YLR454W_p / FMP27

Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR454W / FMP27

Click on Significant Values for Screen Details ID:SGTC_183|Compound:3914-0051|FD-Score:-3.32|P-value:2.58E-4 ID:SGTC_348|Compound:k064-0012|FD-Score:3.37|P-value:2.16E-4 ID:SGTC_574|Compound:1315-0397|FD-Score:4.64|P-value:6.51E-7 ID:SGTC_575|Compound:k072-0246|FD-Score:-3.20|P-value:4.18E-4 ID:SGTC_578|Compound:3460-0051|FD-Score:5.21|P-value:2.73E-8 ID:SGTC_585|Compound:0kpi-0023|FD-Score:4.22|P-value:5.24E-6 ID:SGTC_664|Compound:1222-0054|FD-Score:3.67|P-value:6.50E-5 ID:SGTC_715|Compound:0868-0130|FD-Score:3.29|P-value:3.00E-4 ID:SGTC_814|Compound:3342-0569|FD-Score:2.98|P-value:9.19E-4 ID:SGTC_817|Compound:1391-0715|FD-Score:5.29|P-value:1.65E-8 ID:SGTC_818|Compound:4072-2707|FD-Score:3.07|P-value:6.66E-4 ID:SGTC_922|Compound:1866-0035|FD-Score:3.53|P-value:1.16E-4 ID:SGTC_944|Compound:3370-0224|FD-Score:3.00|P-value:8.69E-4 ID:SGTC_980|Compound:1473-0395|FD-Score:5.29|P-value:1.63E-8 ID:SGTC_984|Compound:1492-0255|FD-Score:3.08|P-value:6.50E-4 ID:SGTC_1044|Compound:1222-0021|FD-Score:3.07|P-value:6.75E-4 ID:SGTC_1064|Compound:honokiol|FD-Score:3.76|P-value:4.40E-5 ID:SGTC_1074|Compound:carmofur|FD-Score:4.14|P-value:7.89E-6 ID:SGTC_1080|Compound:nisoldipine|FD-Score:-3.30|P-value:2.82E-4 ID:SGTC_1134|Compound:3477-0009|FD-Score:3.97|P-value:1.69E-5 ID:SGTC_1168|Compound:k815-0004|FD-Score:4.78|P-value:2.96E-7 ID:SGTC_1209|Compound:2323-2347|FD-Score:3.59|P-value:8.78E-5 ID:SGTC_1218|Compound:1348-1416|FD-Score:5.38|P-value:9.64E-9 ID:SGTC_1309|Compound:pyrazolanthrone|FD-Score:3.78|P-value:4.02E-5 ID:SGTC_1347|Compound:1493-0251|FD-Score:3.90|P-value:2.36E-5 ID:SGTC_1577|Compound:3(2'-chlorophenyl)-7-ethoxycoumarin|FD-Score:4.00|P-value:1.47E-5 ID:SGTC_1606|Compound:st000094|FD-Score:3.30|P-value:2.87E-4 ID:SGTC_1652|Compound:st011932|FD-Score:3.01|P-value:8.46E-4 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:4.74|P-value:3.68E-7 ID:SGTC_1725|Compound:st036284|FD-Score:5.73|P-value:1.13E-9 ID:SGTC_1731|Compound:st035964|FD-Score:3.34|P-value:2.46E-4 ID:SGTC_1735|Compound:st034310|FD-Score:3.69|P-value:5.89E-5 ID:SGTC_1753|Compound:st043925|FD-Score:3.98|P-value:1.61E-5 ID:SGTC_1773|Compound:st048542|FD-Score:2.97|P-value:9.69E-4 ID:SGTC_1810|Compound:st050138|FD-Score:3.37|P-value:2.18E-4 ID:SGTC_1863|Compound:st057641|FD-Score:3.80|P-value:3.58E-5 ID:SGTC_2038|Compound:4100038|FD-Score:3.94|P-value:1.94E-5 ID:SGTC_2292|Compound:7671323|FD-Score:6.47|P-value:6.92E-12 ID:SGTC_2299|Compound:7976368|FD-Score:3.89|P-value:2.48E-5 ID:SGTC_2308|Compound:7584454|FD-Score:3.08|P-value:6.44E-4 ID:SGTC_2411|Compound:st077133|FD-Score:-3.01|P-value:8.23E-4 ID:SGTC_2471|Compound:5466956|FD-Score:4.04|P-value:1.22E-5 ID:SGTC_2472|Compound:5377652|FD-Score:3.76|P-value:4.39E-5 ID:SGTC_2473|Compound:5854593|FD-Score:-3.30|P-value:2.81E-4 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:-3.86|P-value:2.76E-5 ID:SGTC_2569|Compound:tetrandrine|FD-Score:4.32|P-value:3.26E-6 ID:SGTC_2575|Compound:plumbagin|FD-Score:3.03|P-value:7.89E-4 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:-3.21|P-value:3.92E-4 ID:SGTC_2581|Compound:avocatin a|FD-Score:4.73|P-value:3.85E-7 ID:SGTC_2594|Compound:a-mangostin|FD-Score:-5.73|P-value:1.09E-9 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:3.49|P-value:1.35E-4 ID:SGTC_2602|Compound:kawain|FD-Score:-6.74|P-value:9.70E-13 ID:SGTC_2622|Compound:2-methoxyxanthone|FD-Score:5.24|P-value:2.20E-8 ID:SGTC_2624|Compound:nerol|FD-Score:3.21|P-value:4.03E-4 ID:SGTC_2666|Compound:tannic acid|FD-Score:3.51|P-value:1.24E-4 ID:SGTC_2723|Compound:salbutamol|FD-Score:4.28|P-value:4.01E-6 ID:SGTC_2752|Compound:diclazuril|FD-Score:4.53|P-value:1.14E-6 ID:SGTC_2821|Compound:7996764|FD-Score:3.61|P-value:8.20E-5 ID:SGTC_2865|Compound:9030313|FD-Score:3.12|P-value:5.74E-4 ID:SGTC_2868|Compound:9035608|FD-Score:3.92|P-value:2.18E-5 ID:SGTC_2934|Compound:9036370|FD-Score:3.08|P-value:6.53E-4 ID:SGTC_3074|Compound:9116018|FD-Score:3.10|P-value:6.06E-4 ID:SGTC_3093|Compound:9117344|FD-Score:4.19|P-value:6.22E-6 ID:SGTC_3096|Compound:9117468|FD-Score:3.36|P-value:2.24E-4 ID:SGTC_3103|Compound:9120822|FD-Score:3.94|P-value:1.98E-5 ID:SGTC_3108|Compound:9121785|FD-Score:4.43|P-value:1.86E-6 ID:SGTC_3109|Compound:9122853|FD-Score:3.87|P-value:2.62E-5 ID:SGTC_3112|Compound:9123419|FD-Score:-3.56|P-value:1.02E-4 ID:SGTC_3135|Compound:9127742|FD-Score:-3.19|P-value:4.31E-4 ID:SGTC_3143|Compound:9086658|FD-Score:6.37|P-value:1.42E-11 ID:SGTC_3149|Compound:9097855|FD-Score:3.30|P-value:2.91E-4 ID:SGTC_3182|Compound:9108849|FD-Score:2.99|P-value:8.95E-4 ID:SGTC_3189|Compound:9110682|FD-Score:3.69|P-value:5.80E-5 ID:SGTC_3198|Compound:9112019|FD-Score:-3.26|P-value:3.29E-4 ID:SGTC_183|Compound:3914-0051|FD-Score:-3.32|P-value:2.58E-4 ID:SGTC_348|Compound:k064-0012|FD-Score:3.37|P-value:2.16E-4 ID:SGTC_574|Compound:1315-0397|FD-Score:4.64|P-value:6.51E-7 ID:SGTC_575|Compound:k072-0246|FD-Score:-3.20|P-value:4.18E-4 ID:SGTC_578|Compound:3460-0051|FD-Score:5.21|P-value:2.73E-8 ID:SGTC_585|Compound:0kpi-0023|FD-Score:4.22|P-value:5.24E-6 ID:SGTC_664|Compound:1222-0054|FD-Score:3.67|P-value:6.50E-5 ID:SGTC_715|Compound:0868-0130|FD-Score:3.29|P-value:3.00E-4 ID:SGTC_814|Compound:3342-0569|FD-Score:2.98|P-value:9.19E-4 ID:SGTC_817|Compound:1391-0715|FD-Score:5.29|P-value:1.65E-8 ID:SGTC_818|Compound:4072-2707|FD-Score:3.07|P-value:6.66E-4 ID:SGTC_922|Compound:1866-0035|FD-Score:3.53|P-value:1.16E-4 ID:SGTC_944|Compound:3370-0224|FD-Score:3.00|P-value:8.69E-4 ID:SGTC_980|Compound:1473-0395|FD-Score:5.29|P-value:1.63E-8 ID:SGTC_984|Compound:1492-0255|FD-Score:3.08|P-value:6.50E-4 ID:SGTC_1044|Compound:1222-0021|FD-Score:3.07|P-value:6.75E-4 ID:SGTC_1064|Compound:honokiol|FD-Score:3.76|P-value:4.40E-5 ID:SGTC_1074|Compound:carmofur|FD-Score:4.14|P-value:7.89E-6 ID:SGTC_1080|Compound:nisoldipine|FD-Score:-3.30|P-value:2.82E-4 ID:SGTC_1134|Compound:3477-0009|FD-Score:3.97|P-value:1.69E-5 ID:SGTC_1168|Compound:k815-0004|FD-Score:4.78|P-value:2.96E-7 ID:SGTC_1209|Compound:2323-2347|FD-Score:3.59|P-value:8.78E-5 ID:SGTC_1218|Compound:1348-1416|FD-Score:5.38|P-value:9.64E-9 ID:SGTC_1309|Compound:pyrazolanthrone|FD-Score:3.78|P-value:4.02E-5 ID:SGTC_1347|Compound:1493-0251|FD-Score:3.90|P-value:2.36E-5 ID:SGTC_1577|Compound:3(2'-chlorophenyl)-7-ethoxycoumarin|FD-Score:4.00|P-value:1.47E-5 ID:SGTC_1606|Compound:st000094|FD-Score:3.30|P-value:2.87E-4 ID:SGTC_1652|Compound:st011932|FD-Score:3.01|P-value:8.46E-4 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:4.74|P-value:3.68E-7 ID:SGTC_1725|Compound:st036284|FD-Score:5.73|P-value:1.13E-9 ID:SGTC_1731|Compound:st035964|FD-Score:3.34|P-value:2.46E-4 ID:SGTC_1735|Compound:st034310|FD-Score:3.69|P-value:5.89E-5 ID:SGTC_1753|Compound:st043925|FD-Score:3.98|P-value:1.61E-5 ID:SGTC_1773|Compound:st048542|FD-Score:2.97|P-value:9.69E-4 ID:SGTC_1810|Compound:st050138|FD-Score:3.37|P-value:2.18E-4 ID:SGTC_1863|Compound:st057641|FD-Score:3.80|P-value:3.58E-5 ID:SGTC_2038|Compound:4100038|FD-Score:3.94|P-value:1.94E-5 ID:SGTC_2292|Compound:7671323|FD-Score:6.47|P-value:6.92E-12 ID:SGTC_2299|Compound:7976368|FD-Score:3.89|P-value:2.48E-5 ID:SGTC_2308|Compound:7584454|FD-Score:3.08|P-value:6.44E-4 ID:SGTC_2411|Compound:st077133|FD-Score:-3.01|P-value:8.23E-4 ID:SGTC_2471|Compound:5466956|FD-Score:4.04|P-value:1.22E-5 ID:SGTC_2472|Compound:5377652|FD-Score:3.76|P-value:4.39E-5 ID:SGTC_2473|Compound:5854593|FD-Score:-3.30|P-value:2.81E-4 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:-3.86|P-value:2.76E-5 ID:SGTC_2569|Compound:tetrandrine|FD-Score:4.32|P-value:3.26E-6 ID:SGTC_2575|Compound:plumbagin|FD-Score:3.03|P-value:7.89E-4 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:-3.21|P-value:3.92E-4 ID:SGTC_2581|Compound:avocatin a|FD-Score:4.73|P-value:3.85E-7 ID:SGTC_2594|Compound:a-mangostin|FD-Score:-5.73|P-value:1.09E-9 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:3.49|P-value:1.35E-4 ID:SGTC_2602|Compound:kawain|FD-Score:-6.74|P-value:9.70E-13 ID:SGTC_2622|Compound:2-methoxyxanthone|FD-Score:5.24|P-value:2.20E-8 ID:SGTC_2624|Compound:nerol|FD-Score:3.21|P-value:4.03E-4 ID:SGTC_2666|Compound:tannic acid|FD-Score:3.51|P-value:1.24E-4 ID:SGTC_2723|Compound:salbutamol|FD-Score:4.28|P-value:4.01E-6 ID:SGTC_2752|Compound:diclazuril|FD-Score:4.53|P-value:1.14E-6 ID:SGTC_2821|Compound:7996764|FD-Score:3.61|P-value:8.20E-5 ID:SGTC_2865|Compound:9030313|FD-Score:3.12|P-value:5.74E-4 ID:SGTC_2868|Compound:9035608|FD-Score:3.92|P-value:2.18E-5 ID:SGTC_2934|Compound:9036370|FD-Score:3.08|P-value:6.53E-4 ID:SGTC_3074|Compound:9116018|FD-Score:3.10|P-value:6.06E-4 ID:SGTC_3093|Compound:9117344|FD-Score:4.19|P-value:6.22E-6 ID:SGTC_3096|Compound:9117468|FD-Score:3.36|P-value:2.24E-4 ID:SGTC_3103|Compound:9120822|FD-Score:3.94|P-value:1.98E-5 ID:SGTC_3108|Compound:9121785|FD-Score:4.43|P-value:1.86E-6 ID:SGTC_3109|Compound:9122853|FD-Score:3.87|P-value:2.62E-5 ID:SGTC_3112|Compound:9123419|FD-Score:-3.56|P-value:1.02E-4 ID:SGTC_3135|Compound:9127742|FD-Score:-3.19|P-value:4.31E-4 ID:SGTC_3143|Compound:9086658|FD-Score:6.37|P-value:1.42E-11 ID:SGTC_3149|Compound:9097855|FD-Score:3.30|P-value:2.91E-4 ID:SGTC_3182|Compound:9108849|FD-Score:2.99|P-value:8.95E-4 ID:SGTC_3189|Compound:9110682|FD-Score:3.69|P-value:5.80E-5 ID:SGTC_3198|Compound:9112019|FD-Score:-3.26|P-value:3.29E-4

Top fitness defect scores for YLR454W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2292 7671323 6.47 168.1 µM 6.92E-12 RNA processing & uracil transport 5 4.75E-11
2 SGTC_3143 9086658 6.37 49.5 µM 1.42E-11 8 9.20E-11
3 SGTC_1725 st036284 5.73 20.6 µM 1.13E-9 7 5.15E-9
4 SGTC_1218 1348-1416 5.38 30.7 µM 9.64E-9 SWF1 & branched chain AA biosynthesis 4 3.68E-8
5 SGTC_980 1473-0395 5.29 201.0 µM 1.63E-8 2 5.99E-8
6 SGTC_817 1391-0715 5.29 46.0 µM 1.65E-8 3 6.04E-8
7 SGTC_2622 2-methoxyxanthone 5.24 59.9 µM 2.20E-8 7 7.87E-8
8 SGTC_578 3460-0051 5.21 92.0 µM 2.73E-8 2 9.59E-8
9 SGTC_1168 k815-0004 4.78 80.5 µM 2.96E-7 DNA damage response 6 8.61E-7
10 SGTC_1680 diphenhydramine 4.74 100.0 µM 3.68E-7 NEO1 16 1.05E-6
11 SGTC_2581 avocatin a 4.73 64.0 µM 3.85E-7 sphingolipid biosynthesis & PDR1 38 1.10E-6
12 SGTC_574 1315-0397 4.64 40.0 µM 6.51E-7 21 1.78E-6
13 SGTC_2752 diclazuril 4.53 33.1 µM 1.14E-6 92 2.97E-6
14 SGTC_3108 9121785 4.43 49.5 µM 1.86E-6 4 4.66E-6
15 SGTC_2569 tetrandrine 4.32 100.0 µM 3.26E-6 14 7.82E-6
16 SGTC_2723 salbutamol 4.28 83.6 µM 4.01E-6 7 9.47E-6
17 SGTC_585 0kpi-0023 4.22 191.0 µM 5.24E-6 15 1.21E-5
18 SGTC_3093 9117344 4.19 49.5 µM 6.22E-6 60S ribosome export 12 1.42E-5
19 SGTC_1074 carmofur 4.14 3.8 µM 7.89E-6 exosome 17 1.77E-5
20 SGTC_2471 5466956 4.04 24.8 µM 1.22E-5 mitochondrial processes 10 2.65E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.101 5.14E-9 YBR265W TSC10 het 3-ketosphinganine reductase, catalyzes the second step in phytosphingosine synthesis, essential for growth in the absence of exogenous dihydrosphingosine or phytosphingosine, member of short chain dehydrogenase/reductase protein family
0.097 1.60E-8 YLR236C_d YLR236C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.096 2.44E-8 YOR353C SOG2 het Key component of the RAM signaling network, required for proper cell morphogenesis and cell separation after mitosis
0.092 8.65E-8 YIL132C CSM2 hom Component of the Shu complex, which promotes error-free DNA repair; Shu complex mediates inhibition of Srs2p function; structural analysis reveals a similar DNA-binding region in both Psy3p and Csm2p and that both regions work together to form a single DNA binding site; required for accurate chromosome segregation during meiosis
0.091 1.29E-7 YGL215W CLG1 hom Cyclin-like protein that interacts with Pho85p; has sequence similarity to G1 cyclins PCL1 and PCL2
0.087 4.30E-7 YPR008W HAA1 hom Transcriptional activator involved in adaptation to weak acid stress; activates transcription of TPO2, YRO2, and other genes encoding membrane stress proteins; HAA1 has a paralog, CUP2, that arose from the whole genome duplication; relocalizes from cytoplasm to nucleus upon DNA replication stress
0.086 5.94E-7 YMR305C SCW10 hom Cell wall protein with similarity to glucanases; may play a role in conjugation during mating based on mutant phenotype and its regulation by Ste12p
0.086 6.39E-7 YNL332W THI12 hom Protein involved in synthesis of the thiamine precursor hydroxymethylpyrimidine (HMP); member of a subtelomeric gene family including THI5, THI11, THI12, and THI13
0.085 8.09E-7 YHR193C EGD2 hom Alpha subunit of the heteromeric nascent polypeptide-associated complex (NAC) involved in protein sorting and translocation, associated with cytoplasmic ribosomes
0.084 1.12E-6 YKL021C MAK11 het Protein involved in an early, nucleolar step of 60S ribosomal subunit biogenesis; essential for cell growth and replication of killer M1 dsRNA virus; contains four beta-transducin repeats
0.084 1.22E-6 YMR145C NDE1 hom Mitochondrial external NADH dehydrogenase, a type II NAD(P)H:quinone oxidoreductase that catalyzes the oxidation of cytosolic NADH; Nde1p and Nde2p provide cytosolic NADH to the mitochondrial respiratory chain
0.080 3.15E-6 YDR051C DET1 hom Acid phosphatase involved in the non-vesicular transport of sterols in both directions between the endoplasmic reticulum and plasma membrane; deletion confers sensitivity to nickel
0.079 4.87E-6 YKR094C RPL40B hom Ubiquitin-ribosomal 60S subunit protein L40B fusion protein; cleaved to yield ubiquitin and ribosomal protein L40B; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes; homologous to mammalian ribosomal protein L40, no bacterial homolog; RPL40B has a paralog, RPL40A, that arose from the whole genome duplication
0.072 3.02E-5 YOR382W FIT2 hom Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall
0.071 4.08E-5 YJR019C TES1 hom Peroxisomal acyl-CoA thioesterase likely to be involved in fatty acid oxidation rather than fatty acid synthesis; conserved protein also found in human peroxisomes; TES1 mRNA levels increase during growth on fatty acids