YML031W / NDC1

Subunit of the transmembrane ring of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport, NPC biogenesis and spindle pole body duplication; homologous to human NDC1

Zygosity: Heterozygous strain
fixedexpanded
Profile for YML031W / NDC1

Click on Significant Values for Screen Details ID:SGTC_36|Compound:0335-0881|FD-Score:4.30|P-value:2.16E-5 ID:SGTC_64|Compound:000l-0018|FD-Score:7.68|P-value:1.52E-13 ID:SGTC_67|Compound:0335-0847|FD-Score:3.28|P-value:9.12E-4 ID:SGTC_75|Compound:0159-0059|FD-Score:-3.71|P-value:2.20E-4 ID:SGTC_86|Compound:0417-1630|FD-Score:4.53|P-value:8.42E-6 ID:SGTC_93|Compound:0109-0045|FD-Score:5.53|P-value:7.59E-8 ID:SGTC_97|Compound:0535-0701|FD-Score:-3.93|P-value:9.92E-5 ID:SGTC_118|Compound:0083-0097|FD-Score:5.46|P-value:1.10E-7 ID:SGTC_137|Compound:0438-0332|FD-Score:4.83|P-value:2.22E-6 ID:SGTC_150|Compound:3970-0969|FD-Score:6.23|P-value:1.62E-9 ID:SGTC_180|Compound:1486-1293|FD-Score:3.95|P-value:8.67E-5 ID:SGTC_201|Compound:4262-0159|FD-Score:6.89|P-value:3.11E-11 ID:SGTC_238|Compound:5hr heat shock (37°C) + nsc-638432|FD-Score:4.03|P-value:6.43E-5 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:8.78|P-value:3.77E-17 ID:SGTC_248|Compound:streptozotocin|FD-Score:4.17|P-value:3.65E-5 ID:SGTC_262|Compound:fenpropimorph|FD-Score:6.02|P-value:5.50E-9 ID:SGTC_268|Compound:camptothecin|FD-Score:4.94|P-value:1.32E-6 ID:SGTC_280|Compound:3448-3607|FD-Score:-4.75|P-value:3.33E-6 ID:SGTC_284|Compound:0988-0104|FD-Score:-3.94|P-value:9.65E-5 ID:SGTC_312|Compound:4092-0653|FD-Score:4.74|P-value:3.39E-6 ID:SGTC_320|Compound:4092-0846|FD-Score:3.71|P-value:2.12E-4 ID:SGTC_344|Compound:k064-0035|FD-Score:-6.19|P-value:2.27E-9 ID:SGTC_348|Compound:k064-0012|FD-Score:-4.63|P-value:5.70E-6 ID:SGTC_355|Compound:1311-2252|FD-Score:3.50|P-value:4.34E-4 ID:SGTC_372|Compound:0155-0182|FD-Score:-3.50|P-value:4.55E-4 ID:SGTC_393|Compound:acivicin|FD-Score:-3.44|P-value:5.57E-4 ID:SGTC_490|Compound:phenamil|FD-Score:-6.00|P-value:6.63E-9 ID:SGTC_512|Compound:prima-1|FD-Score:3.91|P-value:1.00E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:-3.97|P-value:8.36E-5 ID:SGTC_515|Compound:4092-1064|FD-Score:4.37|P-value:1.64E-5 ID:SGTC_580|Compound:1123-0028|FD-Score:3.50|P-value:4.43E-4 ID:SGTC_625|Compound:k213-0058|FD-Score:4.88|P-value:1.79E-6 ID:SGTC_644|Compound:1498-1197|FD-Score:3.93|P-value:9.32E-5 ID:SGTC_646|Compound:4092-0839|FD-Score:3.58|P-value:3.31E-4 ID:SGTC_671|Compound:0560-0003|FD-Score:5.06|P-value:7.79E-7 ID:SGTC_673|Compound:1082-0474|FD-Score:6.50|P-value:3.36E-10 ID:SGTC_778|Compound:3456-2434|FD-Score:-3.52|P-value:4.29E-4 ID:SGTC_785|Compound:1270-0111|FD-Score:3.33|P-value:7.80E-4 ID:SGTC_791|Compound:1348-1292|FD-Score:3.62|P-value:2.91E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:10.40|P-value:1.91E-23 ID:SGTC_801|Compound:0866-0028|FD-Score:3.82|P-value:1.43E-4 ID:SGTC_829|Compound:1635-0120|FD-Score:3.93|P-value:9.39E-5 ID:SGTC_831|Compound:k061-1017|FD-Score:4.31|P-value:2.09E-5 ID:SGTC_832|Compound:4083-0019|FD-Score:4.61|P-value:5.97E-6 ID:SGTC_1019|Compound:4262-0212|FD-Score:5.71|P-value:2.97E-8 ID:SGTC_1099|Compound:5-nonyloxytryptamine|FD-Score:5.31|P-value:2.27E-7 ID:SGTC_1105|Compound:epirubicin|FD-Score:5.61|P-value:4.92E-8 ID:SGTC_1126|Compound:isoteolin|FD-Score:5.64|P-value:4.15E-8 ID:SGTC_1153|Compound:4055-0057|FD-Score:4.34|P-value:1.89E-5 ID:SGTC_1216|Compound:1165-0504|FD-Score:4.04|P-value:6.16E-5 ID:SGTC_1245|Compound:0418-0076|FD-Score:4.71|P-value:3.80E-6 ID:SGTC_1255|Compound:0566-0045|FD-Score:-4.27|P-value:2.57E-5 ID:SGTC_1265|Compound:0819-1001|FD-Score:-3.29|P-value:9.15E-4 ID:SGTC_1308|Compound:1187-1617|FD-Score:3.39|P-value:6.44E-4 ID:SGTC_1309|Compound:pyrazolanthrone|FD-Score:7.59|P-value:2.94E-13 ID:SGTC_1374|Compound:2889-5571|FD-Score:3.26|P-value:9.87E-4 ID:SGTC_1470|Compound:k295-0292|FD-Score:3.54|P-value:3.89E-4 ID:SGTC_1476|Compound:4112-3294|FD-Score:-3.71|P-value:2.23E-4 ID:SGTC_1520|Compound:flindersine|FD-Score:4.64|P-value:5.30E-6 ID:SGTC_1522|Compound:st012842|FD-Score:-7.88|P-value:4.12E-14 ID:SGTC_1529|Compound:apigenin|FD-Score:-3.55|P-value:3.81E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:4.82|P-value:2.30E-6 ID:SGTC_1605|Compound:st000082|FD-Score:-3.30|P-value:8.95E-4 ID:SGTC_1609|Compound:st001574|FD-Score:4.34|P-value:1.83E-5 ID:SGTC_1627|Compound:st003713|FD-Score:3.56|P-value:3.53E-4 ID:SGTC_1693|Compound:xanthone|FD-Score:3.48|P-value:4.68E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:-4.52|P-value:9.18E-6 ID:SGTC_1723|Compound:st034307|FD-Score:6.29|P-value:1.14E-9 ID:SGTC_1765|Compound:st044815|FD-Score:6.19|P-value:2.05E-9 ID:SGTC_1771|Compound:st048882|FD-Score:3.40|P-value:6.25E-4 ID:SGTC_1786|Compound:berberine|FD-Score:-3.40|P-value:6.30E-4 ID:SGTC_1798|Compound:st045719|FD-Score:3.89|P-value:1.09E-4 ID:SGTC_1812|Compound:st052057|FD-Score:3.77|P-value:1.72E-4 ID:SGTC_1827|Compound:berberine|FD-Score:-3.74|P-value:1.97E-4 ID:SGTC_1829|Compound:berberine|FD-Score:-3.38|P-value:6.75E-4 ID:SGTC_1847|Compound:st056231|FD-Score:3.40|P-value:6.09E-4 ID:SGTC_1915|Compound:st067105|FD-Score:4.46|P-value:1.15E-5 ID:SGTC_2008|Compound:4012253|FD-Score:4.78|P-value:2.84E-6 ID:SGTC_2036|Compound:5160441|FD-Score:-3.28|P-value:9.39E-4 ID:SGTC_2041|Compound:5107442|FD-Score:8.79|P-value:3.46E-17 ID:SGTC_2045|Compound:5106652|FD-Score:5.44|P-value:1.18E-7 ID:SGTC_2048|Compound:5246248|FD-Score:5.66|P-value:3.88E-8 ID:SGTC_2066|Compound:5222451|FD-Score:-3.54|P-value:4.05E-4 ID:SGTC_2109|Compound:5483026|FD-Score:4.86|P-value:1.99E-6 ID:SGTC_2249|Compound:haloperidol|FD-Score:7.10|P-value:7.68E-12 ID:SGTC_2250|Compound:alverine citrate|FD-Score:3.88|P-value:1.13E-4 ID:SGTC_2281|Compound:7943571|FD-Score:3.45|P-value:5.15E-4 ID:SGTC_2326|Compound:6164455|FD-Score:-4.44|P-value:1.30E-5 ID:SGTC_2346|Compound:9031566|FD-Score:4.56|P-value:7.42E-6 ID:SGTC_2405|Compound:ticlatone|FD-Score:5.09|P-value:6.56E-7 ID:SGTC_2408|Compound:sulbentine|FD-Score:-5.99|P-value:6.66E-9 ID:SGTC_2411|Compound:st077133|FD-Score:-4.14|P-value:4.36E-5 ID:SGTC_2415|Compound:st077333|FD-Score:-3.41|P-value:6.25E-4 ID:SGTC_2526|Compound:patulin|FD-Score:4.52|P-value:8.82E-6 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:-3.83|P-value:1.45E-4 ID:SGTC_2652|Compound:actinonin|FD-Score:4.11|P-value:4.67E-5 ID:SGTC_2700|Compound:st077718|FD-Score:3.53|P-value:3.98E-4 ID:SGTC_2853|Compound:9015042|FD-Score:4.25|P-value:2.65E-5 ID:SGTC_2908|Compound:7930301|FD-Score:3.81|P-value:1.50E-4 ID:SGTC_2977|Compound:9011197|FD-Score:4.58|P-value:6.91E-6 ID:SGTC_3062|Compound:9077494|FD-Score:-5.30|P-value:2.48E-7 ID:SGTC_3141|Compound:9094609|FD-Score:-3.41|P-value:6.25E-4 ID:SGTC_3143|Compound:9086658|FD-Score:-3.54|P-value:3.97E-4 ID:SGTC_3191|Compound:9110352|FD-Score:-5.04|P-value:9.09E-7 ID:SGTC_3197|Compound:9113331|FD-Score:3.89|P-value:1.08E-4 ID:SGTC_3247|Compound:9135149|FD-Score:5.03|P-value:8.85E-7 ID:SGTC_3345|Compound:9148410|FD-Score:-3.66|P-value:2.61E-4 ID:SGTC_3346|Compound:9158254|FD-Score:4.79|P-value:2.73E-6 ID:SGTC_36|Compound:0335-0881|FD-Score:4.30|P-value:2.16E-5 ID:SGTC_64|Compound:000l-0018|FD-Score:7.68|P-value:1.52E-13 ID:SGTC_67|Compound:0335-0847|FD-Score:3.28|P-value:9.12E-4 ID:SGTC_75|Compound:0159-0059|FD-Score:-3.71|P-value:2.20E-4 ID:SGTC_86|Compound:0417-1630|FD-Score:4.53|P-value:8.42E-6 ID:SGTC_93|Compound:0109-0045|FD-Score:5.53|P-value:7.59E-8 ID:SGTC_97|Compound:0535-0701|FD-Score:-3.93|P-value:9.92E-5 ID:SGTC_118|Compound:0083-0097|FD-Score:5.46|P-value:1.10E-7 ID:SGTC_137|Compound:0438-0332|FD-Score:4.83|P-value:2.22E-6 ID:SGTC_150|Compound:3970-0969|FD-Score:6.23|P-value:1.62E-9 ID:SGTC_180|Compound:1486-1293|FD-Score:3.95|P-value:8.67E-5 ID:SGTC_201|Compound:4262-0159|FD-Score:6.89|P-value:3.11E-11 ID:SGTC_238|Compound:5hr heat shock (37°C) + nsc-638432|FD-Score:4.03|P-value:6.43E-5 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:8.78|P-value:3.77E-17 ID:SGTC_248|Compound:streptozotocin|FD-Score:4.17|P-value:3.65E-5 ID:SGTC_262|Compound:fenpropimorph|FD-Score:6.02|P-value:5.50E-9 ID:SGTC_268|Compound:camptothecin|FD-Score:4.94|P-value:1.32E-6 ID:SGTC_280|Compound:3448-3607|FD-Score:-4.75|P-value:3.33E-6 ID:SGTC_284|Compound:0988-0104|FD-Score:-3.94|P-value:9.65E-5 ID:SGTC_312|Compound:4092-0653|FD-Score:4.74|P-value:3.39E-6 ID:SGTC_320|Compound:4092-0846|FD-Score:3.71|P-value:2.12E-4 ID:SGTC_344|Compound:k064-0035|FD-Score:-6.19|P-value:2.27E-9 ID:SGTC_348|Compound:k064-0012|FD-Score:-4.63|P-value:5.70E-6 ID:SGTC_355|Compound:1311-2252|FD-Score:3.50|P-value:4.34E-4 ID:SGTC_372|Compound:0155-0182|FD-Score:-3.50|P-value:4.55E-4 ID:SGTC_393|Compound:acivicin|FD-Score:-3.44|P-value:5.57E-4 ID:SGTC_490|Compound:phenamil|FD-Score:-6.00|P-value:6.63E-9 ID:SGTC_512|Compound:prima-1|FD-Score:3.91|P-value:1.00E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:-3.97|P-value:8.36E-5 ID:SGTC_515|Compound:4092-1064|FD-Score:4.37|P-value:1.64E-5 ID:SGTC_580|Compound:1123-0028|FD-Score:3.50|P-value:4.43E-4 ID:SGTC_625|Compound:k213-0058|FD-Score:4.88|P-value:1.79E-6 ID:SGTC_644|Compound:1498-1197|FD-Score:3.93|P-value:9.32E-5 ID:SGTC_646|Compound:4092-0839|FD-Score:3.58|P-value:3.31E-4 ID:SGTC_671|Compound:0560-0003|FD-Score:5.06|P-value:7.79E-7 ID:SGTC_673|Compound:1082-0474|FD-Score:6.50|P-value:3.36E-10 ID:SGTC_778|Compound:3456-2434|FD-Score:-3.52|P-value:4.29E-4 ID:SGTC_785|Compound:1270-0111|FD-Score:3.33|P-value:7.80E-4 ID:SGTC_791|Compound:1348-1292|FD-Score:3.62|P-value:2.91E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:10.40|P-value:1.91E-23 ID:SGTC_801|Compound:0866-0028|FD-Score:3.82|P-value:1.43E-4 ID:SGTC_829|Compound:1635-0120|FD-Score:3.93|P-value:9.39E-5 ID:SGTC_831|Compound:k061-1017|FD-Score:4.31|P-value:2.09E-5 ID:SGTC_832|Compound:4083-0019|FD-Score:4.61|P-value:5.97E-6 ID:SGTC_1019|Compound:4262-0212|FD-Score:5.71|P-value:2.97E-8 ID:SGTC_1099|Compound:5-nonyloxytryptamine|FD-Score:5.31|P-value:2.27E-7 ID:SGTC_1105|Compound:epirubicin|FD-Score:5.61|P-value:4.92E-8 ID:SGTC_1126|Compound:isoteolin|FD-Score:5.64|P-value:4.15E-8 ID:SGTC_1153|Compound:4055-0057|FD-Score:4.34|P-value:1.89E-5 ID:SGTC_1216|Compound:1165-0504|FD-Score:4.04|P-value:6.16E-5 ID:SGTC_1245|Compound:0418-0076|FD-Score:4.71|P-value:3.80E-6 ID:SGTC_1255|Compound:0566-0045|FD-Score:-4.27|P-value:2.57E-5 ID:SGTC_1265|Compound:0819-1001|FD-Score:-3.29|P-value:9.15E-4 ID:SGTC_1308|Compound:1187-1617|FD-Score:3.39|P-value:6.44E-4 ID:SGTC_1309|Compound:pyrazolanthrone|FD-Score:7.59|P-value:2.94E-13 ID:SGTC_1374|Compound:2889-5571|FD-Score:3.26|P-value:9.87E-4 ID:SGTC_1470|Compound:k295-0292|FD-Score:3.54|P-value:3.89E-4 ID:SGTC_1476|Compound:4112-3294|FD-Score:-3.71|P-value:2.23E-4 ID:SGTC_1520|Compound:flindersine|FD-Score:4.64|P-value:5.30E-6 ID:SGTC_1522|Compound:st012842|FD-Score:-7.88|P-value:4.12E-14 ID:SGTC_1529|Compound:apigenin|FD-Score:-3.55|P-value:3.81E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:4.82|P-value:2.30E-6 ID:SGTC_1605|Compound:st000082|FD-Score:-3.30|P-value:8.95E-4 ID:SGTC_1609|Compound:st001574|FD-Score:4.34|P-value:1.83E-5 ID:SGTC_1627|Compound:st003713|FD-Score:3.56|P-value:3.53E-4 ID:SGTC_1693|Compound:xanthone|FD-Score:3.48|P-value:4.68E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:-4.52|P-value:9.18E-6 ID:SGTC_1723|Compound:st034307|FD-Score:6.29|P-value:1.14E-9 ID:SGTC_1765|Compound:st044815|FD-Score:6.19|P-value:2.05E-9 ID:SGTC_1771|Compound:st048882|FD-Score:3.40|P-value:6.25E-4 ID:SGTC_1786|Compound:berberine|FD-Score:-3.40|P-value:6.30E-4 ID:SGTC_1798|Compound:st045719|FD-Score:3.89|P-value:1.09E-4 ID:SGTC_1812|Compound:st052057|FD-Score:3.77|P-value:1.72E-4 ID:SGTC_1827|Compound:berberine|FD-Score:-3.74|P-value:1.97E-4 ID:SGTC_1829|Compound:berberine|FD-Score:-3.38|P-value:6.75E-4 ID:SGTC_1847|Compound:st056231|FD-Score:3.40|P-value:6.09E-4 ID:SGTC_1915|Compound:st067105|FD-Score:4.46|P-value:1.15E-5 ID:SGTC_2008|Compound:4012253|FD-Score:4.78|P-value:2.84E-6 ID:SGTC_2036|Compound:5160441|FD-Score:-3.28|P-value:9.39E-4 ID:SGTC_2041|Compound:5107442|FD-Score:8.79|P-value:3.46E-17 ID:SGTC_2045|Compound:5106652|FD-Score:5.44|P-value:1.18E-7 ID:SGTC_2048|Compound:5246248|FD-Score:5.66|P-value:3.88E-8 ID:SGTC_2066|Compound:5222451|FD-Score:-3.54|P-value:4.05E-4 ID:SGTC_2109|Compound:5483026|FD-Score:4.86|P-value:1.99E-6 ID:SGTC_2249|Compound:haloperidol|FD-Score:7.10|P-value:7.68E-12 ID:SGTC_2250|Compound:alverine citrate|FD-Score:3.88|P-value:1.13E-4 ID:SGTC_2281|Compound:7943571|FD-Score:3.45|P-value:5.15E-4 ID:SGTC_2326|Compound:6164455|FD-Score:-4.44|P-value:1.30E-5 ID:SGTC_2346|Compound:9031566|FD-Score:4.56|P-value:7.42E-6 ID:SGTC_2405|Compound:ticlatone|FD-Score:5.09|P-value:6.56E-7 ID:SGTC_2408|Compound:sulbentine|FD-Score:-5.99|P-value:6.66E-9 ID:SGTC_2411|Compound:st077133|FD-Score:-4.14|P-value:4.36E-5 ID:SGTC_2415|Compound:st077333|FD-Score:-3.41|P-value:6.25E-4 ID:SGTC_2526|Compound:patulin|FD-Score:4.52|P-value:8.82E-6 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:-3.83|P-value:1.45E-4 ID:SGTC_2652|Compound:actinonin|FD-Score:4.11|P-value:4.67E-5 ID:SGTC_2700|Compound:st077718|FD-Score:3.53|P-value:3.98E-4 ID:SGTC_2853|Compound:9015042|FD-Score:4.25|P-value:2.65E-5 ID:SGTC_2908|Compound:7930301|FD-Score:3.81|P-value:1.50E-4 ID:SGTC_2977|Compound:9011197|FD-Score:4.58|P-value:6.91E-6 ID:SGTC_3062|Compound:9077494|FD-Score:-5.30|P-value:2.48E-7 ID:SGTC_3141|Compound:9094609|FD-Score:-3.41|P-value:6.25E-4 ID:SGTC_3143|Compound:9086658|FD-Score:-3.54|P-value:3.97E-4 ID:SGTC_3191|Compound:9110352|FD-Score:-5.04|P-value:9.09E-7 ID:SGTC_3197|Compound:9113331|FD-Score:3.89|P-value:1.08E-4 ID:SGTC_3247|Compound:9135149|FD-Score:5.03|P-value:8.85E-7 ID:SGTC_3345|Compound:9148410|FD-Score:-3.66|P-value:2.61E-4 ID:SGTC_3346|Compound:9158254|FD-Score:4.79|P-value:2.73E-6

Top fitness defect scores for YML031W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_800 3448-7362 10.40 155.0 µM 1.91E-23 translation 6 8.32E-26 2.06
2 SGTC_2041 5107442 8.79 45.3 µM 3.46E-17 RSC complex & mRNA processing 8 7.24E-19 0.71
3 SGTC_241 5hr heat shock (37°C) + cantharidin 8.78 155.4 µM 3.77E-17 cell wall signaling 3 7.97E-19 1.56
4 SGTC_64 000l-0018 7.68 272.1 µM 1.52E-13 ubiquinone biosynthesis & proteasome 21 7.91E-15 0.31
5 SGTC_1309 pyrazolanthrone 7.59 13.4 µM 2.94E-13 2 1.65E-14 2.20
6 SGTC_2249 haloperidol 7.10 116.4 µM 7.68E-12 ergosterol depletion effects on membrane 10 6.10E-13 0.43
7 SGTC_201 4262-0159 6.89 12.8 µM 3.11E-11 ergosterol depletion effects on membrane 4 2.87E-12 0.05
8 SGTC_673 1082-0474 6.50 110.0 µM 3.36E-10 RSC complex & mRNA processing 26 4.01E-11 0.47
9 SGTC_1723 st034307 6.29 2.5 µM 1.14E-9 mitochondrial processes 4 1.55E-10 0.02
10 SGTC_150 3970-0969 6.23 77.2 µM 1.62E-9 5 2.28E-10 0.58
11 SGTC_1765 st044815 6.19 90.4 µM 2.05E-9 2 2.98E-10 1.22
12 SGTC_262 fenpropimorph 6.02 62.5 µM 5.50E-9 ergosterol depletion effects on membrane 6 8.86E-10 0.08
13 SGTC_1019 4262-0212 5.71 3.4 µM 2.97E-8 ergosterol depletion effects on membrane 5 5.72E-9 0.12
14 SGTC_2048 5246248 5.66 200.0 µM 3.88E-8 1 7.69E-9 1.07
15 SGTC_1126 isoteolin 5.64 1.0 µM 4.15E-8 2 8.29E-9 0.71
16 SGTC_1105 epirubicin 5.61 18.1 µM 4.92E-8 anthracycline transcription coupled DNA repair 3 1.00E-8 0.48
17 SGTC_93 0109-0045 5.53 59.2 µM 7.59E-8 DNA damage response 4 1.62E-8 0.12
18 SGTC_118 0083-0097 5.46 135.3 µM 1.10E-7 translation 7 2.44E-8 0.01
19 SGTC_2045 5106652 5.44 78.0 µM 1.18E-7 1 2.64E-8 1.52
20 SGTC_1099 5-nonyloxytryptamine 5.31 2.9 µM 2.27E-7 2 5.44E-8 1.30

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.224 3.35E-39 YMR314W PRE5 het Alpha 6 subunit of the 20S proteasome; protein abundance increases in response to DNA replication stress
0.199 3.15E-31 YLR021W IRC25 hom Component of a heterodimeric Poc4p-Irc25p chaperone involved in assembly of alpha subunits into the 20S proteasome; may regulate formation of proteasome isoforms with alternative subunits under different conditions
0.198 4.64E-31 YOL038W PRE6 het Alpha 4 subunit of the 20S proteasome; may replace alpha 3 subunit (Pre9p) under stress conditions to create a more active proteasomal isoform; GFP-fusion protein relocates from cytosol to the mitochondrial surface upon oxidative stress
0.194 7.07E-30 YGL011C SCL1 het Alpha 1 subunit of the 20S proteasome involved in the degradation of ubiquitinated substrates; 20S proteasome is the core complex of the 26S proteasome; essential for growth; detected in the mitochondria
0.193 2.22E-29 YFR050C PRE4 het Beta 7 subunit of the 20S proteasome
0.192 2.98E-29 YER094C PUP3 het Beta 3 subunit of the 20S proteasome involved in ubiquitin-dependent catabolism; human homolog is subunit C10
0.188 7.41E-28 YJL081C ARP4 het Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes
0.182 2.66E-26 YGL123W RPS2 het Protein component of the small (40S) subunit; essential for control of translational accuracy; phosphorylation by C-terminal domain kinase I (CTDK-I) enhances translational accuracy; methylated on one or more arginine residues by Hmt1p; homologous to mammalian ribosomal protein S2 and bacterial S5
0.175 1.95E-24 YOR362C PRE10 het Alpha 7 subunit of the 20S proteasome; protein abundance increases in response to DNA replication stress
0.172 8.86E-24 YHL015W RPS20 het Protein component of the small (40S) ribosomal subunit; overproduction suppresses mutations affecting RNA polymerase III-dependent transcription; homologous to mammalian ribosomal protein S20 and bacterial S10
0.169 6.99E-23 YER012W PRE1 het Beta 4 subunit of the 20S proteasome; localizes to the nucleus throughout the cell cycle
0.168 9.37E-23 YMR268C PRP24 het Splicing factor that reanneals U4 and U6 snRNPs during spliceosome recycling
0.166 3.46E-22 YER165W PAB1 het Poly(A) binding protein, part of the 3'-end RNA-processing complex, mediates interactions between the 5' cap structure and the 3' mRNA poly(A) tail, involved in control of poly(A) tail length, interacts with translation factor eIF-4G
0.161 5.52E-21 YML092C PRE8 het Alpha 2 subunit of the 20S proteasome
0.158 2.65E-20 YDR324C UTP4 het Subunit of U3-containing 90S preribosome and Small Subunit (SSU) processome complexes involved in production of 18S rRNA and assembly of small ribosomal subunit; member of t-Utp subcomplex involved with transcription of 35S rRNA transcript