YML009C-A_d

Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain
fixedexpanded
Profile for YML009C-A / YML009C-A

Click on Significant Values for Screen Details ID:SGTC_56|Compound:0957-0365|FD-Score:3.80|P-value:3.09E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:4.06|P-value:1.27E-4 ID:SGTC_146|Compound:3448-8650|FD-Score:-3.44|P-value:9.53E-4 ID:SGTC_158|Compound:k038-0087|FD-Score:-4.20|P-value:7.52E-5 ID:SGTC_615|Compound:k087-0205|FD-Score:3.75|P-value:3.68E-4 ID:SGTC_704|Compound:1310-0270|FD-Score:4.17|P-value:8.62E-5 ID:SGTC_831|Compound:k061-1017|FD-Score:5.11|P-value:2.04E-6 ID:SGTC_864|Compound:0469-0573|FD-Score:4.66|P-value:1.32E-5 ID:SGTC_868|Compound:0527-0199|FD-Score:4.16|P-value:8.75E-5 ID:SGTC_1031|Compound:k035-0009|FD-Score:4.92|P-value:4.52E-6 ID:SGTC_1129|Compound:3453-1384|FD-Score:3.77|P-value:3.39E-4 ID:SGTC_1204|Compound:4049-0315|FD-Score:4.00|P-value:1.54E-4 ID:SGTC_1243|Compound:0416-0003|FD-Score:4.08|P-value:1.17E-4 ID:SGTC_1256|Compound:0570-0116|FD-Score:4.88|P-value:5.45E-6 ID:SGTC_1261|Compound:0712-0010|FD-Score:5.29|P-value:9.14E-7 ID:SGTC_1383|Compound:3049-0032|FD-Score:4.68|P-value:1.25E-5 ID:SGTC_1465|Compound:k213-0056|FD-Score:4.77|P-value:8.45E-6 ID:SGTC_1466|Compound:k213-0079|FD-Score:4.16|P-value:8.73E-5 ID:SGTC_1482|Compound:3346-2049|FD-Score:3.66|P-value:4.92E-4 ID:SGTC_1484|Compound:3473-2379|FD-Score:7.08|P-value:8.85E-11 ID:SGTC_1518|Compound:st038567|FD-Score:3.88|P-value:2.32E-4 ID:SGTC_1588|Compound:farnesol|FD-Score:3.46|P-value:9.09E-4 ID:SGTC_1599|Compound:8-chlro-1-tetrahydronorharmanone|FD-Score:3.86|P-value:2.54E-4 ID:SGTC_1689|Compound:st020265|FD-Score:4.91|P-value:4.77E-6 ID:SGTC_1693|Compound:xanthone|FD-Score:4.18|P-value:8.29E-5 ID:SGTC_1981|Compound:st071826|FD-Score:4.13|P-value:9.93E-5 ID:SGTC_1995|Compound:st072814|FD-Score:-4.42|P-value:3.35E-5 ID:SGTC_2038|Compound:4100038|FD-Score:3.44|P-value:9.77E-4 ID:SGTC_2065|Compound:5221596|FD-Score:-3.72|P-value:4.02E-4 ID:SGTC_2169|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:4.59|P-value:1.75E-5 ID:SGTC_2325|Compound:6158266|FD-Score:3.51|P-value:7.77E-4 ID:SGTC_2368|Compound:9071271|FD-Score:7.06|P-value:9.97E-11 ID:SGTC_2398|Compound:5228213|FD-Score:-4.00|P-value:1.54E-4 ID:SGTC_2510|Compound:benzyl isothiocyanate|FD-Score:3.60|P-value:5.93E-4 ID:SGTC_2586|Compound:curcumin|FD-Score:-4.10|P-value:1.07E-4 ID:SGTC_2591|Compound:skatole|FD-Score:4.47|P-value:2.79E-5 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:4.02|P-value:1.43E-4 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:4.05|P-value:1.31E-4 ID:SGTC_2657|Compound:nystatin|FD-Score:3.75|P-value:3.64E-4 ID:SGTC_2709|Compound:st078560|FD-Score:-4.33|P-value:4.71E-5 ID:SGTC_2896|Compound:9052656|FD-Score:-8.52|P-value:8.10E-15 ID:SGTC_2985|Compound:9022375|FD-Score:3.43|P-value:9.84E-4 ID:SGTC_3075|Compound:9116269|FD-Score:3.78|P-value:3.25E-4 ID:SGTC_3196|Compound:9111891|FD-Score:4.56|P-value:1.99E-5 ID:SGTC_3200|Compound:9114385|FD-Score:4.23|P-value:6.94E-5 ID:SGTC_56|Compound:0957-0365|FD-Score:3.80|P-value:3.09E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:4.06|P-value:1.27E-4 ID:SGTC_146|Compound:3448-8650|FD-Score:-3.44|P-value:9.53E-4 ID:SGTC_158|Compound:k038-0087|FD-Score:-4.20|P-value:7.52E-5 ID:SGTC_615|Compound:k087-0205|FD-Score:3.75|P-value:3.68E-4 ID:SGTC_704|Compound:1310-0270|FD-Score:4.17|P-value:8.62E-5 ID:SGTC_831|Compound:k061-1017|FD-Score:5.11|P-value:2.04E-6 ID:SGTC_864|Compound:0469-0573|FD-Score:4.66|P-value:1.32E-5 ID:SGTC_868|Compound:0527-0199|FD-Score:4.16|P-value:8.75E-5 ID:SGTC_1031|Compound:k035-0009|FD-Score:4.92|P-value:4.52E-6 ID:SGTC_1129|Compound:3453-1384|FD-Score:3.77|P-value:3.39E-4 ID:SGTC_1204|Compound:4049-0315|FD-Score:4.00|P-value:1.54E-4 ID:SGTC_1243|Compound:0416-0003|FD-Score:4.08|P-value:1.17E-4 ID:SGTC_1256|Compound:0570-0116|FD-Score:4.88|P-value:5.45E-6 ID:SGTC_1261|Compound:0712-0010|FD-Score:5.29|P-value:9.14E-7 ID:SGTC_1383|Compound:3049-0032|FD-Score:4.68|P-value:1.25E-5 ID:SGTC_1465|Compound:k213-0056|FD-Score:4.77|P-value:8.45E-6 ID:SGTC_1466|Compound:k213-0079|FD-Score:4.16|P-value:8.73E-5 ID:SGTC_1482|Compound:3346-2049|FD-Score:3.66|P-value:4.92E-4 ID:SGTC_1484|Compound:3473-2379|FD-Score:7.08|P-value:8.85E-11 ID:SGTC_1518|Compound:st038567|FD-Score:3.88|P-value:2.32E-4 ID:SGTC_1588|Compound:farnesol|FD-Score:3.46|P-value:9.09E-4 ID:SGTC_1599|Compound:8-chlro-1-tetrahydronorharmanone|FD-Score:3.86|P-value:2.54E-4 ID:SGTC_1689|Compound:st020265|FD-Score:4.91|P-value:4.77E-6 ID:SGTC_1693|Compound:xanthone|FD-Score:4.18|P-value:8.29E-5 ID:SGTC_1981|Compound:st071826|FD-Score:4.13|P-value:9.93E-5 ID:SGTC_1995|Compound:st072814|FD-Score:-4.42|P-value:3.35E-5 ID:SGTC_2038|Compound:4100038|FD-Score:3.44|P-value:9.77E-4 ID:SGTC_2065|Compound:5221596|FD-Score:-3.72|P-value:4.02E-4 ID:SGTC_2169|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:4.59|P-value:1.75E-5 ID:SGTC_2325|Compound:6158266|FD-Score:3.51|P-value:7.77E-4 ID:SGTC_2368|Compound:9071271|FD-Score:7.06|P-value:9.97E-11 ID:SGTC_2398|Compound:5228213|FD-Score:-4.00|P-value:1.54E-4 ID:SGTC_2510|Compound:benzyl isothiocyanate|FD-Score:3.60|P-value:5.93E-4 ID:SGTC_2586|Compound:curcumin|FD-Score:-4.10|P-value:1.07E-4 ID:SGTC_2591|Compound:skatole|FD-Score:4.47|P-value:2.79E-5 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:4.02|P-value:1.43E-4 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:4.05|P-value:1.31E-4 ID:SGTC_2657|Compound:nystatin|FD-Score:3.75|P-value:3.64E-4 ID:SGTC_2709|Compound:st078560|FD-Score:-4.33|P-value:4.71E-5 ID:SGTC_2896|Compound:9052656|FD-Score:-8.52|P-value:8.10E-15 ID:SGTC_2985|Compound:9022375|FD-Score:3.43|P-value:9.84E-4 ID:SGTC_3075|Compound:9116269|FD-Score:3.78|P-value:3.25E-4 ID:SGTC_3196|Compound:9111891|FD-Score:4.56|P-value:1.99E-5 ID:SGTC_3200|Compound:9114385|FD-Score:4.23|P-value:6.94E-5

Top fitness defect scores for YML009C-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1484 3473-2379 7.08 286.0 µM 8.85E-11 1 7.33E-13
2 SGTC_2368 9071271 7.06 200.0 µM 9.97E-11 2 8.49E-13
3 SGTC_1261 0712-0010 5.29 12.7 µM 9.14E-7 RNA processing & uracil transport 6 6.01E-8
4 SGTC_831 k061-1017 5.11 217.0 µM 2.04E-6 translation 19 1.60E-7
5 SGTC_1031 k035-0009 4.92 16.0 µM 4.52E-6 10 4.23E-7
6 SGTC_1689 st020265 4.91 53.5 µM 4.77E-6 9 4.52E-7
7 SGTC_1256 0570-0116 4.88 285.0 µM 5.45E-6 3 5.32E-7
8 SGTC_1465 k213-0056 4.77 144.0 µM 8.45E-6 DNA intercalators 12 9.08E-7
9 SGTC_1383 3049-0032 4.68 20.7 µM 1.25E-5 60S ribosome export 11 1.46E-6
10 SGTC_864 0469-0573 4.66 172.0 µM 1.32E-5 8 1.56E-6
11 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 4.59 49.5 µM 1.75E-5 11 2.20E-6
12 SGTC_3196 9111891 4.56 49.5 µM 1.99E-5 mitochondrial processes 10 2.58E-6
13 SGTC_2591 skatole 4.47 100.0 µM 2.79E-5 22 3.89E-6
14 SGTC_3200 9114385 4.23 49.5 µM 6.94E-5 25 1.18E-5
15 SGTC_1693 xanthone 4.18 101.9 µM 8.29E-5 DNA damage response 12 1.47E-5
16 SGTC_704 1310-0270 4.17 142.0 µM 8.62E-5 29 1.54E-5
17 SGTC_1466 k213-0079 4.16 57.5 µM 8.73E-5 13 1.56E-5
18 SGTC_868 0527-0199 4.16 213.0 µM 8.75E-5 fatty acid desaturase (OLE1) 24 1.57E-5
19 SGTC_1981 st071826 4.13 47.0 µM 9.93E-5 13 1.83E-5
20 SGTC_1243 0416-0003 4.08 5.7 µM 1.17E-4 PDR1 26 2.22E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.135 5.23E-15 YGL246C RAI1 hom Nuclear protein with decapping endonuclease activity targeted toward mRNAs with unmethylated 7-methylguanosine cap structures; binds to and stabilizes the exoribonuclease Rat1p; required for pre-rRNA processing; homologous to human DOM3Z
0.121 1.81E-12 YOR170W_d YOR170W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene LCB4
0.114 3.24E-11 YDR140W MTQ2 hom S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; subunit of complex with Trm112p that methylates translation release factor Sup45p (eRF1) in the ternary complex eRF1-eRF3-GTP; similar to E.coli PrmC
0.113 4.68E-11 YLR264C-A_p YLR264C-A_p hom Putative protein of unknown function
0.110 1.47E-10 YER122C GLO3 hom ADP-ribosylation factor GTPase activating protein (ARF GAP), involved in ER-Golgi transport; shares functional similarity with Gcs1p
0.109 2.14E-10 YPR043W RPL43A hom Ribosomal 60S subunit protein L43A; null mutation confers a dominant lethal phenotype; homologous to mammalian ribosomal protein L37A, no bacterial homolog; RPL43A has a paralog, RPL43B, that arose from the whole genome duplication
0.098 1.41E-8 YPR100W MRPL51 hom Mitochondrial ribosomal protein of the large subunit
0.096 2.62E-8 YMR193W MRPL24 hom Mitochondrial ribosomal protein of the large subunit; two mitochondrial ribosomal proteins, YmL14 and YmL24, have been assigned to the same gene
0.095 3.27E-8 YJR032W CPR7 hom Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds to Hsp82p and contributes to chaperone activity
0.092 9.12E-8 YLR061W RPL22A hom Ribosomal 60S subunit protein L22A; required for the oxidative stress response in yeast; homologous to mammalian ribosomal protein L22, no bacterial homolog; RPL22A has a paralog, RPL22B, that arose from the whole genome duplication
0.091 1.40E-7 YMR257C PET111 hom Mitochondrial translational activator specific for the COX2 mRNA; located in the mitochondrial inner membrane
0.088 3.15E-7 YCR047C BUD23 hom Methyltransferase, methylates residue G1575 of 18S rRNA; required for rRNA processing and nuclear export of 40S ribosomal subunits independently of methylation activity; diploid mutant displays random budding pattern
0.085 8.19E-7 YLR048W RPS0B hom Protein component of the small (40S) ribosomal subunit; RPS0B has a paralog, RPS0A, that arose from the whole genome duplication; required for maturation of 18S rRNA along with Rps0Ap; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal; homologous to human ribosomal protein SA and bacterial S2
0.084 1.22E-6 YOR282W_d YOR282W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps essential, verified gene PLP2/YOR281C
0.083 1.45E-6 YML094W GIM5 hom Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it