YML034W / SRC1

Inner nuclear membrane protein; functions in regulation of subtelomeric genes and is linked to TREX (transcription export) factors; SRC1 produces 2 splice variant proteins with different functions; alternative splicing of SRC1 pre-mRNA is promoted by Hub1p; mutant has aneuploidy tolerance

Zygosity: Homozygous strain
fixedexpanded
Profile for YML034W / SRC1

Click on Significant Values for Screen Details ID:SGTC_7|Compound:0192-1582|FD-Score:10.80|P-value:1.18E-22 ID:SGTC_23|Compound:0213-0011|FD-Score:8.09|P-value:1.55E-13 ID:SGTC_34|Compound:0469-0683|FD-Score:6.73|P-value:6.84E-10 ID:SGTC_36|Compound:0335-0881|FD-Score:4.51|P-value:2.60E-5 ID:SGTC_64|Compound:000l-0018|FD-Score:10.80|P-value:8.84E-23 ID:SGTC_67|Compound:0335-0847|FD-Score:6.98|P-value:1.65E-10 ID:SGTC_86|Compound:0417-1630|FD-Score:16.50|P-value:1.14E-50 ID:SGTC_96|Compound:0929-0093|FD-Score:3.60|P-value:6.34E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:3.63|P-value:5.64E-4 ID:SGTC_107|Compound:0358-0022|FD-Score:16.30|P-value:1.78E-49 ID:SGTC_108|Compound:0509-0257|FD-Score:3.66|P-value:5.15E-4 ID:SGTC_114|Compound:0364-0001|FD-Score:5.03|P-value:3.07E-6 ID:SGTC_137|Compound:0438-0332|FD-Score:16.00|P-value:1.94E-47 ID:SGTC_142|Compound:0335-0849|FD-Score:19.30|P-value:4.55E-68 ID:SGTC_158|Compound:k038-0087|FD-Score:18.00|P-value:7.48E-60 ID:SGTC_163|Compound:1327-0036|FD-Score:6.19|P-value:1.30E-8 ID:SGTC_165|Compound:k038-0023|FD-Score:5.85|P-value:7.25E-8 ID:SGTC_188|Compound:3229-0966|FD-Score:9.06|P-value:1.56E-16 ID:SGTC_200|Compound:k038-0079|FD-Score:9.41|P-value:1.06E-17 ID:SGTC_216|Compound:k038-0035|FD-Score:5.83|P-value:7.97E-8 ID:SGTC_255|Compound:tunicamycin|FD-Score:9.55|P-value:3.72E-18 ID:SGTC_281|Compound:1672-3440|FD-Score:5.50|P-value:3.78E-7 ID:SGTC_283|Compound:0987-0079|FD-Score:3.95|P-value:1.97E-4 ID:SGTC_293|Compound:4049-0273|FD-Score:-3.58|P-value:5.35E-4 ID:SGTC_294|Compound:k038-0071|FD-Score:10.50|P-value:2.10E-21 ID:SGTC_305|Compound:1682-2595|FD-Score:9.35|P-value:1.78E-17 ID:SGTC_306|Compound:1672-3436|FD-Score:4.99|P-value:3.62E-6 ID:SGTC_340|Compound:k038-0059|FD-Score:6.68|P-value:8.86E-10 ID:SGTC_367|Compound:0335-0881|FD-Score:4.25|P-value:6.90E-5 ID:SGTC_426|Compound:0988-0037|FD-Score:3.69|P-value:4.73E-4 ID:SGTC_498|Compound:2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ)|FD-Score:-4.79|P-value:6.31E-6 ID:SGTC_501|Compound:nsc-95397|FD-Score:3.74|P-value:3.94E-4 ID:SGTC_555|Compound:4296-0685|FD-Score:5.19|P-value:1.51E-6 ID:SGTC_565|Compound:1418-0001|FD-Score:3.48|P-value:9.16E-4 ID:SGTC_566|Compound:0958-0068|FD-Score:4.98|P-value:3.73E-6 ID:SGTC_567|Compound:1080-0542|FD-Score:4.63|P-value:1.61E-5 ID:SGTC_571|Compound:k831-0106|FD-Score:9.17|P-value:6.61E-17 ID:SGTC_635|Compound:k038-0028|FD-Score:3.92|P-value:2.19E-4 ID:SGTC_639|Compound:0833-0042|FD-Score:3.65|P-value:5.31E-4 ID:SGTC_642|Compound:0335-0876|FD-Score:10.70|P-value:2.88E-22 ID:SGTC_676|Compound:falcarinol|FD-Score:5.31|P-value:8.81E-7 ID:SGTC_718|Compound:1130-0073|FD-Score:5.50|P-value:3.73E-7 ID:SGTC_794|Compound:k038-0031|FD-Score:18.30|P-value:1.36E-61 ID:SGTC_820|Compound:1582-0060|FD-Score:-3.94|P-value:1.59E-4 ID:SGTC_846|Compound:0335-0850|FD-Score:6.40|P-value:4.16E-9 ID:SGTC_852|Compound:0418-0143|FD-Score:7.34|P-value:1.90E-11 ID:SGTC_922|Compound:1866-0035|FD-Score:5.18|P-value:1.63E-6 ID:SGTC_984|Compound:1492-0255|FD-Score:17.60|P-value:2.75E-57 ID:SGTC_985|Compound:1493-0307|FD-Score:7.06|P-value:1.01E-10 ID:SGTC_989|Compound:1501-0895|FD-Score:3.88|P-value:2.47E-4 ID:SGTC_1026|Compound:k007-1105|FD-Score:4.59|P-value:1.86E-5 ID:SGTC_1082|Compound:camptothecin|FD-Score:6.07|P-value:2.36E-8 ID:SGTC_1161|Compound:k007-0610|FD-Score:7.46|P-value:8.97E-12 ID:SGTC_1349|Compound:flufenamic acid|FD-Score:4.41|P-value:3.68E-5 ID:SGTC_1369|Compound:1866-0067|FD-Score:-4.00|P-value:1.33E-4 ID:SGTC_1397|Compound:3532-0190|FD-Score:3.89|P-value:2.44E-4 ID:SGTC_1442|Compound:4112-3290|FD-Score:3.78|P-value:3.54E-4 ID:SGTC_1467|Compound:k284-1082|FD-Score:3.81|P-value:3.21E-4 ID:SGTC_1696|Compound:st025591|FD-Score:4.04|P-value:1.45E-4 ID:SGTC_1723|Compound:st034307|FD-Score:3.59|P-value:6.39E-4 ID:SGTC_1743|Compound:st037606|FD-Score:5.44|P-value:5.08E-7 ID:SGTC_1880|Compound:MG-132|FD-Score:5.79|P-value:9.56E-8 ID:SGTC_1945|Compound:st075991|FD-Score:4.20|P-value:8.01E-5 ID:SGTC_1989|Compound:st071868|FD-Score:4.10|P-value:1.18E-4 ID:SGTC_2028|Compound:5153890|FD-Score:4.19|P-value:8.50E-5 ID:SGTC_2057|Compound:5236571|FD-Score:4.76|P-value:9.44E-6 ID:SGTC_2132|Compound:5317594|FD-Score:5.19|P-value:1.50E-6 ID:SGTC_2185|Compound:6113692|FD-Score:4.94|P-value:4.54E-6 ID:SGTC_2229|Compound:7354935|FD-Score:3.76|P-value:3.72E-4 ID:SGTC_2284|Compound:7945075|FD-Score:-4.87|P-value:4.59E-6 ID:SGTC_2289|Compound:7946404|FD-Score:-4.41|P-value:2.88E-5 ID:SGTC_2312|Compound:7706453|FD-Score:4.12|P-value:1.10E-4 ID:SGTC_2377|Compound:9073351|FD-Score:3.46|P-value:9.68E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:4.48|P-value:2.86E-5 ID:SGTC_2433|Compound:5607874|FD-Score:-3.39|P-value:9.64E-4 ID:SGTC_2452|Compound:5863136|FD-Score:3.50|P-value:8.59E-4 ID:SGTC_2499|Compound:avocadenofuran|FD-Score:4.00|P-value:1.63E-4 ID:SGTC_2508|Compound:celastrol|FD-Score:4.80|P-value:8.16E-6 ID:SGTC_2651|Compound:1327-0036|FD-Score:3.45|P-value:9.86E-4 ID:SGTC_2659|Compound:sanguinarine|FD-Score:4.79|P-value:8.53E-6 ID:SGTC_2695|Compound:st077686|FD-Score:3.95|P-value:1.96E-4 ID:SGTC_2798|Compound:7813637|FD-Score:3.69|P-value:4.65E-4 ID:SGTC_2858|Compound:9025781|FD-Score:3.62|P-value:5.95E-4 ID:SGTC_2923|Compound:7992654|FD-Score:3.48|P-value:9.08E-4 ID:SGTC_2925|Compound:9010536|FD-Score:3.52|P-value:8.05E-4 ID:SGTC_2961|Compound:9083290|FD-Score:3.48|P-value:9.05E-4 ID:SGTC_2971|Compound:9092186|FD-Score:5.74|P-value:1.22E-7 ID:SGTC_2972|Compound:9093619|FD-Score:4.38|P-value:4.13E-5 ID:SGTC_2973|Compound:9094665|FD-Score:5.25|P-value:1.19E-6 ID:SGTC_2974|Compound:9094440|FD-Score:7.74|P-value:1.55E-12 ID:SGTC_3022|Compound:9087993|FD-Score:3.58|P-value:6.72E-4 ID:SGTC_3059|Compound:1327-0034|FD-Score:7.39|P-value:1.36E-11 ID:SGTC_3063|Compound:1327-0034|FD-Score:4.45|P-value:3.22E-5 ID:SGTC_3137|Compound:9097352|FD-Score:-3.77|P-value:2.92E-4 ID:SGTC_3139|Compound:9095020|FD-Score:-4.19|P-value:6.49E-5 ID:SGTC_3144|Compound:9087057|FD-Score:-4.47|P-value:2.28E-5 ID:SGTC_3172|Compound:9105863|FD-Score:3.65|P-value:5.30E-4 ID:SGTC_3337|Compound:9144342|FD-Score:4.26|P-value:6.67E-5 ID:SGTC_7|Compound:0192-1582|FD-Score:10.80|P-value:1.18E-22 ID:SGTC_23|Compound:0213-0011|FD-Score:8.09|P-value:1.55E-13 ID:SGTC_34|Compound:0469-0683|FD-Score:6.73|P-value:6.84E-10 ID:SGTC_36|Compound:0335-0881|FD-Score:4.51|P-value:2.60E-5 ID:SGTC_64|Compound:000l-0018|FD-Score:10.80|P-value:8.84E-23 ID:SGTC_67|Compound:0335-0847|FD-Score:6.98|P-value:1.65E-10 ID:SGTC_86|Compound:0417-1630|FD-Score:16.50|P-value:1.14E-50 ID:SGTC_96|Compound:0929-0093|FD-Score:3.60|P-value:6.34E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:3.63|P-value:5.64E-4 ID:SGTC_107|Compound:0358-0022|FD-Score:16.30|P-value:1.78E-49 ID:SGTC_108|Compound:0509-0257|FD-Score:3.66|P-value:5.15E-4 ID:SGTC_114|Compound:0364-0001|FD-Score:5.03|P-value:3.07E-6 ID:SGTC_137|Compound:0438-0332|FD-Score:16.00|P-value:1.94E-47 ID:SGTC_142|Compound:0335-0849|FD-Score:19.30|P-value:4.55E-68 ID:SGTC_158|Compound:k038-0087|FD-Score:18.00|P-value:7.48E-60 ID:SGTC_163|Compound:1327-0036|FD-Score:6.19|P-value:1.30E-8 ID:SGTC_165|Compound:k038-0023|FD-Score:5.85|P-value:7.25E-8 ID:SGTC_188|Compound:3229-0966|FD-Score:9.06|P-value:1.56E-16 ID:SGTC_200|Compound:k038-0079|FD-Score:9.41|P-value:1.06E-17 ID:SGTC_216|Compound:k038-0035|FD-Score:5.83|P-value:7.97E-8 ID:SGTC_255|Compound:tunicamycin|FD-Score:9.55|P-value:3.72E-18 ID:SGTC_281|Compound:1672-3440|FD-Score:5.50|P-value:3.78E-7 ID:SGTC_283|Compound:0987-0079|FD-Score:3.95|P-value:1.97E-4 ID:SGTC_293|Compound:4049-0273|FD-Score:-3.58|P-value:5.35E-4 ID:SGTC_294|Compound:k038-0071|FD-Score:10.50|P-value:2.10E-21 ID:SGTC_305|Compound:1682-2595|FD-Score:9.35|P-value:1.78E-17 ID:SGTC_306|Compound:1672-3436|FD-Score:4.99|P-value:3.62E-6 ID:SGTC_340|Compound:k038-0059|FD-Score:6.68|P-value:8.86E-10 ID:SGTC_367|Compound:0335-0881|FD-Score:4.25|P-value:6.90E-5 ID:SGTC_426|Compound:0988-0037|FD-Score:3.69|P-value:4.73E-4 ID:SGTC_498|Compound:2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ)|FD-Score:-4.79|P-value:6.31E-6 ID:SGTC_501|Compound:nsc-95397|FD-Score:3.74|P-value:3.94E-4 ID:SGTC_555|Compound:4296-0685|FD-Score:5.19|P-value:1.51E-6 ID:SGTC_565|Compound:1418-0001|FD-Score:3.48|P-value:9.16E-4 ID:SGTC_566|Compound:0958-0068|FD-Score:4.98|P-value:3.73E-6 ID:SGTC_567|Compound:1080-0542|FD-Score:4.63|P-value:1.61E-5 ID:SGTC_571|Compound:k831-0106|FD-Score:9.17|P-value:6.61E-17 ID:SGTC_635|Compound:k038-0028|FD-Score:3.92|P-value:2.19E-4 ID:SGTC_639|Compound:0833-0042|FD-Score:3.65|P-value:5.31E-4 ID:SGTC_642|Compound:0335-0876|FD-Score:10.70|P-value:2.88E-22 ID:SGTC_676|Compound:falcarinol|FD-Score:5.31|P-value:8.81E-7 ID:SGTC_718|Compound:1130-0073|FD-Score:5.50|P-value:3.73E-7 ID:SGTC_794|Compound:k038-0031|FD-Score:18.30|P-value:1.36E-61 ID:SGTC_820|Compound:1582-0060|FD-Score:-3.94|P-value:1.59E-4 ID:SGTC_846|Compound:0335-0850|FD-Score:6.40|P-value:4.16E-9 ID:SGTC_852|Compound:0418-0143|FD-Score:7.34|P-value:1.90E-11 ID:SGTC_922|Compound:1866-0035|FD-Score:5.18|P-value:1.63E-6 ID:SGTC_984|Compound:1492-0255|FD-Score:17.60|P-value:2.75E-57 ID:SGTC_985|Compound:1493-0307|FD-Score:7.06|P-value:1.01E-10 ID:SGTC_989|Compound:1501-0895|FD-Score:3.88|P-value:2.47E-4 ID:SGTC_1026|Compound:k007-1105|FD-Score:4.59|P-value:1.86E-5 ID:SGTC_1082|Compound:camptothecin|FD-Score:6.07|P-value:2.36E-8 ID:SGTC_1161|Compound:k007-0610|FD-Score:7.46|P-value:8.97E-12 ID:SGTC_1349|Compound:flufenamic acid|FD-Score:4.41|P-value:3.68E-5 ID:SGTC_1369|Compound:1866-0067|FD-Score:-4.00|P-value:1.33E-4 ID:SGTC_1397|Compound:3532-0190|FD-Score:3.89|P-value:2.44E-4 ID:SGTC_1442|Compound:4112-3290|FD-Score:3.78|P-value:3.54E-4 ID:SGTC_1467|Compound:k284-1082|FD-Score:3.81|P-value:3.21E-4 ID:SGTC_1696|Compound:st025591|FD-Score:4.04|P-value:1.45E-4 ID:SGTC_1723|Compound:st034307|FD-Score:3.59|P-value:6.39E-4 ID:SGTC_1743|Compound:st037606|FD-Score:5.44|P-value:5.08E-7 ID:SGTC_1880|Compound:MG-132|FD-Score:5.79|P-value:9.56E-8 ID:SGTC_1945|Compound:st075991|FD-Score:4.20|P-value:8.01E-5 ID:SGTC_1989|Compound:st071868|FD-Score:4.10|P-value:1.18E-4 ID:SGTC_2028|Compound:5153890|FD-Score:4.19|P-value:8.50E-5 ID:SGTC_2057|Compound:5236571|FD-Score:4.76|P-value:9.44E-6 ID:SGTC_2132|Compound:5317594|FD-Score:5.19|P-value:1.50E-6 ID:SGTC_2185|Compound:6113692|FD-Score:4.94|P-value:4.54E-6 ID:SGTC_2229|Compound:7354935|FD-Score:3.76|P-value:3.72E-4 ID:SGTC_2284|Compound:7945075|FD-Score:-4.87|P-value:4.59E-6 ID:SGTC_2289|Compound:7946404|FD-Score:-4.41|P-value:2.88E-5 ID:SGTC_2312|Compound:7706453|FD-Score:4.12|P-value:1.10E-4 ID:SGTC_2377|Compound:9073351|FD-Score:3.46|P-value:9.68E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:4.48|P-value:2.86E-5 ID:SGTC_2433|Compound:5607874|FD-Score:-3.39|P-value:9.64E-4 ID:SGTC_2452|Compound:5863136|FD-Score:3.50|P-value:8.59E-4 ID:SGTC_2499|Compound:avocadenofuran|FD-Score:4.00|P-value:1.63E-4 ID:SGTC_2508|Compound:celastrol|FD-Score:4.80|P-value:8.16E-6 ID:SGTC_2651|Compound:1327-0036|FD-Score:3.45|P-value:9.86E-4 ID:SGTC_2659|Compound:sanguinarine|FD-Score:4.79|P-value:8.53E-6 ID:SGTC_2695|Compound:st077686|FD-Score:3.95|P-value:1.96E-4 ID:SGTC_2798|Compound:7813637|FD-Score:3.69|P-value:4.65E-4 ID:SGTC_2858|Compound:9025781|FD-Score:3.62|P-value:5.95E-4 ID:SGTC_2923|Compound:7992654|FD-Score:3.48|P-value:9.08E-4 ID:SGTC_2925|Compound:9010536|FD-Score:3.52|P-value:8.05E-4 ID:SGTC_2961|Compound:9083290|FD-Score:3.48|P-value:9.05E-4 ID:SGTC_2971|Compound:9092186|FD-Score:5.74|P-value:1.22E-7 ID:SGTC_2972|Compound:9093619|FD-Score:4.38|P-value:4.13E-5 ID:SGTC_2973|Compound:9094665|FD-Score:5.25|P-value:1.19E-6 ID:SGTC_2974|Compound:9094440|FD-Score:7.74|P-value:1.55E-12 ID:SGTC_3022|Compound:9087993|FD-Score:3.58|P-value:6.72E-4 ID:SGTC_3059|Compound:1327-0034|FD-Score:7.39|P-value:1.36E-11 ID:SGTC_3063|Compound:1327-0034|FD-Score:4.45|P-value:3.22E-5 ID:SGTC_3137|Compound:9097352|FD-Score:-3.77|P-value:2.92E-4 ID:SGTC_3139|Compound:9095020|FD-Score:-4.19|P-value:6.49E-5 ID:SGTC_3144|Compound:9087057|FD-Score:-4.47|P-value:2.28E-5 ID:SGTC_3172|Compound:9105863|FD-Score:3.65|P-value:5.30E-4 ID:SGTC_3337|Compound:9144342|FD-Score:4.26|P-value:6.67E-5

Top fitness defect scores for YML034W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_142 0335-0849 19.30 62.7 µM 4.55E-68 ubiquinone biosynthesis & proteasome 6 6.49E-83
2 SGTC_794 k038-0031 18.30 316.0 µM 1.36E-61 ubiquinone biosynthesis & proteasome 2 5.36E-75
3 SGTC_158 k038-0087 18.00 26.4 µM 7.48E-60 ubiquinone biosynthesis & proteasome 8 7.17E-73
4 SGTC_984 1492-0255 17.60 2.9 µM 2.75E-57 SWF1 & branched chain AA biosynthesis 2 9.81E-70
5 SGTC_86 0417-1630 16.50 471.9 µM 1.14E-50 ubiquinone biosynthesis & proteasome 13 1.20E-61
6 SGTC_107 0358-0022 16.30 2.7 µM 1.78E-49 SWF1 & branched chain AA biosynthesis 4 3.46E-60
7 SGTC_137 0438-0332 16.00 85.4 µM 1.94E-47 ubiquinone biosynthesis & proteasome 12 1.08E-57
8 SGTC_64 000l-0018 10.80 272.1 µM 8.84E-23 ubiquinone biosynthesis & proteasome 34 1.51E-27
9 SGTC_7 0192-1582 10.80 4.2 µM 1.18E-22 6 2.13E-27
10 SGTC_642 0335-0876 10.70 158.0 µM 2.88E-22 ubiquinone biosynthesis & proteasome 6 6.38E-27
11 SGTC_294 k038-0071 10.50 157.0 µM 2.10E-21 ubiquinone biosynthesis & proteasome 1 7.24E-26
12 SGTC_255 tunicamycin 9.55 200.5 nM 3.72E-18 unfolded protein response 13 6.76E-22
13 SGTC_200 k038-0079 9.41 37.5 µM 1.06E-17 ubiquinone biosynthesis & proteasome 10 2.43E-21
14 SGTC_305 1682-2595 9.35 20.8 µM 1.78E-17 RNA processing & uracil transport 3 4.59E-21
15 SGTC_571 k831-0106 9.17 44.2 µM 6.61E-17 1 2.28E-20
16 SGTC_188 3229-0966 9.06 278.5 µM 1.56E-16 1 6.49E-20
17 SGTC_23 0213-0011 8.09 40.0 µM 1.55E-13 copper-dependent oxidative stress 6 3.00E-16
18 SGTC_2974 9094440 7.74 9.7 µM 1.55E-12 ergosterol biosynthesis 3 4.99E-15
19 SGTC_1161 k007-0610 7.46 110.0 µM 8.97E-12 ERAD & cell cycle 33 4.27E-14
20 SGTC_3059 1327-0034 7.39 3.0 µM 1.36E-11 21 7.12E-14

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.592 4.71E-316 YML034C-A_d YML034C-A_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.538 1.50E-250 YDL183C YDL183C hom Mitochondrial inner-membrane protein thought to be involved in the formation of an active mitochondrial K+/H+ exchanger (KHE) system; non-essential gene
0.521 3.22E-233 YOR254C SEC63 het Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
0.489 3.76E-201 YPR146C_d YPR146C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.474 1.99E-187 YER041W YEN1 hom Holliday junction resolvase; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation; homolog of human GEN1 and has similarity to S. cerevisiae endonuclease Rth1p
0.463 1.26E-177 YJL193W_p YJL193W_p hom Putative protein of unknown function, predicted to encode a triose phosphate transporter subfamily member based on phylogenetic analysis; similar to YOR307C/SLY41; deletion mutant has a respiratory growth defect
0.460 1.64E-175 YPR064W_d YPR064W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.455 1.53E-170 YCL014W BUD3 hom Protein involved in bud-site selection and required for axial budding pattern; localizes with septins to bud neck in mitosis and may constitute an axial landmark for next round of budding
0.446 2.11E-163 YFR007W YFH7 hom Putative kinase with similarity to the phosphoribulokinase/uridine kinase/bacterial pantothenate kinase (PRK/URK/PANK) subfamily of P-loop kinases
0.446 1.99E-163 YJL155C FBP26 hom Fructose-2,6-bisphosphatase, required for glucose metabolism; protein abundance increases in response to DNA replication stress
0.435 1.03E-154 YMR110C HFD1 hom Hexadecenal dehydrogenase; involved in the conversion of sphingosine 1-phosphate breakdown product hexadecenal to hexadecenoic acid; located in the mitochondrial outer membrane and also in lipid particles; has similarity to ALDH3A2, a human fatty aldehyde dehydrogenase (FALDH) mutated in Sjogren-Larsson syndrome, a neurocutaneous disorder
0.431 2.08E-151 YDR537C_d YDR537C_d hom Dubious open reading frame unlikely to encode a protein, almost completely overlaps verified ORF PAD1/YDR538W
0.428 1.23E-149 YPR065W ROX1 hom Heme-dependent repressor of hypoxic genes; mediates aerobic transcriptional repression of hypoxia induced genes such as COX5b and CYC7; repressor function regulated through decreased promoter occupancy in response to oxidative stress; contains an HMG domain that is responsible for DNA bending activity; involved in the hyperosmotic stress resistance
0.421 2.80E-144 YLR201C COQ9 hom Protein required for ubiquinone (coenzyme Q) biosynthesis and respiratory growth; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes
0.421 6.12E-144 YGL119W COQ8 hom Protein required for ubiquinone biosynthesis and respiratory growth; exhibits genetic interaction with COQ9, suggesting a common function; similar to prokaryotic proteins involved in early steps of ubiquinone biosynthesis; COQ8 has a paralog, YBR230W-A, that arose from the whole genome duplication