YML023C / NSE5

Component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair

Zygosity: Heterozygous strain
fixedexpanded
Profile for YML023C / NSE5

Click on Significant Values for Screen Details ID:SGTC_71|Compound:0417-1750|FD-Score:-2.89|P-value:5.27E-4 ID:SGTC_99|Compound:0109-0120|FD-Score:-3.38|P-value:6.23E-5 ID:SGTC_110|Compound:0850-0284|FD-Score:-2.76|P-value:8.50E-4 ID:SGTC_245|Compound:methotrexate|FD-Score:3.95|P-value:4.59E-6 ID:SGTC_345|Compound:1362-0200|FD-Score:2.91|P-value:5.39E-4 ID:SGTC_379|Compound:3970-0972|FD-Score:-3.81|P-value:7.93E-6 ID:SGTC_413|Compound:propylparaben|FD-Score:2.90|P-value:5.78E-4 ID:SGTC_417|Compound:st075190|FD-Score:3.41|P-value:6.28E-5 ID:SGTC_493|Compound:zm226600|FD-Score:-5.10|P-value:3.91E-9 ID:SGTC_494|Compound:Boc-Gly-Val-Val-CHO|FD-Score:-2.94|P-value:4.17E-4 ID:SGTC_509|Compound:pifithrin|FD-Score:-2.82|P-value:6.73E-4 ID:SGTC_527|Compound:4476-4215|FD-Score:2.76|P-value:9.60E-4 ID:SGTC_605|Compound:1315-0399|FD-Score:2.93|P-value:5.09E-4 ID:SGTC_628|Compound:1636-0253|FD-Score:2.78|P-value:8.91E-4 ID:SGTC_635|Compound:k038-0028|FD-Score:3.16|P-value:1.93E-4 ID:SGTC_1120|Compound:ficusin|FD-Score:-2.89|P-value:5.27E-4 ID:SGTC_1134|Compound:3477-0009|FD-Score:3.94|P-value:4.62E-6 ID:SGTC_1229|Compound:0139-0193|FD-Score:-2.83|P-value:6.48E-4 ID:SGTC_1231|Compound:0242-0792|FD-Score:3.69|P-value:1.68E-5 ID:SGTC_1270|Compound:0831-1170|FD-Score:2.94|P-value:4.77E-4 ID:SGTC_1446|Compound:4239-0190|FD-Score:3.05|P-value:3.08E-4 ID:SGTC_1523|Compound:st012844|FD-Score:4.11|P-value:1.87E-6 ID:SGTC_1572|Compound:epiandrosterone|FD-Score:-2.74|P-value:9.32E-4 ID:SGTC_1606|Compound:st000094|FD-Score:3.03|P-value:3.40E-4 ID:SGTC_1721|Compound:st082152|FD-Score:3.59|P-value:2.70E-5 ID:SGTC_1756|Compound:st041558|FD-Score:-2.81|P-value:7.11E-4 ID:SGTC_1850|Compound:st056238|FD-Score:2.84|P-value:7.13E-4 ID:SGTC_1857|Compound:st056007|FD-Score:-3.52|P-value:3.34E-5 ID:SGTC_1860|Compound:st056228|FD-Score:-3.18|P-value:1.56E-4 ID:SGTC_1914|Compound:st062367|FD-Score:-2.73|P-value:9.52E-4 ID:SGTC_2018|Compound:5133068|FD-Score:-2.89|P-value:5.14E-4 ID:SGTC_2054|Compound:5233173|FD-Score:-3.03|P-value:2.95E-4 ID:SGTC_2081|Compound:5214970|FD-Score:-4.89|P-value:1.50E-8 ID:SGTC_2197|Compound:6588183|FD-Score:-2.79|P-value:7.60E-4 ID:SGTC_2246|Compound:7293507|FD-Score:3.39|P-value:7.05E-5 ID:SGTC_2369|Compound:9071472|FD-Score:2.94|P-value:4.91E-4 ID:SGTC_2563|Compound:tomatine|FD-Score:-3.43|P-value:4.91E-5 ID:SGTC_2591|Compound:skatole|FD-Score:-2.74|P-value:9.24E-4 ID:SGTC_2695|Compound:st077686|FD-Score:3.02|P-value:3.44E-4 ID:SGTC_2830|Compound:7992007|FD-Score:-4.01|P-value:2.76E-6 ID:SGTC_2832|Compound:7992762|FD-Score:-3.26|P-value:1.10E-4 ID:SGTC_2972|Compound:9093619|FD-Score:3.59|P-value:2.70E-5 ID:SGTC_2973|Compound:9094665|FD-Score:3.16|P-value:1.94E-4 ID:SGTC_3212|Compound:9128307|FD-Score:-3.67|P-value:1.59E-5 ID:SGTC_71|Compound:0417-1750|FD-Score:-2.89|P-value:5.27E-4 ID:SGTC_99|Compound:0109-0120|FD-Score:-3.38|P-value:6.23E-5 ID:SGTC_110|Compound:0850-0284|FD-Score:-2.76|P-value:8.50E-4 ID:SGTC_245|Compound:methotrexate|FD-Score:3.95|P-value:4.59E-6 ID:SGTC_345|Compound:1362-0200|FD-Score:2.91|P-value:5.39E-4 ID:SGTC_379|Compound:3970-0972|FD-Score:-3.81|P-value:7.93E-6 ID:SGTC_413|Compound:propylparaben|FD-Score:2.90|P-value:5.78E-4 ID:SGTC_417|Compound:st075190|FD-Score:3.41|P-value:6.28E-5 ID:SGTC_493|Compound:zm226600|FD-Score:-5.10|P-value:3.91E-9 ID:SGTC_494|Compound:Boc-Gly-Val-Val-CHO|FD-Score:-2.94|P-value:4.17E-4 ID:SGTC_509|Compound:pifithrin|FD-Score:-2.82|P-value:6.73E-4 ID:SGTC_527|Compound:4476-4215|FD-Score:2.76|P-value:9.60E-4 ID:SGTC_605|Compound:1315-0399|FD-Score:2.93|P-value:5.09E-4 ID:SGTC_628|Compound:1636-0253|FD-Score:2.78|P-value:8.91E-4 ID:SGTC_635|Compound:k038-0028|FD-Score:3.16|P-value:1.93E-4 ID:SGTC_1120|Compound:ficusin|FD-Score:-2.89|P-value:5.27E-4 ID:SGTC_1134|Compound:3477-0009|FD-Score:3.94|P-value:4.62E-6 ID:SGTC_1229|Compound:0139-0193|FD-Score:-2.83|P-value:6.48E-4 ID:SGTC_1231|Compound:0242-0792|FD-Score:3.69|P-value:1.68E-5 ID:SGTC_1270|Compound:0831-1170|FD-Score:2.94|P-value:4.77E-4 ID:SGTC_1446|Compound:4239-0190|FD-Score:3.05|P-value:3.08E-4 ID:SGTC_1523|Compound:st012844|FD-Score:4.11|P-value:1.87E-6 ID:SGTC_1572|Compound:epiandrosterone|FD-Score:-2.74|P-value:9.32E-4 ID:SGTC_1606|Compound:st000094|FD-Score:3.03|P-value:3.40E-4 ID:SGTC_1721|Compound:st082152|FD-Score:3.59|P-value:2.70E-5 ID:SGTC_1756|Compound:st041558|FD-Score:-2.81|P-value:7.11E-4 ID:SGTC_1850|Compound:st056238|FD-Score:2.84|P-value:7.13E-4 ID:SGTC_1857|Compound:st056007|FD-Score:-3.52|P-value:3.34E-5 ID:SGTC_1860|Compound:st056228|FD-Score:-3.18|P-value:1.56E-4 ID:SGTC_1914|Compound:st062367|FD-Score:-2.73|P-value:9.52E-4 ID:SGTC_2018|Compound:5133068|FD-Score:-2.89|P-value:5.14E-4 ID:SGTC_2054|Compound:5233173|FD-Score:-3.03|P-value:2.95E-4 ID:SGTC_2081|Compound:5214970|FD-Score:-4.89|P-value:1.50E-8 ID:SGTC_2197|Compound:6588183|FD-Score:-2.79|P-value:7.60E-4 ID:SGTC_2246|Compound:7293507|FD-Score:3.39|P-value:7.05E-5 ID:SGTC_2369|Compound:9071472|FD-Score:2.94|P-value:4.91E-4 ID:SGTC_2563|Compound:tomatine|FD-Score:-3.43|P-value:4.91E-5 ID:SGTC_2591|Compound:skatole|FD-Score:-2.74|P-value:9.24E-4 ID:SGTC_2695|Compound:st077686|FD-Score:3.02|P-value:3.44E-4 ID:SGTC_2830|Compound:7992007|FD-Score:-4.01|P-value:2.76E-6 ID:SGTC_2832|Compound:7992762|FD-Score:-3.26|P-value:1.10E-4 ID:SGTC_2972|Compound:9093619|FD-Score:3.59|P-value:2.70E-5 ID:SGTC_2973|Compound:9094665|FD-Score:3.16|P-value:1.94E-4 ID:SGTC_3212|Compound:9128307|FD-Score:-3.67|P-value:1.59E-5

Top fitness defect scores for YML023C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1523 st012844 4.11 44.7 µM 1.87E-6 60S ribosome export 3 1.94E-5 0.16
2 SGTC_245 methotrexate 3.95 289.6 µM 4.59E-6 14 3.97E-5 0.00
3 SGTC_1134 3477-0009 3.94 42.5 µM 4.62E-6 12 3.99E-5 0.06
4 SGTC_1231 0242-0792 3.69 125.0 µM 1.68E-5 2 1.11E-4 0.16
5 SGTC_1721 st082152 3.59 9.3 µM 2.70E-5 60S ribosome export 13 1.63E-4 0.08
6 SGTC_2972 9093619 3.59 59.9 µM 2.70E-5 8 1.63E-4 0.02
7 SGTC_417 st075190 3.41 100.0 µM 6.28E-5 3 3.20E-4 0.00
8 SGTC_2246 7293507 3.39 91.6 µM 7.05E-5 18 3.51E-4 0.01
9 SGTC_635 k038-0028 3.16 24.7 µM 1.93E-4 ubiquinone biosynthesis & proteasome 30 7.87E-4 0.01
10 SGTC_2973 9094665 3.16 18.0 µM 1.94E-4 NEO1 26 7.89E-4 0.08
11 SGTC_1446 4239-0190 3.05 62.0 µM 3.08E-4 16 0.00114 0.00
12 SGTC_1606 st000094 3.03 49.2 µM 3.40E-4 60S ribosome export 17 0.00124 0.04
13 SGTC_2695 st077686 3.02 52.0 µM 3.44E-4 9 0.00125 0.04
14 SGTC_1270 0831-1170 2.94 17.3 µM 4.77E-4 6 0.00162 0.09
15 SGTC_2369 9071472 2.94 200.0 µM 4.91E-4 15 0.00166 0.02
16 SGTC_605 1315-0399 2.93 119.0 µM 5.09E-4 Golgi 20 0.00171 0.01
17 SGTC_345 1362-0200 2.91 395.0 µM 5.39E-4 11 0.00179 0.01
18 SGTC_413 propylparaben 2.90 100.0 µM 5.78E-4 amide catabolism 17 0.00189 0.08
19 SGTC_1850 st056238 2.84 17.0 µM 7.13E-4 RPP1 & pyrimidine depletion 17 0.00224 0.02
20 SGTC_628 1636-0253 2.78 16.0 µM 8.91E-4 sphingolipid biosynthesis & PDR1 30 0.00268 0.00

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.175 1.60E-24 YDL218W_p YDL218W_p hom Putative protein of unknown function; YDL218W transcription is regulated by Azf1p and induced by starvation and aerobic conditions; expression also induced in cells treated with the mycotoxin patulin
0.133 8.68E-15 YLR066W SPC3 het Subunit of signal peptidase complex (Spc1p, Spc2p, Spc3p, Sec11p), which catalyzes cleavage of N-terminal signal sequences of proteins targeted to the secretory pathway; homologous to mammalian SPC22/23
0.129 6.56E-14 YLL048C YBT1 hom Transporter of the ATP-binding cassette (ABC) family; involved in bile acid transport; negative regulator of vacuole fusion; regulates the release of lumenal Ca2+ stores; similar to mammalian bile transporters
0.114 4.13E-11 YOR083W WHI5 hom Repressor of G1 transcription that binds to SCB binding factor (SBF) at SCB target promoters in early G1; phosphorylation of Whi5p by the CDK, Cln3p/Cdc28p relieves repression and promoter binding by Whi5; periodically expressed in G1
0.112 7.29E-11 YHL041W_d YHL041W_d hom Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data
0.105 1.19E-9 YLR428C_d YLR428C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CRN1
0.097 1.92E-8 YOR074C CDC21 het Thymidylate synthase, required for de novo biosynthesis of pyrimidine deoxyribonucleotides; expression is induced at G1/S
0.094 4.62E-8 YER056C FCY2 hom Purine-cytosine permease; mediates purine (adenine, guanine, and hypoxanthine) and cytosine accumulation; relative distribution to the vacuole increases upon DNA replication stress
0.093 7.02E-8 YER013W PRP22 het DEAH-box RNA-dependent ATPase/ATP-dependent RNA helicase, associates with lariat intermediates before the second catalytic step of splicing; mediates ATP-dependent mRNA release from the spliceosome and unwinds RNA duplexes
0.092 1.08E-7 YMR140W SIP5 hom Protein of unknown function; interacts with both the Reg1p/Glc7p phosphatase and the Snf1p kinase; forms cytoplasmic foci upon DNA replication stress
0.091 1.31E-7 YIL152W_p YIL152W_p hom Putative protein of unknown function
0.091 1.44E-7 YOL164W-A_p YOL164W-A_p hom Putative protein of unknown function; identified by fungal homology and RT-PCR
0.090 1.80E-7 YBL002W HTB2 hom Histone H2B, core histone protein required for chromatin assembly and chromosome function; nearly identical to HTB1; Rad6p-Bre1p-Lge1p mediated ubiquitination regulates transcriptional activation, meiotic DSB formation and H3 methylation
0.088 3.21E-7 YNL104C LEU4 hom Alpha-isopropylmalate synthase (2-isopropylmalate synthase); the main isozyme responsible for the first step in the leucine biosynthesis pathway; LEU4 has a paralog, LEU9, that arose from the whole genome duplication
0.086 5.81E-7 YJR016C ILV3 het Dihydroxyacid dehydratase, catalyzes third step in the common pathway leading to biosynthesis of branched-chain amino acids