YML002W_p

Putative protein of unknown function; expression induced by heat and by calcium shortage

Zygosity: Homozygous strain
fixedexpanded
Profile for YML002W / YML002W

Click on Significant Values for Screen Details ID:SGTC_128|Compound:0906-2981|FD-Score:-3.48|P-value:2.31E-4 ID:SGTC_130|Compound:0136-0219|FD-Score:-3.16|P-value:7.63E-4 ID:SGTC_261|Compound:5-fluorouridine|FD-Score:-4.94|P-value:2.87E-7 ID:SGTC_326|Compound:k292-0812|FD-Score:3.85|P-value:2.82E-5 ID:SGTC_356|Compound:1634-0012|FD-Score:-3.10|P-value:9.30E-4 ID:SGTC_379|Compound:3970-0972|FD-Score:-3.20|P-value:6.52E-4 ID:SGTC_417|Compound:st075190|FD-Score:3.70|P-value:5.31E-5 ID:SGTC_427|Compound:1354-0053|FD-Score:-3.58|P-value:1.57E-4 ID:SGTC_449|Compound:xestospongin c|FD-Score:4.38|P-value:2.43E-6 ID:SGTC_475|Compound:α-linolenic acid|FD-Score:3.60|P-value:8.07E-5 ID:SGTC_536|Compound:3852-0578|FD-Score:3.02|P-value:7.62E-4 ID:SGTC_538|Compound:2922-0838|FD-Score:3.36|P-value:2.15E-4 ID:SGTC_540|Compound:1187-0821|FD-Score:3.14|P-value:4.92E-4 ID:SGTC_653|Compound:0203-0016|FD-Score:-3.13|P-value:8.41E-4 ID:SGTC_654|Compound:1124-0271|FD-Score:3.16|P-value:4.62E-4 ID:SGTC_807|Compound:1315-0151|FD-Score:3.52|P-value:1.14E-4 ID:SGTC_845|Compound:0330-0138|FD-Score:2.99|P-value:8.47E-4 ID:SGTC_957|Compound:1187-1561|FD-Score:3.84|P-value:2.99E-5 ID:SGTC_1039|Compound:k821-0043|FD-Score:-3.12|P-value:8.72E-4 ID:SGTC_1040|Compound:k898-0338|FD-Score:-3.45|P-value:2.56E-4 ID:SGTC_1176|Compound:0848-0131|FD-Score:4.56|P-value:9.75E-7 ID:SGTC_1179|Compound:1021-1431|FD-Score:2.98|P-value:8.80E-4 ID:SGTC_1340|Compound:1486-1359|FD-Score:3.44|P-value:1.58E-4 ID:SGTC_1531|Compound:st059297|FD-Score:3.63|P-value:7.26E-5 ID:SGTC_1535|Compound:tetrahydropapaveroline hydrobromide|FD-Score:3.64|P-value:6.82E-5 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:4.47|P-value:1.55E-6 ID:SGTC_1573|Compound:oleylamine|FD-Score:3.75|P-value:4.42E-5 ID:SGTC_1586|Compound:deoxycorticosterone acetate|FD-Score:2.97|P-value:8.95E-4 ID:SGTC_1764|Compound:st044502|FD-Score:3.32|P-value:2.47E-4 ID:SGTC_1997|Compound:st073024|FD-Score:3.60|P-value:8.05E-5 ID:SGTC_2000|Compound:st075254|FD-Score:3.18|P-value:4.25E-4 ID:SGTC_2113|Compound:5491891|FD-Score:-3.45|P-value:2.62E-4 ID:SGTC_2128|Compound:5255449|FD-Score:6.40|P-value:1.55E-11 ID:SGTC_2129|Compound:girgensonine|FD-Score:3.20|P-value:3.98E-4 ID:SGTC_2265|Compound:7929201|FD-Score:3.10|P-value:5.67E-4 ID:SGTC_2266|Compound:7929956|FD-Score:5.96|P-value:2.88E-10 ID:SGTC_2279|Compound:7948423|FD-Score:-3.61|P-value:1.37E-4 ID:SGTC_2311|Compound:7694451|FD-Score:3.45|P-value:1.48E-4 ID:SGTC_2316|Compound:5844804|FD-Score:3.28|P-value:2.93E-4 ID:SGTC_2439|Compound:5492030|FD-Score:3.41|P-value:1.73E-4 ID:SGTC_2453|Compound:5731132|FD-Score:2.96|P-value:9.30E-4 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:-4.43|P-value:3.82E-6 ID:SGTC_2800|Compound:7887935|FD-Score:5.49|P-value:5.81E-9 ID:SGTC_2801|Compound:7907800|FD-Score:-3.09|P-value:9.70E-4 ID:SGTC_2935|Compound:9038016|FD-Score:2.97|P-value:8.89E-4 ID:SGTC_128|Compound:0906-2981|FD-Score:-3.48|P-value:2.31E-4 ID:SGTC_130|Compound:0136-0219|FD-Score:-3.16|P-value:7.63E-4 ID:SGTC_261|Compound:5-fluorouridine|FD-Score:-4.94|P-value:2.87E-7 ID:SGTC_326|Compound:k292-0812|FD-Score:3.85|P-value:2.82E-5 ID:SGTC_356|Compound:1634-0012|FD-Score:-3.10|P-value:9.30E-4 ID:SGTC_379|Compound:3970-0972|FD-Score:-3.20|P-value:6.52E-4 ID:SGTC_417|Compound:st075190|FD-Score:3.70|P-value:5.31E-5 ID:SGTC_427|Compound:1354-0053|FD-Score:-3.58|P-value:1.57E-4 ID:SGTC_449|Compound:xestospongin c|FD-Score:4.38|P-value:2.43E-6 ID:SGTC_475|Compound:α-linolenic acid|FD-Score:3.60|P-value:8.07E-5 ID:SGTC_536|Compound:3852-0578|FD-Score:3.02|P-value:7.62E-4 ID:SGTC_538|Compound:2922-0838|FD-Score:3.36|P-value:2.15E-4 ID:SGTC_540|Compound:1187-0821|FD-Score:3.14|P-value:4.92E-4 ID:SGTC_653|Compound:0203-0016|FD-Score:-3.13|P-value:8.41E-4 ID:SGTC_654|Compound:1124-0271|FD-Score:3.16|P-value:4.62E-4 ID:SGTC_807|Compound:1315-0151|FD-Score:3.52|P-value:1.14E-4 ID:SGTC_845|Compound:0330-0138|FD-Score:2.99|P-value:8.47E-4 ID:SGTC_957|Compound:1187-1561|FD-Score:3.84|P-value:2.99E-5 ID:SGTC_1039|Compound:k821-0043|FD-Score:-3.12|P-value:8.72E-4 ID:SGTC_1040|Compound:k898-0338|FD-Score:-3.45|P-value:2.56E-4 ID:SGTC_1176|Compound:0848-0131|FD-Score:4.56|P-value:9.75E-7 ID:SGTC_1179|Compound:1021-1431|FD-Score:2.98|P-value:8.80E-4 ID:SGTC_1340|Compound:1486-1359|FD-Score:3.44|P-value:1.58E-4 ID:SGTC_1531|Compound:st059297|FD-Score:3.63|P-value:7.26E-5 ID:SGTC_1535|Compound:tetrahydropapaveroline hydrobromide|FD-Score:3.64|P-value:6.82E-5 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:4.47|P-value:1.55E-6 ID:SGTC_1573|Compound:oleylamine|FD-Score:3.75|P-value:4.42E-5 ID:SGTC_1586|Compound:deoxycorticosterone acetate|FD-Score:2.97|P-value:8.95E-4 ID:SGTC_1764|Compound:st044502|FD-Score:3.32|P-value:2.47E-4 ID:SGTC_1997|Compound:st073024|FD-Score:3.60|P-value:8.05E-5 ID:SGTC_2000|Compound:st075254|FD-Score:3.18|P-value:4.25E-4 ID:SGTC_2113|Compound:5491891|FD-Score:-3.45|P-value:2.62E-4 ID:SGTC_2128|Compound:5255449|FD-Score:6.40|P-value:1.55E-11 ID:SGTC_2129|Compound:girgensonine|FD-Score:3.20|P-value:3.98E-4 ID:SGTC_2265|Compound:7929201|FD-Score:3.10|P-value:5.67E-4 ID:SGTC_2266|Compound:7929956|FD-Score:5.96|P-value:2.88E-10 ID:SGTC_2279|Compound:7948423|FD-Score:-3.61|P-value:1.37E-4 ID:SGTC_2311|Compound:7694451|FD-Score:3.45|P-value:1.48E-4 ID:SGTC_2316|Compound:5844804|FD-Score:3.28|P-value:2.93E-4 ID:SGTC_2439|Compound:5492030|FD-Score:3.41|P-value:1.73E-4 ID:SGTC_2453|Compound:5731132|FD-Score:2.96|P-value:9.30E-4 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:-4.43|P-value:3.82E-6 ID:SGTC_2800|Compound:7887935|FD-Score:5.49|P-value:5.81E-9 ID:SGTC_2801|Compound:7907800|FD-Score:-3.09|P-value:9.70E-4 ID:SGTC_2935|Compound:9038016|FD-Score:2.97|P-value:8.89E-4

Top fitness defect scores for YML002W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2128 5255449 6.40 168.5 µM 1.55E-11 3 7.89E-11
2 SGTC_2266 7929956 5.96 200.0 µM 2.88E-10 8 1.23E-9
3 SGTC_2800 7887935 5.49 81.8 µM 5.81E-9 RPP1 & pyrimidine depletion 5 2.06E-8
4 SGTC_1176 0848-0131 4.56 83.3 µM 9.75E-7 Golgi 12 2.51E-6
5 SGTC_1565 sinapyl alcohol 4.47 95.1 µM 1.55E-6 16 3.87E-6
6 SGTC_449 xestospongin c 4.38 11.2 µM 2.43E-6 NEO1-PIK1 49 5.91E-6
7 SGTC_326 k292-0812 3.85 17.5 µM 2.82E-5 8 5.87E-5
8 SGTC_957 1187-1561 3.84 14.1 µM 2.99E-5 26 6.19E-5
9 SGTC_1573 oleylamine 3.75 1.1 µM 4.42E-5 35 8.93E-5
10 SGTC_417 st075190 3.70 100.0 µM 5.31E-5 13 1.06E-4
11 SGTC_1535 tetrahydropapaveroline hydrobromide 3.64 54.3 µM 6.82E-5 RPP1 & pyrimidine depletion 17 1.34E-4
12 SGTC_1531 st059297 3.63 52.4 µM 7.26E-5 26 1.42E-4
13 SGTC_1997 st073024 3.60 93.8 µM 8.05E-5 14 1.56E-4
14 SGTC_475 α-linolenic acid 3.60 10.0 µM 8.07E-5 excess fatty acid 26 1.57E-4
15 SGTC_807 1315-0151 3.52 48.0 µM 1.14E-4 43 2.17E-4
16 SGTC_2311 7694451 3.45 200.0 µM 1.48E-4 36 2.76E-4
17 SGTC_1340 1486-1359 3.44 257.0 µM 1.58E-4 42 2.93E-4
18 SGTC_2439 5492030 3.41 7.2 µM 1.73E-4 25 3.20E-4
19 SGTC_538 2922-0838 3.36 53.3 µM 2.15E-4 Golgi 53 3.92E-4
20 SGTC_1764 st044502 3.32 93.5 µM 2.47E-4 43 4.46E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.114 3.98E-11 YER130C_p YER130C_p hom Protein of unknown function; transcription is regulated by Haa1p, Sok2p and Zap1p transcriptional activators; computational analysis suggests a role as a transcription factor; C. albicans homolog (MNL1) plays a role in adaptation to stress
0.107 5.59E-10 YOR055W_d YOR055W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.101 4.40E-9 YMR111C YMR111C hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YMR111C is not an essential gene; forms nuclear foci upon DNA replication stress
0.097 2.10E-8 YLL035W GRC3 het Polynucleotide kinase present on rDNA that is required for efficient transcription termination by RNA polymerase I; required for cell growth; mRNA is cell-cycle regulated
0.094 5.02E-8 YKR074W AIM29 hom Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm; YKR074W is not an essential gene; null mutant displays elevated frequency of mitochondrial genome loss
0.091 1.24E-7 YDR218C SPR28 hom Sporulation-specific homolog of the yeast CDC3/10/11/12 family of bud neck microfilament genes; meiotic septin expressed at high levels during meiotic divisions and ascospore formation
0.091 1.42E-7 YDL086W_p YDL086W_p hom Putative carboxymethylenebutenolidase; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YDL086W is not an essential gene
0.085 7.82E-7 YOR005C DNL4 hom DNA ligase required for nonhomologous end-joining (NHEJ), forms stable heterodimer with required cofactor Lif1p, interacts with Nej1p; involved in meiosis, not essential for vegetative growth
0.083 1.38E-6 YLL056C_p YLL056C_p hom Putative protein of unknown function, transcription is activated by paralogous transcription factors Yrm1p and Yrr1p and genes involved in pleiotropic drug resistance (PDR); expression is induced in cells treated with the mycotoxin patulin
0.080 3.58E-6 YGR243W FMP43 hom Highly conserved subunit of the mitochondrial pyruvate carrier; a mitochondrial inner membrane complex comprised of Fmp37p/Mpc1p and either Mpc2p or Fmp43p/Mpc3p mediates mitochondrial pyruvate uptake; more highly expressed in glucose-containing minimal medium than in lactate-containing medium; expression regulated by osmotic and alkaline stresses; protein abundance increases in response to DNA replication stress
0.078 6.14E-6 YCR028C FEN2 hom Plasma membrane H+-pantothenate symporter; confers sensitivity to the antifungal agent fenpropimorph; relocalizes from vacuole to cytoplasm upon DNA replication stress
0.078 6.19E-6 YAL028W FRT2 hom Tail-anchored ER membrane protein of unknown function; interacts with homolog Frt1p; promotes growth in conditions of high Na+, alkaline pH, or cell wall stress, possibly via a role in posttranslational translocation; potential Cdc28p substrate; FRT2 has a paralog, FRT1, that arose from the whole genome duplication
0.077 8.00E-6 YJL045W YJL045W hom Minor succinate dehydrogenase isozyme; homologous to Sdh1p, the major isozyme reponsible for the oxidation of succinate and transfer of electrons to ubiquinone; induced during the diauxic shift in a Cat8p-dependent manner
0.077 8.88E-6 YMR251W-A HOR7 hom Protein of unknown function; overexpression suppresses Ca2+ sensitivity of mutants lacking inositol phosphorylceramide mannosyltransferases Csg1p and Csh1p; transcription is induced under hyperosmotic stress and repressed by alpha factor; HOR7 has a paralog, DDR2, that arose from the whole genome duplication
0.075 1.45E-5 YML104C MDM1 hom Intermediate filament protein, required for nuclear and mitochondrial transmission to daughter buds; contains a Phox homology (PX) domain and specifically binds phosphatidylinositol 3-phosphate (PtdIns-3-P)