YML009W-B_d

Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data; deletion mutation confers an increase in Ty1 transposition

Zygosity: Homozygous strain
fixedexpanded
Profile for YML009W-B / YML009W-B

Click on Significant Values for Screen Details ID:SGTC_31|Compound:0508-1974|FD-Score:3.30|P-value:5.32E-4 ID:SGTC_65|Compound:0798-0905|FD-Score:-3.82|P-value:7.01E-5 ID:SGTC_70|Compound:0141-0289|FD-Score:-3.41|P-value:3.36E-4 ID:SGTC_73|Compound:0327-0325|FD-Score:3.16|P-value:8.73E-4 ID:SGTC_117|Compound:lucigenin|FD-Score:4.21|P-value:1.47E-5 ID:SGTC_118|Compound:0083-0097|FD-Score:7.30|P-value:2.08E-13 ID:SGTC_310|Compound:1273-0058|FD-Score:3.18|P-value:8.00E-4 ID:SGTC_335|Compound:4077-0256|FD-Score:-3.56|P-value:1.92E-4 ID:SGTC_353|Compound:1988-1175|FD-Score:-3.41|P-value:3.36E-4 ID:SGTC_578|Compound:3460-0051|FD-Score:3.51|P-value:2.49E-4 ID:SGTC_589|Compound:1227-0070|FD-Score:3.19|P-value:7.82E-4 ID:SGTC_665|Compound:3914-0008|FD-Score:3.83|P-value:7.36E-5 ID:SGTC_765|Compound:1319-0117|FD-Score:4.20|P-value:1.55E-5 ID:SGTC_894|Compound:0960-0238|FD-Score:-3.18|P-value:7.48E-4 ID:SGTC_920|Compound:mycophenolic acid|FD-Score:3.68|P-value:1.29E-4 ID:SGTC_931|Compound:2812-0076|FD-Score:4.22|P-value:1.43E-5 ID:SGTC_1103|Compound:duloxetine|FD-Score:4.04|P-value:3.00E-5 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:-3.39|P-value:3.54E-4 ID:SGTC_1119|Compound:parthenolide|FD-Score:3.38|P-value:4.04E-4 ID:SGTC_1123|Compound:mangostin|FD-Score:3.94|P-value:4.66E-5 ID:SGTC_1149|Compound:3909-7961|FD-Score:3.45|P-value:3.15E-4 ID:SGTC_1157|Compound:4092-0394|FD-Score:3.17|P-value:8.44E-4 ID:SGTC_1158|Compound:4092-0494|FD-Score:3.88|P-value:5.90E-5 ID:SGTC_1217|Compound:1183-1422|FD-Score:3.33|P-value:4.72E-4 ID:SGTC_1336|Compound:1486-0901|FD-Score:3.46|P-value:3.00E-4 ID:SGTC_1337|Compound:1486-1011|FD-Score:3.58|P-value:1.94E-4 ID:SGTC_1388|Compound:3346-4487|FD-Score:4.35|P-value:8.01E-6 ID:SGTC_1775|Compound:st081588|FD-Score:3.48|P-value:2.75E-4 ID:SGTC_1786|Compound:berberine|FD-Score:4.62|P-value:2.29E-6 ID:SGTC_1845|Compound:st056753|FD-Score:3.92|P-value:5.06E-5 ID:SGTC_1887|Compound:st057648|FD-Score:4.51|P-value:3.80E-6 ID:SGTC_1888|Compound:azatryptophan|FD-Score:3.52|P-value:2.37E-4 ID:SGTC_1893|Compound:st059353|FD-Score:3.56|P-value:2.06E-4 ID:SGTC_2042|Compound:p-Dimethylaminoacetophenone|FD-Score:4.53|P-value:3.51E-6 ID:SGTC_2082|Compound:5219693|FD-Score:3.36|P-value:4.34E-4 ID:SGTC_2133|Compound:5320837|FD-Score:5.20|P-value:1.24E-7 ID:SGTC_2136|Compound:5328288|FD-Score:-3.88|P-value:5.46E-5 ID:SGTC_2149|Compound:5554786|FD-Score:-3.18|P-value:7.45E-4 ID:SGTC_2243|Compound:6634756|FD-Score:3.78|P-value:8.67E-5 ID:SGTC_2250|Compound:alverine citrate|FD-Score:3.50|P-value:2.58E-4 ID:SGTC_2276|Compound:7947513|FD-Score:4.51|P-value:3.84E-6 ID:SGTC_2277|Compound:7947813|FD-Score:3.61|P-value:1.70E-4 ID:SGTC_2376|Compound:9072922|FD-Score:-3.52|P-value:2.19E-4 ID:SGTC_2384|Compound:9036245|FD-Score:3.24|P-value:6.55E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:4.49|P-value:4.23E-6 ID:SGTC_2623|Compound:humulene|FD-Score:-4.06|P-value:2.58E-5 ID:SGTC_2638|Compound:epoxomicin|FD-Score:3.30|P-value:5.26E-4 ID:SGTC_2643|Compound:anethole|FD-Score:6.41|P-value:9.41E-11 ID:SGTC_2678|Compound:equilin|FD-Score:-3.17|P-value:7.81E-4 ID:SGTC_2748|Compound:diazoxide|FD-Score:3.38|P-value:3.97E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-4.99|P-value:3.30E-7 ID:SGTC_2905|Compound:7799065|FD-Score:-3.24|P-value:6.04E-4 ID:SGTC_2970|Compound:9090938|FD-Score:3.57|P-value:1.96E-4 ID:SGTC_2972|Compound:9093619|FD-Score:4.74|P-value:1.29E-6 ID:SGTC_2983|Compound:9022671|FD-Score:3.56|P-value:2.03E-4 ID:SGTC_3072|Compound:9116419|FD-Score:3.32|P-value:5.02E-4 ID:SGTC_3083|Compound:9117465|FD-Score:3.58|P-value:1.93E-4 ID:SGTC_3124|Compound:9127567|FD-Score:3.57|P-value:1.97E-4 ID:SGTC_3127|Compound:9126946|FD-Score:5.84|P-value:3.40E-9 ID:SGTC_3129|Compound:9127257|FD-Score:3.57|P-value:1.97E-4 ID:SGTC_3138|Compound:9097216|FD-Score:3.44|P-value:3.17E-4 ID:SGTC_3140|Compound:9094243|FD-Score:3.44|P-value:3.22E-4 ID:SGTC_3142|Compound:9086498|FD-Score:-4.47|P-value:4.13E-6 ID:SGTC_3151|Compound:9099821|FD-Score:-3.33|P-value:4.51E-4 ID:SGTC_3195|Compound:9113082|FD-Score:-6.72|P-value:1.04E-11 ID:SGTC_31|Compound:0508-1974|FD-Score:3.30|P-value:5.32E-4 ID:SGTC_65|Compound:0798-0905|FD-Score:-3.82|P-value:7.01E-5 ID:SGTC_70|Compound:0141-0289|FD-Score:-3.41|P-value:3.36E-4 ID:SGTC_73|Compound:0327-0325|FD-Score:3.16|P-value:8.73E-4 ID:SGTC_117|Compound:lucigenin|FD-Score:4.21|P-value:1.47E-5 ID:SGTC_118|Compound:0083-0097|FD-Score:7.30|P-value:2.08E-13 ID:SGTC_310|Compound:1273-0058|FD-Score:3.18|P-value:8.00E-4 ID:SGTC_335|Compound:4077-0256|FD-Score:-3.56|P-value:1.92E-4 ID:SGTC_353|Compound:1988-1175|FD-Score:-3.41|P-value:3.36E-4 ID:SGTC_578|Compound:3460-0051|FD-Score:3.51|P-value:2.49E-4 ID:SGTC_589|Compound:1227-0070|FD-Score:3.19|P-value:7.82E-4 ID:SGTC_665|Compound:3914-0008|FD-Score:3.83|P-value:7.36E-5 ID:SGTC_765|Compound:1319-0117|FD-Score:4.20|P-value:1.55E-5 ID:SGTC_894|Compound:0960-0238|FD-Score:-3.18|P-value:7.48E-4 ID:SGTC_920|Compound:mycophenolic acid|FD-Score:3.68|P-value:1.29E-4 ID:SGTC_931|Compound:2812-0076|FD-Score:4.22|P-value:1.43E-5 ID:SGTC_1103|Compound:duloxetine|FD-Score:4.04|P-value:3.00E-5 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:-3.39|P-value:3.54E-4 ID:SGTC_1119|Compound:parthenolide|FD-Score:3.38|P-value:4.04E-4 ID:SGTC_1123|Compound:mangostin|FD-Score:3.94|P-value:4.66E-5 ID:SGTC_1149|Compound:3909-7961|FD-Score:3.45|P-value:3.15E-4 ID:SGTC_1157|Compound:4092-0394|FD-Score:3.17|P-value:8.44E-4 ID:SGTC_1158|Compound:4092-0494|FD-Score:3.88|P-value:5.90E-5 ID:SGTC_1217|Compound:1183-1422|FD-Score:3.33|P-value:4.72E-4 ID:SGTC_1336|Compound:1486-0901|FD-Score:3.46|P-value:3.00E-4 ID:SGTC_1337|Compound:1486-1011|FD-Score:3.58|P-value:1.94E-4 ID:SGTC_1388|Compound:3346-4487|FD-Score:4.35|P-value:8.01E-6 ID:SGTC_1775|Compound:st081588|FD-Score:3.48|P-value:2.75E-4 ID:SGTC_1786|Compound:berberine|FD-Score:4.62|P-value:2.29E-6 ID:SGTC_1845|Compound:st056753|FD-Score:3.92|P-value:5.06E-5 ID:SGTC_1887|Compound:st057648|FD-Score:4.51|P-value:3.80E-6 ID:SGTC_1888|Compound:azatryptophan|FD-Score:3.52|P-value:2.37E-4 ID:SGTC_1893|Compound:st059353|FD-Score:3.56|P-value:2.06E-4 ID:SGTC_2042|Compound:p-Dimethylaminoacetophenone|FD-Score:4.53|P-value:3.51E-6 ID:SGTC_2082|Compound:5219693|FD-Score:3.36|P-value:4.34E-4 ID:SGTC_2133|Compound:5320837|FD-Score:5.20|P-value:1.24E-7 ID:SGTC_2136|Compound:5328288|FD-Score:-3.88|P-value:5.46E-5 ID:SGTC_2149|Compound:5554786|FD-Score:-3.18|P-value:7.45E-4 ID:SGTC_2243|Compound:6634756|FD-Score:3.78|P-value:8.67E-5 ID:SGTC_2250|Compound:alverine citrate|FD-Score:3.50|P-value:2.58E-4 ID:SGTC_2276|Compound:7947513|FD-Score:4.51|P-value:3.84E-6 ID:SGTC_2277|Compound:7947813|FD-Score:3.61|P-value:1.70E-4 ID:SGTC_2376|Compound:9072922|FD-Score:-3.52|P-value:2.19E-4 ID:SGTC_2384|Compound:9036245|FD-Score:3.24|P-value:6.55E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:4.49|P-value:4.23E-6 ID:SGTC_2623|Compound:humulene|FD-Score:-4.06|P-value:2.58E-5 ID:SGTC_2638|Compound:epoxomicin|FD-Score:3.30|P-value:5.26E-4 ID:SGTC_2643|Compound:anethole|FD-Score:6.41|P-value:9.41E-11 ID:SGTC_2678|Compound:equilin|FD-Score:-3.17|P-value:7.81E-4 ID:SGTC_2748|Compound:diazoxide|FD-Score:3.38|P-value:3.97E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-4.99|P-value:3.30E-7 ID:SGTC_2905|Compound:7799065|FD-Score:-3.24|P-value:6.04E-4 ID:SGTC_2970|Compound:9090938|FD-Score:3.57|P-value:1.96E-4 ID:SGTC_2972|Compound:9093619|FD-Score:4.74|P-value:1.29E-6 ID:SGTC_2983|Compound:9022671|FD-Score:3.56|P-value:2.03E-4 ID:SGTC_3072|Compound:9116419|FD-Score:3.32|P-value:5.02E-4 ID:SGTC_3083|Compound:9117465|FD-Score:3.58|P-value:1.93E-4 ID:SGTC_3124|Compound:9127567|FD-Score:3.57|P-value:1.97E-4 ID:SGTC_3127|Compound:9126946|FD-Score:5.84|P-value:3.40E-9 ID:SGTC_3129|Compound:9127257|FD-Score:3.57|P-value:1.97E-4 ID:SGTC_3138|Compound:9097216|FD-Score:3.44|P-value:3.17E-4 ID:SGTC_3140|Compound:9094243|FD-Score:3.44|P-value:3.22E-4 ID:SGTC_3142|Compound:9086498|FD-Score:-4.47|P-value:4.13E-6 ID:SGTC_3151|Compound:9099821|FD-Score:-3.33|P-value:4.51E-4 ID:SGTC_3195|Compound:9113082|FD-Score:-6.72|P-value:1.04E-11

Top fitness defect scores for YML009W-B deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_118 0083-0097 7.30 135.3 µM 2.08E-13 translation 6 1.46E-13
2 SGTC_2643 anethole 6.41 100.0 µM 9.41E-11 1 7.08E-11
3 SGTC_3127 9126946 5.84 49.5 µM 3.40E-9 ERG2 4 2.67E-9
4 SGTC_2133 5320837 5.20 200.0 µM 1.24E-7 ERG2 9 1.02E-7
5 SGTC_2972 9093619 4.74 59.9 µM 1.29E-6 10 1.09E-6
6 SGTC_1786 berberine 4.62 21.6 µM 2.29E-6 60S ribosome export 18 1.94E-6
7 SGTC_2042 p-Dimethylaminoacetophenone 4.53 200.0 µM 3.51E-6 8 2.99E-6
8 SGTC_1887 st057648 4.51 70.8 µM 3.80E-6 3 3.24E-6
9 SGTC_2276 7947513 4.51 42.1 µM 3.84E-6 16 3.28E-6
10 SGTC_2582 agaric acid 4.49 100.0 µM 4.23E-6 redox potentiating 259 3.62E-6
11 SGTC_1388 3346-4487 4.35 254.0 µM 8.01E-6 14 6.90E-6
12 SGTC_931 2812-0076 4.22 566.0 µM 1.43E-5 18 1.24E-5
13 SGTC_117 lucigenin 4.21 22.1 µM 1.47E-5 redox potentiating 76 1.28E-5
14 SGTC_765 1319-0117 4.20 244.0 µM 1.55E-5 60S ribosome export 8 1.34E-5
15 SGTC_1103 duloxetine 4.04 36.1 µM 3.00E-5 28 2.63E-5
16 SGTC_1123 mangostin 3.94 811.3 nM 4.66E-5 mitochondrial response to ROS 40 4.10E-5
17 SGTC_1845 st056753 3.92 3.0 µM 5.06E-5 TSC3-RPN4 37 4.46E-5
18 SGTC_1158 4092-0494 3.88 91.8 µM 5.90E-5 18 5.20E-5
19 SGTC_665 3914-0008 3.83 307.0 µM 7.36E-5 23 6.52E-5
20 SGTC_2243 6634756 3.78 200.0 µM 8.67E-5 22 7.69E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.130 3.94E-14 YPR116W RRG8 hom Putative protein of unknown function, required for mitochondrial genome maintenance; null mutation results in a decrease in plasma membrane electron transport
0.121 2.04E-12 YJL063C MRPL8 hom Mitochondrial ribosomal protein of the large subunit
0.116 1.96E-11 YNL106C INP52 hom Polyphosphatidylinositol phosphatase, dephosphorylates a number of phosphatidylinositols (PIs) to PI; involved in endocytosis; hyperosmotic stress causes translocation to actin patches; synaptojanin-like protein with a Sac1 domain
0.114 4.38E-11 YLL027W ISA1 hom Protein required for maturation of mitochondrial [4Fe-4S] proteins; functions in a complex with Isa2p and possibly Iba57p; isa1 deletion causes loss of mitochondrial DNA and respiratory deficiency; depletion reduces growth on nonfermentable carbon sources; functional ortholog of bacterial A-type ISC proteins
0.107 4.46E-10 YDR194C MSS116 hom DEAD-box protein required for efficient splicing of mitochondrial Group I and II introns; non-polar RNA helicase that also facilities strand annealing
0.106 8.98E-10 YEL003W GIM4 hom Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it
0.104 1.79E-9 YLR061W RPL22A hom Ribosomal 60S subunit protein L22A; required for the oxidative stress response in yeast; homologous to mammalian ribosomal protein L22, no bacterial homolog; RPL22A has a paralog, RPL22B, that arose from the whole genome duplication
0.103 2.26E-9 YMR230W RPS10B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S10, no bacterial homolog; RPS10B has a paralog, RPS10A, that arose from the whole genome duplication
0.103 2.31E-9 YNL027W CRZ1 hom Transcription factor, activates transcription of stress response genes; nuclear localization is positively regulated by calcineurin-mediated dephosphorylation; rapidly localizes to the nucleus under blue light stress
0.102 2.79E-9 YDL001W RMD1 hom Cytoplasmic protein required for sporulation
0.099 7.81E-9 YMR282C AEP2 hom Mitochondrial protein, likely involved in translation of the mitochondrial OLI1 mRNA; exhibits genetic interaction with the OLI1 mRNA 5'-untranslated leader
0.099 8.75E-9 YGR165W MRPS35 hom Mitochondrial ribosomal protein of the small subunit; null mutant does not grow on glycerol, is sensitive to 2,4-dichlorophenol, and accumulates large lipid droplets
0.098 1.45E-8 YBR039W ATP3 hom Gamma subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis
0.097 1.79E-8 YLR139C SLS1 hom Mitochondrial membrane protein that coordinates expression of mitochondrially-encoded genes; may facilitate delivery of mRNA to membrane-bound translation machinery
0.096 2.25E-8 YER077C_p YER077C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; null mutation results in a decrease in plasma membrane electron transport