YML030W / RCF1

Cytochrome c oxidase subunit; required for assembly of the Complex III-Complex IV supercomplex, and for assembly of Cox13p and Rcf2p into cytochrome c oxidase; similar to Rcf2p, and either Rcf1p or Rcf2p is required for late-stage assembly of the Cox12p and Cox13p subunits and for cytochrome c oxidase activity; required for growth under hypoxic conditions; member of the hypoxia induced gene family; C. elegans and human orthologs are functional in yeast

Zygosity: Homozygous strain
fixedexpanded
Profile for YML030W / RCF1

Click on Significant Values for Screen Details ID:SGTC_17|Compound:0960-0276|FD-Score:3.92|P-value:2.89E-5 ID:SGTC_236|Compound:1509-0011|FD-Score:6.40|P-value:2.50E-11 ID:SGTC_259|Compound:usnic acid|FD-Score:4.51|P-value:1.87E-6 ID:SGTC_302|Compound:1094-0063|FD-Score:3.14|P-value:6.53E-4 ID:SGTC_383|Compound:2324-0395|FD-Score:3.73|P-value:6.67E-5 ID:SGTC_387|Compound:norethindrone acetate|FD-Score:-3.27|P-value:3.76E-4 ID:SGTC_511|Compound:blebbistatin|FD-Score:4.97|P-value:1.68E-7 ID:SGTC_512|Compound:prima-1|FD-Score:6.86|P-value:9.76E-13 ID:SGTC_786|Compound:4544-0069|FD-Score:3.56|P-value:1.33E-4 ID:SGTC_1167|Compound:k781-0610|FD-Score:4.00|P-value:2.03E-5 ID:SGTC_1172|Compound:0370-0043|FD-Score:3.50|P-value:1.71E-4 ID:SGTC_1200|Compound:1643-0193|FD-Score:-3.25|P-value:3.93E-4 ID:SGTC_1315|Compound:1237-0019|FD-Score:3.06|P-value:8.72E-4 ID:SGTC_1415|Compound:3966-0071|FD-Score:3.29|P-value:3.76E-4 ID:SGTC_1423|Compound:4048-0112|FD-Score:-3.07|P-value:7.70E-4 ID:SGTC_1440|Compound:4100-1550|FD-Score:4.00|P-value:2.05E-5 ID:SGTC_1562|Compound:morin hydrate|FD-Score:3.88|P-value:3.48E-5 ID:SGTC_1567|Compound:st069303|FD-Score:4.18|P-value:9.11E-6 ID:SGTC_1635|Compound:st007035|FD-Score:5.26|P-value:3.32E-8 ID:SGTC_1636|Compound:st007707|FD-Score:3.11|P-value:7.35E-4 ID:SGTC_1931|Compound:st074438|FD-Score:4.69|P-value:7.58E-7 ID:SGTC_1956|Compound:st077085|FD-Score:3.69|P-value:7.90E-5 ID:SGTC_2003|Compound:4023581|FD-Score:3.14|P-value:6.43E-4 ID:SGTC_2005|Compound:4024620|FD-Score:3.13|P-value:6.66E-4 ID:SGTC_2006|Compound:4011487|FD-Score:-3.84|P-value:3.82E-5 ID:SGTC_2031|Compound:5180455|FD-Score:-3.36|P-value:2.64E-4 ID:SGTC_2043|Compound:5101342|FD-Score:-3.54|P-value:1.31E-4 ID:SGTC_2095|Compound:5432005|FD-Score:-3.59|P-value:1.08E-4 ID:SGTC_2194|Compound:5927483|FD-Score:3.05|P-value:8.87E-4 ID:SGTC_2302|Compound:7771753|FD-Score:4.56|P-value:1.47E-6 ID:SGTC_2411|Compound:st077133|FD-Score:4.13|P-value:1.14E-5 ID:SGTC_2432|Compound:5630864|FD-Score:5.37|P-value:1.79E-8 ID:SGTC_2451|Compound:5856223|FD-Score:3.30|P-value:3.66E-4 ID:SGTC_2559|Compound:tetrahydrosappanone a trimethyl ether|FD-Score:-3.68|P-value:7.33E-5 ID:SGTC_2591|Compound:skatole|FD-Score:7.13|P-value:1.22E-13 ID:SGTC_2629|Compound:bisabolol|FD-Score:5.01|P-value:1.38E-7 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:4.15|P-value:1.03E-5 ID:SGTC_2635|Compound:hydroquinidine|FD-Score:-4.83|P-value:3.22E-7 ID:SGTC_2781|Compound:5567276|FD-Score:3.08|P-value:8.00E-4 ID:SGTC_2803|Compound:7707263|FD-Score:4.53|P-value:1.68E-6 ID:SGTC_2949|Compound:9072542|FD-Score:-3.38|P-value:2.39E-4 ID:SGTC_2952|Compound:9073731|FD-Score:3.52|P-value:1.53E-4 ID:SGTC_3300|Compound:9124615|FD-Score:-3.77|P-value:5.02E-5 ID:SGTC_17|Compound:0960-0276|FD-Score:3.92|P-value:2.89E-5 ID:SGTC_236|Compound:1509-0011|FD-Score:6.40|P-value:2.50E-11 ID:SGTC_259|Compound:usnic acid|FD-Score:4.51|P-value:1.87E-6 ID:SGTC_302|Compound:1094-0063|FD-Score:3.14|P-value:6.53E-4 ID:SGTC_383|Compound:2324-0395|FD-Score:3.73|P-value:6.67E-5 ID:SGTC_387|Compound:norethindrone acetate|FD-Score:-3.27|P-value:3.76E-4 ID:SGTC_511|Compound:blebbistatin|FD-Score:4.97|P-value:1.68E-7 ID:SGTC_512|Compound:prima-1|FD-Score:6.86|P-value:9.76E-13 ID:SGTC_786|Compound:4544-0069|FD-Score:3.56|P-value:1.33E-4 ID:SGTC_1167|Compound:k781-0610|FD-Score:4.00|P-value:2.03E-5 ID:SGTC_1172|Compound:0370-0043|FD-Score:3.50|P-value:1.71E-4 ID:SGTC_1200|Compound:1643-0193|FD-Score:-3.25|P-value:3.93E-4 ID:SGTC_1315|Compound:1237-0019|FD-Score:3.06|P-value:8.72E-4 ID:SGTC_1415|Compound:3966-0071|FD-Score:3.29|P-value:3.76E-4 ID:SGTC_1423|Compound:4048-0112|FD-Score:-3.07|P-value:7.70E-4 ID:SGTC_1440|Compound:4100-1550|FD-Score:4.00|P-value:2.05E-5 ID:SGTC_1562|Compound:morin hydrate|FD-Score:3.88|P-value:3.48E-5 ID:SGTC_1567|Compound:st069303|FD-Score:4.18|P-value:9.11E-6 ID:SGTC_1635|Compound:st007035|FD-Score:5.26|P-value:3.32E-8 ID:SGTC_1636|Compound:st007707|FD-Score:3.11|P-value:7.35E-4 ID:SGTC_1931|Compound:st074438|FD-Score:4.69|P-value:7.58E-7 ID:SGTC_1956|Compound:st077085|FD-Score:3.69|P-value:7.90E-5 ID:SGTC_2003|Compound:4023581|FD-Score:3.14|P-value:6.43E-4 ID:SGTC_2005|Compound:4024620|FD-Score:3.13|P-value:6.66E-4 ID:SGTC_2006|Compound:4011487|FD-Score:-3.84|P-value:3.82E-5 ID:SGTC_2031|Compound:5180455|FD-Score:-3.36|P-value:2.64E-4 ID:SGTC_2043|Compound:5101342|FD-Score:-3.54|P-value:1.31E-4 ID:SGTC_2095|Compound:5432005|FD-Score:-3.59|P-value:1.08E-4 ID:SGTC_2194|Compound:5927483|FD-Score:3.05|P-value:8.87E-4 ID:SGTC_2302|Compound:7771753|FD-Score:4.56|P-value:1.47E-6 ID:SGTC_2411|Compound:st077133|FD-Score:4.13|P-value:1.14E-5 ID:SGTC_2432|Compound:5630864|FD-Score:5.37|P-value:1.79E-8 ID:SGTC_2451|Compound:5856223|FD-Score:3.30|P-value:3.66E-4 ID:SGTC_2559|Compound:tetrahydrosappanone a trimethyl ether|FD-Score:-3.68|P-value:7.33E-5 ID:SGTC_2591|Compound:skatole|FD-Score:7.13|P-value:1.22E-13 ID:SGTC_2629|Compound:bisabolol|FD-Score:5.01|P-value:1.38E-7 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:4.15|P-value:1.03E-5 ID:SGTC_2635|Compound:hydroquinidine|FD-Score:-4.83|P-value:3.22E-7 ID:SGTC_2781|Compound:5567276|FD-Score:3.08|P-value:8.00E-4 ID:SGTC_2803|Compound:7707263|FD-Score:4.53|P-value:1.68E-6 ID:SGTC_2949|Compound:9072542|FD-Score:-3.38|P-value:2.39E-4 ID:SGTC_2952|Compound:9073731|FD-Score:3.52|P-value:1.53E-4 ID:SGTC_3300|Compound:9124615|FD-Score:-3.77|P-value:5.02E-5

Top fitness defect scores for YML030W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2591 skatole 7.13 100.0 µM 1.22E-13 3 4.91E-13
2 SGTC_512 prima-1 6.86 270.0 µM 9.76E-13 DNA intercalators 2 3.52E-12
3 SGTC_236 1509-0011 6.40 5.3 µM 2.50E-11 282 7.62E-11
4 SGTC_2432 5630864 5.37 12.2 µM 1.79E-8 5 3.90E-8
5 SGTC_1635 st007035 5.26 42.4 µM 3.32E-8 157 7.03E-8
6 SGTC_2629 bisabolol 5.01 100.0 µM 1.38E-7 9 2.71E-7
7 SGTC_511 blebbistatin 4.97 171.0 µM 1.68E-7 DNA intercalators 7 3.27E-7
8 SGTC_1931 st074438 4.69 57.1 µM 7.58E-7 6 1.37E-6
9 SGTC_2302 7771753 4.56 200.0 µM 1.47E-6 27 2.58E-6
10 SGTC_2803 7707263 4.53 71.4 µM 1.68E-6 22 2.92E-6
11 SGTC_259 usnic acid 4.51 108.9 µM 1.87E-6 10 3.24E-6
12 SGTC_1567 st069303 4.18 68.4 µM 9.11E-6 mitochondrial processes 16 1.46E-5
13 SGTC_2634 4'-methoxyflavone 4.15 100.0 µM 1.03E-5 26 1.64E-5
14 SGTC_2411 st077133 4.13 39.9 µM 1.14E-5 RNA pol III & RNase P/MRP 26 1.80E-5
15 SGTC_1167 k781-0610 4.00 148.0 µM 2.03E-5 RNA processing & uracil transport 23 3.12E-5
16 SGTC_1440 4100-1550 4.00 40.0 µM 2.05E-5 3 3.15E-5
17 SGTC_17 0960-0276 3.92 49.8 µM 2.89E-5 31 4.36E-5
18 SGTC_1562 morin hydrate 3.88 59.1 µM 3.48E-5 17 5.20E-5
19 SGTC_383 2324-0395 3.73 7.4 µM 6.67E-5 azole & statin 46 9.68E-5
20 SGTC_1956 st077085 3.69 54.0 µM 7.90E-5 24 1.14E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.261 1.61E-53 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.257 8.46E-52 YJR120W YJR120W hom Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p
0.255 5.76E-51 YGR183C QCR9 hom Subunit 9 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; required for electron transfer at the ubiquinol oxidase site of the complex
0.247 1.14E-47 YDR375C BCS1 hom Protein translocase and chaperone required for Complex III assembly; member of the AAA ATPase family; forms a homo-oligomeric complex in the mitochondrial inner membrane that translocates the C-terminal domain of Rip1p from the matrix across the inner membrane, and then delivers it to an assembly intermediate of respiratory Complex III in an ATP-dependent reaction; also required for assembly of the Qcr10p subunit; mutations in human homolog BCS1L linked to neonatal diseases
0.246 1.50E-47 YMR151W_d YIM2_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 5% of ORF overlaps the verified gene IMP1
0.239 1.22E-44 YHR050W-A_p YHR050W-A_p hom Protein of unknown function; identified by expression profiling and mass spectrometry
0.233 1.83E-42 YDR230W_d YDR230W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20
0.232 2.96E-42 YGL237C HAP2 hom Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences sufficient for both complex assembly and DNA binding
0.231 5.28E-42 YMR035W IMP2 hom Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p
0.226 4.73E-40 YPL215W CBP3 hom Mitochondrial protein required for assembly of cytochrome bc1 complex; forms a complex with Cbp6p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.222 7.01E-39 YPL013C MRPS16 hom Mitochondrial ribosomal protein of the small subunit
0.222 9.30E-39 YKL087C CYT2 hom Cytochrome c1 heme lyase, involved in maturation of cytochrome c1, which is a subunit of the mitochondrial ubiquinol-cytochrome-c reductase; links heme covalently to apocytochrome c1
0.221 1.57E-38 YEL059C-A SOM1 hom Subunit of the mitochondrial inner membrane peptidase, which is required for maturation of mitochondrial proteins of the intermembrane space; Som1p facilitates cleavage of a subset of substrates; contains twin cysteine-x9-cysteine motifs
0.217 6.39E-37 YKL109W HAP4 hom Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; provides the principal activation function of the complex
0.214 4.57E-36 YOR065W CYT1 hom Cytochrome c1, component of the mitochondrial respiratory chain; expression is regulated by the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex