YML032C / RAD52

Protein that stimulates strand exchange by facilitating Rad51p binding to single-stranded DNA; anneals complementary single-stranded DNA; involved in the repair of double-strand breaks in DNA during vegetative growth and meiosis

Zygosity: Homozygous strain
fixedexpanded
Profile for YML032C / RAD52

Click on Significant Values for Screen Details ID:SGTC_68|Compound:0986-0284|FD-Score:-2.99|P-value:8.67E-4 ID:SGTC_113|Compound:0099-0221|FD-Score:-3.38|P-value:1.99E-4 ID:SGTC_166|Compound:k072-0058|FD-Score:3.85|P-value:3.48E-5 ID:SGTC_170|Compound:4197-0004|FD-Score:-3.87|P-value:2.60E-5 ID:SGTC_335|Compound:4077-0256|FD-Score:-5.58|P-value:2.76E-9 ID:SGTC_625|Compound:k213-0058|FD-Score:3.51|P-value:1.45E-4 ID:SGTC_675|Compound:1309-0189|FD-Score:3.01|P-value:9.69E-4 ID:SGTC_782|Compound:0083-0095|FD-Score:3.69|P-value:6.91E-5 ID:SGTC_809|Compound:3998-0021|FD-Score:-4.18|P-value:6.12E-6 ID:SGTC_824|Compound:1304-0008|FD-Score:3.05|P-value:8.39E-4 ID:SGTC_826|Compound:1683-5028|FD-Score:3.92|P-value:2.55E-5 ID:SGTC_893|Compound:0958-0369|FD-Score:-4.39|P-value:2.23E-6 ID:SGTC_1063|Compound:disulfiram|FD-Score:3.72|P-value:6.20E-5 ID:SGTC_1082|Compound:camptothecin|FD-Score:3.78|P-value:4.81E-5 ID:SGTC_1170|Compound:0310-0127|FD-Score:3.06|P-value:7.98E-4 ID:SGTC_1179|Compound:1021-1431|FD-Score:3.08|P-value:7.46E-4 ID:SGTC_1329|Compound:1447-1697|FD-Score:3.23|P-value:4.32E-4 ID:SGTC_1562|Compound:morin hydrate|FD-Score:-3.10|P-value:5.91E-4 ID:SGTC_1568|Compound:digitonin|FD-Score:3.12|P-value:6.53E-4 ID:SGTC_1664|Compound:st014217|FD-Score:3.35|P-value:2.77E-4 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:3.28|P-value:3.55E-4 ID:SGTC_1722|Compound:st034304|FD-Score:3.06|P-value:8.18E-4 ID:SGTC_1738|Compound:st035555|FD-Score:4.48|P-value:1.80E-6 ID:SGTC_1891|Compound:st059073|FD-Score:3.20|P-value:4.82E-4 ID:SGTC_2035|Compound:5154463|FD-Score:4.12|P-value:1.04E-5 ID:SGTC_2060|Compound:5238662|FD-Score:4.35|P-value:3.44E-6 ID:SGTC_2300|Compound:7976697|FD-Score:-4.24|P-value:4.59E-6 ID:SGTC_2336|Compound:9001819|FD-Score:4.31|P-value:4.22E-6 ID:SGTC_2385|Compound:9074692|FD-Score:3.30|P-value:3.35E-4 ID:SGTC_2415|Compound:st077333|FD-Score:-3.07|P-value:6.55E-4 ID:SGTC_2430|Compound:5571206|FD-Score:3.39|P-value:2.33E-4 ID:SGTC_2443|Compound:5493264|FD-Score:3.77|P-value:4.95E-5 ID:SGTC_2444|Compound:5485484|FD-Score:4.11|P-value:1.07E-5 ID:SGTC_2445|Compound:5742597|FD-Score:3.30|P-value:3.31E-4 ID:SGTC_2451|Compound:5856223|FD-Score:4.18|P-value:7.68E-6 ID:SGTC_2481|Compound:5478948|FD-Score:3.68|P-value:7.30E-5 ID:SGTC_2488|Compound:5268135|FD-Score:3.54|P-value:1.31E-4 ID:SGTC_2509|Compound:methyl 7-deshydroxypyrogallin-4-carboxylate|FD-Score:4.22|P-value:6.38E-6 ID:SGTC_2563|Compound:tomatine|FD-Score:-4.16|P-value:6.94E-6 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:-3.22|P-value:3.71E-4 ID:SGTC_2724|Compound:maprotiline|FD-Score:-3.09|P-value:5.92E-4 ID:SGTC_2772|Compound:vinpocetine|FD-Score:3.58|P-value:1.08E-4 ID:SGTC_2958|Compound:9077254|FD-Score:-6.81|P-value:6.22E-13 ID:SGTC_2976|Compound:9009005|FD-Score:3.46|P-value:1.81E-4 ID:SGTC_3286|Compound:9117135|FD-Score:4.56|P-value:1.25E-6 ID:SGTC_68|Compound:0986-0284|FD-Score:-2.99|P-value:8.67E-4 ID:SGTC_113|Compound:0099-0221|FD-Score:-3.38|P-value:1.99E-4 ID:SGTC_166|Compound:k072-0058|FD-Score:3.85|P-value:3.48E-5 ID:SGTC_170|Compound:4197-0004|FD-Score:-3.87|P-value:2.60E-5 ID:SGTC_335|Compound:4077-0256|FD-Score:-5.58|P-value:2.76E-9 ID:SGTC_625|Compound:k213-0058|FD-Score:3.51|P-value:1.45E-4 ID:SGTC_675|Compound:1309-0189|FD-Score:3.01|P-value:9.69E-4 ID:SGTC_782|Compound:0083-0095|FD-Score:3.69|P-value:6.91E-5 ID:SGTC_809|Compound:3998-0021|FD-Score:-4.18|P-value:6.12E-6 ID:SGTC_824|Compound:1304-0008|FD-Score:3.05|P-value:8.39E-4 ID:SGTC_826|Compound:1683-5028|FD-Score:3.92|P-value:2.55E-5 ID:SGTC_893|Compound:0958-0369|FD-Score:-4.39|P-value:2.23E-6 ID:SGTC_1063|Compound:disulfiram|FD-Score:3.72|P-value:6.20E-5 ID:SGTC_1082|Compound:camptothecin|FD-Score:3.78|P-value:4.81E-5 ID:SGTC_1170|Compound:0310-0127|FD-Score:3.06|P-value:7.98E-4 ID:SGTC_1179|Compound:1021-1431|FD-Score:3.08|P-value:7.46E-4 ID:SGTC_1329|Compound:1447-1697|FD-Score:3.23|P-value:4.32E-4 ID:SGTC_1562|Compound:morin hydrate|FD-Score:-3.10|P-value:5.91E-4 ID:SGTC_1568|Compound:digitonin|FD-Score:3.12|P-value:6.53E-4 ID:SGTC_1664|Compound:st014217|FD-Score:3.35|P-value:2.77E-4 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:3.28|P-value:3.55E-4 ID:SGTC_1722|Compound:st034304|FD-Score:3.06|P-value:8.18E-4 ID:SGTC_1738|Compound:st035555|FD-Score:4.48|P-value:1.80E-6 ID:SGTC_1891|Compound:st059073|FD-Score:3.20|P-value:4.82E-4 ID:SGTC_2035|Compound:5154463|FD-Score:4.12|P-value:1.04E-5 ID:SGTC_2060|Compound:5238662|FD-Score:4.35|P-value:3.44E-6 ID:SGTC_2300|Compound:7976697|FD-Score:-4.24|P-value:4.59E-6 ID:SGTC_2336|Compound:9001819|FD-Score:4.31|P-value:4.22E-6 ID:SGTC_2385|Compound:9074692|FD-Score:3.30|P-value:3.35E-4 ID:SGTC_2415|Compound:st077333|FD-Score:-3.07|P-value:6.55E-4 ID:SGTC_2430|Compound:5571206|FD-Score:3.39|P-value:2.33E-4 ID:SGTC_2443|Compound:5493264|FD-Score:3.77|P-value:4.95E-5 ID:SGTC_2444|Compound:5485484|FD-Score:4.11|P-value:1.07E-5 ID:SGTC_2445|Compound:5742597|FD-Score:3.30|P-value:3.31E-4 ID:SGTC_2451|Compound:5856223|FD-Score:4.18|P-value:7.68E-6 ID:SGTC_2481|Compound:5478948|FD-Score:3.68|P-value:7.30E-5 ID:SGTC_2488|Compound:5268135|FD-Score:3.54|P-value:1.31E-4 ID:SGTC_2509|Compound:methyl 7-deshydroxypyrogallin-4-carboxylate|FD-Score:4.22|P-value:6.38E-6 ID:SGTC_2563|Compound:tomatine|FD-Score:-4.16|P-value:6.94E-6 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:-3.22|P-value:3.71E-4 ID:SGTC_2724|Compound:maprotiline|FD-Score:-3.09|P-value:5.92E-4 ID:SGTC_2772|Compound:vinpocetine|FD-Score:3.58|P-value:1.08E-4 ID:SGTC_2958|Compound:9077254|FD-Score:-6.81|P-value:6.22E-13 ID:SGTC_2976|Compound:9009005|FD-Score:3.46|P-value:1.81E-4 ID:SGTC_3286|Compound:9117135|FD-Score:4.56|P-value:1.25E-6

Top fitness defect scores for YML032C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3286 9117135 4.56 37.2 µM 1.25E-6 5 2.61E-6
2 SGTC_1738 st035555 4.48 74.0 µM 1.80E-6 TSC3-RPN4 20 3.68E-6
3 SGTC_2060 5238662 4.35 140.0 µM 3.44E-6 20 6.73E-6
4 SGTC_2336 9001819 4.31 198.7 µM 4.22E-6 heme biosynthesis & mitochondrial translocase 41 8.14E-6
5 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 4.22 54.6 µM 6.38E-6 RPP1 & pyrimidine depletion 24 1.20E-5
6 SGTC_2451 5856223 4.18 45.7 µM 7.68E-6 19 1.43E-5
7 SGTC_2035 5154463 4.12 94.6 µM 1.04E-5 13 1.89E-5
8 SGTC_2444 5485484 4.11 36.4 µM 1.07E-5 32 1.95E-5
9 SGTC_826 1683-5028 3.92 118.0 µM 2.55E-5 15 4.38E-5
10 SGTC_166 k072-0058 3.85 166.4 µM 3.48E-5 DNA intercalators 41 5.84E-5
11 SGTC_1082 camptothecin 3.78 424.9 nM 4.81E-5 DNA damage response 45 7.92E-5
12 SGTC_2443 5493264 3.77 126.7 µM 4.95E-5 23 8.13E-5
13 SGTC_1063 disulfiram 3.72 1.8 µM 6.20E-5 28 1.00E-4
14 SGTC_782 0083-0095 3.69 30.5 µM 6.91E-5 36 1.11E-4
15 SGTC_2481 5478948 3.68 45.2 µM 7.30E-5 PDR1 44 1.17E-4
16 SGTC_2772 vinpocetine 3.58 57.1 µM 1.08E-4 34 1.69E-4
17 SGTC_2488 5268135 3.54 45.7 µM 1.31E-4 66 2.02E-4
18 SGTC_625 k213-0058 3.51 121.0 µM 1.45E-4 translation 143 2.23E-4
19 SGTC_2976 9009005 3.46 19.5 µM 1.81E-4 41 2.73E-4
20 SGTC_2430 5571206 3.39 200.0 µM 2.33E-4 80 3.46E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.095 3.07E-8 YOR249C APC5 het Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C); APC/C is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; component of the platform domain of the APC/C, based on structural analysis; relative distribution to nuclear foci decreases upon DNA replication stress
0.091 1.22E-7 YNL057W_d YNL057W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.089 2.67E-7 YBR099C_d YBR099C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified gene MMS4
0.086 6.88E-7 YGL051W MST27 hom Putative integral membrane protein, involved in vesicle formation; forms complex with Mst28p; member of DUP240 gene family; binds COPI and COPII vesicles
0.081 2.43E-6 YBR022W POA1 hom Phosphatase that is highly specific for ADP-ribose 1''-phosphate, a tRNA splicing metabolite; may have a role in regulation of tRNA splicing
0.080 3.29E-6 YNL026W SAM50 het Essential component of the Sorting and Assembly Machinery (SAM or TOB complex) of the mitochondrial outer membrane, which binds precursors of beta-barrel proteins and facilitates their outer membrane insertion; homologous to bacterial Omp85
0.080 3.54E-6 YLR168C UPS2 hom Mitochondrial protein involved in phospholipid metabolism; localizes to the intermembrane space; has a role in regulation of phospholipid metabolism by inhibiting conversion of phosphatidylethanolamine to phosphatidylcholine; null mutant has defects in mitochondrial morphology; similar to Ups1p, Ups3p and to human PRELI
0.078 5.88E-6 YPR088C SRP54 het Signal recognition particle (SRP) subunit (homolog of mammalian SRP54); contains the signal sequence-binding activity of SRP, interacts with the SRP RNA, and mediates binding of SRP to signal receptor; contains GTPase domain
0.076 1.01E-5 YPR159W KRE6 hom Type II integral membrane protein required for beta-1,6 glucan biosynthesis; putative beta-glucan synthase; localizes to the ER, plasma membrane, sites of polarized growth and secretory vesicles; functionally redundant with Skn1p
0.076 1.06E-5 YBR033W_p EDS1_p hom Putative zinc cluster protein, predicted to be a transcription factor; not an essential gene; EDS1 has a paralog, RGT1, that arose from the whole genome duplication
0.076 1.13E-5 YKL119C VPH2 hom Integral membrane protein required for vacuolar H+-ATPase (V-ATPase) function, although not an actual component of the V-ATPase complex; functions in the assembly of the V-ATPase; localized to the endoplasmic reticulum (ER)
0.076 1.17E-5 YCR025C_d YCR025C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YCR025C is not an essential gene
0.075 1.24E-5 YIL113W SDP1 hom Stress-inducible dual-specificity MAP kinase phosphatase, negatively regulates Slt2p MAP kinase by direct dephosphorylation, diffuse localization under normal conditions shifts to punctate localization after heat shock
0.075 1.54E-5 YMR102C_p YMR102C_p hom Protein of unknown function; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance; mutant shows increased resistance to azoles; YMR102C is not an essential gene
0.073 2.21E-5 YLR413W_p YLR413W_p hom Putative protein of unknown function; YLR413W is not an essential gene