YML015C / TAF11

TFIID subunit (40 kDa), involved in RNA polymerase II transcription initiation, similar to histone H3 with atypical histone fold motif of Spt3-like transcription factors

Zygosity: Heterozygous strain
fixedexpanded
Profile for YML015C / TAF11

Click on Significant Values for Screen Details ID:SGTC_44|Compound:0929-0055|FD-Score:-3.48|P-value:3.39E-4 ID:SGTC_105|Compound:0111-0055|FD-Score:-3.30|P-value:6.36E-4 ID:SGTC_186|Compound:3455-3465|FD-Score:3.35|P-value:5.91E-4 ID:SGTC_191|Compound:3914-0123|FD-Score:5.53|P-value:4.09E-8 ID:SGTC_200|Compound:k038-0079|FD-Score:4.22|P-value:2.18E-5 ID:SGTC_201|Compound:4262-0159|FD-Score:4.32|P-value:1.41E-5 ID:SGTC_216|Compound:k038-0035|FD-Score:3.25|P-value:8.19E-4 ID:SGTC_260|Compound:nsc-65238|FD-Score:3.38|P-value:5.40E-4 ID:SGTC_267|Compound:4-Nitroquinoline-1-oxide  (4-NQO)|FD-Score:3.32|P-value:6.54E-4 ID:SGTC_289|Compound:k017-0060|FD-Score:-3.17|P-value:9.90E-4 ID:SGTC_300|Compound:r073-0011|FD-Score:3.74|P-value:1.46E-4 ID:SGTC_312|Compound:4092-0653|FD-Score:4.90|P-value:1.02E-6 ID:SGTC_320|Compound:4092-0846|FD-Score:3.24|P-value:8.60E-4 ID:SGTC_363|Compound:0455-0021|FD-Score:4.90|P-value:1.00E-6 ID:SGTC_401|Compound:neomycin|FD-Score:3.94|P-value:6.80E-5 ID:SGTC_424|Compound:splitomicin|FD-Score:3.35|P-value:5.82E-4 ID:SGTC_573|Compound:3702-0553|FD-Score:3.81|P-value:1.12E-4 ID:SGTC_574|Compound:1315-0397|FD-Score:3.86|P-value:9.05E-5 ID:SGTC_577|Compound:r071-0003|FD-Score:3.89|P-value:8.14E-5 ID:SGTC_591|Compound:4299-0174|FD-Score:3.63|P-value:2.18E-4 ID:SGTC_636|Compound:0kpi-0074|FD-Score:4.23|P-value:2.05E-5 ID:SGTC_767|Compound:0929-0023|FD-Score:-4.45|P-value:7.24E-6 ID:SGTC_770|Compound:0389-1121|FD-Score:-3.70|P-value:1.57E-4 ID:SGTC_789|Compound:1309-1135|FD-Score:-3.21|P-value:8.62E-4 ID:SGTC_941|Compound:3237-0776|FD-Score:-3.28|P-value:6.93E-4 ID:SGTC_1125|Compound:tnp00248|FD-Score:3.49|P-value:3.62E-4 ID:SGTC_1264|Compound:0783-0040|FD-Score:4.11|P-value:3.37E-5 ID:SGTC_1287|Compound:0971-0001|FD-Score:3.71|P-value:1.63E-4 ID:SGTC_1331|Compound:1472-0049|FD-Score:4.71|P-value:2.52E-6 ID:SGTC_1626|Compound:st003712|FD-Score:-3.34|P-value:5.70E-4 ID:SGTC_1667|Compound:st014849|FD-Score:3.49|P-value:3.65E-4 ID:SGTC_1762|Compound:st045503|FD-Score:-3.58|P-value:2.42E-4 ID:SGTC_1885|Compound:st057546|FD-Score:3.38|P-value:5.29E-4 ID:SGTC_1964|Compound:st076914|FD-Score:3.85|P-value:9.65E-5 ID:SGTC_1965|Compound:Pectolinarigenin|FD-Score:3.51|P-value:3.44E-4 ID:SGTC_1978|Compound:st071761|FD-Score:8.85|P-value:4.32E-18 ID:SGTC_1989|Compound:st071868|FD-Score:-4.78|P-value:1.60E-6 ID:SGTC_1991|Compound:st073000|FD-Score:3.42|P-value:4.65E-4 ID:SGTC_2036|Compound:5160441|FD-Score:3.32|P-value:6.44E-4 ID:SGTC_2043|Compound:5101342|FD-Score:3.28|P-value:7.37E-4 ID:SGTC_2147|Compound:5545932|FD-Score:5.16|P-value:2.82E-7 ID:SGTC_2456|Compound:5770359|FD-Score:-3.47|P-value:3.53E-4 ID:SGTC_2554|Compound:13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one|FD-Score:3.69|P-value:1.79E-4 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:3.69|P-value:1.73E-4 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:4.04|P-value:4.62E-5 ID:SGTC_2752|Compound:diclazuril|FD-Score:5.45|P-value:6.27E-8 ID:SGTC_2753|Compound:fluvastatin|FD-Score:3.25|P-value:8.30E-4 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:-4.01|P-value:4.69E-5 ID:SGTC_2936|Compound:9038235|FD-Score:-4.69|P-value:2.48E-6 ID:SGTC_2941|Compound:9056145|FD-Score:4.26|P-value:1.84E-5 ID:SGTC_2946|Compound:9065502|FD-Score:-4.13|P-value:2.79E-5 ID:SGTC_2953|Compound:9074162|FD-Score:-4.92|P-value:8.34E-7 ID:SGTC_2974|Compound:9094440|FD-Score:4.31|P-value:1.50E-5 ID:SGTC_3182|Compound:9108849|FD-Score:3.47|P-value:3.95E-4 ID:SGTC_3208|Compound:9114115|FD-Score:4.40|P-value:1.00E-5 ID:SGTC_3209|Compound:9113616|FD-Score:3.65|P-value:2.03E-4 ID:SGTC_3210|Compound:9128157|FD-Score:-3.57|P-value:2.45E-4 ID:SGTC_3296|Compound:9122258|FD-Score:5.45|P-value:6.41E-8 ID:SGTC_3330|Compound:9141424|FD-Score:-3.66|P-value:1.80E-4 ID:SGTC_3350|Compound:9150499|FD-Score:3.28|P-value:7.58E-4 ID:SGTC_44|Compound:0929-0055|FD-Score:-3.48|P-value:3.39E-4 ID:SGTC_105|Compound:0111-0055|FD-Score:-3.30|P-value:6.36E-4 ID:SGTC_186|Compound:3455-3465|FD-Score:3.35|P-value:5.91E-4 ID:SGTC_191|Compound:3914-0123|FD-Score:5.53|P-value:4.09E-8 ID:SGTC_200|Compound:k038-0079|FD-Score:4.22|P-value:2.18E-5 ID:SGTC_201|Compound:4262-0159|FD-Score:4.32|P-value:1.41E-5 ID:SGTC_216|Compound:k038-0035|FD-Score:3.25|P-value:8.19E-4 ID:SGTC_260|Compound:nsc-65238|FD-Score:3.38|P-value:5.40E-4 ID:SGTC_267|Compound:4-Nitroquinoline-1-oxide  (4-NQO)|FD-Score:3.32|P-value:6.54E-4 ID:SGTC_289|Compound:k017-0060|FD-Score:-3.17|P-value:9.90E-4 ID:SGTC_300|Compound:r073-0011|FD-Score:3.74|P-value:1.46E-4 ID:SGTC_312|Compound:4092-0653|FD-Score:4.90|P-value:1.02E-6 ID:SGTC_320|Compound:4092-0846|FD-Score:3.24|P-value:8.60E-4 ID:SGTC_363|Compound:0455-0021|FD-Score:4.90|P-value:1.00E-6 ID:SGTC_401|Compound:neomycin|FD-Score:3.94|P-value:6.80E-5 ID:SGTC_424|Compound:splitomicin|FD-Score:3.35|P-value:5.82E-4 ID:SGTC_573|Compound:3702-0553|FD-Score:3.81|P-value:1.12E-4 ID:SGTC_574|Compound:1315-0397|FD-Score:3.86|P-value:9.05E-5 ID:SGTC_577|Compound:r071-0003|FD-Score:3.89|P-value:8.14E-5 ID:SGTC_591|Compound:4299-0174|FD-Score:3.63|P-value:2.18E-4 ID:SGTC_636|Compound:0kpi-0074|FD-Score:4.23|P-value:2.05E-5 ID:SGTC_767|Compound:0929-0023|FD-Score:-4.45|P-value:7.24E-6 ID:SGTC_770|Compound:0389-1121|FD-Score:-3.70|P-value:1.57E-4 ID:SGTC_789|Compound:1309-1135|FD-Score:-3.21|P-value:8.62E-4 ID:SGTC_941|Compound:3237-0776|FD-Score:-3.28|P-value:6.93E-4 ID:SGTC_1125|Compound:tnp00248|FD-Score:3.49|P-value:3.62E-4 ID:SGTC_1264|Compound:0783-0040|FD-Score:4.11|P-value:3.37E-5 ID:SGTC_1287|Compound:0971-0001|FD-Score:3.71|P-value:1.63E-4 ID:SGTC_1331|Compound:1472-0049|FD-Score:4.71|P-value:2.52E-6 ID:SGTC_1626|Compound:st003712|FD-Score:-3.34|P-value:5.70E-4 ID:SGTC_1667|Compound:st014849|FD-Score:3.49|P-value:3.65E-4 ID:SGTC_1762|Compound:st045503|FD-Score:-3.58|P-value:2.42E-4 ID:SGTC_1885|Compound:st057546|FD-Score:3.38|P-value:5.29E-4 ID:SGTC_1964|Compound:st076914|FD-Score:3.85|P-value:9.65E-5 ID:SGTC_1965|Compound:Pectolinarigenin|FD-Score:3.51|P-value:3.44E-4 ID:SGTC_1978|Compound:st071761|FD-Score:8.85|P-value:4.32E-18 ID:SGTC_1989|Compound:st071868|FD-Score:-4.78|P-value:1.60E-6 ID:SGTC_1991|Compound:st073000|FD-Score:3.42|P-value:4.65E-4 ID:SGTC_2036|Compound:5160441|FD-Score:3.32|P-value:6.44E-4 ID:SGTC_2043|Compound:5101342|FD-Score:3.28|P-value:7.37E-4 ID:SGTC_2147|Compound:5545932|FD-Score:5.16|P-value:2.82E-7 ID:SGTC_2456|Compound:5770359|FD-Score:-3.47|P-value:3.53E-4 ID:SGTC_2554|Compound:13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one|FD-Score:3.69|P-value:1.79E-4 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:3.69|P-value:1.73E-4 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:4.04|P-value:4.62E-5 ID:SGTC_2752|Compound:diclazuril|FD-Score:5.45|P-value:6.27E-8 ID:SGTC_2753|Compound:fluvastatin|FD-Score:3.25|P-value:8.30E-4 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:-4.01|P-value:4.69E-5 ID:SGTC_2936|Compound:9038235|FD-Score:-4.69|P-value:2.48E-6 ID:SGTC_2941|Compound:9056145|FD-Score:4.26|P-value:1.84E-5 ID:SGTC_2946|Compound:9065502|FD-Score:-4.13|P-value:2.79E-5 ID:SGTC_2953|Compound:9074162|FD-Score:-4.92|P-value:8.34E-7 ID:SGTC_2974|Compound:9094440|FD-Score:4.31|P-value:1.50E-5 ID:SGTC_3182|Compound:9108849|FD-Score:3.47|P-value:3.95E-4 ID:SGTC_3208|Compound:9114115|FD-Score:4.40|P-value:1.00E-5 ID:SGTC_3209|Compound:9113616|FD-Score:3.65|P-value:2.03E-4 ID:SGTC_3210|Compound:9128157|FD-Score:-3.57|P-value:2.45E-4 ID:SGTC_3296|Compound:9122258|FD-Score:5.45|P-value:6.41E-8 ID:SGTC_3330|Compound:9141424|FD-Score:-3.66|P-value:1.80E-4 ID:SGTC_3350|Compound:9150499|FD-Score:3.28|P-value:7.58E-4

Top fitness defect scores for YML015C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1978 st071761 8.85 42.0 µM 4.32E-18 TSC3-RPN4 1 4.29E-19 3.08
2 SGTC_191 3914-0123 5.53 66.5 µM 4.09E-8 60S ribosome export 3 1.59E-8 0.47
3 SGTC_2752 diclazuril 5.45 33.1 µM 6.27E-8 3 2.50E-8 0.66
4 SGTC_3296 9122258 5.45 64.0 µM 6.41E-8 redox potentiating 2 2.56E-8 0.95
5 SGTC_2147 5545932 5.16 89.7 µM 2.82E-7 ergosterol biosynthesis 6 1.23E-7 0.40
6 SGTC_363 0455-0021 4.90 3.1 µM 1.00E-6 azole & statin 12 4.71E-7 0.03
7 SGTC_312 4092-0653 4.90 6.8 µM 1.02E-6 ergosterol depletion effects on membrane 22 4.78E-7 0.16
8 SGTC_1331 1472-0049 4.71 76.2 µM 2.52E-6 2 1.25E-6 0.36
9 SGTC_3208 9114115 4.40 49.5 µM 1.00E-5 6 5.40E-6 0.10
10 SGTC_201 4262-0159 4.32 12.8 µM 1.41E-5 ergosterol depletion effects on membrane 9 7.75E-6 0.15
11 SGTC_2974 9094440 4.31 9.7 µM 1.50E-5 ergosterol biosynthesis 11 8.27E-6 0.09
12 SGTC_2941 9056145 4.26 11.2 µM 1.84E-5 9 1.03E-5 0.11
13 SGTC_636 0kpi-0074 4.23 126.0 µM 2.05E-5 2 1.15E-5 0.01
14 SGTC_200 k038-0079 4.22 37.5 µM 2.18E-5 ubiquinone biosynthesis & proteasome 10 1.23E-5 0.13
15 SGTC_1264 0783-0040 4.11 158.0 µM 3.37E-5 3 1.95E-5 0.52
16 SGTC_2604 4'-hydroxychalcone 4.04 11.3 µM 4.62E-5 13 2.73E-5 0.04
17 SGTC_401 neomycin 3.94 50.0 µM 6.80E-5 3 4.11E-5 0.52
18 SGTC_577 r071-0003 3.89 38.6 µM 8.14E-5 fatty acid desaturase (OLE1) 6 4.96E-5 0.00
19 SGTC_574 1315-0397 3.86 40.0 µM 9.05E-5 11 5.56E-5 0.12
20 SGTC_1964 st076914 3.85 61.0 µM 9.65E-5 RPP1 & pyrimidine depletion 7 5.95E-5 0.09

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.096 2.35E-8 YNL301C RPL18B hom Ribosomal 60S subunit protein L18B; homologous to mammalian ribosomal protein L18, no bacterial homolog; RPL18B has a paralog, RPL18A, that arose from the whole genome duplication
0.093 7.69E-8 YMR201C RAD14 hom Protein that recognizes and binds damaged DNA during nucleotide excision repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); contains zinc finger motif; homolog of human XPA protein
0.092 1.03E-7 YOR048C RAT1 het Nuclear 5' to 3' single-stranded RNA exonuclease, involved in RNA metabolism, including rRNA and snRNA processing as well as poly (A+) dependent and independent mRNA transcription termination
0.091 1.45E-7 YJL087C TRL1 het tRNA ligase, required for tRNA splicing and for both splicing and translation of HAC1 mRNA in the UPR; has phosphodiesterase, polynucleotide kinase, and ligase activities; localized at the inner nuclear envelope and partially to polysomes
0.091 1.51E-7 YMR071C TVP18 hom Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; may interact with ribosomes, based on co-purification experiments
0.087 4.66E-7 YFL047W RGD2 hom GTPase-activating protein (RhoGAP) for Cdc42p and Rho5p; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.087 4.71E-7 YML095C RAD10 hom Single-stranded DNA endonuclease (with Rad1p), cleaves single-stranded DNA during nucleotide excision repair and double-strand break repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); homolog of human ERCC1 protein
0.085 8.48E-7 YJR014W TMA22 hom Protein of unknown function; associates with ribosomes and has a putative RNA binding domain; interacts with Tma20p; similar to human GRAP and human DRP1, which interacts with human Tma20p homolog MCT-1; protein abundance increases in response to DNA replication stress
0.083 1.43E-6 YGR258C RAD2 hom Single-stranded DNA endonuclease, cleaves single-stranded DNA during nucleotide excision repair to excise damaged DNA; subunit of Nucleotide Excision Repair Factor 3 (NEF3); homolog of human XPG protein
0.082 2.08E-6 YIL068C SEC6 het Essential 88kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane prior to SNARE-mediated fusion; anchors the assembled complex to sites of secretion; interacts with SM-like protein and SNARE regulator Sec1p and may recruit it to sites of secretion; interacts with Sec9p and inhibits formation of the t-SNARE complex between Sec9p and Sso1p
0.081 2.70E-6 YNL111C CYB5 hom Cytochrome b5, involved in the sterol and lipid biosynthesis pathways; acts as an electron donor to support sterol C5-6 desaturation
0.081 2.78E-6 YBL010C_p YBL010C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein colocalizes with clathrin-coated vesicles
0.081 2.96E-6 YER008C SEC3 het Subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to sites of exocytosis prior to SNARE-mediated fusion; PtdIns[4,5]P2-binding protein that localizes to exocytic sites in a Rho1p-dependent, actin-independent manner, targeting and anchoring the exocyst to the plasma membrane with Exo70p; direct GTP Rho1p effector; required for ER inheritance; relocalizes away from bud neck upon DNA replication stress
0.080 3.37E-6 YDL105W NSE4 het Component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair
0.080 3.49E-6 YHL027W RIM101 hom Cys2His2 zinc-finger transcriptional repressor; involved in alkaline responsive gene repression as part of adaptation to a alkaline conditions; involved in cell wall assembly; required for alkaline pH-stimulated haploid invasive growth and sporulation; activated by alkaline-dependent proteolytic processing which results in removal of the C-terminal tail; similar to A. nidulans PacC