YML035C / AMD1

AMP deaminase; tetrameric enzyme that catalyzes the deamination of AMP to form IMP and ammonia; thought to be involved in regulation of intracellular purine (adenine, guanine, and inosine) nucleotide pools

Zygosity: Homozygous strain
fixedexpanded
Profile for YML035C / AMD1

Click on Significant Values for Screen Details ID:SGTC_16|Compound:erodoxin|FD-Score:3.90|P-value:5.79E-5 ID:SGTC_69|Compound:0096-0274|FD-Score:-4.70|P-value:1.95E-6 ID:SGTC_73|Compound:0327-0325|FD-Score:5.27|P-value:9.61E-8 ID:SGTC_87|Compound:0100-0052|FD-Score:4.23|P-value:1.45E-5 ID:SGTC_108|Compound:0509-0257|FD-Score:-3.75|P-value:1.16E-4 ID:SGTC_109|Compound:0132-0036|FD-Score:-3.44|P-value:3.69E-4 ID:SGTC_121|Compound:0557-0495|FD-Score:3.50|P-value:2.69E-4 ID:SGTC_149|Compound:3970-0822|FD-Score:13.10|P-value:1.49E-38 ID:SGTC_159|Compound:3970-0959|FD-Score:3.16|P-value:8.63E-4 ID:SGTC_168|Compound:3970-0862|FD-Score:3.45|P-value:3.24E-4 ID:SGTC_169|Compound:k015-0017|FD-Score:-3.32|P-value:5.63E-4 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:6.41|P-value:1.19E-10 ID:SGTC_309|Compound:k408-0051|FD-Score:5.29|P-value:8.45E-8 ID:SGTC_342|Compound:k048-0088|FD-Score:-3.17|P-value:9.58E-4 ID:SGTC_408|Compound:cantharidin|FD-Score:3.96|P-value:4.54E-5 ID:SGTC_422|Compound:cantharidin|FD-Score:4.08|P-value:2.73E-5 ID:SGTC_789|Compound:1309-1135|FD-Score:-4.29|P-value:1.25E-5 ID:SGTC_846|Compound:0335-0850|FD-Score:3.31|P-value:5.27E-4 ID:SGTC_847|Compound:0342-0274|FD-Score:3.58|P-value:1.99E-4 ID:SGTC_859|Compound:0439-0102|FD-Score:3.20|P-value:7.60E-4 ID:SGTC_936|Compound:3005-4620|FD-Score:3.34|P-value:4.72E-4 ID:SGTC_941|Compound:3237-0776|FD-Score:3.40|P-value:3.83E-4 ID:SGTC_1284|Compound:0929-0043|FD-Score:6.61|P-value:3.27E-11 ID:SGTC_1314|Compound:1222-0010|FD-Score:-3.64|P-value:1.80E-4 ID:SGTC_1350|Compound:1495-0454|FD-Score:4.32|P-value:9.47E-6 ID:SGTC_1353|Compound:1498-1206|FD-Score:4.46|P-value:5.13E-6 ID:SGTC_1359|Compound:1582-0056|FD-Score:5.05|P-value:3.01E-7 ID:SGTC_1493|Compound:4348-0038|FD-Score:3.32|P-value:5.10E-4 ID:SGTC_1534|Compound:6-azauridine|FD-Score:7.46|P-value:8.87E-14 ID:SGTC_1772|Compound:st048439|FD-Score:3.58|P-value:1.95E-4 ID:SGTC_2051|Compound:5263410|FD-Score:-3.26|P-value:6.86E-4 ID:SGTC_2052|Compound:5265182|FD-Score:4.33|P-value:9.17E-6 ID:SGTC_2094|Compound:5332512|FD-Score:3.23|P-value:6.98E-4 ID:SGTC_2099|Compound:5377090|FD-Score:4.35|P-value:8.60E-6 ID:SGTC_2122|Compound:5258151|FD-Score:-3.26|P-value:6.90E-4 ID:SGTC_2169|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:5.15|P-value:1.81E-7 ID:SGTC_2177|Compound:5811945|FD-Score:-3.42|P-value:3.94E-4 ID:SGTC_2283|Compound:7944793|FD-Score:4.08|P-value:2.72E-5 ID:SGTC_2359|Compound:9039622|FD-Score:4.37|P-value:7.73E-6 ID:SGTC_2364|Compound:9055074|FD-Score:-5.43|P-value:4.75E-8 ID:SGTC_2406|Compound:ethylparaben|FD-Score:-3.80|P-value:9.75E-5 ID:SGTC_2829|Compound:7992743|FD-Score:6.77|P-value:1.14E-11 ID:SGTC_2830|Compound:7992007|FD-Score:-4.25|P-value:1.48E-5 ID:SGTC_2935|Compound:9038016|FD-Score:3.51|P-value:2.58E-4 ID:SGTC_16|Compound:erodoxin|FD-Score:3.90|P-value:5.79E-5 ID:SGTC_69|Compound:0096-0274|FD-Score:-4.70|P-value:1.95E-6 ID:SGTC_73|Compound:0327-0325|FD-Score:5.27|P-value:9.61E-8 ID:SGTC_87|Compound:0100-0052|FD-Score:4.23|P-value:1.45E-5 ID:SGTC_108|Compound:0509-0257|FD-Score:-3.75|P-value:1.16E-4 ID:SGTC_109|Compound:0132-0036|FD-Score:-3.44|P-value:3.69E-4 ID:SGTC_121|Compound:0557-0495|FD-Score:3.50|P-value:2.69E-4 ID:SGTC_149|Compound:3970-0822|FD-Score:13.10|P-value:1.49E-38 ID:SGTC_159|Compound:3970-0959|FD-Score:3.16|P-value:8.63E-4 ID:SGTC_168|Compound:3970-0862|FD-Score:3.45|P-value:3.24E-4 ID:SGTC_169|Compound:k015-0017|FD-Score:-3.32|P-value:5.63E-4 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:6.41|P-value:1.19E-10 ID:SGTC_309|Compound:k408-0051|FD-Score:5.29|P-value:8.45E-8 ID:SGTC_342|Compound:k048-0088|FD-Score:-3.17|P-value:9.58E-4 ID:SGTC_408|Compound:cantharidin|FD-Score:3.96|P-value:4.54E-5 ID:SGTC_422|Compound:cantharidin|FD-Score:4.08|P-value:2.73E-5 ID:SGTC_789|Compound:1309-1135|FD-Score:-4.29|P-value:1.25E-5 ID:SGTC_846|Compound:0335-0850|FD-Score:3.31|P-value:5.27E-4 ID:SGTC_847|Compound:0342-0274|FD-Score:3.58|P-value:1.99E-4 ID:SGTC_859|Compound:0439-0102|FD-Score:3.20|P-value:7.60E-4 ID:SGTC_936|Compound:3005-4620|FD-Score:3.34|P-value:4.72E-4 ID:SGTC_941|Compound:3237-0776|FD-Score:3.40|P-value:3.83E-4 ID:SGTC_1284|Compound:0929-0043|FD-Score:6.61|P-value:3.27E-11 ID:SGTC_1314|Compound:1222-0010|FD-Score:-3.64|P-value:1.80E-4 ID:SGTC_1350|Compound:1495-0454|FD-Score:4.32|P-value:9.47E-6 ID:SGTC_1353|Compound:1498-1206|FD-Score:4.46|P-value:5.13E-6 ID:SGTC_1359|Compound:1582-0056|FD-Score:5.05|P-value:3.01E-7 ID:SGTC_1493|Compound:4348-0038|FD-Score:3.32|P-value:5.10E-4 ID:SGTC_1534|Compound:6-azauridine|FD-Score:7.46|P-value:8.87E-14 ID:SGTC_1772|Compound:st048439|FD-Score:3.58|P-value:1.95E-4 ID:SGTC_2051|Compound:5263410|FD-Score:-3.26|P-value:6.86E-4 ID:SGTC_2052|Compound:5265182|FD-Score:4.33|P-value:9.17E-6 ID:SGTC_2094|Compound:5332512|FD-Score:3.23|P-value:6.98E-4 ID:SGTC_2099|Compound:5377090|FD-Score:4.35|P-value:8.60E-6 ID:SGTC_2122|Compound:5258151|FD-Score:-3.26|P-value:6.90E-4 ID:SGTC_2169|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:5.15|P-value:1.81E-7 ID:SGTC_2177|Compound:5811945|FD-Score:-3.42|P-value:3.94E-4 ID:SGTC_2283|Compound:7944793|FD-Score:4.08|P-value:2.72E-5 ID:SGTC_2359|Compound:9039622|FD-Score:4.37|P-value:7.73E-6 ID:SGTC_2364|Compound:9055074|FD-Score:-5.43|P-value:4.75E-8 ID:SGTC_2406|Compound:ethylparaben|FD-Score:-3.80|P-value:9.75E-5 ID:SGTC_2829|Compound:7992743|FD-Score:6.77|P-value:1.14E-11 ID:SGTC_2830|Compound:7992007|FD-Score:-4.25|P-value:1.48E-5 ID:SGTC_2935|Compound:9038016|FD-Score:3.51|P-value:2.58E-4

Top fitness defect scores for YML035C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_149 3970-0822 13.10 46.1 µM 1.49E-38 tubulin folding & SWR complex 8 1.49E-39
2 SGTC_1534 6-azauridine 7.46 81.6 µM 8.87E-14 RNA pol III & RNase P/MRP 2 4.40E-14
3 SGTC_2829 7992743 6.77 58.4 µM 1.14E-11 3 6.45E-12
4 SGTC_1284 0929-0043 6.61 16.0 µM 3.27E-11 7 1.90E-11
5 SGTC_241 5hr heat shock (37°C) + cantharidin 6.41 155.4 µM 1.19E-10 cell wall signaling 28 7.18E-11
6 SGTC_309 k408-0051 5.29 1.5 µM 8.45E-8 20 6.05E-8
7 SGTC_73 0327-0325 5.27 16.2 µM 9.61E-8 DNA damage response 21 6.90E-8
8 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 5.15 49.5 µM 1.81E-7 5 1.32E-7
9 SGTC_1359 1582-0056 5.05 520.0 nM 3.01E-7 6 2.23E-7
10 SGTC_1353 1498-1206 4.46 8.1 µM 5.13E-6 mitochondrial response to ROS 39 4.08E-6
11 SGTC_2359 9039622 4.37 200.0 µM 7.73E-6 endomembrane recycling 15 6.21E-6
12 SGTC_2099 5377090 4.35 177.4 µM 8.60E-6 13 6.93E-6
13 SGTC_2052 5265182 4.33 7.1 µM 9.17E-6 19 7.40E-6
14 SGTC_1350 1495-0454 4.32 146.0 µM 9.47E-6 18 7.65E-6
15 SGTC_87 0100-0052 4.23 35.5 µM 1.45E-5 90 1.18E-5
16 SGTC_2283 7944793 4.08 200.0 µM 2.72E-5 37 2.25E-5
17 SGTC_422 cantharidin 4.08 155.0 µM 2.73E-5 cell wall signaling 53 2.27E-5
18 SGTC_408 cantharidin 3.96 100.0 µM 4.54E-5 cell wall signaling 21 3.82E-5
19 SGTC_16 erodoxin 3.90 22.8 µM 5.79E-5 unfolded protein response 64 4.89E-5
20 SGTC_1772 st048439 3.58 82.2 µM 1.95E-4 48 1.69E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.190 2.03E-28 YHR209W CRG1 hom S-AdoMet-dependent methyltransferase involved in lipid homeostasis; mediates resistance to a drug cantharidin
0.151 1.81E-18 YLR352W_p YLR352W_p hom Putative protein of unknown function with similarity to F-box proteins; interacts with Skp1p and Cdc53p; YLR352W is not an essential gene
0.145 4.11E-17 YLR027C AAT2 hom Cytosolic aspartate aminotransferase, involved in nitrogen metabolism; localizes to peroxisomes in oleate-grown cells
0.142 1.49E-16 YNL246W VPS75 hom NAP family histone chaperone; binds to histones and Rtt109p, stimulating histone acetyltransferase activity; possesses nucleosome assembly activity in vitro; proposed role in vacuolar protein sorting and in double-strand break repair; protein abundance increases in response to DNA replication stress
0.138 1.24E-15 YDR069C DOA4 hom Ubiquitin isopeptidase, required for recycling ubiquitin from proteasome-bound ubiquitinated intermediates, acts at the late endosome/prevacuolar compartment to recover ubiquitin from ubiquitinated membrane proteins en route to the vacuole
0.133 9.71E-15 YBL034C STU1 het Component of the mitotic spindle that binds to interpolar microtubules via its association with beta-tubulin (Tub2p); required for interpolar microtubules to provide an outward force on the spindle poles
0.132 1.65E-14 YGL086W MAD1 hom Coiled-coil protein involved in the spindle-assembly checkpoint; required for inhibition of karyopherin/importin Pse1p (aka Kap121p) upon spindle assembly checkpoint arrest; phosphorylated by Mps1p upon checkpoint activation which leads to inhibition of the activity of the anaphase promoting complex; forms a complex with Mad2p
0.131 2.59E-14 YDL146W LDB17 hom Protein involved in the regulation of endocytosis; transiently recruited to actin cortical patches in a SLA1-dependent manner after late coat component assembly; GFP-fusion protein localizes to the periphery, cytoplasm, bud, and bud neck
0.131 3.05E-14 YDR446W ECM11 hom Non-essential protein apparently involved in meiosis, GFP fusion protein is present in discrete clusters in the nucleus throughout mitosis; may be involved in maintaining chromatin structure
0.129 8.21E-14 YOL053W AIM39 hom Putative protein of unknown function; null mutant displays elevated frequency of mitochondrial genome loss
0.128 8.95E-14 YOR091W TMA46 hom Protein of unknown function that associates with translating ribosomes; interacts with GTPase Rbg1p
0.124 6.15E-13 YDR049W VMS1 hom Component of a Cdc48p-complex involved in protein quality control; exhibits cytosolic and ER-membrane localization, with Cdc48p, during normal growth, and contributes to ER-associated degradation (ERAD) of specific substrates at a step after their ubiquitination; forms a mitochondrially-associated complex with Cdc48p and Npl4p under oxidative stress that is required for ubiquitin-mediated mitochondria-associated protein degradation (MAD); conserved in C. elegans and humans
0.120 3.01E-12 YPL089C RLM1 hom MADS-box transcription factor; component of the protein kinase C-mediated MAP kinase pathway involved in the maintenance of cell integrity; phosphorylated and activated by the MAP-kinase Slt2p; RLM1 has a paralog, SMP1, that arose from the whole genome duplication
0.118 6.57E-12 YJL153C INO1 hom Inositol-3-phosphate synthase, involved in synthesis of inositol phosphates and inositol-containing phospholipids; transcription is coregulated with other phospholipid biosynthetic genes by Ino2p and Ino4p, which bind the UASINO DNA element
0.114 3.63E-11 YDR512C EMI1 hom Non-essential protein required for transcriptional induction of the early meiotic-specific transcription factor IME1, also required for sporulation; contains twin cysteine-x9-cysteine motifs