YML016C / PPZ1

Serine/threonine protein phosphatase Z, isoform of Ppz2p; involved in regulation of potassium transport, which affects osmotic stability, cell cycle progression, and halotolerance

Zygosity: Homozygous strain
fixedexpanded
Profile for YML016C / PPZ1

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:12.40|P-value:3.42E-31 ID:SGTC_70|Compound:0141-0289|FD-Score:-3.89|P-value:1.43E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:7.09|P-value:2.24E-11 ID:SGTC_118|Compound:0083-0097|FD-Score:3.47|P-value:6.48E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:4.43|P-value:1.99E-5 ID:SGTC_150|Compound:3970-0969|FD-Score:3.33|P-value:9.95E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:6.43|P-value:1.19E-9 ID:SGTC_351|Compound:caspofungin|FD-Score:4.30|P-value:3.31E-5 ID:SGTC_435|Compound:c-PAF|FD-Score:-4.53|P-value:1.17E-5 ID:SGTC_439|Compound:amiodarone|FD-Score:-5.06|P-value:1.20E-6 ID:SGTC_452|Compound:diindolylmethane|FD-Score:-4.11|P-value:6.21E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-6.89|P-value:6.53E-11 ID:SGTC_472|Compound:calcifediol|FD-Score:3.83|P-value:1.88E-4 ID:SGTC_488|Compound:nitrendipine|FD-Score:4.11|P-value:6.80E-5 ID:SGTC_507|Compound:nimesulide|FD-Score:-3.99|P-value:9.88E-5 ID:SGTC_512|Compound:prima-1|FD-Score:-3.71|P-value:2.62E-4 ID:SGTC_573|Compound:3702-0553|FD-Score:5.04|P-value:1.41E-6 ID:SGTC_582|Compound:0987-0078|FD-Score:8.06|P-value:3.37E-14 ID:SGTC_690|Compound:glyoxal|FD-Score:7.15|P-value:1.54E-11 ID:SGTC_820|Compound:1582-0060|FD-Score:3.50|P-value:5.82E-4 ID:SGTC_1093|Compound:fluphenazine|FD-Score:3.87|P-value:1.64E-4 ID:SGTC_1132|Compound:3456-3614|FD-Score:-3.78|P-value:2.05E-4 ID:SGTC_1197|Compound:1601-0112|FD-Score:4.62|P-value:9.08E-6 ID:SGTC_1549|Compound:4'-methoxyflavonol|FD-Score:3.45|P-value:6.97E-4 ID:SGTC_1635|Compound:st007035|FD-Score:4.31|P-value:3.13E-5 ID:SGTC_1844|Compound:rapamycin|FD-Score:3.73|P-value:2.73E-4 ID:SGTC_1958|Compound:st076513|FD-Score:4.23|P-value:4.26E-5 ID:SGTC_2289|Compound:7946404|FD-Score:4.87|P-value:3.04E-6 ID:SGTC_2381|Compound:9035592|FD-Score:-4.34|P-value:2.53E-5 ID:SGTC_2382|Compound:9035899|FD-Score:-4.87|P-value:2.76E-6 ID:SGTC_2385|Compound:9074692|FD-Score:-3.67|P-value:3.02E-4 ID:SGTC_2390|Compound:9097792|FD-Score:-4.30|P-value:2.94E-5 ID:SGTC_2408|Compound:sulbentine|FD-Score:5.20|P-value:7.04E-7 ID:SGTC_2462|Compound:5162487|FD-Score:-3.37|P-value:8.16E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:6.06|P-value:9.11E-9 ID:SGTC_2693|Compound:st077581|FD-Score:-4.62|P-value:8.02E-6 ID:SGTC_2848|Compound:9016370|FD-Score:-4.18|P-value:4.71E-5 ID:SGTC_3125|Compound:9127534|FD-Score:-3.80|P-value:1.93E-4 ID:SGTC_3135|Compound:9127742|FD-Score:3.86|P-value:1.72E-4 ID:SGTC_3201|Compound:9113999|FD-Score:5.17|P-value:7.78E-7 ID:SGTC_3202|Compound:9113761|FD-Score:-6.36|P-value:1.50E-9 ID:SGTC_3207|Compound:9114163|FD-Score:-4.14|P-value:5.50E-5 ID:SGTC_3210|Compound:9128157|FD-Score:-3.87|P-value:1.50E-4 ID:SGTC_3347|Compound:9188721|FD-Score:3.35|P-value:9.55E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:12.40|P-value:3.42E-31 ID:SGTC_70|Compound:0141-0289|FD-Score:-3.89|P-value:1.43E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:7.09|P-value:2.24E-11 ID:SGTC_118|Compound:0083-0097|FD-Score:3.47|P-value:6.48E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:4.43|P-value:1.99E-5 ID:SGTC_150|Compound:3970-0969|FD-Score:3.33|P-value:9.95E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:6.43|P-value:1.19E-9 ID:SGTC_351|Compound:caspofungin|FD-Score:4.30|P-value:3.31E-5 ID:SGTC_435|Compound:c-PAF|FD-Score:-4.53|P-value:1.17E-5 ID:SGTC_439|Compound:amiodarone|FD-Score:-5.06|P-value:1.20E-6 ID:SGTC_452|Compound:diindolylmethane|FD-Score:-4.11|P-value:6.21E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-6.89|P-value:6.53E-11 ID:SGTC_472|Compound:calcifediol|FD-Score:3.83|P-value:1.88E-4 ID:SGTC_488|Compound:nitrendipine|FD-Score:4.11|P-value:6.80E-5 ID:SGTC_507|Compound:nimesulide|FD-Score:-3.99|P-value:9.88E-5 ID:SGTC_512|Compound:prima-1|FD-Score:-3.71|P-value:2.62E-4 ID:SGTC_573|Compound:3702-0553|FD-Score:5.04|P-value:1.41E-6 ID:SGTC_582|Compound:0987-0078|FD-Score:8.06|P-value:3.37E-14 ID:SGTC_690|Compound:glyoxal|FD-Score:7.15|P-value:1.54E-11 ID:SGTC_820|Compound:1582-0060|FD-Score:3.50|P-value:5.82E-4 ID:SGTC_1093|Compound:fluphenazine|FD-Score:3.87|P-value:1.64E-4 ID:SGTC_1132|Compound:3456-3614|FD-Score:-3.78|P-value:2.05E-4 ID:SGTC_1197|Compound:1601-0112|FD-Score:4.62|P-value:9.08E-6 ID:SGTC_1549|Compound:4'-methoxyflavonol|FD-Score:3.45|P-value:6.97E-4 ID:SGTC_1635|Compound:st007035|FD-Score:4.31|P-value:3.13E-5 ID:SGTC_1844|Compound:rapamycin|FD-Score:3.73|P-value:2.73E-4 ID:SGTC_1958|Compound:st076513|FD-Score:4.23|P-value:4.26E-5 ID:SGTC_2289|Compound:7946404|FD-Score:4.87|P-value:3.04E-6 ID:SGTC_2381|Compound:9035592|FD-Score:-4.34|P-value:2.53E-5 ID:SGTC_2382|Compound:9035899|FD-Score:-4.87|P-value:2.76E-6 ID:SGTC_2385|Compound:9074692|FD-Score:-3.67|P-value:3.02E-4 ID:SGTC_2390|Compound:9097792|FD-Score:-4.30|P-value:2.94E-5 ID:SGTC_2408|Compound:sulbentine|FD-Score:5.20|P-value:7.04E-7 ID:SGTC_2462|Compound:5162487|FD-Score:-3.37|P-value:8.16E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:6.06|P-value:9.11E-9 ID:SGTC_2693|Compound:st077581|FD-Score:-4.62|P-value:8.02E-6 ID:SGTC_2848|Compound:9016370|FD-Score:-4.18|P-value:4.71E-5 ID:SGTC_3125|Compound:9127534|FD-Score:-3.80|P-value:1.93E-4 ID:SGTC_3135|Compound:9127742|FD-Score:3.86|P-value:1.72E-4 ID:SGTC_3201|Compound:9113999|FD-Score:5.17|P-value:7.78E-7 ID:SGTC_3202|Compound:9113761|FD-Score:-6.36|P-value:1.50E-9 ID:SGTC_3207|Compound:9114163|FD-Score:-4.14|P-value:5.50E-5 ID:SGTC_3210|Compound:9128157|FD-Score:-3.87|P-value:1.50E-4 ID:SGTC_3347|Compound:9188721|FD-Score:3.35|P-value:9.55E-4

Top fitness defect scores for YML016C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_58 0957-0393 12.40 9.0 µM 3.42E-31 cell wall 48 9.03E-36
2 SGTC_582 0987-0078 8.06 156.0 µM 3.37E-14 calcium & mitochondrial duress 14 3.71E-16
3 SGTC_690 glyoxal 7.15 20.3 µM 1.54E-11 33 4.33E-13
4 SGTC_103 0844-0104 7.09 51.8 µM 2.24E-11 ERAD & cell cycle 59 6.69E-13
5 SGTC_310 1273-0058 6.43 1.1 µM 1.19E-9 mitochondrial stress 133 6.56E-11
6 SGTC_2688 kanamycin b 6.06 96.7 µM 9.11E-9 calcium & mitochondrial duress 156 6.82E-10
7 SGTC_2408 sulbentine 5.20 18.4 µM 7.04E-7 28 1.02E-7
8 SGTC_3201 9113999 5.17 49.5 µM 7.78E-7 11 1.15E-7
9 SGTC_573 3702-0553 5.04 84.7 µM 1.41E-6 3 2.27E-7
10 SGTC_2289 7946404 4.87 165.1 µM 3.04E-6 61 5.51E-7
11 SGTC_1197 1601-0112 4.62 267.0 µM 9.08E-6 6 1.94E-6
12 SGTC_138 0850-0259 4.43 40.9 µM 1.99E-5 cell wall 170 4.78E-6
13 SGTC_1635 st007035 4.31 42.4 µM 3.13E-5 196 8.04E-6
14 SGTC_351 caspofungin 4.30 25.0 nM 3.31E-5 cell wall 81 8.56E-6
15 SGTC_1958 st076513 4.23 41.9 µM 4.26E-5 60S ribosome export 23 1.15E-5
16 SGTC_488 nitrendipine 4.11 139.0 µM 6.80E-5 44 1.96E-5
17 SGTC_1093 fluphenazine 3.87 8.0 µM 1.64E-4 13 5.41E-5
18 SGTC_3135 9127742 3.86 49.5 µM 1.72E-4 25 5.69E-5
19 SGTC_472 calcifediol 3.83 10.0 µM 1.88E-4 5 6.30E-5
20 SGTC_1844 rapamycin 3.73 4.0 nM 2.73E-4 178 9.70E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.271 2.21E-57 YDR205W MSC2 hom Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids
0.256 2.42E-51 YJR054W KCH1 hom Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family; potential Cdc28p substrate
0.256 3.32E-51 YGR217W CCH1 hom Voltage-gated high-affinity calcium channel involved in calcium influx in response to some environmental stresses as well as exposure to mating pheromones; interacts and co-localizes with Mid1p, suggesting Cch1p and Mid1p function together
0.254 1.20E-50 YOR231W MKK1 hom MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication
0.246 2.65E-47 YBR260C RGD1 hom GTPase-activating protein (RhoGAP) for Rho3p and Rho4p, possibly involved in control of actin cytoskeleton organization
0.245 5.15E-47 YLR443W ECM7 hom Non-essential putative integral membrane protein with a role in calcium uptake; mutant has cell wall defects and Ca+ uptake deficiencies; transcription is induced under conditions of zinc deficiency
0.244 1.21E-46 YIL148W RPL40A hom Ubiquitin-ribosomal 60S subunit protein L40A fusion protein; cleaved to yield ubiquitin and ribosomal protein L40A; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes; homologous to mammalian ribosomal protein L40, no bacterial homolog; RPL40A has a paralog, RPL40B, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
0.243 3.25E-46 YLR331C_d JIP3_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene MID2
0.242 9.31E-46 YLR150W STM1 hom Protein required for optimal translation under nutrient stress; perturbs association of Yef3p with ribosomes; involved in TOR signaling; binds G4 quadruplex and purine motif triplex nucleic acid; helps maintain telomere structure; protein abundance increases in response to DNA replication stress; serves as a ribosome preservation factor both during quiescence and recovery
0.235 3.12E-43 YKL033W-A_p YKL033W-A_p hom Putative protein of unknown function; similar to uncharacterized proteins from other fungi
0.231 8.67E-42 YKR042W UTH1 hom Protein involved in cell wall biogenesis; required for mitochondrial autophagy; mitochondrial outer membrane and cell wall localized SUN family member; involved in the oxidative stress response, life span during starvation, and cell death; UTH1 has a paralog, NCA3, that arose from the whole genome duplication
0.228 1.19E-40 YCL005W LDB16 hom Protein of unknown function; null mutants have decreased net negative cell surface charge; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; native protein is detected in purified mitochondria
0.225 1.29E-39 YJL080C SCP160 hom Essential RNA-binding G protein effector of mating response pathway, mainly associated with nuclear envelope and ER, interacts in mRNA-dependent manner with translating ribosomes via multiple KH domains, similar to vertebrate vigilins
0.222 8.88E-39 YGR058W PEF1 hom Penta-EF-hand protein required for polar bud growth and cell wall abscission; binds calcium and zinc with different affinity; localizes to bud site in G1, bud neck in G2; binds to Sec31p and modulates COPII coat assembly
0.222 1.17E-38 YAL015C NTG1 hom DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase; involved in base excision repair; acts in both nucleus and mitochondrion; creates a double-strand break at mtDNA origins that stimulates replication in response to oxidative stress; NTG1 has a paralog, NTG2, that arose from the whole genome duplication