YML012W / ERV25

Protein that forms a heterotrimeric complex with Erp1, Erp2p, and Emp24, member of the p24 family involved in endoplasmic reticulum to Golgi transport

Zygosity: Homozygous strain
fixedexpanded
Profile for YML012W / ERV25

Click on Significant Values for Screen Details ID:SGTC_31|Compound:0508-1974|FD-Score:3.13|P-value:7.12E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:5.92|P-value:1.15E-9 ID:SGTC_240|Compound:5hr heat shock (37°C) + Streptovitacin|FD-Score:3.72|P-value:8.03E-5 ID:SGTC_243|Compound:5hr heat shock (37°C) + splitomicin|FD-Score:5.74|P-value:3.32E-9 ID:SGTC_247|Compound:mechlorethamine|FD-Score:3.37|P-value:3.12E-4 ID:SGTC_285|Compound:1486-1325|FD-Score:3.04|P-value:9.89E-4 ID:SGTC_312|Compound:4092-0653|FD-Score:3.82|P-value:5.26E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:3.32|P-value:3.64E-4 ID:SGTC_517|Compound:1365-0151|FD-Score:3.18|P-value:6.12E-4 ID:SGTC_684|Compound:1140-0066|FD-Score:3.90|P-value:3.81E-5 ID:SGTC_721|Compound:1187-1332|FD-Score:4.69|P-value:1.05E-6 ID:SGTC_1033|Compound:k072-0102|FD-Score:3.35|P-value:3.29E-4 ID:SGTC_1068|Compound:loratadine|FD-Score:3.40|P-value:2.72E-4 ID:SGTC_1122|Compound:capsaicin|FD-Score:8.17|P-value:9.18E-17 ID:SGTC_1125|Compound:tnp00248|FD-Score:5.12|P-value:1.14E-7 ID:SGTC_1164|Compound:k060-0068|FD-Score:6.09|P-value:3.90E-10 ID:SGTC_1192|Compound:1488-0095|FD-Score:3.36|P-value:3.13E-4 ID:SGTC_1197|Compound:1601-0112|FD-Score:3.28|P-value:4.18E-4 ID:SGTC_1246|Compound:0422-0085|FD-Score:3.63|P-value:1.12E-4 ID:SGTC_1259|Compound:0671-0132|FD-Score:-3.22|P-value:7.62E-4 ID:SGTC_1332|Compound:1480-0653|FD-Score:3.09|P-value:8.17E-4 ID:SGTC_1543|Compound:azetidyl-2-carboxylic acid|FD-Score:3.33|P-value:3.49E-4 ID:SGTC_1573|Compound:oleylamine|FD-Score:3.40|P-value:2.73E-4 ID:SGTC_1608|Compound:st001473|FD-Score:4.35|P-value:5.32E-6 ID:SGTC_1712|Compound:st032288|FD-Score:-3.40|P-value:3.96E-4 ID:SGTC_1910|Compound:st062352|FD-Score:3.22|P-value:5.25E-4 ID:SGTC_2004|Compound:4023728|FD-Score:3.19|P-value:5.79E-4 ID:SGTC_2061|Compound:5245884|FD-Score:5.60|P-value:7.82E-9 ID:SGTC_2064|Compound:5220758|FD-Score:5.43|P-value:2.08E-8 ID:SGTC_2076|Compound:5212012|FD-Score:4.29|P-value:6.95E-6 ID:SGTC_2099|Compound:5377090|FD-Score:3.24|P-value:4.87E-4 ID:SGTC_2241|Compound:6772625|FD-Score:3.09|P-value:8.22E-4 ID:SGTC_2394|Compound:5221648|FD-Score:-3.44|P-value:3.40E-4 ID:SGTC_2399|Compound:5884133|FD-Score:4.19|P-value:1.11E-5 ID:SGTC_2500|Compound:5-alpha-androstan-3,17-dione|FD-Score:4.00|P-value:2.49E-5 ID:SGTC_2506|Compound:ethyl hematommate|FD-Score:3.11|P-value:7.75E-4 ID:SGTC_2569|Compound:tetrandrine|FD-Score:-3.79|P-value:8.85E-5 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:-3.37|P-value:4.47E-4 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:3.33|P-value:3.56E-4 ID:SGTC_2960|Compound:9079389|FD-Score:3.64|P-value:1.09E-4 ID:SGTC_2994|Compound:9053520|FD-Score:4.02|P-value:2.30E-5 ID:SGTC_3209|Compound:9113616|FD-Score:-3.75|P-value:1.04E-4 ID:SGTC_31|Compound:0508-1974|FD-Score:3.13|P-value:7.12E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:5.92|P-value:1.15E-9 ID:SGTC_240|Compound:5hr heat shock (37°C) + Streptovitacin|FD-Score:3.72|P-value:8.03E-5 ID:SGTC_243|Compound:5hr heat shock (37°C) + splitomicin|FD-Score:5.74|P-value:3.32E-9 ID:SGTC_247|Compound:mechlorethamine|FD-Score:3.37|P-value:3.12E-4 ID:SGTC_285|Compound:1486-1325|FD-Score:3.04|P-value:9.89E-4 ID:SGTC_312|Compound:4092-0653|FD-Score:3.82|P-value:5.26E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:3.32|P-value:3.64E-4 ID:SGTC_517|Compound:1365-0151|FD-Score:3.18|P-value:6.12E-4 ID:SGTC_684|Compound:1140-0066|FD-Score:3.90|P-value:3.81E-5 ID:SGTC_721|Compound:1187-1332|FD-Score:4.69|P-value:1.05E-6 ID:SGTC_1033|Compound:k072-0102|FD-Score:3.35|P-value:3.29E-4 ID:SGTC_1068|Compound:loratadine|FD-Score:3.40|P-value:2.72E-4 ID:SGTC_1122|Compound:capsaicin|FD-Score:8.17|P-value:9.18E-17 ID:SGTC_1125|Compound:tnp00248|FD-Score:5.12|P-value:1.14E-7 ID:SGTC_1164|Compound:k060-0068|FD-Score:6.09|P-value:3.90E-10 ID:SGTC_1192|Compound:1488-0095|FD-Score:3.36|P-value:3.13E-4 ID:SGTC_1197|Compound:1601-0112|FD-Score:3.28|P-value:4.18E-4 ID:SGTC_1246|Compound:0422-0085|FD-Score:3.63|P-value:1.12E-4 ID:SGTC_1259|Compound:0671-0132|FD-Score:-3.22|P-value:7.62E-4 ID:SGTC_1332|Compound:1480-0653|FD-Score:3.09|P-value:8.17E-4 ID:SGTC_1543|Compound:azetidyl-2-carboxylic acid|FD-Score:3.33|P-value:3.49E-4 ID:SGTC_1573|Compound:oleylamine|FD-Score:3.40|P-value:2.73E-4 ID:SGTC_1608|Compound:st001473|FD-Score:4.35|P-value:5.32E-6 ID:SGTC_1712|Compound:st032288|FD-Score:-3.40|P-value:3.96E-4 ID:SGTC_1910|Compound:st062352|FD-Score:3.22|P-value:5.25E-4 ID:SGTC_2004|Compound:4023728|FD-Score:3.19|P-value:5.79E-4 ID:SGTC_2061|Compound:5245884|FD-Score:5.60|P-value:7.82E-9 ID:SGTC_2064|Compound:5220758|FD-Score:5.43|P-value:2.08E-8 ID:SGTC_2076|Compound:5212012|FD-Score:4.29|P-value:6.95E-6 ID:SGTC_2099|Compound:5377090|FD-Score:3.24|P-value:4.87E-4 ID:SGTC_2241|Compound:6772625|FD-Score:3.09|P-value:8.22E-4 ID:SGTC_2394|Compound:5221648|FD-Score:-3.44|P-value:3.40E-4 ID:SGTC_2399|Compound:5884133|FD-Score:4.19|P-value:1.11E-5 ID:SGTC_2500|Compound:5-alpha-androstan-3,17-dione|FD-Score:4.00|P-value:2.49E-5 ID:SGTC_2506|Compound:ethyl hematommate|FD-Score:3.11|P-value:7.75E-4 ID:SGTC_2569|Compound:tetrandrine|FD-Score:-3.79|P-value:8.85E-5 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:-3.37|P-value:4.47E-4 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:3.33|P-value:3.56E-4 ID:SGTC_2960|Compound:9079389|FD-Score:3.64|P-value:1.09E-4 ID:SGTC_2994|Compound:9053520|FD-Score:4.02|P-value:2.30E-5 ID:SGTC_3209|Compound:9113616|FD-Score:-3.75|P-value:1.04E-4

Top fitness defect scores for YML012W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1122 capsaicin 8.17 818.6 nM 9.18E-17 1 1.55E-16
2 SGTC_1164 k060-0068 6.09 93.7 µM 3.90E-10 3 5.67E-10
3 SGTC_58 0957-0393 5.92 9.0 µM 1.15E-9 cell wall 219 1.66E-9
4 SGTC_243 5hr heat shock (37°C) + splitomicin 5.74 1.0 µM 3.32E-9 heat shock/prefoldin 17 4.72E-9
5 SGTC_2061 5245884 5.60 81.0 µM 7.82E-9 tubulin folding & SWR complex 6 1.10E-8
6 SGTC_2064 5220758 5.43 200.0 µM 2.08E-8 12 2.89E-8
7 SGTC_1125 tnp00248 5.12 1.3 µM 1.14E-7 10 1.55E-7
8 SGTC_721 1187-1332 4.69 279.0 µM 1.05E-6 cell wall signaling 9 1.39E-6
9 SGTC_1608 st001473 4.35 40.5 µM 5.32E-6 25 6.90E-6
10 SGTC_2076 5212012 4.29 200.0 µM 6.95E-6 3 8.99E-6
11 SGTC_2399 5884133 4.19 200.0 µM 1.11E-5 cell wall signaling 64 1.42E-5
12 SGTC_2994 9053520 4.02 71.4 µM 2.30E-5 RPP1 & pyrimidine depletion 21 2.93E-5
13 SGTC_2500 5-alpha-androstan-3,17-dione 4.00 61.4 µM 2.49E-5 38 3.16E-5
14 SGTC_684 1140-0066 3.90 328.0 µM 3.81E-5 Golgi 25 4.82E-5
15 SGTC_312 4092-0653 3.82 6.8 µM 5.26E-5 ergosterol depletion effects on membrane 91 6.62E-5
16 SGTC_240 5hr heat shock (37°C) + Streptovitacin 3.72 300.0 µM 8.03E-5 heat shock/prefoldin 47 1.00E-4
17 SGTC_2960 9079389 3.64 6.0 µM 1.09E-4 38 1.35E-4
18 SGTC_1246 0422-0085 3.63 105.0 µM 1.12E-4 43 1.39E-4
19 SGTC_1068 loratadine 3.40 26.9 µM 2.72E-4 47 3.34E-4
20 SGTC_1573 oleylamine 3.40 1.1 µM 2.73E-4 49 3.35E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.173 5.43E-24 YBR260C RGD1 hom GTPase-activating protein (RhoGAP) for Rho3p and Rho4p, possibly involved in control of actin cytoskeleton organization
0.150 2.15E-18 YDR205W MSC2 hom Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids
0.147 1.01E-17 YNL314W DAL82 hom Positive regulator of allophanate inducible genes; binds a dodecanucleotide sequence upstream of all genes that are induced by allophanate; contains an UISALL DNA-binding, a transcriptional activation, and a coiled-coil domain
0.145 2.83E-17 YPR054W SMK1 hom Middle sporulation-specific mitogen-activated protein kinase (MAPK) required for production of the outer spore wall layers; negatively regulates activity of the glucan synthase subunit Gsc2p
0.144 6.28E-17 YML101C-A_d YML101C-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.140 3.10E-16 YOR231W MKK1 hom MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication
0.140 4.84E-16 YLR027C AAT2 hom Cytosolic aspartate aminotransferase, involved in nitrogen metabolism; localizes to peroxisomes in oleate-grown cells
0.131 2.40E-14 YCR063W BUD31 hom Component of the SF3b subcomplex of the U2 snRNP; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern; facilitates passage through G1/S Start, but is not required for G2/M transition or exit from mitosis
0.128 1.12E-13 YNL215W IES2 hom Protein that associates with the INO80 chromatin remodeling complex; associates with the INO80 complex under low-salt conditions; essential for growth under anaerobic conditions; protein abundance increases in response to DNA replication stress
0.127 1.39E-13 YDR260C SWM1 hom Subunit of the anaphase-promoting complex, which is an E3 ubiquitin ligase that regulates the metaphase-anaphase transition and exit from mitosis; required for activation of the daughter-specific gene expression and spore wall maturation
0.126 2.32E-13 YIL160C POT1 hom 3-ketoacyl-CoA thiolase with broad chain length specificity, cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids
0.123 6.91E-13 YKR042W UTH1 hom Protein involved in cell wall biogenesis; required for mitochondrial autophagy; mitochondrial outer membrane and cell wall localized SUN family member; involved in the oxidative stress response, life span during starvation, and cell death; UTH1 has a paralog, NCA3, that arose from the whole genome duplication
0.123 7.15E-13 YBR120C CBP6 hom Mitochondrial protein required for translation of the COB mRNA; forms a complex with Cbp3p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.120 2.97E-12 YKL115C_d YKL115C_d hom Dubious open reading frame, unlikely to encode a protein; partially overlaps the verified gene PRR1
0.116 1.82E-11 YGR058W PEF1 hom Penta-EF-hand protein required for polar bud growth and cell wall abscission; binds calcium and zinc with different affinity; localizes to bud site in G1, bud neck in G2; binds to Sec31p and modulates COPII coat assembly