YML034C-A_d

Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain
fixedexpanded
Profile for YML034C-A / YML034C-A

Click on Significant Values for Screen Details ID:SGTC_7|Compound:0192-1582|FD-Score:3.48|P-value:3.83E-4 ID:SGTC_23|Compound:0213-0011|FD-Score:7.92|P-value:5.85E-15 ID:SGTC_36|Compound:0335-0881|FD-Score:11.80|P-value:3.32E-31 ID:SGTC_64|Compound:000l-0018|FD-Score:7.87|P-value:8.90E-15 ID:SGTC_67|Compound:0335-0847|FD-Score:10.20|P-value:1.13E-23 ID:SGTC_86|Compound:0417-1630|FD-Score:16.40|P-value:5.26E-58 ID:SGTC_137|Compound:0438-0332|FD-Score:18.10|P-value:1.99E-70 ID:SGTC_142|Compound:0335-0849|FD-Score:18.20|P-value:5.89E-71 ID:SGTC_158|Compound:k038-0087|FD-Score:14.60|P-value:1.18E-46 ID:SGTC_165|Compound:k038-0023|FD-Score:11.90|P-value:1.41E-31 ID:SGTC_188|Compound:3229-0966|FD-Score:3.28|P-value:7.66E-4 ID:SGTC_200|Compound:k038-0079|FD-Score:5.77|P-value:1.03E-8 ID:SGTC_216|Compound:k038-0035|FD-Score:4.18|P-value:2.55E-5 ID:SGTC_255|Compound:tunicamycin|FD-Score:6.03|P-value:2.27E-9 ID:SGTC_294|Compound:k038-0071|FD-Score:5.26|P-value:1.62E-7 ID:SGTC_340|Compound:k038-0059|FD-Score:8.73|P-value:8.79E-18 ID:SGTC_345|Compound:1362-0200|FD-Score:3.50|P-value:3.65E-4 ID:SGTC_346|Compound:4513-0042|FD-Score:3.34|P-value:6.23E-4 ID:SGTC_366|Compound:0181-0206|FD-Score:-3.39|P-value:3.68E-4 ID:SGTC_367|Compound:0335-0881|FD-Score:8.92|P-value:1.75E-18 ID:SGTC_373|Compound:0844-0104|FD-Score:3.78|P-value:1.28E-4 ID:SGTC_380|Compound:3970-0968|FD-Score:3.35|P-value:6.17E-4 ID:SGTC_440|Compound:fluspirilene|FD-Score:-3.33|P-value:4.64E-4 ID:SGTC_642|Compound:0335-0876|FD-Score:5.53|P-value:3.99E-8 ID:SGTC_743|Compound:1275-0778|FD-Score:3.82|P-value:1.09E-4 ID:SGTC_765|Compound:1319-0117|FD-Score:-3.19|P-value:7.50E-4 ID:SGTC_794|Compound:k038-0031|FD-Score:8.17|P-value:8.24E-16 ID:SGTC_801|Compound:0866-0028|FD-Score:3.56|P-value:2.86E-4 ID:SGTC_841|Compound:0251-0215|FD-Score:3.43|P-value:4.66E-4 ID:SGTC_846|Compound:0335-0850|FD-Score:8.05|P-value:2.14E-15 ID:SGTC_920|Compound:mycophenolic acid|FD-Score:3.57|P-value:2.85E-4 ID:SGTC_948|Compound:3448-0295|FD-Score:-3.77|P-value:8.84E-5 ID:SGTC_984|Compound:1492-0255|FD-Score:5.72|P-value:1.37E-8 ID:SGTC_995|Compound:3931-2021|FD-Score:-3.82|P-value:7.38E-5 ID:SGTC_1402|Compound:3909-7673|FD-Score:3.48|P-value:3.88E-4 ID:SGTC_1478|Compound:0453-0656|FD-Score:-3.62|P-value:1.60E-4 ID:SGTC_1494|Compound:4358-1428|FD-Score:3.57|P-value:2.85E-4 ID:SGTC_1497|Compound:4476-2978|FD-Score:-4.62|P-value:2.35E-6 ID:SGTC_1500|Compound:4488-1866|FD-Score:4.17|P-value:2.64E-5 ID:SGTC_1502|Compound:4534-4282|FD-Score:4.61|P-value:3.92E-6 ID:SGTC_1568|Compound:digitonin|FD-Score:-3.68|P-value:1.26E-4 ID:SGTC_1595|Compound:6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin|FD-Score:3.98|P-value:5.90E-5 ID:SGTC_1639|Compound:Lupinine o-methylbenzoicacid ester hydrochloride|FD-Score:3.51|P-value:3.54E-4 ID:SGTC_1665|Compound:st014639|FD-Score:4.67|P-value:2.92E-6 ID:SGTC_1696|Compound:st025591|FD-Score:3.47|P-value:4.01E-4 ID:SGTC_1743|Compound:st037606|FD-Score:5.87|P-value:5.71E-9 ID:SGTC_1762|Compound:st045503|FD-Score:3.89|P-value:8.51E-5 ID:SGTC_1793|Compound:st048256|FD-Score:3.31|P-value:7.01E-4 ID:SGTC_1812|Compound:st052057|FD-Score:3.21|P-value:9.85E-4 ID:SGTC_1821|Compound:st053465|FD-Score:-3.50|P-value:2.48E-4 ID:SGTC_1845|Compound:st056753|FD-Score:5.44|P-value:6.34E-8 ID:SGTC_1849|Compound:st056239|FD-Score:4.48|P-value:7.05E-6 ID:SGTC_1913|Compound:st060213|FD-Score:3.27|P-value:7.96E-4 ID:SGTC_2025|Compound:5147754|FD-Score:3.41|P-value:4.93E-4 ID:SGTC_2076|Compound:5212012|FD-Score:4.00|P-value:5.48E-5 ID:SGTC_2082|Compound:5219693|FD-Score:3.34|P-value:6.40E-4 ID:SGTC_2147|Compound:5545932|FD-Score:3.51|P-value:3.42E-4 ID:SGTC_2149|Compound:5554786|FD-Score:3.29|P-value:7.45E-4 ID:SGTC_2190|Compound:6049624|FD-Score:-3.41|P-value:3.48E-4 ID:SGTC_2212|Compound:7123476|FD-Score:4.86|P-value:1.21E-6 ID:SGTC_2247|Compound:cerulenin|FD-Score:5.51|P-value:4.35E-8 ID:SGTC_2651|Compound:1327-0036|FD-Score:3.81|P-value:1.16E-4 ID:SGTC_2659|Compound:sanguinarine|FD-Score:5.77|P-value:1.00E-8 ID:SGTC_2704|Compound:st078022|FD-Score:3.31|P-value:6.88E-4 ID:SGTC_2773|Compound:thioridazine|FD-Score:3.53|P-value:3.24E-4 ID:SGTC_2781|Compound:5567276|FD-Score:3.60|P-value:2.53E-4 ID:SGTC_2858|Compound:9025781|FD-Score:3.24|P-value:8.71E-4 ID:SGTC_2863|Compound:9028737|FD-Score:4.03|P-value:4.83E-5 ID:SGTC_2878|Compound:9043973|FD-Score:3.33|P-value:6.51E-4 ID:SGTC_2912|Compound:7964298|FD-Score:-3.47|P-value:2.82E-4 ID:SGTC_2935|Compound:9038016|FD-Score:3.20|P-value:9.98E-4 ID:SGTC_3003|Compound:9075612|FD-Score:3.44|P-value:4.44E-4 ID:SGTC_3214|Compound:9129694|FD-Score:3.36|P-value:5.86E-4 ID:SGTC_3284|Compound:9108171|FD-Score:3.41|P-value:4.96E-4 ID:SGTC_7|Compound:0192-1582|FD-Score:3.48|P-value:3.83E-4 ID:SGTC_23|Compound:0213-0011|FD-Score:7.92|P-value:5.85E-15 ID:SGTC_36|Compound:0335-0881|FD-Score:11.80|P-value:3.32E-31 ID:SGTC_64|Compound:000l-0018|FD-Score:7.87|P-value:8.90E-15 ID:SGTC_67|Compound:0335-0847|FD-Score:10.20|P-value:1.13E-23 ID:SGTC_86|Compound:0417-1630|FD-Score:16.40|P-value:5.26E-58 ID:SGTC_137|Compound:0438-0332|FD-Score:18.10|P-value:1.99E-70 ID:SGTC_142|Compound:0335-0849|FD-Score:18.20|P-value:5.89E-71 ID:SGTC_158|Compound:k038-0087|FD-Score:14.60|P-value:1.18E-46 ID:SGTC_165|Compound:k038-0023|FD-Score:11.90|P-value:1.41E-31 ID:SGTC_188|Compound:3229-0966|FD-Score:3.28|P-value:7.66E-4 ID:SGTC_200|Compound:k038-0079|FD-Score:5.77|P-value:1.03E-8 ID:SGTC_216|Compound:k038-0035|FD-Score:4.18|P-value:2.55E-5 ID:SGTC_255|Compound:tunicamycin|FD-Score:6.03|P-value:2.27E-9 ID:SGTC_294|Compound:k038-0071|FD-Score:5.26|P-value:1.62E-7 ID:SGTC_340|Compound:k038-0059|FD-Score:8.73|P-value:8.79E-18 ID:SGTC_345|Compound:1362-0200|FD-Score:3.50|P-value:3.65E-4 ID:SGTC_346|Compound:4513-0042|FD-Score:3.34|P-value:6.23E-4 ID:SGTC_366|Compound:0181-0206|FD-Score:-3.39|P-value:3.68E-4 ID:SGTC_367|Compound:0335-0881|FD-Score:8.92|P-value:1.75E-18 ID:SGTC_373|Compound:0844-0104|FD-Score:3.78|P-value:1.28E-4 ID:SGTC_380|Compound:3970-0968|FD-Score:3.35|P-value:6.17E-4 ID:SGTC_440|Compound:fluspirilene|FD-Score:-3.33|P-value:4.64E-4 ID:SGTC_642|Compound:0335-0876|FD-Score:5.53|P-value:3.99E-8 ID:SGTC_743|Compound:1275-0778|FD-Score:3.82|P-value:1.09E-4 ID:SGTC_765|Compound:1319-0117|FD-Score:-3.19|P-value:7.50E-4 ID:SGTC_794|Compound:k038-0031|FD-Score:8.17|P-value:8.24E-16 ID:SGTC_801|Compound:0866-0028|FD-Score:3.56|P-value:2.86E-4 ID:SGTC_841|Compound:0251-0215|FD-Score:3.43|P-value:4.66E-4 ID:SGTC_846|Compound:0335-0850|FD-Score:8.05|P-value:2.14E-15 ID:SGTC_920|Compound:mycophenolic acid|FD-Score:3.57|P-value:2.85E-4 ID:SGTC_948|Compound:3448-0295|FD-Score:-3.77|P-value:8.84E-5 ID:SGTC_984|Compound:1492-0255|FD-Score:5.72|P-value:1.37E-8 ID:SGTC_995|Compound:3931-2021|FD-Score:-3.82|P-value:7.38E-5 ID:SGTC_1402|Compound:3909-7673|FD-Score:3.48|P-value:3.88E-4 ID:SGTC_1478|Compound:0453-0656|FD-Score:-3.62|P-value:1.60E-4 ID:SGTC_1494|Compound:4358-1428|FD-Score:3.57|P-value:2.85E-4 ID:SGTC_1497|Compound:4476-2978|FD-Score:-4.62|P-value:2.35E-6 ID:SGTC_1500|Compound:4488-1866|FD-Score:4.17|P-value:2.64E-5 ID:SGTC_1502|Compound:4534-4282|FD-Score:4.61|P-value:3.92E-6 ID:SGTC_1568|Compound:digitonin|FD-Score:-3.68|P-value:1.26E-4 ID:SGTC_1595|Compound:6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin|FD-Score:3.98|P-value:5.90E-5 ID:SGTC_1639|Compound:Lupinine o-methylbenzoicacid ester hydrochloride|FD-Score:3.51|P-value:3.54E-4 ID:SGTC_1665|Compound:st014639|FD-Score:4.67|P-value:2.92E-6 ID:SGTC_1696|Compound:st025591|FD-Score:3.47|P-value:4.01E-4 ID:SGTC_1743|Compound:st037606|FD-Score:5.87|P-value:5.71E-9 ID:SGTC_1762|Compound:st045503|FD-Score:3.89|P-value:8.51E-5 ID:SGTC_1793|Compound:st048256|FD-Score:3.31|P-value:7.01E-4 ID:SGTC_1812|Compound:st052057|FD-Score:3.21|P-value:9.85E-4 ID:SGTC_1821|Compound:st053465|FD-Score:-3.50|P-value:2.48E-4 ID:SGTC_1845|Compound:st056753|FD-Score:5.44|P-value:6.34E-8 ID:SGTC_1849|Compound:st056239|FD-Score:4.48|P-value:7.05E-6 ID:SGTC_1913|Compound:st060213|FD-Score:3.27|P-value:7.96E-4 ID:SGTC_2025|Compound:5147754|FD-Score:3.41|P-value:4.93E-4 ID:SGTC_2076|Compound:5212012|FD-Score:4.00|P-value:5.48E-5 ID:SGTC_2082|Compound:5219693|FD-Score:3.34|P-value:6.40E-4 ID:SGTC_2147|Compound:5545932|FD-Score:3.51|P-value:3.42E-4 ID:SGTC_2149|Compound:5554786|FD-Score:3.29|P-value:7.45E-4 ID:SGTC_2190|Compound:6049624|FD-Score:-3.41|P-value:3.48E-4 ID:SGTC_2212|Compound:7123476|FD-Score:4.86|P-value:1.21E-6 ID:SGTC_2247|Compound:cerulenin|FD-Score:5.51|P-value:4.35E-8 ID:SGTC_2651|Compound:1327-0036|FD-Score:3.81|P-value:1.16E-4 ID:SGTC_2659|Compound:sanguinarine|FD-Score:5.77|P-value:1.00E-8 ID:SGTC_2704|Compound:st078022|FD-Score:3.31|P-value:6.88E-4 ID:SGTC_2773|Compound:thioridazine|FD-Score:3.53|P-value:3.24E-4 ID:SGTC_2781|Compound:5567276|FD-Score:3.60|P-value:2.53E-4 ID:SGTC_2858|Compound:9025781|FD-Score:3.24|P-value:8.71E-4 ID:SGTC_2863|Compound:9028737|FD-Score:4.03|P-value:4.83E-5 ID:SGTC_2878|Compound:9043973|FD-Score:3.33|P-value:6.51E-4 ID:SGTC_2912|Compound:7964298|FD-Score:-3.47|P-value:2.82E-4 ID:SGTC_2935|Compound:9038016|FD-Score:3.20|P-value:9.98E-4 ID:SGTC_3003|Compound:9075612|FD-Score:3.44|P-value:4.44E-4 ID:SGTC_3214|Compound:9129694|FD-Score:3.36|P-value:5.86E-4 ID:SGTC_3284|Compound:9108171|FD-Score:3.41|P-value:4.96E-4

Top fitness defect scores for YML034C-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_142 0335-0849 18.20 62.7 µM 5.89E-71 ubiquinone biosynthesis & proteasome 11 4.00E-74
2 SGTC_137 0438-0332 18.10 85.4 µM 1.99E-70 ubiquinone biosynthesis & proteasome 6 1.42E-73
3 SGTC_86 0417-1630 16.40 471.9 µM 5.26E-58 ubiquinone biosynthesis & proteasome 14 1.29E-60
4 SGTC_158 k038-0087 14.60 26.4 µM 1.18E-46 ubiquinone biosynthesis & proteasome 11 9.04E-49
5 SGTC_165 k038-0023 11.90 64.4 µM 1.41E-31 ubiquinone biosynthesis & proteasome 5 4.96E-33
6 SGTC_36 0335-0881 11.80 14.2 µM 3.32E-31 ubiquinone biosynthesis & proteasome 16 1.21E-32
7 SGTC_67 0335-0847 10.20 266.0 µM 1.13E-23 ubiquinone biosynthesis & proteasome 21 8.91E-25
8 SGTC_367 0335-0881 8.92 7.1 µM 1.75E-18 ubiquinone biosynthesis & proteasome 7 2.38E-19
9 SGTC_340 k038-0059 8.73 454.0 µM 8.79E-18 ubiquinone biosynthesis & proteasome 5 1.28E-18
10 SGTC_794 k038-0031 8.17 316.0 µM 8.24E-16 ubiquinone biosynthesis & proteasome 30 1.48E-16
11 SGTC_846 0335-0850 8.05 148.0 µM 2.14E-15 ubiquinone biosynthesis & proteasome 7 4.02E-16
12 SGTC_23 0213-0011 7.92 40.0 µM 5.85E-15 copper-dependent oxidative stress 7 1.15E-15
13 SGTC_64 000l-0018 7.87 272.1 µM 8.90E-15 ubiquinone biosynthesis & proteasome 51 1.78E-15
14 SGTC_255 tunicamycin 6.03 200.5 nM 2.27E-9 unfolded protein response 33 8.13E-10
15 SGTC_1743 st037606 5.87 46.4 µM 5.71E-9 3 2.14E-9
16 SGTC_2659 sanguinarine 5.77 24.2 µM 1.00E-8 9 3.85E-9
17 SGTC_200 k038-0079 5.77 37.5 µM 1.03E-8 ubiquinone biosynthesis & proteasome 28 3.99E-9
18 SGTC_984 1492-0255 5.72 2.9 µM 1.37E-8 SWF1 & branched chain AA biosynthesis 10 5.35E-9
19 SGTC_642 0335-0876 5.53 158.0 µM 3.99E-8 ubiquinone biosynthesis & proteasome 17 1.64E-8
20 SGTC_2247 cerulenin 5.51 830.0 nM 4.35E-8 4 1.80E-8

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.679 0 YOR254C SEC63 het Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
0.592 4.71E-316 YML034W SRC1 hom Inner nuclear membrane protein; functions in regulation of subtelomeric genes and is linked to TREX (transcription export) factors; SRC1 produces 2 splice variant proteins with different functions; alternative splicing of SRC1 pre-mRNA is promoted by Hub1p; mutant has aneuploidy tolerance
0.573 9.44E-292 YNR042W_d YNR042W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene COQ2
0.572 6.89E-291 YPR064W_d YPR064W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.554 4.44E-269 YMR110C HFD1 hom Hexadecenal dehydrogenase; involved in the conversion of sphingosine 1-phosphate breakdown product hexadecenal to hexadecenoic acid; located in the mitochondrial outer membrane and also in lipid particles; has similarity to ALDH3A2, a human fatty aldehyde dehydrogenase (FALDH) mutated in Sjogren-Larsson syndrome, a neurocutaneous disorder
0.537 2.74E-250 YLR201C COQ9 hom Protein required for ubiquinone (coenzyme Q) biosynthesis and respiratory growth; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes
0.526 6.20E-238 YPR065W ROX1 hom Heme-dependent repressor of hypoxic genes; mediates aerobic transcriptional repression of hypoxia induced genes such as COX5b and CYC7; repressor function regulated through decreased promoter occupancy in response to oxidative stress; contains an HMG domain that is responsible for DNA bending activity; involved in the hyperosmotic stress resistance
0.525 4.09E-237 YJL193W_p YJL193W_p hom Putative protein of unknown function, predicted to encode a triose phosphate transporter subfamily member based on phylogenetic analysis; similar to YOR307C/SLY41; deletion mutant has a respiratory growth defect
0.525 1.73E-236 YGL119W COQ8 hom Protein required for ubiquinone biosynthesis and respiratory growth; exhibits genetic interaction with COQ9, suggesting a common function; similar to prokaryotic proteins involved in early steps of ubiquinone biosynthesis; COQ8 has a paralog, YBR230W-A, that arose from the whole genome duplication
0.518 1.73E-229 YPR146C_d YPR146C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.513 2.86E-224 YDR204W COQ4 hom Protein with a role in ubiquinone (Coenzyme Q) biosynthesis, possibly functioning in stabilization of Coq7p; located on the matrix face of the mitochondrial inner membrane; component of a mitochondrial ubiquinone-synthesizing complex
0.512 7.47E-224 YNR041C COQ2 hom Para hydroxybenzoate: polyprenyl transferase, catalyzes the second step in ubiquinone (coenzyme Q) biosynthesis
0.510 1.64E-221 YBR003W COQ1 hom Hexaprenyl pyrophosphate synthetase, catalyzes the first step in ubiquinone (coenzyme Q) biosynthesis
0.506 8.60E-218 YDL183C YDL183C hom Mitochondrial inner-membrane protein thought to be involved in the formation of an active mitochondrial K+/H+ exchanger (KHE) system; non-essential gene
0.493 3.28E-205 YNL111C CYB5 hom Cytochrome b5, involved in the sterol and lipid biosynthesis pathways; acts as an electron donor to support sterol C5-6 desaturation