 SGTC_158 k038-0087 5.06 26.4 µM 6.72E-8 ubiquinone biosynthesis & proteasome 88 2.12E-7
8 SGTC_577 r071-0003 4.97 38.6 µM 1.10E-7 fatty acid desaturase (OLE1) 25 3.34E-7
9 SGTC_1441 4106-0040 4.93 13.0 µM 1.35E-7 1 4.03E-7
10 SGTC_911 3456-4043 4.86 236.0 µM 2.00E-7 mitochondrial processes 12 5.77E-7
11 SGTC_1496 4469-0713 4.80 57.4 µM 2.80E-7 12 7.88E-7
12 SGTC_2364 9055074 4.79 200.0 µM 3.04E-7 9 8.49E-7
13 SGTC_3339 9145883 4.66 14.9 µM 5.92E-7 6 1.57E-6
14 SGTC_1833 st055984 4.57 71.0 µM 9.48E-7 9 2.43E-6
15 SGTC_912 3474-0017 4.49 2.2 µM 1.45E-6 14 3.59E-6
16 SGTC_114 0364-0001 4.45 490.3 µM 1.80E-6 31 4.38E-6
17 SGTC_1320 1313-0481 4.44 95.3 µM 1.83E-6 16 4.45E-6
18 SGTC_164 4100-3994 4.31 89.6 µM 3.58E-6 20 8.26E-6
19 SGTC_2873 9040596 4.21 71.4 µM 5.85E-6 39 1.30E-5
20 SGTC_1845 st056753 4.18 3.0 µM 6.76E-6 TSC3-RPN4 30 1.49E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.115 2.27E-11 YLR378C SEC61 het Essential subunit of Sec61 complex (Sec61p, Sbh1p, and Sss1p); forms a channel for SRP-dependent protein import and retrograde transport of misfolded proteins out of the ER; with Sec63 complex allows SRP-independent protein import into ER
0.096 2.78E-8 YGR255C COQ6 hom Putative flavin-dependent monooxygenase; involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes; human COX6 can rescue a yeast cox6 mutant and is implicated in steroid-resistant nephrotic syndrome (SRNS)
0.089 2.41E-7 YLR387C REH1 hom Cytoplasmic 60S subunit biogenesis factor, associates with pre-60S particles; similar to Rei1p and shares partially redundant function in cytoplasmic 60S subunit maturation; contains dispersed C2H2 zinc finger domains
0.088 3.30E-7 YBR137W YBR137W hom Protein of unknown function; localized to the cytoplasm; binds to Replication Protein A (RPA); also interacts with Sgt2p; YBR137W is not an essential gene
0.087 4.12E-7 YML034C-A_d YML034C-A_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.087 5.07E-7 YMR110C HFD1 hom Hexadecenal dehydrogenase; involved in the conversion of sphingosine 1-phosphate breakdown product hexadecenal to hexadecenoic acid; located in the mitochondrial outer membrane and also in lipid particles; has similarity to ALDH3A2, a human fatty aldehyde dehydrogenase (FALDH) mutated in Sjogren-Larsson syndrome, a neurocutaneous disorder
0.086 6.50E-7 YBR275C RIF1 hom Protein that binds to the Rap1p C-terminus and acts synergistically with Rif2p to help control telomere length and establish telomeric silencing; deletion results in telomere elongation
0.084 9.76E-7 YDR154C_d YDR154C_d hom Dubious open reading frame, null mutant exhibits synthetic phenotype with alpha-synuclein
0.084 1.16E-6 YOR245C DGA1 hom Diacylglycerol acyltransferase, catalyzes the terminal step of triacylglycerol (TAG) formation, acylates diacylglycerol using acyl-CoA as an acyl donor, localized to lipid particles
0.082 2.18E-6 YNR042W_d YNR042W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene COQ2
0.081 2.60E-6 YJL037W IRC18 hom Putative protein of unknown function; expression induced in respiratory-deficient cells and in carbon-limited chemostat cultures; similar to adjacent ORF, YJL038C; null mutant displays increased levels of spontaneous Rad52p foci
0.081 2.71E-6 YGL209W MIG2 hom Zinc finger transcriptional repressor; cooperates with Mig1p in glucose-induced repression of many genes; under low glucose conditions Mig2p relocalizes to mitochondrion, where it interacts with Ups1p and antagonizes mitochondrial fission factor, Dnm1p, indicative of a role in mitochondrial fusion or regulating morphology; regulates filamentous growth along with Mig2p in response to glucose depletion; MIG2 has a paralog, MIG3, that arose from the whole genome duplication
0.080 3.35E-6 YMR156C TPP1 hom DNA 3'-phosphatase; functions in repair of endogenous damage of double-stranded DNA, activity is specific for removal of 3' phosphates at strand breaks; similar to the l-2-haloacid dehalogenase superfamily; homolog of human polynucleotide kinase/3′-phosphatase
0.080 3.74E-6 YNR041C COQ2 hom Para hydroxybenzoate: polyprenyl transferase, catalyzes the second step in ubiquinone (coenzyme Q) biosynthesis
0.079 4.30E-6 YOL151W GRE2 hom 3-methylbutanal reductase and NADPH-dependent methylglyoxal reductase (D-lactaldehyde dehydrogenase); stress induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway; protein abundance increases in response to DNA replication stress