YML038C / YMD8

Putative nucleotide sugar transporter, has similarity to Vrg4p

Zygosity: Homozygous strain
fixedexpanded
Profile for YML038C / YMD8

Click on Significant Values for Screen Details ID:SGTC_12|Compound:0849-0099|FD-Score:3.69|P-value:1.21E-4 ID:SGTC_18|Compound:0111-0177|FD-Score:4.52|P-value:3.49E-6 ID:SGTC_182|Compound:3448-4371|FD-Score:3.92|P-value:4.92E-5 ID:SGTC_497|Compound:capsazepine|FD-Score:4.24|P-value:1.23E-5 ID:SGTC_503|Compound:tyrphostin 8|FD-Score:3.82|P-value:7.28E-5 ID:SGTC_519|Compound:k048-0011|FD-Score:-5.30|P-value:6.52E-8 ID:SGTC_638|Compound:3970-0837|FD-Score:3.35|P-value:4.42E-4 ID:SGTC_651|Compound:3253-0966|FD-Score:4.48|P-value:4.24E-6 ID:SGTC_669|Compound:0108-0021|FD-Score:5.76|P-value:5.12E-9 ID:SGTC_743|Compound:1275-0778|FD-Score:3.34|P-value:4.58E-4 ID:SGTC_866|Compound:0495-0101|FD-Score:3.25|P-value:6.29E-4 ID:SGTC_966|Compound:1300-0360|FD-Score:4.00|P-value:3.51E-5 ID:SGTC_994|Compound:3910-0338|FD-Score:5.43|P-value:3.38E-8 ID:SGTC_1014|Compound:4130-3005|FD-Score:-3.52|P-value:2.30E-4 ID:SGTC_1070|Compound:indatraline|FD-Score:3.13|P-value:9.23E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:-3.66|P-value:1.31E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.01|P-value:3.19E-5 ID:SGTC_1128|Compound:3448-9350|FD-Score:-3.34|P-value:4.33E-4 ID:SGTC_1233|Compound:0325-0408|FD-Score:3.61|P-value:1.64E-4 ID:SGTC_1236|Compound:0330-0013|FD-Score:3.94|P-value:4.40E-5 ID:SGTC_1355|Compound:1499-0035|FD-Score:3.53|P-value:2.22E-4 ID:SGTC_1465|Compound:k213-0056|FD-Score:-3.77|P-value:8.64E-5 ID:SGTC_1650|Compound:st011916|FD-Score:3.11|P-value:9.83E-4 ID:SGTC_1675|Compound:st018485|FD-Score:3.46|P-value:2.89E-4 ID:SGTC_1743|Compound:st037606|FD-Score:3.75|P-value:9.83E-5 ID:SGTC_1794|Compound:st048918|FD-Score:4.84|P-value:7.56E-7 ID:SGTC_2024|Compound:5144227|FD-Score:-3.38|P-value:3.82E-4 ID:SGTC_2316|Compound:5844804|FD-Score:-5.82|P-value:3.37E-9 ID:SGTC_2321|Compound:7390090|FD-Score:6.01|P-value:1.11E-9 ID:SGTC_2332|Compound:7982454|FD-Score:-3.12|P-value:9.50E-4 ID:SGTC_2393|Compound:9031399|FD-Score:-6.68|P-value:1.50E-11 ID:SGTC_2400|Compound:5203494|FD-Score:-7.79|P-value:4.30E-15 ID:SGTC_2401|Compound:5128683|FD-Score:-7.70|P-value:8.99E-15 ID:SGTC_2403|Compound:6032726|FD-Score:6.97|P-value:2.09E-12 ID:SGTC_2404|Compound:5161160|FD-Score:5.37|P-value:4.76E-8 ID:SGTC_2484|Compound:5809818|FD-Score:4.41|P-value:5.68E-6 ID:SGTC_2543|Compound:pimpinellin|FD-Score:-3.91|P-value:4.96E-5 ID:SGTC_2610|Compound:ononetin|FD-Score:3.78|P-value:8.63E-5 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:3.21|P-value:7.11E-4 ID:SGTC_2656|Compound:pseudo-anisatin|FD-Score:3.26|P-value:5.94E-4 ID:SGTC_2708|Compound:st078559|FD-Score:-3.96|P-value:4.08E-5 ID:SGTC_2712|Compound:st079126|FD-Score:3.20|P-value:7.23E-4 ID:SGTC_2801|Compound:7907800|FD-Score:3.44|P-value:3.14E-4 ID:SGTC_2807|Compound:7945238|FD-Score:3.48|P-value:2.68E-4 ID:SGTC_2979|Compound:9012552|FD-Score:5.67|P-value:8.80E-9 ID:SGTC_2984|Compound:9022109|FD-Score:3.99|P-value:3.60E-5 ID:SGTC_12|Compound:0849-0099|FD-Score:3.69|P-value:1.21E-4 ID:SGTC_18|Compound:0111-0177|FD-Score:4.52|P-value:3.49E-6 ID:SGTC_182|Compound:3448-4371|FD-Score:3.92|P-value:4.92E-5 ID:SGTC_497|Compound:capsazepine|FD-Score:4.24|P-value:1.23E-5 ID:SGTC_503|Compound:tyrphostin 8|FD-Score:3.82|P-value:7.28E-5 ID:SGTC_519|Compound:k048-0011|FD-Score:-5.30|P-value:6.52E-8 ID:SGTC_638|Compound:3970-0837|FD-Score:3.35|P-value:4.42E-4 ID:SGTC_651|Compound:3253-0966|FD-Score:4.48|P-value:4.24E-6 ID:SGTC_669|Compound:0108-0021|FD-Score:5.76|P-value:5.12E-9 ID:SGTC_743|Compound:1275-0778|FD-Score:3.34|P-value:4.58E-4 ID:SGTC_866|Compound:0495-0101|FD-Score:3.25|P-value:6.29E-4 ID:SGTC_966|Compound:1300-0360|FD-Score:4.00|P-value:3.51E-5 ID:SGTC_994|Compound:3910-0338|FD-Score:5.43|P-value:3.38E-8 ID:SGTC_1014|Compound:4130-3005|FD-Score:-3.52|P-value:2.30E-4 ID:SGTC_1070|Compound:indatraline|FD-Score:3.13|P-value:9.23E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:-3.66|P-value:1.31E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.01|P-value:3.19E-5 ID:SGTC_1128|Compound:3448-9350|FD-Score:-3.34|P-value:4.33E-4 ID:SGTC_1233|Compound:0325-0408|FD-Score:3.61|P-value:1.64E-4 ID:SGTC_1236|Compound:0330-0013|FD-Score:3.94|P-value:4.40E-5 ID:SGTC_1355|Compound:1499-0035|FD-Score:3.53|P-value:2.22E-4 ID:SGTC_1465|Compound:k213-0056|FD-Score:-3.77|P-value:8.64E-5 ID:SGTC_1650|Compound:st011916|FD-Score:3.11|P-value:9.83E-4 ID:SGTC_1675|Compound:st018485|FD-Score:3.46|P-value:2.89E-4 ID:SGTC_1743|Compound:st037606|FD-Score:3.75|P-value:9.83E-5 ID:SGTC_1794|Compound:st048918|FD-Score:4.84|P-value:7.56E-7 ID:SGTC_2024|Compound:5144227|FD-Score:-3.38|P-value:3.82E-4 ID:SGTC_2316|Compound:5844804|FD-Score:-5.82|P-value:3.37E-9 ID:SGTC_2321|Compound:7390090|FD-Score:6.01|P-value:1.11E-9 ID:SGTC_2332|Compound:7982454|FD-Score:-3.12|P-value:9.50E-4 ID:SGTC_2393|Compound:9031399|FD-Score:-6.68|P-value:1.50E-11 ID:SGTC_2400|Compound:5203494|FD-Score:-7.79|P-value:4.30E-15 ID:SGTC_2401|Compound:5128683|FD-Score:-7.70|P-value:8.99E-15 ID:SGTC_2403|Compound:6032726|FD-Score:6.97|P-value:2.09E-12 ID:SGTC_2404|Compound:5161160|FD-Score:5.37|P-value:4.76E-8 ID:SGTC_2484|Compound:5809818|FD-Score:4.41|P-value:5.68E-6 ID:SGTC_2543|Compound:pimpinellin|FD-Score:-3.91|P-value:4.96E-5 ID:SGTC_2610|Compound:ononetin|FD-Score:3.78|P-value:8.63E-5 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:3.21|P-value:7.11E-4 ID:SGTC_2656|Compound:pseudo-anisatin|FD-Score:3.26|P-value:5.94E-4 ID:SGTC_2708|Compound:st078559|FD-Score:-3.96|P-value:4.08E-5 ID:SGTC_2712|Compound:st079126|FD-Score:3.20|P-value:7.23E-4 ID:SGTC_2801|Compound:7907800|FD-Score:3.44|P-value:3.14E-4 ID:SGTC_2807|Compound:7945238|FD-Score:3.48|P-value:2.68E-4 ID:SGTC_2979|Compound:9012552|FD-Score:5.67|P-value:8.80E-9 ID:SGTC_2984|Compound:9022109|FD-Score:3.99|P-value:3.60E-5

Top fitness defect scores for YML038C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2403 6032726 6.97 181.2 µM 2.09E-12 7 1.60E-12
2 SGTC_2321 7390090 6.01 138.8 µM 1.11E-9 5 9.02E-10
3 SGTC_669 0108-0021 5.76 26.2 µM 5.12E-9 fatty acid desaturase (OLE1) 25 4.24E-9
4 SGTC_2979 9012552 5.67 45.5 µM 8.80E-9 1 7.33E-9
5 SGTC_994 3910-0338 5.43 138.0 µM 3.38E-8 calcium & mitochondrial duress 18 2.85E-8
6 SGTC_2404 5161160 5.37 200.0 µM 4.76E-8 5 4.04E-8
7 SGTC_1794 st048918 4.84 76.9 µM 7.56E-7 6 6.59E-7
8 SGTC_18 0111-0177 4.52 500.0 nM 3.49E-6 44 3.09E-6
9 SGTC_651 3253-0966 4.48 34.4 µM 4.24E-6 calcium & mitochondrial duress 21 3.76E-6
10 SGTC_2484 5809818 4.41 12.0 µM 5.68E-6 12 5.05E-6
11 SGTC_497 capsazepine 4.24 133.0 µM 1.23E-5 8 1.10E-5
12 SGTC_966 1300-0360 4.00 30.2 µM 3.51E-5 heme requiring 23 3.18E-5
13 SGTC_2984 9022109 3.99 39.0 µM 3.60E-5 5 3.27E-5
14 SGTC_1236 0330-0013 3.94 258.0 µM 4.40E-5 6 4.00E-5
15 SGTC_182 3448-4371 3.92 550.5 µM 4.92E-5 22 4.48E-5
16 SGTC_503 tyrphostin 8 3.82 294.0 µM 7.28E-5 TSC3-RPN4 34 6.65E-5
17 SGTC_2610 ononetin 3.78 44.2 µM 8.63E-5 51 7.90E-5
18 SGTC_1743 st037606 3.75 46.4 µM 9.83E-5 26 9.01E-5
19 SGTC_12 0849-0099 3.69 9.3 µM 1.21E-4 26 1.11E-4
20 SGTC_1233 0325-0408 3.61 14.2 µM 1.64E-4 28 1.51E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.180 8.96E-26 YPL092W SSU1 hom Plasma membrane sulfite pump involved in sulfite metabolism and required for efficient sulfite efflux; major facilitator superfamily protein
0.144 4.77E-17 YOR269W PAC1 hom Involved in nuclear migration, part of the dynein/dynactin pathway; targets dynein to microtubule tips, which is necessary for sliding of microtubules along bud cortex; serves at interface between dynein's ATPase site and its microtubule binding stalk, causing individual dynein motors to remain attached to microtubules for long periods; synthetic lethal with bni1; homolog of human LIS1, mutations in which cause the severe brain disorder lissencephaly
0.130 3.93E-14 YKL122C SRP21 het Subunit of the signal recognition particle (SRP), which functions in protein targeting to the endoplasmic reticulum membrane; not found in mammalian SRP; forms a pre-SRP structure in the nucleolus that is translocated to the cytoplasm
0.128 1.16E-13 YKL220C FRE2 hom Ferric reductase and cupric reductase, reduces siderophore-bound iron and oxidized copper prior to uptake by transporters; expression induced by low iron levels but not by low copper levels
0.124 6.55E-13 YDL133C-A RPL41B hom Ribosomal 60S subunit protein L41B; comprises only 25 amino acids; rpl41a rpl41b double null mutant is viable; homologous to mammalian ribosomal protein L41, no bacterial homolog; RPL41B has a paralog, RPL41A, that arose from the whole genome duplication
0.121 1.75E-12 YBR118W TEF2 hom Translational elongation factor EF-1 alpha; also encoded by TEF1; functions in the binding reaction of aminoacyl-tRNA (AA-tRNA) to ribosomes; may also have a role in tRNA re-export from the nucleus; TEF2 has a paralog, TEF1, that arose from the whole genome duplication
0.115 2.25E-11 YER063W THO1 hom Conserved nuclear RNA-binding protein; specifically binds to transcribed chromatin in a THO- and RNA-dependent manner, genetically interacts with shuttling hnRNP NAB2; overproduction suppresses transcriptional defect caused by hpr1 mutation
0.115 2.58E-11 YKR102W FLO10 hom Member of the FLO family of cell wall flocculation proteins; not expressed in most lab strains; overproduction induces flocculation that can be inhibited by mannose, sucrose, or glucose; overproduction also promotes haploid invasive growth and diploid filamentous growth
0.113 4.89E-11 YPL249C GYP5 hom GTPase-activating protein (GAP) for yeast Rab family members; involved in ER to Golgi trafficking; exhibits GAP activity toward Ypt1p that is stimulated by Gyl1p, also acts on Sec4p; interacts with Gyl1p, Rvs161p and Rvs167p; involved in recruiting Rvs167p to the bud tip during polarized growth; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.110 1.77E-10 YBR090C_p YBR090C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
0.110 1.80E-10 YDL131W LYS21 hom Homocitrate synthase isozyme; catalyzes the condensation of acetyl-CoA and alpha-ketoglutarate to form homocitrate, which is the first step in the lysine biosynthesis pathway; LYS21 has a paralog, LYS20, that arose from the whole genome duplication
0.101 4.61E-9 YOR037W CYC2 hom Mitochondrial peripheral inner membrane protein, contains a FAD cofactor in a domain exposed in the intermembrane space; exhibits redox activity in vitro; likely participates in ligation of heme to acytochromes c and c1 (Cyc1p and Cyt1p)
0.094 4.99E-8 YMR135W-A_d YMR135W-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.094 5.10E-8 YIL059C_d YIL059C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YIL060W
0.094 5.39E-8 YBR083W TEC1 hom Transcription factor targeting filamentation genes and Ty1 expression; Ste12p activation of most filamentation gene promoters depends on Tec1p and Tec1p transcriptional activity is dependent on its association with Ste12p; binds to TCS elements upstream of filamentation genes, which are regulated by Tec1p/Ste12p/Dig1p complex; competes with Dig2p for binding to Ste12p/Dig1p; positive regulator of chronological life span; TEA/ATTS DNA-binding domain family member