YLR458W_d

Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps 5' end of essential NBP1 gene required for mitosis

Zygosity: Heterozygous strain
fixedexpanded
Profile for YLR458W / YLR458W

Click on Significant Values for Screen Details ID:SGTC_6|Compound:0844-0013|FD-Score:3.67|P-value:6.54E-5 ID:SGTC_13|Compound:0199-0087|FD-Score:4.69|P-value:4.97E-7 ID:SGTC_136|Compound:0097-0015|FD-Score:3.81|P-value:3.53E-5 ID:SGTC_160|Compound:3453-0671|FD-Score:5.69|P-value:1.51E-9 ID:SGTC_359|Compound:0081-0058|FD-Score:-3.17|P-value:4.63E-4 ID:SGTC_625|Compound:k213-0058|FD-Score:-3.10|P-value:5.95E-4 ID:SGTC_764|Compound:1951-2361|FD-Score:4.02|P-value:1.41E-5 ID:SGTC_811|Compound:0416-0114|FD-Score:3.00|P-value:9.03E-4 ID:SGTC_815|Compound:1582-0027|FD-Score:4.67|P-value:5.65E-7 ID:SGTC_840|Compound:0245-0196|FD-Score:3.43|P-value:1.73E-4 ID:SGTC_949|Compound:1165-0505|FD-Score:4.88|P-value:1.79E-7 ID:SGTC_1082|Compound:camptothecin|FD-Score:6.58|P-value:3.50E-12 ID:SGTC_1158|Compound:4092-0494|FD-Score:3.45|P-value:1.62E-4 ID:SGTC_1191|Compound:1487-1166|FD-Score:3.12|P-value:5.80E-4 ID:SGTC_1192|Compound:1488-0095|FD-Score:3.34|P-value:2.46E-4 ID:SGTC_1344|Compound:1488-0097|FD-Score:3.53|P-value:1.19E-4 ID:SGTC_1360|Compound:1598-0022|FD-Score:4.06|P-value:1.18E-5 ID:SGTC_1362|Compound:1611-0397|FD-Score:-3.19|P-value:4.37E-4 ID:SGTC_1363|Compound:1636-0063|FD-Score:-3.83|P-value:3.20E-5 ID:SGTC_1441|Compound:4106-0040|FD-Score:3.51|P-value:1.28E-4 ID:SGTC_1541|Compound:2',3',6-trimethoxyflavone|FD-Score:4.10|P-value:9.48E-6 ID:SGTC_1621|Compound:st003705|FD-Score:-3.73|P-value:4.84E-5 ID:SGTC_1802|Compound:st050112|FD-Score:3.24|P-value:3.62E-4 ID:SGTC_1815|Compound:st051655|FD-Score:5.31|P-value:1.57E-8 ID:SGTC_1845|Compound:st056753|FD-Score:4.55|P-value:1.05E-6 ID:SGTC_1991|Compound:st073000|FD-Score:3.84|P-value:3.14E-5 ID:SGTC_2133|Compound:5320837|FD-Score:4.42|P-value:2.08E-6 ID:SGTC_2193|Compound:5925765|FD-Score:-3.52|P-value:1.17E-4 ID:SGTC_2204|Compound:7233102|FD-Score:3.14|P-value:5.40E-4 ID:SGTC_2363|Compound:9053361|FD-Score:3.18|P-value:4.61E-4 ID:SGTC_2452|Compound:5863136|FD-Score:-3.42|P-value:1.80E-4 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:3.67|P-value:6.70E-5 ID:SGTC_2562|Compound:3',7'-dimethoxyflavone|FD-Score:3.36|P-value:2.29E-4 ID:SGTC_2583|Compound:asiatic acid|FD-Score:4.09|P-value:1.01E-5 ID:SGTC_2711|Compound:st079103|FD-Score:3.59|P-value:9.14E-5 ID:SGTC_2832|Compound:7992762|FD-Score:3.15|P-value:5.13E-4 ID:SGTC_2945|Compound:9067681|FD-Score:5.02|P-value:8.48E-8 ID:SGTC_3136|Compound:9095672|FD-Score:4.44|P-value:1.83E-6 ID:SGTC_3187|Compound:9109394|FD-Score:3.21|P-value:4.10E-4 ID:SGTC_3217|Compound:9129673|FD-Score:-3.64|P-value:7.11E-5 ID:SGTC_6|Compound:0844-0013|FD-Score:3.67|P-value:6.54E-5 ID:SGTC_13|Compound:0199-0087|FD-Score:4.69|P-value:4.97E-7 ID:SGTC_136|Compound:0097-0015|FD-Score:3.81|P-value:3.53E-5 ID:SGTC_160|Compound:3453-0671|FD-Score:5.69|P-value:1.51E-9 ID:SGTC_359|Compound:0081-0058|FD-Score:-3.17|P-value:4.63E-4 ID:SGTC_625|Compound:k213-0058|FD-Score:-3.10|P-value:5.95E-4 ID:SGTC_764|Compound:1951-2361|FD-Score:4.02|P-value:1.41E-5 ID:SGTC_811|Compound:0416-0114|FD-Score:3.00|P-value:9.03E-4 ID:SGTC_815|Compound:1582-0027|FD-Score:4.67|P-value:5.65E-7 ID:SGTC_840|Compound:0245-0196|FD-Score:3.43|P-value:1.73E-4 ID:SGTC_949|Compound:1165-0505|FD-Score:4.88|P-value:1.79E-7 ID:SGTC_1082|Compound:camptothecin|FD-Score:6.58|P-value:3.50E-12 ID:SGTC_1158|Compound:4092-0494|FD-Score:3.45|P-value:1.62E-4 ID:SGTC_1191|Compound:1487-1166|FD-Score:3.12|P-value:5.80E-4 ID:SGTC_1192|Compound:1488-0095|FD-Score:3.34|P-value:2.46E-4 ID:SGTC_1344|Compound:1488-0097|FD-Score:3.53|P-value:1.19E-4 ID:SGTC_1360|Compound:1598-0022|FD-Score:4.06|P-value:1.18E-5 ID:SGTC_1362|Compound:1611-0397|FD-Score:-3.19|P-value:4.37E-4 ID:SGTC_1363|Compound:1636-0063|FD-Score:-3.83|P-value:3.20E-5 ID:SGTC_1441|Compound:4106-0040|FD-Score:3.51|P-value:1.28E-4 ID:SGTC_1541|Compound:2',3',6-trimethoxyflavone|FD-Score:4.10|P-value:9.48E-6 ID:SGTC_1621|Compound:st003705|FD-Score:-3.73|P-value:4.84E-5 ID:SGTC_1802|Compound:st050112|FD-Score:3.24|P-value:3.62E-4 ID:SGTC_1815|Compound:st051655|FD-Score:5.31|P-value:1.57E-8 ID:SGTC_1845|Compound:st056753|FD-Score:4.55|P-value:1.05E-6 ID:SGTC_1991|Compound:st073000|FD-Score:3.84|P-value:3.14E-5 ID:SGTC_2133|Compound:5320837|FD-Score:4.42|P-value:2.08E-6 ID:SGTC_2193|Compound:5925765|FD-Score:-3.52|P-value:1.17E-4 ID:SGTC_2204|Compound:7233102|FD-Score:3.14|P-value:5.40E-4 ID:SGTC_2363|Compound:9053361|FD-Score:3.18|P-value:4.61E-4 ID:SGTC_2452|Compound:5863136|FD-Score:-3.42|P-value:1.80E-4 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:3.67|P-value:6.70E-5 ID:SGTC_2562|Compound:3',7'-dimethoxyflavone|FD-Score:3.36|P-value:2.29E-4 ID:SGTC_2583|Compound:asiatic acid|FD-Score:4.09|P-value:1.01E-5 ID:SGTC_2711|Compound:st079103|FD-Score:3.59|P-value:9.14E-5 ID:SGTC_2832|Compound:7992762|FD-Score:3.15|P-value:5.13E-4 ID:SGTC_2945|Compound:9067681|FD-Score:5.02|P-value:8.48E-8 ID:SGTC_3136|Compound:9095672|FD-Score:4.44|P-value:1.83E-6 ID:SGTC_3187|Compound:9109394|FD-Score:3.21|P-value:4.10E-4 ID:SGTC_3217|Compound:9129673|FD-Score:-3.64|P-value:7.11E-5

Top fitness defect scores for YLR458W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1082 camptothecin 6.58 424.9 nM 3.50E-12 DNA damage response 3 2.38E-11 0.25
2 SGTC_160 3453-0671 5.69 289.7 µM 1.51E-9 2 6.36E-9 0.91
3 SGTC_1815 st051655 5.31 58.2 µM 1.57E-8 TSC3-RPN4 5 5.51E-8 0.03
4 SGTC_2945 9067681 5.02 61.8 µM 8.48E-8 1 2.61E-7 0.63
5 SGTC_949 1165-0505 4.88 146.0 µM 1.79E-7 3 5.19E-7 0.15
6 SGTC_13 0199-0087 4.69 65.0 µM 4.97E-7 ERG2 2 1.33E-6 0.73
7 SGTC_815 1582-0027 4.67 36.9 µM 5.65E-7 3 1.50E-6 1.00
8 SGTC_1845 st056753 4.55 3.0 µM 1.05E-6 TSC3-RPN4 4 2.66E-6 0.01
9 SGTC_3136 9095672 4.44 49.5 µM 1.83E-6 2 4.45E-6 0.13
10 SGTC_2133 5320837 4.42 200.0 µM 2.08E-6 ERG2 4 5.00E-6 0.38
11 SGTC_1541 2',3',6-trimethoxyflavone 4.10 64.0 µM 9.48E-6 3 2.03E-5 0.10
12 SGTC_2583 asiatic acid 4.09 100.0 µM 1.01E-5 8 2.16E-5 0.12
13 SGTC_1360 1598-0022 4.06 39.8 µM 1.18E-5 ERG2 8 2.48E-5 0.02
14 SGTC_764 1951-2361 4.02 146.0 µM 1.41E-5 10 2.93E-5 0.07
15 SGTC_1991 st073000 3.84 8.9 µM 3.14E-5 NEO1 17 6.13E-5 0.21
16 SGTC_136 0097-0015 3.81 404.5 µM 3.53E-5 60S ribosome export 11 6.84E-5 0.02
17 SGTC_6 0844-0013 3.67 19.8 µM 6.54E-5 10 1.21E-4 0.03
18 SGTC_2531 methyl deoxycholate 3.67 70.1 µM 6.70E-5 8 1.24E-4 0.06
19 SGTC_2711 st079103 3.59 59.1 µM 9.14E-5 4 1.65E-4 0.39
20 SGTC_1344 1488-0097 3.53 29.1 µM 1.19E-4 6 2.10E-4 0.15

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.153 4.80E-19 YBR099C_d YBR099C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified gene MMS4
0.140 4.38E-16 YDR386W MUS81 hom Subunit of the structure-specific Mms4p-Mus81p endonuclease that cleaves branched DNA; involved in DNA repair, replication fork stability, and joint molecule formation/resolution during meiotic recombination; helix-hairpin-helix protein; phosphorylation of the non-catalytic subunit Mms4p by Cdc28p and Cdcp during mitotic cell cycle activates the function of Mms4p-Mus81p
0.118 7.25E-12 YJL047C RTT101 hom Cullin subunit of a Roc1p-dependent E3 ubiquitin ligase complex with a role in anaphase progression; implicated in Mms22-dependent DNA repair; involved with Mms1p in nonfunctional rRNA decay; modified by the ubiquitin-like protein, Rub1p
0.115 2.77E-11 YDL059C RAD59 hom Protein involved DNA double-strand break repair; repairs breaks in DNA during vegetative growth via recombination and single-strand annealing; anneals complementary single-stranded DNA; forms nuclear foci upon DNA replication stress; required for loading of Rad52p to DSBs; paralog of Rad52p
0.106 8.27E-10 YBR098W MMS4 hom Subunit of the structure-specific Mms4p-Mus81p endonuclease that cleaves branched DNA; involved in recombination, DNA repair, and joint molecule formation/resolution during meiotic recombination; phosphorylation of the non-catalytic subunit Mms4p by Cdc28p and Cdcp during mitotic cell cycle activates the function of Mms4p-Mus81p
0.095 3.49E-8 YBL088C TEL1 hom Protein kinase primarily involved in telomere length regulation; contributes to cell cycle checkpoint control in response to DNA damage; functionally redundant with Mec1p; regulates P-body formation induced by replication stress; homolog of human ataxia-telangiectasia mutated (ATM) gene, the gene responsible for ataxia telangiectasia (AT) (OMIM 607585)
0.094 5.49E-8 YGR232W NAS6 hom Proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasomal regulatory particle (RP); ortholog of human oncoprotein gankyrin, which interacts with the Rb tumor suppressor and CDK4/6
0.092 9.45E-8 YPL228W CET1 het Beta (RNA 5'-triphosphatase) subunit of the mRNA capping enzyme, a heterodimer (the other subunit is CEG1, a guanylyltransferase) involved in adding the 5' cap to mRNA; the mammalian enzyme is a single bifunctional polypeptide
0.091 1.51E-7 YLR131C ACE2 hom Transcription factor required for septum destruction after cytokinesis; phosphorylation by Cbk1p blocks nuclear exit during M/G1 transition, causing localization to daughter cell nuclei, and also increases Ace2p activity; phosphorylation by Cdc28p and Pho85p prevents nuclear import during cell cycle phases other than cytokinesis; part of RAM network that regulates cellular polarity and morphogenesis; ACE2 has a paralog, SWI5, that arose from the whole genome duplication
0.087 4.31E-7 YPR148C YPR148C hom Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
0.086 5.49E-7 YOR155C ISN1 hom Inosine 5'-monophosphate (IMP)-specific 5'-nucleotidase, catalyzes the breakdown of IMP to inosine, does not show similarity to known 5'-nucleotidases from other organisms
0.086 6.29E-7 YER095W RAD51 hom Strand exchange protein, forms a helical filament with DNA that searches for homology; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; homolog of Dmc1p and bacterial RecA protein
0.085 9.51E-7 YKR009C FOX2 hom Multifunctional enzyme of the peroxisomal fatty acid beta-oxidation pathway; has 3-hydroxyacyl-CoA dehydrogenase and enoyl-CoA hydratase activities
0.084 9.65E-7 YPR046W MCM16 hom Component of the Ctf19 complex and the COMA subcomplex; involved in kinetochore-microtubule mediated chromosome segregation; binds to centromere DNA; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-H and fission yeast fta3
0.079 4.99E-6 YEL023C_p YEL023C_p hom Putative protein of unknown function; expression is increased greatly during sporulation; YEL023C is not an essential gene