YLR459W / GAB1

GPI transamidase subunit, involved in attachment of glycosylphosphatidylinositol (GPI) anchors to proteins; may have a role in recognition of the attachment signal or of the lipid portion of GPI

Zygosity: Heterozygous strain
fixedexpanded
Profile for YLR459W / GAB1

Click on Significant Values for Screen Details ID:SGTC_87|Compound:0100-0052|FD-Score:3.07|P-value:5.28E-4 ID:SGTC_98|Compound:0074-0023|FD-Score:3.47|P-value:1.09E-4 ID:SGTC_271|Compound:rotenone|FD-Score:3.83|P-value:2.32E-5 ID:SGTC_342|Compound:k048-0088|FD-Score:4.26|P-value:3.06E-6 ID:SGTC_420|Compound:mitomycin C|FD-Score:3.48|P-value:1.07E-4 ID:SGTC_468|Compound:gf-109203x|FD-Score:-3.06|P-value:7.46E-4 ID:SGTC_566|Compound:0958-0068|FD-Score:3.10|P-value:4.85E-4 ID:SGTC_572|Compound:0960-0087|FD-Score:3.00|P-value:6.87E-4 ID:SGTC_573|Compound:3702-0553|FD-Score:3.56|P-value:7.55E-5 ID:SGTC_646|Compound:4092-0839|FD-Score:3.22|P-value:3.06E-4 ID:SGTC_657|Compound:3534-0529|FD-Score:3.73|P-value:3.63E-5 ID:SGTC_664|Compound:1222-0054|FD-Score:3.11|P-value:4.66E-4 ID:SGTC_880|Compound:0833-0487|FD-Score:2.91|P-value:9.54E-4 ID:SGTC_909|Compound:3448-9333|FD-Score:3.00|P-value:6.87E-4 ID:SGTC_918|Compound:glabranin|FD-Score:-3.11|P-value:6.20E-4 ID:SGTC_1128|Compound:3448-9350|FD-Score:-2.98|P-value:9.90E-4 ID:SGTC_1132|Compound:3456-3614|FD-Score:-4.34|P-value:3.05E-6 ID:SGTC_1221|Compound:2958-7315|FD-Score:4.29|P-value:2.58E-6 ID:SGTC_1234|Compound:0326-0494|FD-Score:2.91|P-value:9.50E-4 ID:SGTC_1325|Compound:1431-0015|FD-Score:3.60|P-value:6.47E-5 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.58|P-value:9.80E-5 ID:SGTC_1771|Compound:st048882|FD-Score:-3.27|P-value:3.37E-4 ID:SGTC_1796|Compound:st049173|FD-Score:3.28|P-value:2.43E-4 ID:SGTC_1974|Compound:st069448|FD-Score:-3.18|P-value:4.81E-4 ID:SGTC_1994|Compound:st072947|FD-Score:3.07|P-value:5.30E-4 ID:SGTC_2012|Compound:4023501|FD-Score:4.88|P-value:1.12E-7 ID:SGTC_2298|Compound:7976326|FD-Score:-4.34|P-value:3.00E-6 ID:SGTC_2299|Compound:7976368|FD-Score:2.99|P-value:7.13E-4 ID:SGTC_2310|Compound:7668677|FD-Score:-4.25|P-value:4.58E-6 ID:SGTC_2316|Compound:5844804|FD-Score:3.02|P-value:6.52E-4 ID:SGTC_2477|Compound:5967686|FD-Score:-3.82|P-value:3.46E-5 ID:SGTC_2520|Compound:obtusaquinone|FD-Score:2.90|P-value:9.75E-4 ID:SGTC_2524|Compound:avocatin b|FD-Score:-3.10|P-value:6.28E-4 ID:SGTC_2570|Compound:licareol|FD-Score:-3.17|P-value:4.90E-4 ID:SGTC_2682|Compound:pyrogallin|FD-Score:3.43|P-value:1.29E-4 ID:SGTC_2856|Compound:9022925|FD-Score:-3.66|P-value:6.87E-5 ID:SGTC_2925|Compound:9010536|FD-Score:-3.12|P-value:5.91E-4 ID:SGTC_2936|Compound:9038235|FD-Score:3.87|P-value:1.97E-5 ID:SGTC_2971|Compound:9092186|FD-Score:-3.80|P-value:3.85E-5 ID:SGTC_2999|Compound:9069765|FD-Score:-3.89|P-value:2.47E-5 ID:SGTC_3055|Compound:9094636|FD-Score:4.32|P-value:2.23E-6 ID:SGTC_3057|Compound:9095946|FD-Score:3.53|P-value:8.57E-5 ID:SGTC_3106|Compound:9121286|FD-Score:-3.30|P-value:2.99E-4 ID:SGTC_3153|Compound:9100258|FD-Score:-3.80|P-value:3.82E-5 ID:SGTC_3283|Compound:9109332|FD-Score:-3.05|P-value:7.60E-4 ID:SGTC_3309|Compound:9129340|FD-Score:3.32|P-value:2.06E-4 ID:SGTC_87|Compound:0100-0052|FD-Score:3.07|P-value:5.28E-4 ID:SGTC_98|Compound:0074-0023|FD-Score:3.47|P-value:1.09E-4 ID:SGTC_271|Compound:rotenone|FD-Score:3.83|P-value:2.32E-5 ID:SGTC_342|Compound:k048-0088|FD-Score:4.26|P-value:3.06E-6 ID:SGTC_420|Compound:mitomycin C|FD-Score:3.48|P-value:1.07E-4 ID:SGTC_468|Compound:gf-109203x|FD-Score:-3.06|P-value:7.46E-4 ID:SGTC_566|Compound:0958-0068|FD-Score:3.10|P-value:4.85E-4 ID:SGTC_572|Compound:0960-0087|FD-Score:3.00|P-value:6.87E-4 ID:SGTC_573|Compound:3702-0553|FD-Score:3.56|P-value:7.55E-5 ID:SGTC_646|Compound:4092-0839|FD-Score:3.22|P-value:3.06E-4 ID:SGTC_657|Compound:3534-0529|FD-Score:3.73|P-value:3.63E-5 ID:SGTC_664|Compound:1222-0054|FD-Score:3.11|P-value:4.66E-4 ID:SGTC_880|Compound:0833-0487|FD-Score:2.91|P-value:9.54E-4 ID:SGTC_909|Compound:3448-9333|FD-Score:3.00|P-value:6.87E-4 ID:SGTC_918|Compound:glabranin|FD-Score:-3.11|P-value:6.20E-4 ID:SGTC_1128|Compound:3448-9350|FD-Score:-2.98|P-value:9.90E-4 ID:SGTC_1132|Compound:3456-3614|FD-Score:-4.34|P-value:3.05E-6 ID:SGTC_1221|Compound:2958-7315|FD-Score:4.29|P-value:2.58E-6 ID:SGTC_1234|Compound:0326-0494|FD-Score:2.91|P-value:9.50E-4 ID:SGTC_1325|Compound:1431-0015|FD-Score:3.60|P-value:6.47E-5 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.58|P-value:9.80E-5 ID:SGTC_1771|Compound:st048882|FD-Score:-3.27|P-value:3.37E-4 ID:SGTC_1796|Compound:st049173|FD-Score:3.28|P-value:2.43E-4 ID:SGTC_1974|Compound:st069448|FD-Score:-3.18|P-value:4.81E-4 ID:SGTC_1994|Compound:st072947|FD-Score:3.07|P-value:5.30E-4 ID:SGTC_2012|Compound:4023501|FD-Score:4.88|P-value:1.12E-7 ID:SGTC_2298|Compound:7976326|FD-Score:-4.34|P-value:3.00E-6 ID:SGTC_2299|Compound:7976368|FD-Score:2.99|P-value:7.13E-4 ID:SGTC_2310|Compound:7668677|FD-Score:-4.25|P-value:4.58E-6 ID:SGTC_2316|Compound:5844804|FD-Score:3.02|P-value:6.52E-4 ID:SGTC_2477|Compound:5967686|FD-Score:-3.82|P-value:3.46E-5 ID:SGTC_2520|Compound:obtusaquinone|FD-Score:2.90|P-value:9.75E-4 ID:SGTC_2524|Compound:avocatin b|FD-Score:-3.10|P-value:6.28E-4 ID:SGTC_2570|Compound:licareol|FD-Score:-3.17|P-value:4.90E-4 ID:SGTC_2682|Compound:pyrogallin|FD-Score:3.43|P-value:1.29E-4 ID:SGTC_2856|Compound:9022925|FD-Score:-3.66|P-value:6.87E-5 ID:SGTC_2925|Compound:9010536|FD-Score:-3.12|P-value:5.91E-4 ID:SGTC_2936|Compound:9038235|FD-Score:3.87|P-value:1.97E-5 ID:SGTC_2971|Compound:9092186|FD-Score:-3.80|P-value:3.85E-5 ID:SGTC_2999|Compound:9069765|FD-Score:-3.89|P-value:2.47E-5 ID:SGTC_3055|Compound:9094636|FD-Score:4.32|P-value:2.23E-6 ID:SGTC_3057|Compound:9095946|FD-Score:3.53|P-value:8.57E-5 ID:SGTC_3106|Compound:9121286|FD-Score:-3.30|P-value:2.99E-4 ID:SGTC_3153|Compound:9100258|FD-Score:-3.80|P-value:3.82E-5 ID:SGTC_3283|Compound:9109332|FD-Score:-3.05|P-value:7.60E-4 ID:SGTC_3309|Compound:9129340|FD-Score:3.32|P-value:2.06E-4

Top fitness defect scores for YLR459W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2012 4023501 4.88 200.0 µM 1.12E-7 5 5.28E-7 0.00
2 SGTC_3055 9094636 4.32 49.5 µM 2.23E-6 4 7.77E-6 0.18
3 SGTC_1221 2958-7315 4.29 257.0 µM 2.58E-6 1 8.87E-6 0.62
4 SGTC_342 k048-0088 4.26 23.3 µM 3.06E-6 RSC & ERG11 9 1.04E-5 0.10
5 SGTC_2936 9038235 3.87 15.6 µM 1.97E-5 7 5.52E-5 0.04
6 SGTC_271 rotenone 3.83 740.0 µM 2.32E-5 3 6.38E-5 0.72
7 SGTC_657 3534-0529 3.73 86.7 µM 3.63E-5 4 9.56E-5 0.01
8 SGTC_1325 1431-0015 3.60 227.0 µM 6.47E-5 Golgi 4 1.61E-4 0.03
9 SGTC_573 3702-0553 3.56 84.7 µM 7.55E-5 7 1.85E-4 0.05
10 SGTC_3057 9095946 3.53 49.5 µM 8.57E-5 Golgi 6 2.07E-4 0.19
11 SGTC_420 mitomycin C 3.48 81.9 mM 1.07E-4 7 2.53E-4 0.15
12 SGTC_98 0074-0023 3.47 107.7 µM 1.09E-4 Golgi 3 2.56E-4 0.20
13 SGTC_2682 pyrogallin 3.43 40.0 µM 1.29E-4 copper-dependent oxidative stress 5 2.98E-4 0.07
14 SGTC_3309 9129340 3.32 25.8 µM 2.06E-4 4 4.55E-4 0.14
15 SGTC_1796 st049173 3.28 110.4 µM 2.43E-4 7 5.28E-4 0.04
16 SGTC_646 4092-0839 3.22 27.3 µM 3.06E-4 plasma membrane duress 16 6.50E-4 0.17
17 SGTC_664 1222-0054 3.11 14.9 µM 4.66E-4 sphingolipid biosynthesis & PDR1 17 9.48E-4 0.10
18 SGTC_566 0958-0068 3.10 16.5 µM 4.85E-4 RSC & ERG11 31 9.83E-4 0.06
19 SGTC_87 0100-0052 3.07 35.5 µM 5.28E-4 35 0.00106 0.12
20 SGTC_1994 st072947 3.07 40.9 µM 5.30E-4 17 0.00106 0.07

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.124 4.52E-13 YDL234C GYP7 hom GTPase-activating protein for yeast Rab family members including: Ypt7p (most effective), Ypt1p, Ypt31p, and Ypt32p (in vitro); involved in vesicle mediated protein trafficking
0.104 1.37E-9 YOR215C AIM41 hom Putative protein of unknown function; the authentic protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays reduced frequency of mitochondrial genome loss
0.102 2.96E-9 YNR073C_p YNR073C_p hom Putative mannitol dehydrogenase; identical in amino acid sequence to Dsf1p
0.090 2.06E-7 YGR045C_d YGR045C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.089 2.57E-7 YPR180W AOS1 het Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Uba2p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability
0.087 3.91E-7 YGR022C_d YGR022C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W
0.087 4.62E-7 YHR021W-A_p ECM12_p hom Putative protein of unknown function; may contribute to cell wall biosynthesis, mutants display zymolyase hypersensitivity
0.087 4.97E-7 YMR107W SPG4 hom Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources
0.085 7.48E-7 YNR049C MSO1 hom Probable component of the secretory vesicle docking complex; acts at a late step in secretion; shows genetic and physical interactions with Sec1p; required for prospore membrane formation during sporulation; relocalizes from bud neck to nucleus upon DNA replication stress
0.084 9.79E-7 YJL171C YJL171C hom GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress
0.083 1.65E-6 YER010C YER010C hom Protein of unknown function, forms a ring-shaped homotrimer; has similarity to members of the prokaryotic rraA family; possibly involved in a phosphotransfer reaction
0.082 1.91E-6 YBL063W KIP1 hom Kinesin-related motor protein required for mitotic spindle assembly, chromosome segregation, and 2 micron plasmid partitioning; functionally redundant with Cin8p for chromosomal but not plasmid functions
0.082 2.22E-6 YDL085C-A_p YDL085C-A_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
0.080 3.22E-6 YOR267C HRK1 hom Protein kinase; implicated in activation of the plasma membrane H(+)-ATPase Pma1p in response to glucose metabolism; plays a role in ion homeostasis; protein abundance increases in response to DNA replication stress
0.080 3.78E-6 YGR077C PEX8 hom Intraperoxisomal organizer of the peroxisomal import machinery; organizes the formation of the importomer complex, bridging the docking complex with the RING finger complex; tightly associated with the lumenal face of the peroxisomal membrane; essential for peroxisome biogenesis; binds PTS1-signal receptor Pex5p, and PTS2-signal receptor Pex7p