YML012C-A_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene SEL1

Zygosity: Homozygous strain
fixedexpanded
Profile for YML012C-A / YML012C-A

Click on Significant Values for Screen Details ID:SGTC_36|Compound:0335-0881|FD-Score:3.76|P-value:2.10E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:3.47|P-value:5.78E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:5.40|P-value:2.08E-7 ID:SGTC_67|Compound:0335-0847|FD-Score:5.09|P-value:9.54E-7 ID:SGTC_86|Compound:0417-1630|FD-Score:5.53|P-value:1.13E-7 ID:SGTC_103|Compound:0844-0104|FD-Score:5.82|P-value:2.54E-8 ID:SGTC_137|Compound:0438-0332|FD-Score:3.50|P-value:5.15E-4 ID:SGTC_141|Compound:0443-0274|FD-Score:3.68|P-value:2.83E-4 ID:SGTC_142|Compound:0335-0849|FD-Score:3.53|P-value:4.69E-4 ID:SGTC_158|Compound:k038-0087|FD-Score:3.34|P-value:8.59E-4 ID:SGTC_165|Compound:k038-0023|FD-Score:7.40|P-value:2.22E-12 ID:SGTC_263|Compound:alizarin|FD-Score:3.34|P-value:8.56E-4 ID:SGTC_288|Compound:1315-0019|FD-Score:4.34|P-value:2.39E-5 ID:SGTC_291|Compound:4130-1278|FD-Score:6.32|P-value:1.66E-9 ID:SGTC_294|Compound:k038-0071|FD-Score:5.57|P-value:9.03E-8 ID:SGTC_299|Compound:1273-0059|FD-Score:-5.87|P-value:2.24E-8 ID:SGTC_308|Compound:4092-1169|FD-Score:-3.63|P-value:3.63E-4 ID:SGTC_309|Compound:k408-0051|FD-Score:3.99|P-value:9.34E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:-9.31|P-value:1.86E-18 ID:SGTC_314|Compound:1671-0008|FD-Score:-3.74|P-value:2.50E-4 ID:SGTC_316|Compound:k060-0003|FD-Score:4.98|P-value:1.52E-6 ID:SGTC_373|Compound:0844-0104|FD-Score:4.15|P-value:5.12E-5 ID:SGTC_426|Compound:0988-0037|FD-Score:7.72|P-value:2.50E-13 ID:SGTC_449|Compound:xestospongin c|FD-Score:4.27|P-value:3.17E-5 ID:SGTC_566|Compound:0958-0068|FD-Score:4.15|P-value:4.96E-5 ID:SGTC_568|Compound:1193-0097|FD-Score:10.40|P-value:1.64E-22 ID:SGTC_575|Compound:k072-0246|FD-Score:8.49|P-value:9.73E-16 ID:SGTC_576|Compound:1073-0113|FD-Score:7.49|P-value:1.20E-12 ID:SGTC_637|Compound:1181-0519|FD-Score:3.40|P-value:7.19E-4 ID:SGTC_660|Compound:4031-1742|FD-Score:4.11|P-value:5.88E-5 ID:SGTC_689|Compound:0833-0039|FD-Score:-3.70|P-value:2.88E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:-4.75|P-value:4.81E-6 ID:SGTC_733|Compound:4069-0007|FD-Score:9.53|P-value:2.34E-19 ID:SGTC_773|Compound:4358-1457|FD-Score:4.35|P-value:2.33E-5 ID:SGTC_813|Compound:k007-0158|FD-Score:4.63|P-value:7.07E-6 ID:SGTC_837|Compound:0091-0265|FD-Score:4.80|P-value:3.45E-6 ID:SGTC_842|Compound:0271-0008|FD-Score:5.27|P-value:3.94E-7 ID:SGTC_868|Compound:0527-0199|FD-Score:3.67|P-value:2.92E-4 ID:SGTC_951|Compound:1171-0579|FD-Score:6.66|P-value:2.20E-10 ID:SGTC_967|Compound:1306-0166|FD-Score:3.61|P-value:3.56E-4 ID:SGTC_1000|Compound:4048-0884|FD-Score:4.36|P-value:2.18E-5 ID:SGTC_1031|Compound:k035-0009|FD-Score:6.13|P-value:4.71E-9 ID:SGTC_1036|Compound:k216-0215|FD-Score:12.90|P-value:7.72E-34 ID:SGTC_1044|Compound:1222-0021|FD-Score:8.70|P-value:1.92E-16 ID:SGTC_1063|Compound:disulfiram|FD-Score:3.47|P-value:5.74E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:4.47|P-value:1.41E-5 ID:SGTC_1165|Compound:k072-0275|FD-Score:4.35|P-value:2.28E-5 ID:SGTC_1247|Compound:0448-0043|FD-Score:-3.45|P-value:6.50E-4 ID:SGTC_1250|Compound:0485-0349|FD-Score:3.71|P-value:2.52E-4 ID:SGTC_1323|Compound:1348-1351|FD-Score:-3.46|P-value:6.37E-4 ID:SGTC_1353|Compound:1498-1206|FD-Score:4.69|P-value:5.50E-6 ID:SGTC_1366|Compound:1683-0113|FD-Score:3.71|P-value:2.49E-4 ID:SGTC_1417|Compound:3966-0327|FD-Score:3.66|P-value:3.05E-4 ID:SGTC_1438|Compound:4092-1045|FD-Score:3.30|P-value:9.88E-4 ID:SGTC_1470|Compound:k295-0292|FD-Score:4.44|P-value:1.56E-5 ID:SGTC_1635|Compound:st007035|FD-Score:-3.44|P-value:6.74E-4 ID:SGTC_1755|Compound:st041960|FD-Score:3.30|P-value:9.72E-4 ID:SGTC_1766|Compound:st045414|FD-Score:3.66|P-value:2.98E-4 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:5.29|P-value:3.65E-7 ID:SGTC_1880|Compound:MG-132|FD-Score:3.93|P-value:1.15E-4 ID:SGTC_1884|Compound:5633444|FD-Score:3.37|P-value:7.76E-4 ID:SGTC_1957|Compound:st077035|FD-Score:-4.04|P-value:8.48E-5 ID:SGTC_2022|Compound:5136654|FD-Score:4.50|P-value:1.26E-5 ID:SGTC_2054|Compound:5233173|FD-Score:6.28|P-value:2.02E-9 ID:SGTC_2066|Compound:5222451|FD-Score:5.53|P-value:1.10E-7 ID:SGTC_2131|Compound:toluylene red|FD-Score:3.45|P-value:6.02E-4 ID:SGTC_2149|Compound:5554786|FD-Score:3.37|P-value:7.89E-4 ID:SGTC_2183|Compound:6420625|FD-Score:5.61|P-value:7.33E-8 ID:SGTC_2213|Compound:7173844|FD-Score:4.28|P-value:3.00E-5 ID:SGTC_2322|Compound:7413319|FD-Score:8.36|P-value:2.54E-15 ID:SGTC_2346|Compound:9031566|FD-Score:3.62|P-value:3.48E-4 ID:SGTC_2366|Compound:9070441|FD-Score:3.54|P-value:4.46E-4 ID:SGTC_2378|Compound:9074213|FD-Score:3.58|P-value:3.88E-4 ID:SGTC_2385|Compound:9074692|FD-Score:7.37|P-value:2.71E-12 ID:SGTC_2408|Compound:sulbentine|FD-Score:-4.31|P-value:3.00E-5 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:3.51|P-value:4.98E-4 ID:SGTC_2500|Compound:5-alpha-androstan-3,17-dione|FD-Score:5.76|P-value:3.49E-8 ID:SGTC_2502|Compound:avocadyne acetate|FD-Score:7.41|P-value:1.97E-12 ID:SGTC_2569|Compound:tetrandrine|FD-Score:-3.36|P-value:8.72E-4 ID:SGTC_2666|Compound:tannic acid|FD-Score:4.57|P-value:9.40E-6 ID:SGTC_2695|Compound:st077686|FD-Score:4.78|P-value:3.83E-6 ID:SGTC_2730|Compound:imipramine|FD-Score:3.92|P-value:1.21E-4 ID:SGTC_2766|Compound:oltipraz|FD-Score:4.39|P-value:1.94E-5 ID:SGTC_2810|Compound:7959871|FD-Score:5.93|P-value:1.39E-8 ID:SGTC_2902|Compound:5787006|FD-Score:3.31|P-value:9.48E-4 ID:SGTC_2918|Compound:7977171|FD-Score:4.87|P-value:2.50E-6 ID:SGTC_2965|Compound:9082772|FD-Score:5.73|P-value:4.04E-8 ID:SGTC_3030|Compound:9087619|FD-Score:3.53|P-value:4.69E-4 ID:SGTC_3037|Compound:9091026|FD-Score:-6.04|P-value:8.88E-9 ID:SGTC_3038|Compound:9091290|FD-Score:-4.05|P-value:7.91E-5 ID:SGTC_3044|Compound:9093193|FD-Score:3.51|P-value:5.02E-4 ID:SGTC_3062|Compound:9077494|FD-Score:6.05|P-value:7.28E-9 ID:SGTC_3136|Compound:9095672|FD-Score:-3.53|P-value:5.10E-4 ID:SGTC_3141|Compound:9094609|FD-Score:6.11|P-value:5.30E-9 ID:SGTC_3145|Compound:9085516|FD-Score:-3.49|P-value:5.83E-4 ID:SGTC_3165|Compound:9101544|FD-Score:3.30|P-value:9.97E-4 ID:SGTC_3166|Compound:9102297|FD-Score:4.22|P-value:3.79E-5 ID:SGTC_3199|Compound:9111318|FD-Score:3.75|P-value:2.21E-4 ID:SGTC_3277|Compound:9138724|FD-Score:4.24|P-value:3.52E-5 ID:SGTC_3334|Compound:9142812|FD-Score:4.56|P-value:9.70E-6 ID:SGTC_36|Compound:0335-0881|FD-Score:3.76|P-value:2.10E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:3.47|P-value:5.78E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:5.40|P-value:2.08E-7 ID:SGTC_67|Compound:0335-0847|FD-Score:5.09|P-value:9.54E-7 ID:SGTC_86|Compound:0417-1630|FD-Score:5.53|P-value:1.13E-7 ID:SGTC_103|Compound:0844-0104|FD-Score:5.82|P-value:2.54E-8 ID:SGTC_137|Compound:0438-0332|FD-Score:3.50|P-value:5.15E-4 ID:SGTC_141|Compound:0443-0274|FD-Score:3.68|P-value:2.83E-4 ID:SGTC_142|Compound:0335-0849|FD-Score:3.53|P-value:4.69E-4 ID:SGTC_158|Compound:k038-0087|FD-Score:3.34|P-value:8.59E-4 ID:SGTC_165|Compound:k038-0023|FD-Score:7.40|P-value:2.22E-12 ID:SGTC_263|Compound:alizarin|FD-Score:3.34|P-value:8.56E-4 ID:SGTC_288|Compound:1315-0019|FD-Score:4.34|P-value:2.39E-5 ID:SGTC_291|Compound:4130-1278|FD-Score:6.32|P-value:1.66E-9 ID:SGTC_294|Compound:k038-0071|FD-Score:5.57|P-value:9.03E-8 ID:SGTC_299|Compound:1273-0059|FD-Score:-5.87|P-value:2.24E-8 ID:SGTC_308|Compound:4092-1169|FD-Score:-3.63|P-value:3.63E-4 ID:SGTC_309|Compound:k408-0051|FD-Score:3.99|P-value:9.34E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:-9.31|P-value:1.86E-18 ID:SGTC_314|Compound:1671-0008|FD-Score:-3.74|P-value:2.50E-4 ID:SGTC_316|Compound:k060-0003|FD-Score:4.98|P-value:1.52E-6 ID:SGTC_373|Compound:0844-0104|FD-Score:4.15|P-value:5.12E-5 ID:SGTC_426|Compound:0988-0037|FD-Score:7.72|P-value:2.50E-13 ID:SGTC_449|Compound:xestospongin c|FD-Score:4.27|P-value:3.17E-5 ID:SGTC_566|Compound:0958-0068|FD-Score:4.15|P-value:4.96E-5 ID:SGTC_568|Compound:1193-0097|FD-Score:10.40|P-value:1.64E-22 ID:SGTC_575|Compound:k072-0246|FD-Score:8.49|P-value:9.73E-16 ID:SGTC_576|Compound:1073-0113|FD-Score:7.49|P-value:1.20E-12 ID:SGTC_637|Compound:1181-0519|FD-Score:3.40|P-value:7.19E-4 ID:SGTC_660|Compound:4031-1742|FD-Score:4.11|P-value:5.88E-5 ID:SGTC_689|Compound:0833-0039|FD-Score:-3.70|P-value:2.88E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:-4.75|P-value:4.81E-6 ID:SGTC_733|Compound:4069-0007|FD-Score:9.53|P-value:2.34E-19 ID:SGTC_773|Compound:4358-1457|FD-Score:4.35|P-value:2.33E-5 ID:SGTC_813|Compound:k007-0158|FD-Score:4.63|P-value:7.07E-6 ID:SGTC_837|Compound:0091-0265|FD-Score:4.80|P-value:3.45E-6 ID:SGTC_842|Compound:0271-0008|FD-Score:5.27|P-value:3.94E-7 ID:SGTC_868|Compound:0527-0199|FD-Score:3.67|P-value:2.92E-4 ID:SGTC_951|Compound:1171-0579|FD-Score:6.66|P-value:2.20E-10 ID:SGTC_967|Compound:1306-0166|FD-Score:3.61|P-value:3.56E-4 ID:SGTC_1000|Compound:4048-0884|FD-Score:4.36|P-value:2.18E-5 ID:SGTC_1031|Compound:k035-0009|FD-Score:6.13|P-value:4.71E-9 ID:SGTC_1036|Compound:k216-0215|FD-Score:12.90|P-value:7.72E-34 ID:SGTC_1044|Compound:1222-0021|FD-Score:8.70|P-value:1.92E-16 ID:SGTC_1063|Compound:disulfiram|FD-Score:3.47|P-value:5.74E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:4.47|P-value:1.41E-5 ID:SGTC_1165|Compound:k072-0275|FD-Score:4.35|P-value:2.28E-5 ID:SGTC_1247|Compound:0448-0043|FD-Score:-3.45|P-value:6.50E-4 ID:SGTC_1250|Compound:0485-0349|FD-Score:3.71|P-value:2.52E-4 ID:SGTC_1323|Compound:1348-1351|FD-Score:-3.46|P-value:6.37E-4 ID:SGTC_1353|Compound:1498-1206|FD-Score:4.69|P-value:5.50E-6 ID:SGTC_1366|Compound:1683-0113|FD-Score:3.71|P-value:2.49E-4 ID:SGTC_1417|Compound:3966-0327|FD-Score:3.66|P-value:3.05E-4 ID:SGTC_1438|Compound:4092-1045|FD-Score:3.30|P-value:9.88E-4 ID:SGTC_1470|Compound:k295-0292|FD-Score:4.44|P-value:1.56E-5 ID:SGTC_1635|Compound:st007035|FD-Score:-3.44|P-value:6.74E-4 ID:SGTC_1755|Compound:st041960|FD-Score:3.30|P-value:9.72E-4 ID:SGTC_1766|Compound:st045414|FD-Score:3.66|P-value:2.98E-4 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:5.29|P-value:3.65E-7 ID:SGTC_1880|Compound:MG-132|FD-Score:3.93|P-value:1.15E-4 ID:SGTC_1884|Compound:5633444|FD-Score:3.37|P-value:7.76E-4 ID:SGTC_1957|Compound:st077035|FD-Score:-4.04|P-value:8.48E-5 ID:SGTC_2022|Compound:5136654|FD-Score:4.50|P-value:1.26E-5 ID:SGTC_2054|Compound:5233173|FD-Score:6.28|P-value:2.02E-9 ID:SGTC_2066|Compound:5222451|FD-Score:5.53|P-value:1.10E-7 ID:SGTC_2131|Compound:toluylene red|FD-Score:3.45|P-value:6.02E-4 ID:SGTC_2149|Compound:5554786|FD-Score:3.37|P-value:7.89E-4 ID:SGTC_2183|Compound:6420625|FD-Score:5.61|P-value:7.33E-8 ID:SGTC_2213|Compound:7173844|FD-Score:4.28|P-value:3.00E-5 ID:SGTC_2322|Compound:7413319|FD-Score:8.36|P-value:2.54E-15 ID:SGTC_2346|Compound:9031566|FD-Score:3.62|P-value:3.48E-4 ID:SGTC_2366|Compound:9070441|FD-Score:3.54|P-value:4.46E-4 ID:SGTC_2378|Compound:9074213|FD-Score:3.58|P-value:3.88E-4 ID:SGTC_2385|Compound:9074692|FD-Score:7.37|P-value:2.71E-12 ID:SGTC_2408|Compound:sulbentine|FD-Score:-4.31|P-value:3.00E-5 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:3.51|P-value:4.98E-4 ID:SGTC_2500|Compound:5-alpha-androstan-3,17-dione|FD-Score:5.76|P-value:3.49E-8 ID:SGTC_2502|Compound:avocadyne acetate|FD-Score:7.41|P-value:1.97E-12 ID:SGTC_2569|Compound:tetrandrine|FD-Score:-3.36|P-value:8.72E-4 ID:SGTC_2666|Compound:tannic acid|FD-Score:4.57|P-value:9.40E-6 ID:SGTC_2695|Compound:st077686|FD-Score:4.78|P-value:3.83E-6 ID:SGTC_2730|Compound:imipramine|FD-Score:3.92|P-value:1.21E-4 ID:SGTC_2766|Compound:oltipraz|FD-Score:4.39|P-value:1.94E-5 ID:SGTC_2810|Compound:7959871|FD-Score:5.93|P-value:1.39E-8 ID:SGTC_2902|Compound:5787006|FD-Score:3.31|P-value:9.48E-4 ID:SGTC_2918|Compound:7977171|FD-Score:4.87|P-value:2.50E-6 ID:SGTC_2965|Compound:9082772|FD-Score:5.73|P-value:4.04E-8 ID:SGTC_3030|Compound:9087619|FD-Score:3.53|P-value:4.69E-4 ID:SGTC_3037|Compound:9091026|FD-Score:-6.04|P-value:8.88E-9 ID:SGTC_3038|Compound:9091290|FD-Score:-4.05|P-value:7.91E-5 ID:SGTC_3044|Compound:9093193|FD-Score:3.51|P-value:5.02E-4 ID:SGTC_3062|Compound:9077494|FD-Score:6.05|P-value:7.28E-9 ID:SGTC_3136|Compound:9095672|FD-Score:-3.53|P-value:5.10E-4 ID:SGTC_3141|Compound:9094609|FD-Score:6.11|P-value:5.30E-9 ID:SGTC_3145|Compound:9085516|FD-Score:-3.49|P-value:5.83E-4 ID:SGTC_3165|Compound:9101544|FD-Score:3.30|P-value:9.97E-4 ID:SGTC_3166|Compound:9102297|FD-Score:4.22|P-value:3.79E-5 ID:SGTC_3199|Compound:9111318|FD-Score:3.75|P-value:2.21E-4 ID:SGTC_3277|Compound:9138724|FD-Score:4.24|P-value:3.52E-5 ID:SGTC_3334|Compound:9142812|FD-Score:4.56|P-value:9.70E-6

Top fitness defect scores for YML012C-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1036 k216-0215 12.90 33.5 µM 7.72E-34 mitochondrial response to ROS 2 2.16E-38
2 SGTC_568 1193-0097 10.40 7.5 µM 1.64E-22 ERAD & cell cycle 22 1.91E-25
3 SGTC_733 4069-0007 9.53 56.1 µM 2.34E-19 ERAD & cell cycle 17 7.63E-22
4 SGTC_1044 1222-0021 8.70 1.8 µM 1.92E-16 heme biosynthesis & mitochondrial translocase 6 1.63E-18
5 SGTC_575 k072-0246 8.49 11.9 µM 9.73E-16 4 1.03E-17
6 SGTC_2322 7413319 8.36 38.2 µM 2.54E-15 ERAD & cell cycle 31 3.09E-17
7 SGTC_426 0988-0037 7.72 14.6 µM 2.50E-13 ERAD & cell cycle 7 5.82E-15
8 SGTC_576 1073-0113 7.49 22.7 µM 1.20E-12 redox potentiating 9 3.49E-14
9 SGTC_2502 avocadyne acetate 7.41 18.6 µM 1.97E-12 3 6.12E-14
10 SGTC_165 k038-0023 7.40 64.4 µM 2.22E-12 ubiquinone biosynthesis & proteasome 11 7.03E-14
11 SGTC_2385 9074692 7.37 200.0 µM 2.71E-12 5 8.80E-14
12 SGTC_951 1171-0579 6.66 82.7 µM 2.20E-10 cell wall 25 1.32E-11
13 SGTC_291 4130-1278 6.32 35.5 µM 1.66E-9 Golgi 1 1.33E-10
14 SGTC_2054 5233173 6.28 129.0 µM 2.02E-9 mitochondrial response to ROS 15 1.66E-10
15 SGTC_1031 k035-0009 6.13 16.0 µM 4.71E-9 6 4.36E-10
16 SGTC_3141 9094609 6.11 49.5 µM 5.30E-9 iron homeostasis 5 4.98E-10
17 SGTC_3062 9077494 6.05 49.5 µM 7.28E-9 mitochondrial response to ROS 13 7.14E-10
18 SGTC_2810 7959871 5.93 45.5 µM 1.39E-8 copper-dependent oxidative stress 11 1.50E-9
19 SGTC_103 0844-0104 5.82 51.8 µM 2.54E-8 ERAD & cell cycle 80 2.96E-9
20 SGTC_2500 5-alpha-androstan-3,17-dione 5.76 61.4 µM 3.49E-8 14 4.26E-9

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.327 2.71E-84 YMR022W UBC7 hom Ubiquitin conjugating enzyme, involved in the ER-associated protein degradation pathway; requires Cue1p for recruitment to the ER membrane; proposed to be involved in chromatin assembly
0.310 9.69E-76 YML014W TRM9 hom tRNA methyltransferase; catalyzes modification of wobble bases in tRNA anticodons to 2, 5-methoxycarbonylmethyluridine and 5-methoxycarbonylmethyl-2-thiouridine; may act as part of a complex with Trm112p; deletion mutation increases translational infidelity, including amino acid misincorporation and -1 frameshifting, and also confers resistance to zymocin; null mutant displays activation of stress responses
0.267 1.12E-55 YDL020C RPN4 hom Transcription factor that stimulates expression of proteasome genes; Rpn4p levels are in turn regulated by the 26S proteasome in a negative feedback control mechanism; RPN4 is transcriptionally regulated by various stress responses; relative distribution to the nucleus increases upon DNA replication stress
0.266 2.34E-55 YMR067C UBX4 hom UBX domain-containing protein that interacts with Cdc48p; involved in degradation of polyubiquitinated proteins via the ERAD (ER-associated degradation) pathway; modulates the Cdc48p-Nplp-Ufd1p AAA ATPase complex during its role in delivery of misfolded proteins to the proteasome; protein abundance increases in response to DNA replication stress
0.251 1.96E-49 YIL030C SSM4 hom Ubiquitin-protein ligase involved in ER-associated protein degradation; located in the ER/nuclear envelope; ssm4 mutation suppresses mRNA instability caused by an rna14 mutation
0.240 3.50E-45 YOL002C IZH2 hom Plasma membrane protein involved in zinc homeostasis and osmotin-induced apoptosis; transcription regulated by Zap1p, zinc and fatty acid levels; similar to mammalian adiponectins; deletion increases sensitivity to elevated zinc
0.238 2.82E-44 YOR246C ENV9 hom Protein proposed to be involved in vacuolar functions; mutant shows defect in CPY processing and defects in vacuolar morphology; has similarity to oxidoreductases, found in lipid particles; required for replication of Brome mosaic virus in S. cerevisiae, a model system for studying replication of positive-strand RNA viruses in their natural hosts
0.237 4.70E-44 YER019C-A SBH2 hom Ssh1p-Sss1p-Sbh2p complex component, involved in protein translocation into the endoplasmic reticulum; homologous to Sbh1p
0.229 3.19E-41 YDR086C SSS1 het Subunit of the Sec61p translocation complex (Sec61p-Sss1p-Sbh1p) that forms a channel for passage of secretory proteins through the endoplasmic reticulum membrane, and of the Ssh1p complex (Ssh1p-Sbh2p-Sss1p); interacts with Ost4p and Wbp1p
0.222 1.34E-38 YER084W_p YER084W_p hom Protein of unknown function; expressed at both mRNA and protein levels
0.221 1.76E-38 YDR200C VPS64 hom Protein required for cytoplasm to vacuole targeting of proteins; forms a complex with Far3p and Far7p to Far11p involved in recovery from pheromone-induced cell cycle arrest; mutant has increased aneuploidy tolerance
0.220 6.15E-38 YLR378C SEC61 het Essential subunit of Sec61 complex (Sec61p, Sbh1p, and Sss1p); forms a channel for SRP-dependent protein import and retrograde transport of misfolded proteins out of the ER; with Sec63 complex allows SRP-independent protein import into ER
0.219 1.03E-37 YDR199W_d YDR199W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene VPS64; computationally predicted to have thiol-disulfide oxidoreductase activity
0.210 8.57E-35 YMR264W CUE1 hom Ubiquitin-binding protein; endoplasmic reticulum membrane protein that recruits the ubiquitin-conjugating enzyme Ubc7p to the ER where it functions in protein degradation; contains a CUE domain that binds ubiquitin to facilitate intramolecular monoubiquitination; CUE1 has a paralog, CUE4, that arose from the whole genome duplication
0.204 6.40E-33 YOR254C SEC63 het Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER