YLR460C_p

Member of the quinone oxidoreductase family, up-regulated in response to the fungicide mancozeb; possibly up-regulated by iodine

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR460C / YLR460C

Click on Significant Values for Screen Details ID:SGTC_134|Compound:0269-0018|FD-Score:3.40|P-value:3.46E-4 ID:SGTC_174|Compound:3553-0389|FD-Score:3.17|P-value:7.48E-4 ID:SGTC_331|Compound:k048-0133|FD-Score:3.69|P-value:1.18E-4 ID:SGTC_591|Compound:4299-0174|FD-Score:3.71|P-value:1.07E-4 ID:SGTC_637|Compound:1181-0519|FD-Score:3.09|P-value:9.86E-4 ID:SGTC_686|Compound:1319-0111|FD-Score:3.33|P-value:4.34E-4 ID:SGTC_811|Compound:0416-0114|FD-Score:3.62|P-value:1.53E-4 ID:SGTC_879|Compound:0831-1030|FD-Score:-3.46|P-value:4.83E-4 ID:SGTC_921|Compound:1561-0023|FD-Score:3.43|P-value:3.08E-4 ID:SGTC_964|Compound:1287-0107|FD-Score:3.24|P-value:5.97E-4 ID:SGTC_1081|Compound:sertraline|FD-Score:6.54|P-value:5.10E-11 ID:SGTC_1149|Compound:3909-7961|FD-Score:3.91|P-value:4.91E-5 ID:SGTC_1226|Compound:3909-7979|FD-Score:3.20|P-value:6.82E-4 ID:SGTC_1264|Compound:0783-0040|FD-Score:3.97|P-value:3.79E-5 ID:SGTC_1331|Compound:1472-0049|FD-Score:3.26|P-value:5.64E-4 ID:SGTC_1410|Compound:3909-8106|FD-Score:-3.60|P-value:2.94E-4 ID:SGTC_1428|Compound:4049-0204|FD-Score:3.32|P-value:4.54E-4 ID:SGTC_1628|Compound:st004252|FD-Score:3.81|P-value:7.21E-5 ID:SGTC_1958|Compound:st076513|FD-Score:3.11|P-value:9.07E-4 ID:SGTC_1967|Compound:st070177|FD-Score:3.85|P-value:6.31E-5 ID:SGTC_2002|Compound:4023503|FD-Score:3.59|P-value:1.70E-4 ID:SGTC_2012|Compound:4023501|FD-Score:3.78|P-value:8.34E-5 ID:SGTC_2019|Compound:4016004|FD-Score:3.37|P-value:3.81E-4 ID:SGTC_2341|Compound:7987486|FD-Score:4.21|P-value:1.42E-5 ID:SGTC_2342|Compound:7990637|FD-Score:5.08|P-value:2.31E-7 ID:SGTC_2351|Compound:9026858|FD-Score:5.19|P-value:1.35E-7 ID:SGTC_2401|Compound:5128683|FD-Score:3.14|P-value:8.29E-4 ID:SGTC_2552|Compound:juarezic acid|FD-Score:3.72|P-value:1.05E-4 ID:SGTC_2569|Compound:tetrandrine|FD-Score:3.96|P-value:4.05E-5 ID:SGTC_2845|Compound:9003024|FD-Score:3.58|P-value:1.73E-4 ID:SGTC_2848|Compound:9016370|FD-Score:5.38|P-value:4.96E-8 ID:SGTC_2854|Compound:9024559|FD-Score:7.65|P-value:2.26E-14 ID:SGTC_2856|Compound:9022925|FD-Score:3.42|P-value:3.20E-4 ID:SGTC_2950|Compound:9072895|FD-Score:-3.40|P-value:6.01E-4 ID:SGTC_2968|Compound:9090663|FD-Score:3.63|P-value:1.45E-4 ID:SGTC_2973|Compound:9094665|FD-Score:4.02|P-value:3.10E-5 ID:SGTC_3008|Compound:9078912|FD-Score:4.24|P-value:1.22E-5 ID:SGTC_3016|Compound:9080866|FD-Score:3.18|P-value:7.27E-4 ID:SGTC_3109|Compound:9122853|FD-Score:3.75|P-value:9.21E-5 ID:SGTC_3113|Compound:9123498|FD-Score:5.46|P-value:3.20E-8 ID:SGTC_3120|Compound:9124077|FD-Score:4.06|P-value:2.70E-5 ID:SGTC_3204|Compound:9114183|FD-Score:4.23|P-value:1.30E-5 ID:SGTC_3236|Compound:9132701|FD-Score:3.96|P-value:4.03E-5 ID:SGTC_3246|Compound:9135460|FD-Score:4.99|P-value:3.71E-7 ID:SGTC_3274|Compound:9138298|FD-Score:3.17|P-value:7.56E-4 ID:SGTC_3286|Compound:9117135|FD-Score:3.61|P-value:1.56E-4 ID:SGTC_3289|Compound:9119912|FD-Score:5.93|P-value:2.23E-9 ID:SGTC_3298|Compound:9116858|FD-Score:3.41|P-value:3.32E-4 ID:SGTC_134|Compound:0269-0018|FD-Score:3.40|P-value:3.46E-4 ID:SGTC_174|Compound:3553-0389|FD-Score:3.17|P-value:7.48E-4 ID:SGTC_331|Compound:k048-0133|FD-Score:3.69|P-value:1.18E-4 ID:SGTC_591|Compound:4299-0174|FD-Score:3.71|P-value:1.07E-4 ID:SGTC_637|Compound:1181-0519|FD-Score:3.09|P-value:9.86E-4 ID:SGTC_686|Compound:1319-0111|FD-Score:3.33|P-value:4.34E-4 ID:SGTC_811|Compound:0416-0114|FD-Score:3.62|P-value:1.53E-4 ID:SGTC_879|Compound:0831-1030|FD-Score:-3.46|P-value:4.83E-4 ID:SGTC_921|Compound:1561-0023|FD-Score:3.43|P-value:3.08E-4 ID:SGTC_964|Compound:1287-0107|FD-Score:3.24|P-value:5.97E-4 ID:SGTC_1081|Compound:sertraline|FD-Score:6.54|P-value:5.10E-11 ID:SGTC_1149|Compound:3909-7961|FD-Score:3.91|P-value:4.91E-5 ID:SGTC_1226|Compound:3909-7979|FD-Score:3.20|P-value:6.82E-4 ID:SGTC_1264|Compound:0783-0040|FD-Score:3.97|P-value:3.79E-5 ID:SGTC_1331|Compound:1472-0049|FD-Score:3.26|P-value:5.64E-4 ID:SGTC_1410|Compound:3909-8106|FD-Score:-3.60|P-value:2.94E-4 ID:SGTC_1428|Compound:4049-0204|FD-Score:3.32|P-value:4.54E-4 ID:SGTC_1628|Compound:st004252|FD-Score:3.81|P-value:7.21E-5 ID:SGTC_1958|Compound:st076513|FD-Score:3.11|P-value:9.07E-4 ID:SGTC_1967|Compound:st070177|FD-Score:3.85|P-value:6.31E-5 ID:SGTC_2002|Compound:4023503|FD-Score:3.59|P-value:1.70E-4 ID:SGTC_2012|Compound:4023501|FD-Score:3.78|P-value:8.34E-5 ID:SGTC_2019|Compound:4016004|FD-Score:3.37|P-value:3.81E-4 ID:SGTC_2341|Compound:7987486|FD-Score:4.21|P-value:1.42E-5 ID:SGTC_2342|Compound:7990637|FD-Score:5.08|P-value:2.31E-7 ID:SGTC_2351|Compound:9026858|FD-Score:5.19|P-value:1.35E-7 ID:SGTC_2401|Compound:5128683|FD-Score:3.14|P-value:8.29E-4 ID:SGTC_2552|Compound:juarezic acid|FD-Score:3.72|P-value:1.05E-4 ID:SGTC_2569|Compound:tetrandrine|FD-Score:3.96|P-value:4.05E-5 ID:SGTC_2845|Compound:9003024|FD-Score:3.58|P-value:1.73E-4 ID:SGTC_2848|Compound:9016370|FD-Score:5.38|P-value:4.96E-8 ID:SGTC_2854|Compound:9024559|FD-Score:7.65|P-value:2.26E-14 ID:SGTC_2856|Compound:9022925|FD-Score:3.42|P-value:3.20E-4 ID:SGTC_2950|Compound:9072895|FD-Score:-3.40|P-value:6.01E-4 ID:SGTC_2968|Compound:9090663|FD-Score:3.63|P-value:1.45E-4 ID:SGTC_2973|Compound:9094665|FD-Score:4.02|P-value:3.10E-5 ID:SGTC_3008|Compound:9078912|FD-Score:4.24|P-value:1.22E-5 ID:SGTC_3016|Compound:9080866|FD-Score:3.18|P-value:7.27E-4 ID:SGTC_3109|Compound:9122853|FD-Score:3.75|P-value:9.21E-5 ID:SGTC_3113|Compound:9123498|FD-Score:5.46|P-value:3.20E-8 ID:SGTC_3120|Compound:9124077|FD-Score:4.06|P-value:2.70E-5 ID:SGTC_3204|Compound:9114183|FD-Score:4.23|P-value:1.30E-5 ID:SGTC_3236|Compound:9132701|FD-Score:3.96|P-value:4.03E-5 ID:SGTC_3246|Compound:9135460|FD-Score:4.99|P-value:3.71E-7 ID:SGTC_3274|Compound:9138298|FD-Score:3.17|P-value:7.56E-4 ID:SGTC_3286|Compound:9117135|FD-Score:3.61|P-value:1.56E-4 ID:SGTC_3289|Compound:9119912|FD-Score:5.93|P-value:2.23E-9 ID:SGTC_3298|Compound:9116858|FD-Score:3.41|P-value:3.32E-4

Top fitness defect scores for YLR460C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2854 9024559 7.65 71.4 µM 2.26E-14 1 1.01E-14
2 SGTC_1081 sertraline 6.54 6.0 µM 5.10E-11 60S ribosome export 8 3.05E-11
3 SGTC_3289 9119912 5.93 71.4 µM 2.23E-9 4 1.53E-9
4 SGTC_3113 9123498 5.46 49.5 µM 3.20E-8 1 2.40E-8
5 SGTC_2848 9016370 5.38 26.0 µM 4.96E-8 6 3.78E-8
6 SGTC_2351 9026858 5.19 72.3 µM 1.35E-7 RNA processing & uracil transport 9 1.06E-7
7 SGTC_2342 7990637 5.08 118.9 µM 2.31E-7 RNA processing & uracil transport 11 1.85E-7
8 SGTC_3246 9135460 4.99 33.0 µM 3.71E-7 2 3.01E-7
9 SGTC_3008 9078912 4.24 71.4 µM 1.22E-5 9 1.10E-5
10 SGTC_3204 9114183 4.23 49.5 µM 1.30E-5 25 1.18E-5
11 SGTC_2341 7987486 4.21 176.7 µM 1.42E-5 16 1.29E-5
12 SGTC_3120 9124077 4.06 49.5 µM 2.70E-5 18 2.50E-5
13 SGTC_2973 9094665 4.02 18.0 µM 3.10E-5 NEO1 30 2.88E-5
14 SGTC_1264 0783-0040 3.97 158.0 µM 3.79E-5 29 3.55E-5
15 SGTC_3236 9132701 3.96 49.5 µM 4.03E-5 TSC3-RPN4 28 3.77E-5
16 SGTC_2569 tetrandrine 3.96 100.0 µM 4.05E-5 20 3.79E-5
17 SGTC_1149 3909-7961 3.91 23.3 µM 4.91E-5 20 4.63E-5
18 SGTC_1967 st070177 3.85 51.4 µM 6.31E-5 16 5.98E-5
19 SGTC_1628 st004252 3.81 77.7 µM 7.21E-5 24 6.87E-5
20 SGTC_2012 4023501 3.78 200.0 µM 8.34E-5 33 7.97E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.114 3.24E-11 YMR059W SEN15 het Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p
0.109 2.59E-10 YNL093W YPT53 hom Rab family GTPase; similar to Ypt51p and Ypt52p and to mammalian rab5; required for vacuolar protein sorting and endocytosis; YPT53 has a paralog, VPS21, that arose from the whole genome duplication
0.099 8.22E-9 YLR307W CDA1 hom Chitin deacetylase, together with Cda2p involved in the biosynthesis ascospore wall component, chitosan; required for proper rigidity of the ascospore wall
0.094 4.17E-8 YGL155W CDC43 het Beta subunit of geranylgeranyltransferase type I, catalyzes geranylgeranylation to the cysteine residue in proteins containing a C-terminal CaaX sequence ending in Leu or Phe; has substrates important for morphogenesis
0.082 2.12E-6 YBR296C-A_p YBR296C-A_p hom Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
0.073 2.50E-5 YLR230W_d YLR230W_d het Dubious open reading frame unlikely to encode a functional protein; overlaps 5' end of essential CDC42 gene which encodes a small Rho-like GTPase essential for establishment and maintenance of cell polarity
0.073 2.53E-5 YDR050C TPI1 het Triose phosphate isomerase, abundant glycolytic enzyme; mRNA half-life is regulated by iron availability; transcription is controlled by activators Reb1p, Gcr1p, and Rap1p through binding sites in the 5' non-coding region; inhibition of Tpi1p activity by PEP (phosphoenolpyruvate) stimulates redox metabolism in respiring cells; E104D mutation in human TPI causes a rare autosomal disease
0.072 2.78E-5 YNL146W_p YNL146W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YNL146W is not an essential gene
0.072 3.06E-5 YKL198C PTK1 hom Putative serine/threonine protein kinase that regulates spermine uptake; involved in polyamine transport; possible mitochondrial protein
0.072 3.32E-5 YOL055C THI20 hom Trifunctional enzyme of thiamine biosynthesis, degradation and salvage; has hydroxymethylpyrimidine (HMP) kinase, HMP-phosphate (HMP-P) kinase and thiaminase activities; member of a gene family with THI21 and THI22; HMP and HMP-P kinase activity redundant with Thi21p
0.071 4.26E-5 YPL231W FAS2 het Alpha subunit of fatty acid synthetase, which catalyzes the synthesis of long-chain saturated fatty acids; contains the acyl-carrier protein domain and beta-ketoacyl reductase, beta-ketoacyl synthase and self-pantetheinylation activities
0.069 5.76E-5 YMR054W STV1 hom Subunit a of the vacuolar-ATPase V0 domain, one of two isoforms (Stv1p and Vph1p); Stv1p is located in V-ATPase complexes of the Golgi and endosomes while Vph1p is located in V-ATPase complexes of the vacuole
0.069 6.52E-5 YOR027W STI1 hom Hsp90 cochaperone, interacts with the Ssa group of the cytosolic Hsp70 chaperones and activates Ssa1p ATPase activity; interacts with Hsp90 chaperones and inhibits their ATPase activity; homolog of mammalian Hop
0.069 6.57E-5 YHR077C NMD2 hom Protein involved in the nonsense-mediated mRNA decay (NMD) pathway; interacts with Nam7p and Upf3p; involved in telomere maintenance
0.069 6.79E-5 YKL019W RAM2 het Alpha subunit of both the farnesyltransferase and type I geranylgeranyltransferase that catalyze prenylation of proteins containing a CAAX consensus motif; essential protein required for membrane localization of Ras proteins and a-factor