YML027W / YOX1

Homeobox transcriptional repressor; binds to Mcm1p and to early cell cycle boxes (ECBs) in the promoters of cell cycle-regulated genes expressed in M/G1 phase; expression is cell cycle-regulated; potential Cdc28p substrate; relocalizes from nucleus to cytoplasm upon DNA replication stress; YOX1 has a paralog, YHP1, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YML027W / YOX1

Click on Significant Values for Screen Details ID:SGTC_159|Compound:3970-0959|FD-Score:-5.63|P-value:6.74E-10 ID:SGTC_162|Compound:k030-0015|FD-Score:4.33|P-value:1.79E-6 ID:SGTC_169|Compound:k015-0017|FD-Score:4.66|P-value:2.92E-7 ID:SGTC_175|Compound:3793-3120|FD-Score:-3.07|P-value:4.59E-4 ID:SGTC_182|Compound:3448-4371|FD-Score:2.90|P-value:9.61E-4 ID:SGTC_284|Compound:0988-0104|FD-Score:3.28|P-value:2.27E-4 ID:SGTC_396|Compound:dithiazanine|FD-Score:3.45|P-value:1.12E-4 ID:SGTC_405|Compound:ebelactone b|FD-Score:-3.10|P-value:4.17E-4 ID:SGTC_470|Compound:aa-861|FD-Score:3.58|P-value:6.33E-5 ID:SGTC_513|Compound:4245-1575|FD-Score:3.90|P-value:1.47E-5 ID:SGTC_595|Compound:3909-8003|FD-Score:-3.02|P-value:5.55E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:5.07|P-value:2.77E-8 ID:SGTC_772|Compound:k072-0172|FD-Score:3.71|P-value:3.57E-5 ID:SGTC_908|Compound:3448-7491|FD-Score:-3.48|P-value:8.70E-5 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:3.98|P-value:1.00E-5 ID:SGTC_916|Compound:4466-0038|FD-Score:2.89|P-value:9.85E-4 ID:SGTC_938|Compound:3126-1755|FD-Score:3.00|P-value:6.59E-4 ID:SGTC_1034|Compound:k072-0165|FD-Score:3.20|P-value:3.11E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:4.12|P-value:5.03E-6 ID:SGTC_1186|Compound:1319-0216|FD-Score:3.37|P-value:1.54E-4 ID:SGTC_1219|Compound:1469-0211|FD-Score:3.07|P-value:5.17E-4 ID:SGTC_1331|Compound:1472-0049|FD-Score:4.66|P-value:2.99E-7 ID:SGTC_1339|Compound:1486-1321|FD-Score:-3.11|P-value:3.95E-4 ID:SGTC_1603|Compound:st002045|FD-Score:4.13|P-value:4.85E-6 ID:SGTC_1770|Compound:st043884|FD-Score:-3.28|P-value:2.00E-4 ID:SGTC_1855|Compound:st056195|FD-Score:3.24|P-value:2.59E-4 ID:SGTC_1903|Compound:st060211|FD-Score:4.26|P-value:2.53E-6 ID:SGTC_1909|Compound:st060837|FD-Score:3.00|P-value:6.77E-4 ID:SGTC_2052|Compound:5265182|FD-Score:4.26|P-value:2.50E-6 ID:SGTC_2088|Compound:5278280|FD-Score:3.28|P-value:2.22E-4 ID:SGTC_2297|Compound:7971671|FD-Score:6.39|P-value:3.60E-12 ID:SGTC_2305|Compound:7443522|FD-Score:3.35|P-value:1.67E-4 ID:SGTC_2358|Compound:9037157|FD-Score:4.46|P-value:8.84E-7 ID:SGTC_2405|Compound:ticlatone|FD-Score:-3.82|P-value:1.93E-5 ID:SGTC_2416|Compound:tofa|FD-Score:-3.65|P-value:4.19E-5 ID:SGTC_2417|Compound:cerulenin|FD-Score:-3.08|P-value:4.37E-4 ID:SGTC_2418|Compound:pentamidine|FD-Score:-3.18|P-value:3.02E-4 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:-3.90|P-value:1.28E-5 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:-4.06|P-value:5.97E-6 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:3.87|P-value:1.69E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:-3.73|P-value:2.94E-5 ID:SGTC_2692|Compound:st077426|FD-Score:4.47|P-value:8.27E-7 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:-4.10|P-value:5.00E-6 ID:SGTC_2822|Compound:7994718|FD-Score:-3.74|P-value:2.79E-5 ID:SGTC_2827|Compound:7993847|FD-Score:-2.99|P-value:6.25E-4 ID:SGTC_2828|Compound:7998861|FD-Score:4.22|P-value:3.02E-6 ID:SGTC_2990|Compound:9074105|FD-Score:-3.42|P-value:1.12E-4 ID:SGTC_2995|Compound:9067767|FD-Score:-4.29|P-value:1.85E-6 ID:SGTC_3302|Compound:9125395|FD-Score:2.92|P-value:8.91E-4 ID:SGTC_3315|Compound:9136395|FD-Score:3.25|P-value:2.53E-4 ID:SGTC_159|Compound:3970-0959|FD-Score:-5.63|P-value:6.74E-10 ID:SGTC_162|Compound:k030-0015|FD-Score:4.33|P-value:1.79E-6 ID:SGTC_169|Compound:k015-0017|FD-Score:4.66|P-value:2.92E-7 ID:SGTC_175|Compound:3793-3120|FD-Score:-3.07|P-value:4.59E-4 ID:SGTC_182|Compound:3448-4371|FD-Score:2.90|P-value:9.61E-4 ID:SGTC_284|Compound:0988-0104|FD-Score:3.28|P-value:2.27E-4 ID:SGTC_396|Compound:dithiazanine|FD-Score:3.45|P-value:1.12E-4 ID:SGTC_405|Compound:ebelactone b|FD-Score:-3.10|P-value:4.17E-4 ID:SGTC_470|Compound:aa-861|FD-Score:3.58|P-value:6.33E-5 ID:SGTC_513|Compound:4245-1575|FD-Score:3.90|P-value:1.47E-5 ID:SGTC_595|Compound:3909-8003|FD-Score:-3.02|P-value:5.55E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:5.07|P-value:2.77E-8 ID:SGTC_772|Compound:k072-0172|FD-Score:3.71|P-value:3.57E-5 ID:SGTC_908|Compound:3448-7491|FD-Score:-3.48|P-value:8.70E-5 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:3.98|P-value:1.00E-5 ID:SGTC_916|Compound:4466-0038|FD-Score:2.89|P-value:9.85E-4 ID:SGTC_938|Compound:3126-1755|FD-Score:3.00|P-value:6.59E-4 ID:SGTC_1034|Compound:k072-0165|FD-Score:3.20|P-value:3.11E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:4.12|P-value:5.03E-6 ID:SGTC_1186|Compound:1319-0216|FD-Score:3.37|P-value:1.54E-4 ID:SGTC_1219|Compound:1469-0211|FD-Score:3.07|P-value:5.17E-4 ID:SGTC_1331|Compound:1472-0049|FD-Score:4.66|P-value:2.99E-7 ID:SGTC_1339|Compound:1486-1321|FD-Score:-3.11|P-value:3.95E-4 ID:SGTC_1603|Compound:st002045|FD-Score:4.13|P-value:4.85E-6 ID:SGTC_1770|Compound:st043884|FD-Score:-3.28|P-value:2.00E-4 ID:SGTC_1855|Compound:st056195|FD-Score:3.24|P-value:2.59E-4 ID:SGTC_1903|Compound:st060211|FD-Score:4.26|P-value:2.53E-6 ID:SGTC_1909|Compound:st060837|FD-Score:3.00|P-value:6.77E-4 ID:SGTC_2052|Compound:5265182|FD-Score:4.26|P-value:2.50E-6 ID:SGTC_2088|Compound:5278280|FD-Score:3.28|P-value:2.22E-4 ID:SGTC_2297|Compound:7971671|FD-Score:6.39|P-value:3.60E-12 ID:SGTC_2305|Compound:7443522|FD-Score:3.35|P-value:1.67E-4 ID:SGTC_2358|Compound:9037157|FD-Score:4.46|P-value:8.84E-7 ID:SGTC_2405|Compound:ticlatone|FD-Score:-3.82|P-value:1.93E-5 ID:SGTC_2416|Compound:tofa|FD-Score:-3.65|P-value:4.19E-5 ID:SGTC_2417|Compound:cerulenin|FD-Score:-3.08|P-value:4.37E-4 ID:SGTC_2418|Compound:pentamidine|FD-Score:-3.18|P-value:3.02E-4 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:-3.90|P-value:1.28E-5 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:-4.06|P-value:5.97E-6 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:3.87|P-value:1.69E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:-3.73|P-value:2.94E-5 ID:SGTC_2692|Compound:st077426|FD-Score:4.47|P-value:8.27E-7 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:-4.10|P-value:5.00E-6 ID:SGTC_2822|Compound:7994718|FD-Score:-3.74|P-value:2.79E-5 ID:SGTC_2827|Compound:7993847|FD-Score:-2.99|P-value:6.25E-4 ID:SGTC_2828|Compound:7998861|FD-Score:4.22|P-value:3.02E-6 ID:SGTC_2990|Compound:9074105|FD-Score:-3.42|P-value:1.12E-4 ID:SGTC_2995|Compound:9067767|FD-Score:-4.29|P-value:1.85E-6 ID:SGTC_3302|Compound:9125395|FD-Score:2.92|P-value:8.91E-4 ID:SGTC_3315|Compound:9136395|FD-Score:3.25|P-value:2.53E-4

Top fitness defect scores for YML027W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2297 7971671 6.39 152.3 µM 3.60E-12 RNA processing & uracil transport 6 8.20E-11
2 SGTC_669 0108-0021 5.07 26.2 µM 2.77E-8 fatty acid desaturase (OLE1) 36 1.99E-7
3 SGTC_169 k015-0017 4.66 16.0 µM 2.92E-7 13 1.56E-6
4 SGTC_1331 1472-0049 4.66 76.2 µM 2.99E-7 7 1.59E-6
5 SGTC_2692 st077426 4.47 47.7 µM 8.27E-7 15 3.86E-6
6 SGTC_2358 9037157 4.46 4.0 µM 8.84E-7 19 4.09E-6
7 SGTC_162 k030-0015 4.33 37.8 µM 1.79E-6 iron homeostasis 18 7.59E-6
8 SGTC_2052 5265182 4.26 7.1 µM 2.50E-6 21 1.01E-5
9 SGTC_1903 st060211 4.26 78.3 µM 2.53E-6 18 1.03E-5
10 SGTC_2828 7998861 4.22 71.4 µM 3.02E-6 13 1.20E-5
11 SGTC_1603 st002045 4.13 67.8 µM 4.85E-6 TSC3-RPN4 16 1.81E-5
12 SGTC_1083 didemethylchlorpromazine sulfoxide 4.12 707.4 nM 5.03E-6 redox potentiating 68 1.87E-5
13 SGTC_915 methyl methanesulfonate (MMS) 3.98 110.0 mM 1.00E-5 DNA damage response 42 3.41E-5
14 SGTC_513 4245-1575 3.90 41.7 µM 1.47E-5 unfolded protein response 120 4.78E-5
15 SGTC_2636 apigenin dimethyl ether 3.87 100.0 µM 1.69E-5 50 5.40E-5
16 SGTC_772 k072-0172 3.71 35.3 µM 3.57E-5 23 1.04E-4
17 SGTC_470 aa-861 3.58 153.0 µM 6.33E-5 sphingolipid biosynthesis & PDR1 71 1.71E-4
18 SGTC_396 dithiazanine 3.45 1.2 µM 1.12E-4 16 2.83E-4
19 SGTC_1186 1319-0216 3.37 26.0 µM 1.54E-4 39 3.73E-4
20 SGTC_2305 7443522 3.35 69.2 µM 1.67E-4 28 4.02E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.142 1.59E-16 YPL251W_d YPL251W_d het Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps 5' end of the verified, essential gene YAH1/YPL252C
0.128 1.17E-13 YBL066C SEF1 hom Putative transcription factor, has homolog in Kluyveromyces lactis
0.125 3.27E-13 YPL252C YAH1 het Ferredoxin of the mitochondrial matrix required for formation of cellular iron-sulfur proteins; involved in heme A biosynthesis; homologous to human adrenodoxin
0.115 2.30E-11 YJR117W STE24 hom Highly conserved zinc metalloprotease that functions in two steps of a-factor maturation, C-terminal CAAX proteolysis and the first step of N-terminal proteolytic processing; contains multiple transmembrane spans
0.113 5.01E-11 YOR364W_d YOR364W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YOR365C
0.109 2.33E-10 YPL026C SKS1 hom Putative serine/threonine protein kinase; involved in the adaptation to low concentrations of glucose independent of the SNF3 regulated pathway
0.105 1.11E-9 YDR431W_d YDR431W_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.100 5.70E-9 YDL113C ATG20 hom Sorting nexin family member required for the cytoplasm-to-vacuole targeting (Cvt) pathway and for endosomal sorting; has a Phox homology domain that binds phosphatidylinositol-3-phosphate; interacts with Snx4p; potential Cdc28p substrate
0.099 8.82E-9 YDL133C-A RPL41B hom Ribosomal 60S subunit protein L41B; comprises only 25 amino acids; rpl41a rpl41b double null mutant is viable; homologous to mammalian ribosomal protein L41, no bacterial homolog; RPL41B has a paralog, RPL41A, that arose from the whole genome duplication
0.099 9.47E-9 YNL011C_p YNL011C_p hom Putative protein of unknown function; YNL011C is not an essential gene
0.097 1.66E-8 YBR294W SUL1 hom High affinity sulfate permease of the SulP anion transporter family; sulfate uptake is mediated by specific sulfate transporters Sul1p and Sul2p, which control the concentration of endogenous activated sulfate intermediates
0.097 1.75E-8 YGL165C_d YGL165C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CUP2/YGL166W
0.097 1.75E-8 YFL056C AAD6 hom Putative aryl-alcohol dehydrogenase; involved in oxidative stress response; similar to P. chrysosporium aryl-alcohol dehydrogenase; expression induced in cells treated with the mycotoxin patulin
0.097 1.82E-8 YGR123C PPT1 hom Protein serine/threonine phosphatase, regulates Hsp90 chaperone by affecting its ATPase and cochaperone binding activities; has similarity to human phosphatase PP5; present in both the nucleus and cytoplasm; expressed during logarithmic growth
0.094 4.85E-8 YMR129W POM152 hom Glycoprotein subunit of the transmembrane ring of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport, NPC biogenesis and spindle pole body duplication; homologous to human NUP210