YML011C / RAD33

Protein involved in nucleotide excision repair; green fluorescent protein (GFP)-fusion protein localizes to the nucleus

Zygosity: Homozygous strain
fixedexpanded
Profile for YML011C / RAD33

Click on Significant Values for Screen Details ID:SGTC_432|Compound:NS 1619|FD-Score:5.26|P-value:1.41E-8 ID:SGTC_435|Compound:c-PAF|FD-Score:3.33|P-value:2.17E-4 ID:SGTC_471|Compound:1-acyl-paf|FD-Score:-3.34|P-value:2.36E-4 ID:SGTC_473|Compound:2-arachidonoylglycerol|FD-Score:4.29|P-value:2.93E-6 ID:SGTC_489|Compound:paxilline|FD-Score:-2.98|P-value:9.13E-4 ID:SGTC_604|Compound:1000-0114|FD-Score:3.02|P-value:7.13E-4 ID:SGTC_705|Compound:1124-0212|FD-Score:3.43|P-value:1.46E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-3.78|P-value:3.79E-5 ID:SGTC_785|Compound:1270-0111|FD-Score:3.01|P-value:7.23E-4 ID:SGTC_870|Compound:0573-2213|FD-Score:-3.77|P-value:4.04E-5 ID:SGTC_1039|Compound:k821-0043|FD-Score:3.21|P-value:3.45E-4 ID:SGTC_1104|Compound:tacrolimus|FD-Score:3.33|P-value:2.20E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-8.06|P-value:1.36E-17 ID:SGTC_1109|Compound:tnp00067|FD-Score:-3.66|P-value:6.49E-5 ID:SGTC_1115|Compound:galangin|FD-Score:4.60|P-value:6.03E-7 ID:SGTC_1283|Compound:0922-0125|FD-Score:3.03|P-value:6.76E-4 ID:SGTC_1305|Compound:1181-0477|FD-Score:3.96|P-value:1.44E-5 ID:SGTC_1359|Compound:1582-0056|FD-Score:3.13|P-value:4.71E-4 ID:SGTC_1387|Compound:3342-1166|FD-Score:4.06|P-value:9.13E-6 ID:SGTC_1677|Compound:st019204|FD-Score:3.14|P-value:4.44E-4 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:4.12|P-value:6.81E-6 ID:SGTC_1831|Compound:st055328|FD-Score:3.00|P-value:7.59E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:3.42|P-value:1.51E-4 ID:SGTC_1961|Compound:st076550|FD-Score:-3.24|P-value:3.54E-4 ID:SGTC_1966|Compound:st070145|FD-Score:-3.09|P-value:6.15E-4 ID:SGTC_1974|Compound:st069448|FD-Score:3.68|P-value:5.00E-5 ID:SGTC_1978|Compound:st071761|FD-Score:-3.33|P-value:2.50E-4 ID:SGTC_1983|Compound:st071813|FD-Score:-4.61|P-value:6.82E-7 ID:SGTC_1995|Compound:st072814|FD-Score:3.59|P-value:7.40E-5 ID:SGTC_2036|Compound:5160441|FD-Score:3.78|P-value:3.25E-5 ID:SGTC_2047|Compound:4141938|FD-Score:3.27|P-value:2.69E-4 ID:SGTC_2066|Compound:5222451|FD-Score:-3.78|P-value:3.76E-5 ID:SGTC_2083|Compound:5306046|FD-Score:3.52|P-value:1.01E-4 ID:SGTC_2101|Compound:5377231|FD-Score:3.12|P-value:4.78E-4 ID:SGTC_2279|Compound:7948423|FD-Score:3.80|P-value:2.93E-5 ID:SGTC_2312|Compound:7706453|FD-Score:-3.82|P-value:3.13E-5 ID:SGTC_2365|Compound:9042475|FD-Score:-3.30|P-value:2.79E-4 ID:SGTC_2366|Compound:9070441|FD-Score:-4.53|P-value:1.03E-6 ID:SGTC_2368|Compound:9071271|FD-Score:-4.73|P-value:3.59E-7 ID:SGTC_2405|Compound:ticlatone|FD-Score:-7.91|P-value:5.52E-17 ID:SGTC_2419|Compound:paclitaxel|FD-Score:3.19|P-value:3.70E-4 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:4.74|P-value:2.85E-7 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:4.94|P-value:9.20E-8 ID:SGTC_2622|Compound:2-methoxyxanthone|FD-Score:3.07|P-value:5.84E-4 ID:SGTC_2629|Compound:bisabolol|FD-Score:3.12|P-value:4.81E-4 ID:SGTC_2659|Compound:sanguinarine|FD-Score:-2.99|P-value:9.03E-4 ID:SGTC_2671|Compound:danthron|FD-Score:3.23|P-value:3.15E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:4.44|P-value:1.38E-6 ID:SGTC_2836|Compound:9010338|FD-Score:3.46|P-value:1.30E-4 ID:SGTC_2857|Compound:9024691|FD-Score:3.69|P-value:4.79E-5 ID:SGTC_2872|Compound:9044037|FD-Score:3.35|P-value:1.99E-4 ID:SGTC_2881|Compound:9058953|FD-Score:-3.63|P-value:7.37E-5 ID:SGTC_2886|Compound:9058944|FD-Score:-3.36|P-value:2.21E-4 ID:SGTC_2920|Compound:7982904|FD-Score:-3.25|P-value:3.35E-4 ID:SGTC_2921|Compound:7974240|FD-Score:4.56|P-value:7.36E-7 ID:SGTC_2923|Compound:7992654|FD-Score:-3.75|P-value:4.30E-5 ID:SGTC_2933|Compound:9026794|FD-Score:4.21|P-value:4.46E-6 ID:SGTC_2935|Compound:9038016|FD-Score:-2.97|P-value:9.58E-4 ID:SGTC_2942|Compound:9052777|FD-Score:4.93|P-value:9.90E-8 ID:SGTC_3061|Compound:glucosamine|FD-Score:3.67|P-value:5.34E-5 ID:SGTC_3154|Compound:9100113|FD-Score:3.49|P-value:1.14E-4 ID:SGTC_3183|Compound:9108214|FD-Score:-3.16|P-value:4.83E-4 ID:SGTC_3185|Compound:9108267|FD-Score:4.10|P-value:7.51E-6 ID:SGTC_3268|Compound:9137683|FD-Score:4.39|P-value:1.82E-6 ID:SGTC_3269|Compound:9137823|FD-Score:-2.97|P-value:9.53E-4 ID:SGTC_3272|Compound:9137413|FD-Score:4.32|P-value:2.55E-6 ID:SGTC_3277|Compound:9138724|FD-Score:-3.91|P-value:2.10E-5 ID:SGTC_3325|Compound:9138760|FD-Score:3.39|P-value:1.72E-4 ID:SGTC_432|Compound:NS 1619|FD-Score:5.26|P-value:1.41E-8 ID:SGTC_435|Compound:c-PAF|FD-Score:3.33|P-value:2.17E-4 ID:SGTC_471|Compound:1-acyl-paf|FD-Score:-3.34|P-value:2.36E-4 ID:SGTC_473|Compound:2-arachidonoylglycerol|FD-Score:4.29|P-value:2.93E-6 ID:SGTC_489|Compound:paxilline|FD-Score:-2.98|P-value:9.13E-4 ID:SGTC_604|Compound:1000-0114|FD-Score:3.02|P-value:7.13E-4 ID:SGTC_705|Compound:1124-0212|FD-Score:3.43|P-value:1.46E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-3.78|P-value:3.79E-5 ID:SGTC_785|Compound:1270-0111|FD-Score:3.01|P-value:7.23E-4 ID:SGTC_870|Compound:0573-2213|FD-Score:-3.77|P-value:4.04E-5 ID:SGTC_1039|Compound:k821-0043|FD-Score:3.21|P-value:3.45E-4 ID:SGTC_1104|Compound:tacrolimus|FD-Score:3.33|P-value:2.20E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-8.06|P-value:1.36E-17 ID:SGTC_1109|Compound:tnp00067|FD-Score:-3.66|P-value:6.49E-5 ID:SGTC_1115|Compound:galangin|FD-Score:4.60|P-value:6.03E-7 ID:SGTC_1283|Compound:0922-0125|FD-Score:3.03|P-value:6.76E-4 ID:SGTC_1305|Compound:1181-0477|FD-Score:3.96|P-value:1.44E-5 ID:SGTC_1359|Compound:1582-0056|FD-Score:3.13|P-value:4.71E-4 ID:SGTC_1387|Compound:3342-1166|FD-Score:4.06|P-value:9.13E-6 ID:SGTC_1677|Compound:st019204|FD-Score:3.14|P-value:4.44E-4 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:4.12|P-value:6.81E-6 ID:SGTC_1831|Compound:st055328|FD-Score:3.00|P-value:7.59E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:3.42|P-value:1.51E-4 ID:SGTC_1961|Compound:st076550|FD-Score:-3.24|P-value:3.54E-4 ID:SGTC_1966|Compound:st070145|FD-Score:-3.09|P-value:6.15E-4 ID:SGTC_1974|Compound:st069448|FD-Score:3.68|P-value:5.00E-5 ID:SGTC_1978|Compound:st071761|FD-Score:-3.33|P-value:2.50E-4 ID:SGTC_1983|Compound:st071813|FD-Score:-4.61|P-value:6.82E-7 ID:SGTC_1995|Compound:st072814|FD-Score:3.59|P-value:7.40E-5 ID:SGTC_2036|Compound:5160441|FD-Score:3.78|P-value:3.25E-5 ID:SGTC_2047|Compound:4141938|FD-Score:3.27|P-value:2.69E-4 ID:SGTC_2066|Compound:5222451|FD-Score:-3.78|P-value:3.76E-5 ID:SGTC_2083|Compound:5306046|FD-Score:3.52|P-value:1.01E-4 ID:SGTC_2101|Compound:5377231|FD-Score:3.12|P-value:4.78E-4 ID:SGTC_2279|Compound:7948423|FD-Score:3.80|P-value:2.93E-5 ID:SGTC_2312|Compound:7706453|FD-Score:-3.82|P-value:3.13E-5 ID:SGTC_2365|Compound:9042475|FD-Score:-3.30|P-value:2.79E-4 ID:SGTC_2366|Compound:9070441|FD-Score:-4.53|P-value:1.03E-6 ID:SGTC_2368|Compound:9071271|FD-Score:-4.73|P-value:3.59E-7 ID:SGTC_2405|Compound:ticlatone|FD-Score:-7.91|P-value:5.52E-17 ID:SGTC_2419|Compound:paclitaxel|FD-Score:3.19|P-value:3.70E-4 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:4.74|P-value:2.85E-7 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:4.94|P-value:9.20E-8 ID:SGTC_2622|Compound:2-methoxyxanthone|FD-Score:3.07|P-value:5.84E-4 ID:SGTC_2629|Compound:bisabolol|FD-Score:3.12|P-value:4.81E-4 ID:SGTC_2659|Compound:sanguinarine|FD-Score:-2.99|P-value:9.03E-4 ID:SGTC_2671|Compound:danthron|FD-Score:3.23|P-value:3.15E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:4.44|P-value:1.38E-6 ID:SGTC_2836|Compound:9010338|FD-Score:3.46|P-value:1.30E-4 ID:SGTC_2857|Compound:9024691|FD-Score:3.69|P-value:4.79E-5 ID:SGTC_2872|Compound:9044037|FD-Score:3.35|P-value:1.99E-4 ID:SGTC_2881|Compound:9058953|FD-Score:-3.63|P-value:7.37E-5 ID:SGTC_2886|Compound:9058944|FD-Score:-3.36|P-value:2.21E-4 ID:SGTC_2920|Compound:7982904|FD-Score:-3.25|P-value:3.35E-4 ID:SGTC_2921|Compound:7974240|FD-Score:4.56|P-value:7.36E-7 ID:SGTC_2923|Compound:7992654|FD-Score:-3.75|P-value:4.30E-5 ID:SGTC_2933|Compound:9026794|FD-Score:4.21|P-value:4.46E-6 ID:SGTC_2935|Compound:9038016|FD-Score:-2.97|P-value:9.58E-4 ID:SGTC_2942|Compound:9052777|FD-Score:4.93|P-value:9.90E-8 ID:SGTC_3061|Compound:glucosamine|FD-Score:3.67|P-value:5.34E-5 ID:SGTC_3154|Compound:9100113|FD-Score:3.49|P-value:1.14E-4 ID:SGTC_3183|Compound:9108214|FD-Score:-3.16|P-value:4.83E-4 ID:SGTC_3185|Compound:9108267|FD-Score:4.10|P-value:7.51E-6 ID:SGTC_3268|Compound:9137683|FD-Score:4.39|P-value:1.82E-6 ID:SGTC_3269|Compound:9137823|FD-Score:-2.97|P-value:9.53E-4 ID:SGTC_3272|Compound:9137413|FD-Score:4.32|P-value:2.55E-6 ID:SGTC_3277|Compound:9138724|FD-Score:-3.91|P-value:2.10E-5 ID:SGTC_3325|Compound:9138760|FD-Score:3.39|P-value:1.72E-4

Top fitness defect scores for YML011C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_432 NS 1619 5.26 61.3 µM 1.41E-8 6 7.09E-8
2 SGTC_2621 lithochol-11-enic acid 4.94 100.0 µM 9.20E-8 7 3.87E-7
3 SGTC_2942 9052777 4.93 62.2 µM 9.90E-8 12 4.13E-7
4 SGTC_2420 aureobasidin a 4.74 50.0 nM 2.85E-7 24 1.07E-6
5 SGTC_1115 galangin 4.60 695.7 nM 6.03E-7 RPP1 & pyrimidine depletion 3 2.12E-6
6 SGTC_2921 7974240 4.56 10.7 µM 7.36E-7 34 2.53E-6
7 SGTC_2679 rapamycin 4.44 1.0 nM 1.38E-6 119 4.47E-6
8 SGTC_3268 9137683 4.39 49.5 µM 1.82E-6 6 5.76E-6
9 SGTC_3272 9137413 4.32 49.5 µM 2.55E-6 8 7.80E-6
10 SGTC_473 2-arachidonoylglycerol 4.29 10.0 µM 2.93E-6 18 8.86E-6
11 SGTC_2933 9026794 4.21 32.5 µM 4.46E-6 11 1.30E-5
12 SGTC_1680 diphenhydramine 4.12 100.0 µM 6.81E-6 NEO1 24 1.90E-5
13 SGTC_3185 9108267 4.10 49.5 µM 7.51E-6 60S ribosome export 14 2.08E-5
14 SGTC_1387 3342-1166 4.06 1.8 µM 9.13E-6 mitochondrial processes 13 2.48E-5
15 SGTC_1305 1181-0477 3.96 144.0 µM 1.44E-5 14 3.75E-5
16 SGTC_2279 7948423 3.80 32.9 µM 2.93E-5 16 7.11E-5
17 SGTC_2036 5160441 3.78 105.0 µM 3.25E-5 NEO1 87 7.81E-5
18 SGTC_2857 9024691 3.69 58.4 µM 4.79E-5 31 1.11E-4
19 SGTC_1974 st069448 3.68 26.9 µM 5.00E-5 30 1.16E-4
20 SGTC_3061 glucosamine 3.67 200.0 µM 5.34E-5 16 1.23E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.201 6.63E-32 YGL081W_p YGL081W_p hom Putative protein of unknown function; non-essential gene; interacts genetically with CHS5, a gene involved in chitin biosynthesis
0.197 7.94E-31 YOR298C-A MBF1 hom Transcriptional coactivator; bridges the DNA-binding region of Gcn4p and TATA-binding protein Spt15p; suppressor of frameshift mutations; protein abundance increases in response to DNA replication stress
0.189 3.02E-28 YDL174C DLD1 hom D-lactate dehydrogenase, oxidizes D-lactate to pyruvate, transcription is heme-dependent, repressed by glucose, and derepressed in ethanol or lactate; located in the mitochondrial inner membrane
0.168 1.34E-22 YCR102W-A_d YCR102W-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.166 4.08E-22 YKL131W_d YKL131W_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.153 6.16E-19 YMR210W YMR210W hom Putative acyltransferase with similarity to Eeb1p and Eht1p, has a minor role in medium-chain fatty acid ethyl ester biosynthesis; may be involved in lipid metabolism and detoxification
0.151 1.19E-18 YER060W-A FCY22 hom Putative purine-cytosine permease, very similar to Fcy2p but cannot substitute for its function
0.145 2.90E-17 YKL179C COY1 hom Golgi membrane protein with similarity to mammalian CASP; genetic interactions with GOS1 (encoding a Golgi snare protein) suggest a role in Golgi function
0.143 9.79E-17 YBL036C YBL036C hom Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS
0.142 1.18E-16 YAL045C_d YAL045C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; almost completely overlaps YAL044W-A
0.141 2.00E-16 YER064C VHR2 hom Non-essential nuclear protein; null mutation has global effects on transcription; VHR2 has a paralog, VHR1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
0.138 1.09E-15 YDR037W KRS1 het Lysyl-tRNA synthetase
0.137 1.41E-15 YKL220C FRE2 hom Ferric reductase and cupric reductase, reduces siderophore-bound iron and oxidized copper prior to uptake by transporters; expression induced by low iron levels but not by low copper levels
0.134 5.57E-15 YLR223C IFH1 het Coactivator that regulates transcription of ribosomal protein (RP) genes; recruited to RP gene promoters during optimal growth conditions via Fhl1p; subunit of CURI, a complex that coordinates RP production and pre-rRNA processing
0.134 7.65E-15 YHR003C YHR003C hom Protein of unknown function, localized to the mitochondrial outer membrane