YML014W / TRM9

tRNA methyltransferase; catalyzes modification of wobble bases in tRNA anticodons to 2, 5-methoxycarbonylmethyluridine and 5-methoxycarbonylmethyl-2-thiouridine; may act as part of a complex with Trm112p; deletion mutation increases translational infidelity, including amino acid misincorporation and -1 frameshifting, and also confers resistance to zymocin; null mutant displays activation of stress responses

Zygosity: Homozygous strain
fixedexpanded
Profile for YML014W / TRM9

Click on Significant Values for Screen Details ID:SGTC_36|Compound:0335-0881|FD-Score:3.77|P-value:4.35E-5 ID:SGTC_64|Compound:000l-0018|FD-Score:22.90|P-value:6.15E-122 ID:SGTC_67|Compound:0335-0847|FD-Score:6.18|P-value:8.69E-11 ID:SGTC_73|Compound:0327-0325|FD-Score:4.52|P-value:1.38E-6 ID:SGTC_86|Compound:0417-1630|FD-Score:7.29|P-value:2.76E-14 ID:SGTC_102|Compound:gallobenzophenone|FD-Score:4.61|P-value:8.81E-7 ID:SGTC_103|Compound:0844-0104|FD-Score:8.48|P-value:1.22E-18 ID:SGTC_137|Compound:0438-0332|FD-Score:3.03|P-value:7.60E-4 ID:SGTC_142|Compound:0335-0849|FD-Score:3.91|P-value:2.43E-5 ID:SGTC_158|Compound:k038-0087|FD-Score:8.08|P-value:4.22E-17 ID:SGTC_165|Compound:k038-0023|FD-Score:3.34|P-value:2.44E-4 ID:SGTC_176|Compound:1486-1328|FD-Score:3.09|P-value:6.20E-4 ID:SGTC_216|Compound:k038-0035|FD-Score:3.45|P-value:1.60E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:-3.29|P-value:5.03E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:-3.97|P-value:3.46E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:-6.51|P-value:2.54E-11 ID:SGTC_373|Compound:0844-0104|FD-Score:4.83|P-value:2.75E-7 ID:SGTC_383|Compound:2324-0395|FD-Score:3.75|P-value:4.71E-5 ID:SGTC_384|Compound:k007-0144|FD-Score:3.30|P-value:2.86E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-9.29|P-value:2.56E-21 ID:SGTC_467|Compound:ro 31-8220|FD-Score:2.99|P-value:8.85E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:-4.97|P-value:2.86E-7 ID:SGTC_514|Compound:4466-0038|FD-Score:4.23|P-value:5.74E-6 ID:SGTC_525|Compound:k781-2675|FD-Score:3.75|P-value:4.81E-5 ID:SGTC_528|Compound:3492-0019|FD-Score:4.27|P-value:4.59E-6 ID:SGTC_547|Compound:1120-0019|FD-Score:3.20|P-value:4.18E-4 ID:SGTC_575|Compound:k072-0246|FD-Score:3.62|P-value:8.14E-5 ID:SGTC_576|Compound:1073-0113|FD-Score:4.84|P-value:2.63E-7 ID:SGTC_637|Compound:1181-0519|FD-Score:3.74|P-value:4.91E-5 ID:SGTC_655|Compound:k060-0012|FD-Score:3.03|P-value:7.75E-4 ID:SGTC_691|Compound:1548-0686|FD-Score:-3.62|P-value:1.45E-4 ID:SGTC_704|Compound:1310-0270|FD-Score:3.81|P-value:3.64E-5 ID:SGTC_707|Compound:0865-0008|FD-Score:-3.28|P-value:5.30E-4 ID:SGTC_733|Compound:4069-0007|FD-Score:18.00|P-value:1.26E-76 ID:SGTC_774|Compound:k060-0086|FD-Score:-4.59|P-value:1.97E-6 ID:SGTC_785|Compound:1270-0111|FD-Score:3.80|P-value:3.78E-5 ID:SGTC_794|Compound:k038-0031|FD-Score:4.25|P-value:5.04E-6 ID:SGTC_805|Compound:3852-0218|FD-Score:5.28|P-value:2.37E-8 ID:SGTC_813|Compound:k007-0158|FD-Score:3.67|P-value:6.55E-5 ID:SGTC_837|Compound:0091-0265|FD-Score:9.50|P-value:7.41E-23 ID:SGTC_863|Compound:0466-0191|FD-Score:7.51|P-value:4.91E-15 ID:SGTC_902|Compound:1120-0002|FD-Score:3.35|P-value:2.43E-4 ID:SGTC_922|Compound:1866-0035|FD-Score:3.25|P-value:3.45E-4 ID:SGTC_945|Compound:3381-0768|FD-Score:3.07|P-value:6.76E-4 ID:SGTC_951|Compound:1171-0579|FD-Score:4.25|P-value:5.14E-6 ID:SGTC_961|Compound:1252-1571|FD-Score:5.94|P-value:4.32E-10 ID:SGTC_965|Compound:1291-5240|FD-Score:3.13|P-value:5.34E-4 ID:SGTC_1015|Compound:4130-4525|FD-Score:-3.89|P-value:4.79E-5 ID:SGTC_1016|Compound:4226-1401|FD-Score:3.00|P-value:8.71E-4 ID:SGTC_1017|Compound:4239-0030|FD-Score:-3.41|P-value:3.30E-4 ID:SGTC_1026|Compound:k007-1105|FD-Score:15.60|P-value:8.30E-58 ID:SGTC_1094|Compound:duloxetine|FD-Score:3.06|P-value:6.92E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:4.22|P-value:5.85E-6 ID:SGTC_1165|Compound:k072-0275|FD-Score:5.67|P-value:2.31E-9 ID:SGTC_1199|Compound:1638-0010|FD-Score:3.09|P-value:6.33E-4 ID:SGTC_1228|Compound:0124-0032|FD-Score:3.47|P-value:1.48E-4 ID:SGTC_1306|Compound:1185-0270|FD-Score:3.49|P-value:1.39E-4 ID:SGTC_1381|Compound:2324-0066|FD-Score:6.24|P-value:5.68E-11 ID:SGTC_1388|Compound:3346-4487|FD-Score:5.61|P-value:3.33E-9 ID:SGTC_1389|Compound:3405-0187|FD-Score:-4.07|P-value:2.20E-5 ID:SGTC_1394|Compound:3474-0001|FD-Score:4.61|P-value:8.72E-7 ID:SGTC_1436|Compound:4092-1007|FD-Score:4.49|P-value:1.60E-6 ID:SGTC_1670|Compound:st016595|FD-Score:3.99|P-value:1.67E-5 ID:SGTC_1712|Compound:st032288|FD-Score:5.20|P-value:3.74E-8 ID:SGTC_1717|Compound:st033143|FD-Score:3.64|P-value:7.41E-5 ID:SGTC_1754|Compound:st042065|FD-Score:3.55|P-value:1.11E-4 ID:SGTC_1762|Compound:st045503|FD-Score:4.51|P-value:1.47E-6 ID:SGTC_1800|Compound:st050079|FD-Score:3.11|P-value:5.79E-4 ID:SGTC_1801|Compound:st050089|FD-Score:4.78|P-value:3.74E-7 ID:SGTC_1803|Compound:st050068|FD-Score:3.05|P-value:7.22E-4 ID:SGTC_1846|Compound:st056244|FD-Score:6.97|P-value:3.25E-13 ID:SGTC_1884|Compound:5633444|FD-Score:8.16|P-value:2.16E-17 ID:SGTC_1901|Compound:st060216|FD-Score:3.41|P-value:1.88E-4 ID:SGTC_1920|Compound:st075728|FD-Score:3.21|P-value:4.05E-4 ID:SGTC_1968|Compound:st069590|FD-Score:3.41|P-value:1.91E-4 ID:SGTC_1972|Compound:st070201|FD-Score:3.75|P-value:4.86E-5 ID:SGTC_2057|Compound:5236571|FD-Score:3.01|P-value:8.32E-4 ID:SGTC_2322|Compound:7413319|FD-Score:5.67|P-value:2.29E-9 ID:SGTC_2385|Compound:9074692|FD-Score:3.47|P-value:1.48E-4 ID:SGTC_2485|Compound:5633444|FD-Score:3.22|P-value:3.94E-4 ID:SGTC_2525|Compound:harmine|FD-Score:3.62|P-value:8.12E-5 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:-4.26|P-value:9.37E-6 ID:SGTC_2584|Compound:androsterone|FD-Score:4.24|P-value:5.45E-6 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:4.23|P-value:5.59E-6 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.45|P-value:1.64E-4 ID:SGTC_2743|Compound:auranofin|FD-Score:3.11|P-value:5.86E-4 ID:SGTC_2744|Compound:captopril|FD-Score:3.39|P-value:2.02E-4 ID:SGTC_2825|Compound:7998094|FD-Score:3.97|P-value:1.83E-5 ID:SGTC_2896|Compound:9052656|FD-Score:-4.02|P-value:2.83E-5 ID:SGTC_3089|Compound:9117425|FD-Score:5.58|P-value:3.96E-9 ID:SGTC_3152|Compound:9099253|FD-Score:3.88|P-value:2.68E-5 ID:SGTC_3154|Compound:9100113|FD-Score:-4.27|P-value:9.16E-6 ID:SGTC_3157|Compound:9099274|FD-Score:4.79|P-value:3.49E-7 ID:SGTC_3321|Compound:9137793|FD-Score:3.00|P-value:8.54E-4 ID:SGTC_3334|Compound:9142812|FD-Score:3.47|P-value:1.50E-4 ID:SGTC_36|Compound:0335-0881|FD-Score:3.77|P-value:4.35E-5 ID:SGTC_64|Compound:000l-0018|FD-Score:22.90|P-value:6.15E-122 ID:SGTC_67|Compound:0335-0847|FD-Score:6.18|P-value:8.69E-11 ID:SGTC_73|Compound:0327-0325|FD-Score:4.52|P-value:1.38E-6 ID:SGTC_86|Compound:0417-1630|FD-Score:7.29|P-value:2.76E-14 ID:SGTC_102|Compound:gallobenzophenone|FD-Score:4.61|P-value:8.81E-7 ID:SGTC_103|Compound:0844-0104|FD-Score:8.48|P-value:1.22E-18 ID:SGTC_137|Compound:0438-0332|FD-Score:3.03|P-value:7.60E-4 ID:SGTC_142|Compound:0335-0849|FD-Score:3.91|P-value:2.43E-5 ID:SGTC_158|Compound:k038-0087|FD-Score:8.08|P-value:4.22E-17 ID:SGTC_165|Compound:k038-0023|FD-Score:3.34|P-value:2.44E-4 ID:SGTC_176|Compound:1486-1328|FD-Score:3.09|P-value:6.20E-4 ID:SGTC_216|Compound:k038-0035|FD-Score:3.45|P-value:1.60E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:-3.29|P-value:5.03E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:-3.97|P-value:3.46E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:-6.51|P-value:2.54E-11 ID:SGTC_373|Compound:0844-0104|FD-Score:4.83|P-value:2.75E-7 ID:SGTC_383|Compound:2324-0395|FD-Score:3.75|P-value:4.71E-5 ID:SGTC_384|Compound:k007-0144|FD-Score:3.30|P-value:2.86E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-9.29|P-value:2.56E-21 ID:SGTC_467|Compound:ro 31-8220|FD-Score:2.99|P-value:8.85E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:-4.97|P-value:2.86E-7 ID:SGTC_514|Compound:4466-0038|FD-Score:4.23|P-value:5.74E-6 ID:SGTC_525|Compound:k781-2675|FD-Score:3.75|P-value:4.81E-5 ID:SGTC_528|Compound:3492-0019|FD-Score:4.27|P-value:4.59E-6 ID:SGTC_547|Compound:1120-0019|FD-Score:3.20|P-value:4.18E-4 ID:SGTC_575|Compound:k072-0246|FD-Score:3.62|P-value:8.14E-5 ID:SGTC_576|Compound:1073-0113|FD-Score:4.84|P-value:2.63E-7 ID:SGTC_637|Compound:1181-0519|FD-Score:3.74|P-value:4.91E-5 ID:SGTC_655|Compound:k060-0012|FD-Score:3.03|P-value:7.75E-4 ID:SGTC_691|Compound:1548-0686|FD-Score:-3.62|P-value:1.45E-4 ID:SGTC_704|Compound:1310-0270|FD-Score:3.81|P-value:3.64E-5 ID:SGTC_707|Compound:0865-0008|FD-Score:-3.28|P-value:5.30E-4 ID:SGTC_733|Compound:4069-0007|FD-Score:18.00|P-value:1.26E-76 ID:SGTC_774|Compound:k060-0086|FD-Score:-4.59|P-value:1.97E-6 ID:SGTC_785|Compound:1270-0111|FD-Score:3.80|P-value:3.78E-5 ID:SGTC_794|Compound:k038-0031|FD-Score:4.25|P-value:5.04E-6 ID:SGTC_805|Compound:3852-0218|FD-Score:5.28|P-value:2.37E-8 ID:SGTC_813|Compound:k007-0158|FD-Score:3.67|P-value:6.55E-5 ID:SGTC_837|Compound:0091-0265|FD-Score:9.50|P-value:7.41E-23 ID:SGTC_863|Compound:0466-0191|FD-Score:7.51|P-value:4.91E-15 ID:SGTC_902|Compound:1120-0002|FD-Score:3.35|P-value:2.43E-4 ID:SGTC_922|Compound:1866-0035|FD-Score:3.25|P-value:3.45E-4 ID:SGTC_945|Compound:3381-0768|FD-Score:3.07|P-value:6.76E-4 ID:SGTC_951|Compound:1171-0579|FD-Score:4.25|P-value:5.14E-6 ID:SGTC_961|Compound:1252-1571|FD-Score:5.94|P-value:4.32E-10 ID:SGTC_965|Compound:1291-5240|FD-Score:3.13|P-value:5.34E-4 ID:SGTC_1015|Compound:4130-4525|FD-Score:-3.89|P-value:4.79E-5 ID:SGTC_1016|Compound:4226-1401|FD-Score:3.00|P-value:8.71E-4 ID:SGTC_1017|Compound:4239-0030|FD-Score:-3.41|P-value:3.30E-4 ID:SGTC_1026|Compound:k007-1105|FD-Score:15.60|P-value:8.30E-58 ID:SGTC_1094|Compound:duloxetine|FD-Score:3.06|P-value:6.92E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:4.22|P-value:5.85E-6 ID:SGTC_1165|Compound:k072-0275|FD-Score:5.67|P-value:2.31E-9 ID:SGTC_1199|Compound:1638-0010|FD-Score:3.09|P-value:6.33E-4 ID:SGTC_1228|Compound:0124-0032|FD-Score:3.47|P-value:1.48E-4 ID:SGTC_1306|Compound:1185-0270|FD-Score:3.49|P-value:1.39E-4 ID:SGTC_1381|Compound:2324-0066|FD-Score:6.24|P-value:5.68E-11 ID:SGTC_1388|Compound:3346-4487|FD-Score:5.61|P-value:3.33E-9 ID:SGTC_1389|Compound:3405-0187|FD-Score:-4.07|P-value:2.20E-5 ID:SGTC_1394|Compound:3474-0001|FD-Score:4.61|P-value:8.72E-7 ID:SGTC_1436|Compound:4092-1007|FD-Score:4.49|P-value:1.60E-6 ID:SGTC_1670|Compound:st016595|FD-Score:3.99|P-value:1.67E-5 ID:SGTC_1712|Compound:st032288|FD-Score:5.20|P-value:3.74E-8 ID:SGTC_1717|Compound:st033143|FD-Score:3.64|P-value:7.41E-5 ID:SGTC_1754|Compound:st042065|FD-Score:3.55|P-value:1.11E-4 ID:SGTC_1762|Compound:st045503|FD-Score:4.51|P-value:1.47E-6 ID:SGTC_1800|Compound:st050079|FD-Score:3.11|P-value:5.79E-4 ID:SGTC_1801|Compound:st050089|FD-Score:4.78|P-value:3.74E-7 ID:SGTC_1803|Compound:st050068|FD-Score:3.05|P-value:7.22E-4 ID:SGTC_1846|Compound:st056244|FD-Score:6.97|P-value:3.25E-13 ID:SGTC_1884|Compound:5633444|FD-Score:8.16|P-value:2.16E-17 ID:SGTC_1901|Compound:st060216|FD-Score:3.41|P-value:1.88E-4 ID:SGTC_1920|Compound:st075728|FD-Score:3.21|P-value:4.05E-4 ID:SGTC_1968|Compound:st069590|FD-Score:3.41|P-value:1.91E-4 ID:SGTC_1972|Compound:st070201|FD-Score:3.75|P-value:4.86E-5 ID:SGTC_2057|Compound:5236571|FD-Score:3.01|P-value:8.32E-4 ID:SGTC_2322|Compound:7413319|FD-Score:5.67|P-value:2.29E-9 ID:SGTC_2385|Compound:9074692|FD-Score:3.47|P-value:1.48E-4 ID:SGTC_2485|Compound:5633444|FD-Score:3.22|P-value:3.94E-4 ID:SGTC_2525|Compound:harmine|FD-Score:3.62|P-value:8.12E-5 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:-4.26|P-value:9.37E-6 ID:SGTC_2584|Compound:androsterone|FD-Score:4.24|P-value:5.45E-6 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:4.23|P-value:5.59E-6 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.45|P-value:1.64E-4 ID:SGTC_2743|Compound:auranofin|FD-Score:3.11|P-value:5.86E-4 ID:SGTC_2744|Compound:captopril|FD-Score:3.39|P-value:2.02E-4 ID:SGTC_2825|Compound:7998094|FD-Score:3.97|P-value:1.83E-5 ID:SGTC_2896|Compound:9052656|FD-Score:-4.02|P-value:2.83E-5 ID:SGTC_3089|Compound:9117425|FD-Score:5.58|P-value:3.96E-9 ID:SGTC_3152|Compound:9099253|FD-Score:3.88|P-value:2.68E-5 ID:SGTC_3154|Compound:9100113|FD-Score:-4.27|P-value:9.16E-6 ID:SGTC_3157|Compound:9099274|FD-Score:4.79|P-value:3.49E-7 ID:SGTC_3321|Compound:9137793|FD-Score:3.00|P-value:8.54E-4 ID:SGTC_3334|Compound:9142812|FD-Score:3.47|P-value:1.50E-4

Top fitness defect scores for YML014W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_64 000l-0018 22.90 272.1 µM 6.15E-122 ubiquinone biosynthesis & proteasome 6 2.12E-116
2 SGTC_733 4069-0007 18.00 56.1 µM 1.26E-76 ERAD & cell cycle 5 4.65E-73
3 SGTC_1026 k007-1105 15.60 30.6 µM 8.30E-58 ERAD & cell cycle 4 4.51E-55
4 SGTC_837 0091-0265 9.50 12.5 µM 7.41E-23 ubiquinone biosynthesis & proteasome 4 1.04E-21
5 SGTC_103 0844-0104 8.48 51.8 µM 1.22E-18 ERAD & cell cycle 44 1.08E-17
6 SGTC_1884 5633444 8.16 25.0 µM 2.16E-17 redox potentiating 19 1.66E-16
7 SGTC_158 k038-0087 8.08 26.4 µM 4.22E-17 ubiquinone biosynthesis & proteasome 48 3.15E-16
8 SGTC_863 0466-0191 7.51 129.0 µM 4.91E-15 cell wall 21 2.91E-14
9 SGTC_86 0417-1630 7.29 471.9 µM 2.76E-14 ubiquinone biosynthesis & proteasome 68 1.51E-13
10 SGTC_1846 st056244 6.97 14.8 µM 3.25E-13 2 1.58E-12
11 SGTC_1381 2324-0066 6.24 62.1 µM 5.68E-11 6 2.13E-10
12 SGTC_67 0335-0847 6.18 266.0 µM 8.69E-11 ubiquinone biosynthesis & proteasome 64 3.19E-10
13 SGTC_961 1252-1571 5.94 372.0 µM 4.32E-10 8 1.46E-9
14 SGTC_2322 7413319 5.67 38.2 µM 2.29E-9 ERAD & cell cycle 69 7.15E-9
15 SGTC_1165 k072-0275 5.67 30.3 µM 2.31E-9 14 7.20E-9
16 SGTC_1388 3346-4487 5.61 254.0 µM 3.33E-9 3 1.02E-8
17 SGTC_3089 9117425 5.58 49.5 µM 3.96E-9 2 1.20E-8
18 SGTC_805 3852-0218 5.28 479.0 µM 2.37E-8 ERAD & cell cycle 31 6.55E-8
19 SGTC_1712 st032288 5.20 53.4 µM 3.74E-8 calcium & mitochondrial duress 107 1.01E-7
20 SGTC_576 1073-0113 4.84 22.7 µM 2.63E-7 redox potentiating 43 6.42E-7

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.512 9.48E-224 YMR022W UBC7 hom Ubiquitin conjugating enzyme, involved in the ER-associated protein degradation pathway; requires Cue1p for recruitment to the ER membrane; proposed to be involved in chromatin assembly
0.404 9.94E-132 YIL030C SSM4 hom Ubiquitin-protein ligase involved in ER-associated protein degradation; located in the ER/nuclear envelope; ssm4 mutation suppresses mRNA instability caused by an rna14 mutation
0.402 1.33E-130 YOL002C IZH2 hom Plasma membrane protein involved in zinc homeostasis and osmotin-induced apoptosis; transcription regulated by Zap1p, zinc and fatty acid levels; similar to mammalian adiponectins; deletion increases sensitivity to elevated zinc
0.363 6.27E-105 YER041W YEN1 hom Holliday junction resolvase; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation; homolog of human GEN1 and has similarity to S. cerevisiae endonuclease Rth1p
0.358 6.62E-102 YMR067C UBX4 hom UBX domain-containing protein that interacts with Cdc48p; involved in degradation of polyubiquitinated proteins via the ERAD (ER-associated degradation) pathway; modulates the Cdc48p-Nplp-Ufd1p AAA ATPase complex during its role in delivery of misfolded proteins to the proteasome; protein abundance increases in response to DNA replication stress
0.346 4.44E-95 YJL168C SET2 hom Histone methyltransferase with a role in transcriptional elongation; methylates H3 lysine 36, which suppresses incorporation of acetylated histones and signals for the deacetylation of these histones within transcribed genes; associates with the C-terminal domain of Rpo21p; histone methylation activity is regulated by phosphorylation status of Rpo21p
0.341 6.70E-92 YLR021W IRC25 hom Component of a heterodimeric Poc4p-Irc25p chaperone involved in assembly of alpha subunits into the 20S proteasome; may regulate formation of proteasome isoforms with alternative subunits under different conditions
0.339 3.05E-91 YMR264W CUE1 hom Ubiquitin-binding protein; endoplasmic reticulum membrane protein that recruits the ubiquitin-conjugating enzyme Ubc7p to the ER where it functions in protein degradation; contains a CUE domain that binds ubiquitin to facilitate intramolecular monoubiquitination; CUE1 has a paralog, CUE4, that arose from the whole genome duplication
0.337 9.68E-90 YOR246C ENV9 hom Protein proposed to be involved in vacuolar functions; mutant shows defect in CPY processing and defects in vacuolar morphology; has similarity to oxidoreductases, found in lipid particles; required for replication of Brome mosaic virus in S. cerevisiae, a model system for studying replication of positive-strand RNA viruses in their natural hosts
0.334 3.84E-88 YDR199W_d YDR199W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene VPS64; computationally predicted to have thiol-disulfide oxidoreductase activity
0.331 2.41E-86 YPR146C_d YPR146C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.331 3.33E-86 YER019C-A SBH2 hom Ssh1p-Sss1p-Sbh2p complex component, involved in protein translocation into the endoplasmic reticulum; homologous to Sbh1p
0.321 3.39E-81 YNL111C CYB5 hom Cytochrome b5, involved in the sterol and lipid biosynthesis pathways; acts as an electron donor to support sterol C5-6 desaturation
0.320 5.46E-81 YNL070W TOM7 hom Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; promotes assembly and stability of the TOM complex
0.317 4.72E-79 YDL020C RPN4 hom Transcription factor that stimulates expression of proteasome genes; Rpn4p levels are in turn regulated by the 26S proteasome in a negative feedback control mechanism; RPN4 is transcriptionally regulated by various stress responses; relative distribution to the nucleus increases upon DNA replication stress