YML017W / PSP2

Asn rich cytoplasmic protein that contains RGG motifs; high-copy suppressor of group II intron-splicing defects of a mutation in MRS2 and of a conditional mutation in POL1 (DNA polymerase alpha); possible role in mitochondrial mRNA splicing

Zygosity: Homozygous strain
fixedexpanded
Profile for YML017W / PSP2

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:8.13|P-value:3.52E-14 ID:SGTC_71|Compound:0417-1750|FD-Score:-3.49|P-value:6.01E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:4.15|P-value:6.97E-5 ID:SGTC_138|Compound:0850-0259|FD-Score:6.43|P-value:1.68E-9 ID:SGTC_160|Compound:3453-0671|FD-Score:5.31|P-value:5.36E-7 ID:SGTC_168|Compound:3970-0862|FD-Score:-4.56|P-value:1.21E-5 ID:SGTC_197|Compound:4544-0043|FD-Score:4.47|P-value:2.03E-5 ID:SGTC_255|Compound:tunicamycin|FD-Score:4.33|P-value:3.41E-5 ID:SGTC_263|Compound:alizarin|FD-Score:3.71|P-value:3.26E-4 ID:SGTC_416|Compound:estradiol valerate|FD-Score:3.60|P-value:4.77E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:4.24|P-value:4.87E-5 ID:SGTC_505|Compound:gw-5074|FD-Score:3.38|P-value:9.61E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:7.82|P-value:3.17E-13 ID:SGTC_716|Compound:1683-5115|FD-Score:3.61|P-value:4.63E-4 ID:SGTC_780|Compound:0109-0199|FD-Score:3.97|P-value:1.31E-4 ID:SGTC_861|Compound:0443-0273|FD-Score:3.78|P-value:2.61E-4 ID:SGTC_864|Compound:0469-0573|FD-Score:3.53|P-value:5.89E-4 ID:SGTC_871|Compound:0574-0004|FD-Score:4.61|P-value:1.13E-5 ID:SGTC_879|Compound:0831-1030|FD-Score:4.45|P-value:2.18E-5 ID:SGTC_1050|Compound:3232-1156|FD-Score:-3.85|P-value:1.81E-4 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:4.08|P-value:8.80E-5 ID:SGTC_1161|Compound:k007-0610|FD-Score:4.71|P-value:7.52E-6 ID:SGTC_1324|Compound:1418-0026|FD-Score:3.54|P-value:5.75E-4 ID:SGTC_1341|Compound:1486-1360|FD-Score:3.92|P-value:1.59E-4 ID:SGTC_1495|Compound:4469-0029|FD-Score:3.59|P-value:4.84E-4 ID:SGTC_1511|Compound:0906-3109|FD-Score:3.88|P-value:1.83E-4 ID:SGTC_1531|Compound:st059297|FD-Score:-3.72|P-value:2.85E-4 ID:SGTC_1545|Compound:lovastatin|FD-Score:-3.35|P-value:9.51E-4 ID:SGTC_1547|Compound:harmine|FD-Score:3.57|P-value:5.16E-4 ID:SGTC_1687|Compound:st020778|FD-Score:4.52|P-value:1.62E-5 ID:SGTC_1707|Compound:st032323|FD-Score:5.41|P-value:3.35E-7 ID:SGTC_1726|Compound:st035556|FD-Score:-3.61|P-value:4.09E-4 ID:SGTC_1738|Compound:st035555|FD-Score:3.56|P-value:5.47E-4 ID:SGTC_1841|Compound:st054148|FD-Score:3.37|P-value:9.87E-4 ID:SGTC_1901|Compound:st060216|FD-Score:3.51|P-value:6.29E-4 ID:SGTC_1974|Compound:st069448|FD-Score:3.80|P-value:2.39E-4 ID:SGTC_2054|Compound:5233173|FD-Score:4.31|P-value:3.80E-5 ID:SGTC_2061|Compound:5245884|FD-Score:3.90|P-value:1.70E-4 ID:SGTC_2094|Compound:5332512|FD-Score:3.84|P-value:2.11E-4 ID:SGTC_2335|Compound:9018011|FD-Score:3.71|P-value:3.29E-4 ID:SGTC_2336|Compound:9001819|FD-Score:4.93|P-value:2.94E-6 ID:SGTC_2350|Compound:9023895|FD-Score:3.90|P-value:1.70E-4 ID:SGTC_2435|Compound:5706476|FD-Score:3.56|P-value:5.36E-4 ID:SGTC_2437|Compound:5741531|FD-Score:3.64|P-value:4.17E-4 ID:SGTC_2445|Compound:5742597|FD-Score:3.96|P-value:1.37E-4 ID:SGTC_2479|Compound:5617353|FD-Score:3.57|P-value:5.29E-4 ID:SGTC_2606|Compound:farnesol|FD-Score:4.08|P-value:9.08E-5 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:4.79|P-value:5.35E-6 ID:SGTC_2612|Compound:dictamnine|FD-Score:4.48|P-value:1.94E-5 ID:SGTC_2619|Compound:obliquin|FD-Score:8.96|P-value:7.77E-17 ID:SGTC_2651|Compound:1327-0036|FD-Score:3.48|P-value:7.03E-4 ID:SGTC_2653|Compound:dihydrofissinolide|FD-Score:-3.44|P-value:7.07E-4 ID:SGTC_2684|Compound:capsaicin|FD-Score:3.46|P-value:7.50E-4 ID:SGTC_2717|Compound:st081029|FD-Score:3.76|P-value:2.80E-4 ID:SGTC_2799|Compound:7812892|FD-Score:3.89|P-value:1.75E-4 ID:SGTC_2806|Compound:7952793|FD-Score:3.80|P-value:2.46E-4 ID:SGTC_2811|Compound:7967822|FD-Score:-4.90|P-value:2.95E-6 ID:SGTC_2867|Compound:9039098|FD-Score:4.51|P-value:1.72E-5 ID:SGTC_2896|Compound:9052656|FD-Score:5.73|P-value:6.89E-8 ID:SGTC_2986|Compound:9022445|FD-Score:4.74|P-value:6.51E-6 ID:SGTC_3120|Compound:9124077|FD-Score:5.74|P-value:6.55E-8 ID:SGTC_3142|Compound:9086498|FD-Score:4.37|P-value:2.92E-5 ID:SGTC_3288|Compound:9119690|FD-Score:5.05|P-value:1.71E-6 ID:SGTC_3304|Compound:9125678|FD-Score:8.36|P-value:7.24E-15 ID:SGTC_3311|Compound:9131146|FD-Score:4.64|P-value:1.00E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:8.13|P-value:3.52E-14 ID:SGTC_71|Compound:0417-1750|FD-Score:-3.49|P-value:6.01E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:4.15|P-value:6.97E-5 ID:SGTC_138|Compound:0850-0259|FD-Score:6.43|P-value:1.68E-9 ID:SGTC_160|Compound:3453-0671|FD-Score:5.31|P-value:5.36E-7 ID:SGTC_168|Compound:3970-0862|FD-Score:-4.56|P-value:1.21E-5 ID:SGTC_197|Compound:4544-0043|FD-Score:4.47|P-value:2.03E-5 ID:SGTC_255|Compound:tunicamycin|FD-Score:4.33|P-value:3.41E-5 ID:SGTC_263|Compound:alizarin|FD-Score:3.71|P-value:3.26E-4 ID:SGTC_416|Compound:estradiol valerate|FD-Score:3.60|P-value:4.77E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:4.24|P-value:4.87E-5 ID:SGTC_505|Compound:gw-5074|FD-Score:3.38|P-value:9.61E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:7.82|P-value:3.17E-13 ID:SGTC_716|Compound:1683-5115|FD-Score:3.61|P-value:4.63E-4 ID:SGTC_780|Compound:0109-0199|FD-Score:3.97|P-value:1.31E-4 ID:SGTC_861|Compound:0443-0273|FD-Score:3.78|P-value:2.61E-4 ID:SGTC_864|Compound:0469-0573|FD-Score:3.53|P-value:5.89E-4 ID:SGTC_871|Compound:0574-0004|FD-Score:4.61|P-value:1.13E-5 ID:SGTC_879|Compound:0831-1030|FD-Score:4.45|P-value:2.18E-5 ID:SGTC_1050|Compound:3232-1156|FD-Score:-3.85|P-value:1.81E-4 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:4.08|P-value:8.80E-5 ID:SGTC_1161|Compound:k007-0610|FD-Score:4.71|P-value:7.52E-6 ID:SGTC_1324|Compound:1418-0026|FD-Score:3.54|P-value:5.75E-4 ID:SGTC_1341|Compound:1486-1360|FD-Score:3.92|P-value:1.59E-4 ID:SGTC_1495|Compound:4469-0029|FD-Score:3.59|P-value:4.84E-4 ID:SGTC_1511|Compound:0906-3109|FD-Score:3.88|P-value:1.83E-4 ID:SGTC_1531|Compound:st059297|FD-Score:-3.72|P-value:2.85E-4 ID:SGTC_1545|Compound:lovastatin|FD-Score:-3.35|P-value:9.51E-4 ID:SGTC_1547|Compound:harmine|FD-Score:3.57|P-value:5.16E-4 ID:SGTC_1687|Compound:st020778|FD-Score:4.52|P-value:1.62E-5 ID:SGTC_1707|Compound:st032323|FD-Score:5.41|P-value:3.35E-7 ID:SGTC_1726|Compound:st035556|FD-Score:-3.61|P-value:4.09E-4 ID:SGTC_1738|Compound:st035555|FD-Score:3.56|P-value:5.47E-4 ID:SGTC_1841|Compound:st054148|FD-Score:3.37|P-value:9.87E-4 ID:SGTC_1901|Compound:st060216|FD-Score:3.51|P-value:6.29E-4 ID:SGTC_1974|Compound:st069448|FD-Score:3.80|P-value:2.39E-4 ID:SGTC_2054|Compound:5233173|FD-Score:4.31|P-value:3.80E-5 ID:SGTC_2061|Compound:5245884|FD-Score:3.90|P-value:1.70E-4 ID:SGTC_2094|Compound:5332512|FD-Score:3.84|P-value:2.11E-4 ID:SGTC_2335|Compound:9018011|FD-Score:3.71|P-value:3.29E-4 ID:SGTC_2336|Compound:9001819|FD-Score:4.93|P-value:2.94E-6 ID:SGTC_2350|Compound:9023895|FD-Score:3.90|P-value:1.70E-4 ID:SGTC_2435|Compound:5706476|FD-Score:3.56|P-value:5.36E-4 ID:SGTC_2437|Compound:5741531|FD-Score:3.64|P-value:4.17E-4 ID:SGTC_2445|Compound:5742597|FD-Score:3.96|P-value:1.37E-4 ID:SGTC_2479|Compound:5617353|FD-Score:3.57|P-value:5.29E-4 ID:SGTC_2606|Compound:farnesol|FD-Score:4.08|P-value:9.08E-5 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:4.79|P-value:5.35E-6 ID:SGTC_2612|Compound:dictamnine|FD-Score:4.48|P-value:1.94E-5 ID:SGTC_2619|Compound:obliquin|FD-Score:8.96|P-value:7.77E-17 ID:SGTC_2651|Compound:1327-0036|FD-Score:3.48|P-value:7.03E-4 ID:SGTC_2653|Compound:dihydrofissinolide|FD-Score:-3.44|P-value:7.07E-4 ID:SGTC_2684|Compound:capsaicin|FD-Score:3.46|P-value:7.50E-4 ID:SGTC_2717|Compound:st081029|FD-Score:3.76|P-value:2.80E-4 ID:SGTC_2799|Compound:7812892|FD-Score:3.89|P-value:1.75E-4 ID:SGTC_2806|Compound:7952793|FD-Score:3.80|P-value:2.46E-4 ID:SGTC_2811|Compound:7967822|FD-Score:-4.90|P-value:2.95E-6 ID:SGTC_2867|Compound:9039098|FD-Score:4.51|P-value:1.72E-5 ID:SGTC_2896|Compound:9052656|FD-Score:5.73|P-value:6.89E-8 ID:SGTC_2986|Compound:9022445|FD-Score:4.74|P-value:6.51E-6 ID:SGTC_3120|Compound:9124077|FD-Score:5.74|P-value:6.55E-8 ID:SGTC_3142|Compound:9086498|FD-Score:4.37|P-value:2.92E-5 ID:SGTC_3288|Compound:9119690|FD-Score:5.05|P-value:1.71E-6 ID:SGTC_3304|Compound:9125678|FD-Score:8.36|P-value:7.24E-15 ID:SGTC_3311|Compound:9131146|FD-Score:4.64|P-value:1.00E-5

Top fitness defect scores for YML017W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2619 obliquin 8.96 87.9 µM 7.77E-17 cell wall 32 1.56E-19
2 SGTC_3304 9125678 8.36 46.1 µM 7.24E-15 4 3.21E-17
3 SGTC_58 0957-0393 8.13 9.0 µM 3.52E-14 cell wall 118 2.06E-16
4 SGTC_514 4466-0038 7.82 2.6 nM 3.17E-13 cell wall 43 2.73E-15
5 SGTC_138 0850-0259 6.43 40.9 µM 1.68E-9 cell wall 94 6.46E-11
6 SGTC_3120 9124077 5.74 49.5 µM 6.55E-8 8 4.77E-9
7 SGTC_2896 9052656 5.73 71.4 µM 6.89E-8 endomembrane recycling 43 5.05E-9
8 SGTC_1707 st032323 5.41 6.3 µM 3.35E-7 DNA damage response 27 3.24E-8
9 SGTC_160 3453-0671 5.31 289.7 µM 5.36E-7 17 5.61E-8
10 SGTC_3288 9119690 5.05 36.2 µM 1.71E-6 13 2.18E-7
11 SGTC_2336 9001819 4.93 198.7 µM 2.94E-6 heme biosynthesis & mitochondrial translocase 23 4.14E-7
12 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 4.79 70.0 µM 5.35E-6 redox potentiating 49 8.33E-7
13 SGTC_2986 9022445 4.74 71.4 µM 6.51E-6 6 1.05E-6
14 SGTC_1161 k007-0610 4.71 110.0 µM 7.52E-6 ERAD & cell cycle 88 1.24E-6
15 SGTC_3311 9131146 4.64 2.9 µM 1.00E-5 cell wall 94 1.74E-6
16 SGTC_871 0574-0004 4.61 149.0 µM 1.13E-5 32 2.00E-6
17 SGTC_1687 st020778 4.52 55.4 µM 1.62E-5 147 3.04E-6
18 SGTC_2867 9039098 4.51 71.4 µM 1.72E-5 iron homeostasis 21 3.26E-6
19 SGTC_2612 dictamnine 4.48 15.5 µM 1.94E-5 RNA pol III & RNase P/MRP 31 3.76E-6
20 SGTC_197 4544-0043 4.47 41.6 µM 2.03E-5 endomembrane recycling 35 3.97E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.290 6.32E-66 YJL159W HSP150 hom O-mannosylated heat shock protein; secreted and covalently attached to the cell wall via beta-1,3-glucan and disulfide bridges; required for cell wall stability; induced by heat shock, oxidative stress, and nitrogen limitation; HSP150 has a paralog, PIR3, that arose from the whole genome duplication
0.285 6.86E-64 YKL019W RAM2 het Alpha subunit of both the farnesyltransferase and type I geranylgeranyltransferase that catalyze prenylation of proteins containing a CAAX consensus motif; essential protein required for membrane localization of Ras proteins and a-factor
0.272 7.01E-58 YGL155W CDC43 het Beta subunit of geranylgeranyltransferase type I, catalyzes geranylgeranylation to the cysteine residue in proteins containing a C-terminal CaaX sequence ending in Leu or Phe; has substrates important for morphogenesis
0.265 3.39E-55 YGL033W HOP2 hom Meiosis-specific protein that localizes to chromosomes, preventing synapsis between nonhomologous chromosomes and ensuring synapsis between homologs; complexes with Mnd1p to promote homolog pairing and meiotic double-strand break repair
0.252 8.98E-50 YBR020W GAL1 hom Galactokinase; phosphorylates alpha-D-galactose to alpha-D-galactose-1-phosphate in the first step of galactose catabolism; expression regulated by Gal4p; GAL1 has a paralog, GAL3, that arose from the whole genome duplication
0.248 3.28E-48 YMR121C RPL15B hom Ribosomal 60S subunit protein L15B; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L15, no bacterial homolog; RPL15B has a paralog, RPL15A, that arose from the whole genome duplication; relocalizes from nucleus to nucleolus upon DNA replication stress
0.241 1.90E-45 YJR142W_p YJR142W_p hom Putative protein of unknown function; GST fusion protein is a Dbf2p-Mob1p phosphorylation target in a proteome chip analysis; synthetic lethal with PH085 deletion; plays a role in restricting Ty1 transposition; nudix hydrolase family member
0.239 6.60E-45 YMR124W_p YMR124W_p hom Protein of unknown function; GFP-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; interacts with Crm1p in two-hybrid assay; YMR124W is not an essential gene; predicted to have a role in organelle organization
0.237 3.16E-44 YPR061C JID1 hom Probable Hsp40p co-chaperone, has a DnaJ-like domain and appears to be involved in ER-associated degradation of misfolded proteins containing a tightly folded cytoplasmic domain; inhibits replication of Brome mosaic virus in S. cerevisiae
0.234 4.55E-43 YDR335W MSN5 hom Karyopherin involved in nuclear import and export of proteins, including import of replication protein A and export of Swi6p, Far1p, and Pho4p; required for re-export of mature tRNAs after their retrograde import from the cytoplasm
0.233 1.81E-42 YLL032C YLL032C hom Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLL032C is not an essential gene
0.232 2.75E-42 YOL003C PFA4 hom Palmitoyltransferase with autoacylation activity, required for palmitoylation of amino acid permeases containing a C-terminal Phe-Trp-Cys site; required for modification of Chs3p; member of the DHHC family of putative palmitoyltransferases
0.232 4.35E-42 YML117W NAB6 hom Putative RNA-binding protein that associates with mRNAs encoding cell wall proteins in high-throughput studies; deletion mutants display increased sensitivity to some cell wall disrupting agents; expression negatively regulated by cAMP
0.225 8.18E-40 YOR091W TMA46 hom Protein of unknown function that associates with translating ribosomes; interacts with GTPase Rbg1p
0.212 2.29E-35 YLL021W SPA2 hom Component of the polarisome, which functions in actin cytoskeletal organization during polarized growth; acts as a scaffold for Mkk1p and Mpk1p cell wall integrity signaling components; potential Cdc28p substrate