YML003W_p

Putative protein of unknown function

Zygosity: Homozygous strain
fixedexpanded
Profile for YML003W / YML003W

Click on Significant Values for Screen Details ID:SGTC_6|Compound:0844-0013|FD-Score:4.32|P-value:1.76E-6 ID:SGTC_344|Compound:k064-0035|FD-Score:3.46|P-value:1.01E-4 ID:SGTC_375|Compound:3970-0961|FD-Score:3.21|P-value:2.79E-4 ID:SGTC_432|Compound:NS 1619|FD-Score:-3.22|P-value:3.06E-4 ID:SGTC_433|Compound:pimozide|FD-Score:4.59|P-value:4.27E-7 ID:SGTC_438|Compound:sphingosine|FD-Score:4.05|P-value:6.69E-6 ID:SGTC_440|Compound:fluspirilene|FD-Score:-3.98|P-value:1.12E-5 ID:SGTC_868|Compound:0527-0199|FD-Score:3.05|P-value:5.24E-4 ID:SGTC_923|Compound:1900-2434|FD-Score:3.65|P-value:4.48E-5 ID:SGTC_1066|Compound:ketoconazole|FD-Score:3.50|P-value:8.63E-5 ID:SGTC_1371|Compound:2421-0008|FD-Score:4.26|P-value:2.36E-6 ID:SGTC_1437|Compound:4092-1038|FD-Score:2.89|P-value:9.33E-4 ID:SGTC_1521|Compound:st012942|FD-Score:-3.07|P-value:5.34E-4 ID:SGTC_2045|Compound:5106652|FD-Score:3.27|P-value:2.17E-4 ID:SGTC_2117|Compound:5521686|FD-Score:2.93|P-value:8.11E-4 ID:SGTC_2266|Compound:7929956|FD-Score:3.49|P-value:8.85E-5 ID:SGTC_2270|Compound:7924575|FD-Score:3.33|P-value:1.76E-4 ID:SGTC_2273|Compound:7815444|FD-Score:3.80|P-value:2.27E-5 ID:SGTC_2304|Compound:7443016|FD-Score:5.49|P-value:2.01E-9 ID:SGTC_2314|Compound:7727897|FD-Score:4.72|P-value:2.00E-7 ID:SGTC_2417|Compound:cerulenin|FD-Score:2.98|P-value:6.87E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:3.07|P-value:4.81E-4 ID:SGTC_2509|Compound:methyl 7-deshydroxypyrogallin-4-carboxylate|FD-Score:-3.31|P-value:2.16E-4 ID:SGTC_2524|Compound:avocatin b|FD-Score:-3.02|P-value:6.45E-4 ID:SGTC_2542|Compound:2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene|FD-Score:3.17|P-value:3.32E-4 ID:SGTC_2543|Compound:pimpinellin|FD-Score:-4.33|P-value:2.01E-6 ID:SGTC_2553|Compound:4-methylesculetin|FD-Score:3.73|P-value:3.11E-5 ID:SGTC_2593|Compound:nobiletin|FD-Score:5.20|P-value:1.23E-8 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:3.60|P-value:5.45E-5 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:-3.16|P-value:3.83E-4 ID:SGTC_2695|Compound:st077686|FD-Score:3.79|P-value:2.39E-5 ID:SGTC_2785|Compound:7756463|FD-Score:-3.78|P-value:2.85E-5 ID:SGTC_2787|Compound:5284540|FD-Score:-4.30|P-value:2.33E-6 ID:SGTC_2792|Compound:7535235|FD-Score:3.29|P-value:2.01E-4 ID:SGTC_2865|Compound:9030313|FD-Score:-3.65|P-value:5.13E-5 ID:SGTC_2866|Compound:9034245|FD-Score:-3.01|P-value:6.70E-4 ID:SGTC_2904|Compound:7225135|FD-Score:3.87|P-value:1.63E-5 ID:SGTC_2917|Compound:7979103|FD-Score:4.89|P-value:7.60E-8 ID:SGTC_2927|Compound:9011802|FD-Score:-3.15|P-value:3.95E-4 ID:SGTC_2950|Compound:9072895|FD-Score:2.90|P-value:9.21E-4 ID:SGTC_2967|Compound:9089538|FD-Score:-4.19|P-value:3.96E-6 ID:SGTC_2970|Compound:9090938|FD-Score:3.49|P-value:9.05E-5 ID:SGTC_2986|Compound:9022445|FD-Score:-3.35|P-value:1.79E-4 ID:SGTC_3019|Compound:9081971|FD-Score:3.44|P-value:1.12E-4 ID:SGTC_3147|Compound:9097027|FD-Score:5.67|P-value:5.97E-10 ID:SGTC_3148|Compound:9097893|FD-Score:2.91|P-value:8.63E-4 ID:SGTC_3159|Compound:9100096|FD-Score:-3.17|P-value:3.71E-4 ID:SGTC_3231|Compound:9132313|FD-Score:-3.99|P-value:1.05E-5 ID:SGTC_3258|Compound:9138477|FD-Score:3.32|P-value:1.77E-4 ID:SGTC_3329|Compound:9141233|FD-Score:4.93|P-value:6.02E-8 ID:SGTC_6|Compound:0844-0013|FD-Score:4.32|P-value:1.76E-6 ID:SGTC_344|Compound:k064-0035|FD-Score:3.46|P-value:1.01E-4 ID:SGTC_375|Compound:3970-0961|FD-Score:3.21|P-value:2.79E-4 ID:SGTC_432|Compound:NS 1619|FD-Score:-3.22|P-value:3.06E-4 ID:SGTC_433|Compound:pimozide|FD-Score:4.59|P-value:4.27E-7 ID:SGTC_438|Compound:sphingosine|FD-Score:4.05|P-value:6.69E-6 ID:SGTC_440|Compound:fluspirilene|FD-Score:-3.98|P-value:1.12E-5 ID:SGTC_868|Compound:0527-0199|FD-Score:3.05|P-value:5.24E-4 ID:SGTC_923|Compound:1900-2434|FD-Score:3.65|P-value:4.48E-5 ID:SGTC_1066|Compound:ketoconazole|FD-Score:3.50|P-value:8.63E-5 ID:SGTC_1371|Compound:2421-0008|FD-Score:4.26|P-value:2.36E-6 ID:SGTC_1437|Compound:4092-1038|FD-Score:2.89|P-value:9.33E-4 ID:SGTC_1521|Compound:st012942|FD-Score:-3.07|P-value:5.34E-4 ID:SGTC_2045|Compound:5106652|FD-Score:3.27|P-value:2.17E-4 ID:SGTC_2117|Compound:5521686|FD-Score:2.93|P-value:8.11E-4 ID:SGTC_2266|Compound:7929956|FD-Score:3.49|P-value:8.85E-5 ID:SGTC_2270|Compound:7924575|FD-Score:3.33|P-value:1.76E-4 ID:SGTC_2273|Compound:7815444|FD-Score:3.80|P-value:2.27E-5 ID:SGTC_2304|Compound:7443016|FD-Score:5.49|P-value:2.01E-9 ID:SGTC_2314|Compound:7727897|FD-Score:4.72|P-value:2.00E-7 ID:SGTC_2417|Compound:cerulenin|FD-Score:2.98|P-value:6.87E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:3.07|P-value:4.81E-4 ID:SGTC_2509|Compound:methyl 7-deshydroxypyrogallin-4-carboxylate|FD-Score:-3.31|P-value:2.16E-4 ID:SGTC_2524|Compound:avocatin b|FD-Score:-3.02|P-value:6.45E-4 ID:SGTC_2542|Compound:2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene|FD-Score:3.17|P-value:3.32E-4 ID:SGTC_2543|Compound:pimpinellin|FD-Score:-4.33|P-value:2.01E-6 ID:SGTC_2553|Compound:4-methylesculetin|FD-Score:3.73|P-value:3.11E-5 ID:SGTC_2593|Compound:nobiletin|FD-Score:5.20|P-value:1.23E-8 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:3.60|P-value:5.45E-5 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:-3.16|P-value:3.83E-4 ID:SGTC_2695|Compound:st077686|FD-Score:3.79|P-value:2.39E-5 ID:SGTC_2785|Compound:7756463|FD-Score:-3.78|P-value:2.85E-5 ID:SGTC_2787|Compound:5284540|FD-Score:-4.30|P-value:2.33E-6 ID:SGTC_2792|Compound:7535235|FD-Score:3.29|P-value:2.01E-4 ID:SGTC_2865|Compound:9030313|FD-Score:-3.65|P-value:5.13E-5 ID:SGTC_2866|Compound:9034245|FD-Score:-3.01|P-value:6.70E-4 ID:SGTC_2904|Compound:7225135|FD-Score:3.87|P-value:1.63E-5 ID:SGTC_2917|Compound:7979103|FD-Score:4.89|P-value:7.60E-8 ID:SGTC_2927|Compound:9011802|FD-Score:-3.15|P-value:3.95E-4 ID:SGTC_2950|Compound:9072895|FD-Score:2.90|P-value:9.21E-4 ID:SGTC_2967|Compound:9089538|FD-Score:-4.19|P-value:3.96E-6 ID:SGTC_2970|Compound:9090938|FD-Score:3.49|P-value:9.05E-5 ID:SGTC_2986|Compound:9022445|FD-Score:-3.35|P-value:1.79E-4 ID:SGTC_3019|Compound:9081971|FD-Score:3.44|P-value:1.12E-4 ID:SGTC_3147|Compound:9097027|FD-Score:5.67|P-value:5.97E-10 ID:SGTC_3148|Compound:9097893|FD-Score:2.91|P-value:8.63E-4 ID:SGTC_3159|Compound:9100096|FD-Score:-3.17|P-value:3.71E-4 ID:SGTC_3231|Compound:9132313|FD-Score:-3.99|P-value:1.05E-5 ID:SGTC_3258|Compound:9138477|FD-Score:3.32|P-value:1.77E-4 ID:SGTC_3329|Compound:9141233|FD-Score:4.93|P-value:6.02E-8

Top fitness defect scores for YML003W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3147 9097027 5.67 49.5 µM 5.97E-10 5 7.15E-9
2 SGTC_2304 7443016 5.49 91.4 µM 2.01E-9 8 2.07E-8
3 SGTC_2593 nobiletin 5.20 86.2 µM 1.23E-8 9 1.01E-7
4 SGTC_3329 9141233 4.93 27.6 µM 6.02E-8 7 4.05E-7
5 SGTC_2917 7979103 4.89 53.8 µM 7.60E-8 12 4.97E-7
6 SGTC_2314 7727897 4.72 200.0 µM 2.00E-7 5 1.16E-6
7 SGTC_433 pimozide 4.59 108.0 µM 4.27E-7 9 2.25E-6
8 SGTC_6 0844-0013 4.32 19.8 µM 1.76E-6 61 7.79E-6
9 SGTC_1371 2421-0008 4.26 32.7 µM 2.36E-6 mitochondrial processes 25 1.01E-5
10 SGTC_438 sphingosine 4.05 6.7 µM 6.69E-6 20 2.51E-5
11 SGTC_2904 7225135 3.87 42.0 µM 1.63E-5 8 5.47E-5
12 SGTC_2273 7815444 3.80 169.1 µM 2.27E-5 27 7.32E-5
13 SGTC_2695 st077686 3.79 52.0 µM 2.39E-5 42 7.64E-5
14 SGTC_2553 4-methylesculetin 3.73 85.1 µM 3.11E-5 29 9.63E-5
15 SGTC_923 1900-2434 3.65 73.3 µM 4.48E-5 RNA processing & uracil transport 39 1.33E-4
16 SGTC_2595 hexamethylquercetagetin 3.60 100.0 µM 5.45E-5 36 1.58E-4
17 SGTC_1066 ketoconazole 3.50 628.0 nM 8.63E-5 39 2.36E-4
18 SGTC_2266 7929956 3.49 200.0 µM 8.85E-5 48 2.41E-4
19 SGTC_2970 9090938 3.49 41.9 µM 9.05E-5 RNA processing & uracil transport 66 2.46E-4
20 SGTC_344 k064-0035 3.46 6.4 µM 1.01E-4 60S ribosome export 37 2.71E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.132 1.34E-14 YDR294C DPL1 hom Dihydrosphingosine phosphate lyase, regulates intracellular levels of sphingolipid long-chain base phosphates (LCBPs), degrades phosphorylated long chain bases, prefers C16 dihydrosphingosine-l-phosphate as a substrate
0.121 2.44E-12 YLR366W_d YLR366W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR364C-A
0.120 2.84E-12 YGL103W RPL28 het Ribosomal 60S subunit protein L28; homologous to mammalian ribosomal protein L27A and bacterial L15; may have peptidyl transferase activity; can mutate to cycloheximide resistance
0.117 1.06E-11 YPL249C GYP5 hom GTPase-activating protein (GAP) for yeast Rab family members; involved in ER to Golgi trafficking; exhibits GAP activity toward Ypt1p that is stimulated by Gyl1p, also acts on Sec4p; interacts with Gyl1p, Rvs161p and Rvs167p; involved in recruiting Rvs167p to the bud tip during polarized growth; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.108 3.73E-10 YER063W THO1 hom Conserved nuclear RNA-binding protein; specifically binds to transcribed chromatin in a THO- and RNA-dependent manner, genetically interacts with shuttling hnRNP NAB2; overproduction suppresses transcriptional defect caused by hpr1 mutation
0.107 5.61E-10 YFL030W AGX1 hom Alanine:glyoxylate aminotransferase (AGT), catalyzes the synthesis of glycine from glyoxylate, which is one of three pathways for glycine biosynthesis in yeast; has similarity to mammalian and plant alanine:glyoxylate aminotransferases
0.101 4.37E-9 YCL011C GBP2 hom Poly(A+) RNA-binding protein; involved in the export of mRNAs from the nucleus to the cytoplasm; similar to Npl3p; also binds single-stranded telomeric repeat sequence in vitro; GBP2 has a paralog, HRB1, that arose from the whole genome duplication
0.097 1.54E-8 YOR131C YOR131C hom Putative haloacid dehalogenase-like hydrolase; non-essential gene; overexpression causes a cell cycle delay or arrest; protein abundance increases in response to DNA replication stress
0.095 3.70E-8 YDL049C KNH1 hom Protein with similarity to Kre9p, which is involved in cell wall beta 1,6-glucan synthesis; overproduction suppresses growth defects of a kre9 null mutant; required for propionic acid resistance
0.091 1.29E-7 YKR077W MSA2 hom Putative transcriptional activator, that interacts with G1-specific transcription factor, MBF and G1-specific promoters; ortholog of Msa2p, an MBF and SBF activator that regulates G1-specific transcription and cell cycle initiation
0.091 1.44E-7 YOR103C OST2 het Epsilon subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins
0.090 1.72E-7 YNL176C_p TDA7_p hom Cell cycle-regulated gene of unknown function, promoter bound by Fkh2p; null mutant is sensitive to expression of the top1-T722A allele
0.089 2.51E-7 YDL029W ARP2 het Essential component of the Arp2/3 complex, which is a highly conserved actin nucleation center required for the motility and integrity of actin patches; involved in endocytosis and membrane growth and polarity
0.087 4.68E-7 YDR489W SLD5 het Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery
0.083 1.62E-6 YDL028C MPS1 het Dual-specificity kinase; required for spindle pole body (SPB) duplication and spindle checkpoint function; substrates include SPB proteins Spc42p, Spc110p, and Spc98p, mitotic exit network protein Mob1p, kinetochore protein Cnn1p, and checkpoint protein Mad1p