YLR457C / NBP1

Spindle pole body (SPB) component; required for the insertion of the duplication plaque into the nuclear membrane during SPB duplication; essential for bipolar spindle formation; component of the Mps2p-Bbp1p complex; NBP1 has a paralog, YPR174C, that arose from the whole genome duplication

Zygosity: Heterozygous strain
fixedexpanded
Profile for YLR457C / NBP1

Click on Significant Values for Screen Details ID:SGTC_341|Compound:1486-1430|FD-Score:4.92|P-value:1.58E-7 ID:SGTC_535|Compound:2293-4129|FD-Score:3.98|P-value:1.73E-5 ID:SGTC_602|Compound:3130-1533|FD-Score:-3.17|P-value:5.08E-4 ID:SGTC_945|Compound:3381-0768|FD-Score:-3.19|P-value:4.65E-4 ID:SGTC_1051|Compound:3253-3903|FD-Score:-3.94|P-value:2.18E-5 ID:SGTC_1195|Compound:1502-0147|FD-Score:4.35|P-value:3.00E-6 ID:SGTC_1218|Compound:1348-1416|FD-Score:3.05|P-value:7.50E-4 ID:SGTC_1225|Compound:1216-0074|FD-Score:4.25|P-value:4.95E-6 ID:SGTC_1231|Compound:0242-0792|FD-Score:-3.16|P-value:5.15E-4 ID:SGTC_1234|Compound:0326-0494|FD-Score:3.20|P-value:4.41E-4 ID:SGTC_1262|Compound:0737-0114|FD-Score:3.63|P-value:8.02E-5 ID:SGTC_1265|Compound:0819-1001|FD-Score:3.30|P-value:3.04E-4 ID:SGTC_1268|Compound:0828-0275|FD-Score:3.36|P-value:2.39E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-5.32|P-value:1.64E-8 ID:SGTC_1463|Compound:k081-0032|FD-Score:-6.34|P-value:2.31E-11 ID:SGTC_1501|Compound:4491-0275|FD-Score:3.22|P-value:4.02E-4 ID:SGTC_1708|Compound:st033234|FD-Score:3.14|P-value:5.39E-4 ID:SGTC_1721|Compound:st082152|FD-Score:-3.49|P-value:1.43E-4 ID:SGTC_1960|Compound:st011366|FD-Score:3.48|P-value:1.47E-4 ID:SGTC_1963|Compound:st076565|FD-Score:3.07|P-value:7.01E-4 ID:SGTC_1967|Compound:st070177|FD-Score:4.34|P-value:3.13E-6 ID:SGTC_1975|Compound:st070967|FD-Score:4.08|P-value:1.12E-5 ID:SGTC_1990|Compound:st072050|FD-Score:3.32|P-value:2.76E-4 ID:SGTC_2018|Compound:5133068|FD-Score:3.45|P-value:1.66E-4 ID:SGTC_2084|Compound:5306078|FD-Score:-3.30|P-value:3.13E-4 ID:SGTC_2089|Compound:5281248|FD-Score:-3.17|P-value:5.05E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:-3.19|P-value:4.71E-4 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:6.29|P-value:3.13E-11 ID:SGTC_2622|Compound:2-methoxyxanthone|FD-Score:3.46|P-value:1.59E-4 ID:SGTC_3109|Compound:9122853|FD-Score:3.01|P-value:8.86E-4 ID:SGTC_3127|Compound:9126946|FD-Score:-3.11|P-value:6.19E-4 ID:SGTC_3133|Compound:9127736|FD-Score:-3.51|P-value:1.33E-4 ID:SGTC_3208|Compound:9114115|FD-Score:-6.08|P-value:1.35E-10 ID:SGTC_3324|Compound:9138759|FD-Score:3.67|P-value:6.65E-5 ID:SGTC_3331|Compound:9141060|FD-Score:4.17|P-value:7.19E-6 ID:SGTC_3332|Compound:9141069|FD-Score:4.74|P-value:4.09E-7 ID:SGTC_3333|Compound:9141820|FD-Score:4.53|P-value:1.26E-6 ID:SGTC_341|Compound:1486-1430|FD-Score:4.92|P-value:1.58E-7 ID:SGTC_535|Compound:2293-4129|FD-Score:3.98|P-value:1.73E-5 ID:SGTC_602|Compound:3130-1533|FD-Score:-3.17|P-value:5.08E-4 ID:SGTC_945|Compound:3381-0768|FD-Score:-3.19|P-value:4.65E-4 ID:SGTC_1051|Compound:3253-3903|FD-Score:-3.94|P-value:2.18E-5 ID:SGTC_1195|Compound:1502-0147|FD-Score:4.35|P-value:3.00E-6 ID:SGTC_1218|Compound:1348-1416|FD-Score:3.05|P-value:7.50E-4 ID:SGTC_1225|Compound:1216-0074|FD-Score:4.25|P-value:4.95E-6 ID:SGTC_1231|Compound:0242-0792|FD-Score:-3.16|P-value:5.15E-4 ID:SGTC_1234|Compound:0326-0494|FD-Score:3.20|P-value:4.41E-4 ID:SGTC_1262|Compound:0737-0114|FD-Score:3.63|P-value:8.02E-5 ID:SGTC_1265|Compound:0819-1001|FD-Score:3.30|P-value:3.04E-4 ID:SGTC_1268|Compound:0828-0275|FD-Score:3.36|P-value:2.39E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-5.32|P-value:1.64E-8 ID:SGTC_1463|Compound:k081-0032|FD-Score:-6.34|P-value:2.31E-11 ID:SGTC_1501|Compound:4491-0275|FD-Score:3.22|P-value:4.02E-4 ID:SGTC_1708|Compound:st033234|FD-Score:3.14|P-value:5.39E-4 ID:SGTC_1721|Compound:st082152|FD-Score:-3.49|P-value:1.43E-4 ID:SGTC_1960|Compound:st011366|FD-Score:3.48|P-value:1.47E-4 ID:SGTC_1963|Compound:st076565|FD-Score:3.07|P-value:7.01E-4 ID:SGTC_1967|Compound:st070177|FD-Score:4.34|P-value:3.13E-6 ID:SGTC_1975|Compound:st070967|FD-Score:4.08|P-value:1.12E-5 ID:SGTC_1990|Compound:st072050|FD-Score:3.32|P-value:2.76E-4 ID:SGTC_2018|Compound:5133068|FD-Score:3.45|P-value:1.66E-4 ID:SGTC_2084|Compound:5306078|FD-Score:-3.30|P-value:3.13E-4 ID:SGTC_2089|Compound:5281248|FD-Score:-3.17|P-value:5.05E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:-3.19|P-value:4.71E-4 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:6.29|P-value:3.13E-11 ID:SGTC_2622|Compound:2-methoxyxanthone|FD-Score:3.46|P-value:1.59E-4 ID:SGTC_3109|Compound:9122853|FD-Score:3.01|P-value:8.86E-4 ID:SGTC_3127|Compound:9126946|FD-Score:-3.11|P-value:6.19E-4 ID:SGTC_3133|Compound:9127736|FD-Score:-3.51|P-value:1.33E-4 ID:SGTC_3208|Compound:9114115|FD-Score:-6.08|P-value:1.35E-10 ID:SGTC_3324|Compound:9138759|FD-Score:3.67|P-value:6.65E-5 ID:SGTC_3331|Compound:9141060|FD-Score:4.17|P-value:7.19E-6 ID:SGTC_3332|Compound:9141069|FD-Score:4.74|P-value:4.09E-7 ID:SGTC_3333|Compound:9141820|FD-Score:4.53|P-value:1.26E-6

Top fitness defect scores for YLR457C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2588 indole-3-carbinol 6.29 100.0 µM 3.13E-11 1 1.60E-10 1.38
2 SGTC_341 1486-1430 4.92 230.0 µM 1.58E-7 14 4.35E-7 0.03
3 SGTC_3332 9141069 4.74 11.2 µM 4.09E-7 2 1.05E-6 1.32
4 SGTC_3333 9141820 4.53 12.1 µM 1.26E-6 3 2.99E-6 0.58
5 SGTC_1195 1502-0147 4.35 41.1 µM 3.00E-6 5 6.70E-6 0.20
6 SGTC_1967 st070177 4.34 51.4 µM 3.13E-6 2 6.96E-6 0.34
7 SGTC_1225 1216-0074 4.25 20.6 µM 4.95E-6 3 1.07E-5 1.03
8 SGTC_3331 9141060 4.17 2.0 µM 7.19E-6 cell wall 5 1.51E-5 0.35
9 SGTC_1975 st070967 4.08 30.8 µM 1.12E-5 9 2.27E-5 0.05
10 SGTC_535 2293-4129 3.98 48.2 µM 1.73E-5 NEO1 8 3.41E-5 0.14
11 SGTC_3324 9138759 3.67 60.8 µM 6.65E-5 5 1.19E-4 0.11
12 SGTC_1262 0737-0114 3.63 49.6 µM 8.02E-5 6 1.42E-4 0.06
13 SGTC_1960 st011366 3.48 51.8 µM 1.47E-4 9 2.49E-4 0.10
14 SGTC_2622 2-methoxyxanthone 3.46 59.9 µM 1.59E-4 6 2.68E-4 0.01
15 SGTC_2018 5133068 3.45 143.0 µM 1.66E-4 14 2.80E-4 0.02
16 SGTC_1268 0828-0275 3.36 2.5 µM 2.39E-4 10 3.92E-4 0.09
17 SGTC_1990 st072050 3.32 59.8 µM 2.76E-4 5 4.48E-4 0.11
18 SGTC_1265 0819-1001 3.30 68.8 µM 3.04E-4 14 4.91E-4 0.28
19 SGTC_1501 4491-0275 3.22 38.4 µM 4.02E-4 8 6.36E-4 0.02
20 SGTC_1234 0326-0494 3.20 15.5 µM 4.41E-4 10 6.93E-4 0.03

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.241 2.20E-45 YDR521W_d YDR521W_d hom Dubious ORF that overlaps YDR520C; mutant increases expression of PIS1 and RPL3 in glycerol
0.240 4.93E-45 YJL171C YJL171C hom GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress
0.234 3.72E-43 YGR022C_d YGR022C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W
0.230 1.62E-41 YLL054C_p YLL054C_p hom Putative protein of unknown function with similarity to Pip2p, an oleate-specific transcriptional activator of peroxisome proliferation; YLL054C is not an essential gene
0.226 2.97E-40 YDR169C STB3 hom Ribosomal RNA processing element (RRPE)-binding protein; involved in the glucose-induced transition from quiescence to growth; restricted to nucleus in quiescent cells, released into cytoplasm after glucose repletion; binds Sin3p; relative distribution to the nucleus increases upon DNA replication stress
0.209 3.75E-34 YPR180W AOS1 het Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Uba2p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability
0.202 4.46E-32 YDL157C_p YDL157C_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.201 5.62E-32 YGR077C PEX8 hom Intraperoxisomal organizer of the peroxisomal import machinery; organizes the formation of the importomer complex, bridging the docking complex with the RING finger complex; tightly associated with the lumenal face of the peroxisomal membrane; essential for peroxisome biogenesis; binds PTS1-signal receptor Pex5p, and PTS2-signal receptor Pex7p
0.196 1.55E-30 YBR274W CHK1 hom Serine/threonine kinase and DNA damage checkpoint effector, mediates cell cycle arrest via phosphorylation of Pds1p; phosphorylated by checkpoint signal transducer Mec1p; homolog of S. pombe and mammalian Chk1 checkpoint kinase
0.196 2.17E-30 YLR179C YLR179C hom Protein of unknown function with similarity to Tfs1p; transcription is activated by paralogous proteins Yrm1p and Yrr1p along with proteins involved in multidrug resistance; GFP-tagged protein localizes to the cytoplasm and nucleus
0.192 3.95E-29 YJR146W_p YJR146W_p hom Protein of unknown function; expressed at both mRNA and protein levels; partially overlaps HMS2
0.191 9.57E-29 YNL166C BNI5 hom Protein involved in organization of septins at the mother-bud neck, may interact directly with the Cdc11p septin, localizes to bud neck in a septin-dependent manner
0.186 1.58E-27 YKL166C TPK3 hom cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; partially redundant with Tpk1p and Tpk2p; localizes to P-bodies during stationary phase; TPK3 has a paralog, TPK1, that arose from the whole genome duplication
0.183 1.14E-26 YDL176W YDL176W hom Protein of unknown function, predicted by computational methods to be involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; interacts with components of the GID complex; YDL176W is not an essential gene
0.183 1.50E-26 YFL014W HSP12 hom Plasma membrane protein involved in maintaining membrane organization in stress conditions; induced by heat shock, oxidative stress, osmostress, stationary phase, glucose depletion, oleate and alcohol; protein abundance increased in response to DNA replication stress and dietary restriction; regulated by the HOG and Ras-Pka pathways; required for dietary restriction-induced lifespan extension