YML041C / VPS71

Nucleosome-binding component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for vacuolar protein sorting

Zygosity: Homozygous strain
fixedexpanded
Profile for YML041C / VPS71

Click on Significant Values for Screen Details ID:SGTC_23|Compound:0213-0011|FD-Score:-4.06|P-value:6.99E-4 ID:SGTC_36|Compound:0335-0881|FD-Score:14.40|P-value:3.35E-31 ID:SGTC_58|Compound:0957-0393|FD-Score:4.89|P-value:4.02E-5 ID:SGTC_64|Compound:000l-0018|FD-Score:5.61|P-value:3.18E-6 ID:SGTC_67|Compound:0335-0847|FD-Score:10.60|P-value:9.62E-18 ID:SGTC_137|Compound:0438-0332|FD-Score:15.20|P-value:3.76E-34 ID:SGTC_138|Compound:0850-0259|FD-Score:6.98|P-value:1.02E-8 ID:SGTC_142|Compound:0335-0849|FD-Score:10.20|P-value:1.43E-16 ID:SGTC_158|Compound:k038-0087|FD-Score:8.31|P-value:1.30E-11 ID:SGTC_161|Compound:4065-0411|FD-Score:8.55|P-value:3.50E-12 ID:SGTC_163|Compound:1327-0036|FD-Score:4.71|P-value:7.28E-5 ID:SGTC_165|Compound:k038-0023|FD-Score:16.80|P-value:1.87E-41 ID:SGTC_200|Compound:k038-0079|FD-Score:11.70|P-value:4.67E-21 ID:SGTC_210|Compound:3551-0445|FD-Score:16.10|P-value:2.74E-38 ID:SGTC_212|Compound:3807-4682|FD-Score:9.83|P-value:1.63E-15 ID:SGTC_216|Compound:k038-0035|FD-Score:10.40|P-value:3.86E-17 ID:SGTC_221|Compound:trifluoperazine|FD-Score:27.00|P-value:1.70E-103 ID:SGTC_229|Compound:benomyl|FD-Score:20.70|P-value:1.52E-61 ID:SGTC_256|Compound:clotrimazole|FD-Score:4.97|P-value:3.13E-5 ID:SGTC_286|Compound:k060-0067|FD-Score:10.40|P-value:3.47E-17 ID:SGTC_294|Compound:k038-0071|FD-Score:4.93|P-value:3.55E-5 ID:SGTC_340|Compound:k038-0059|FD-Score:7.94|P-value:9.32E-11 ID:SGTC_367|Compound:0335-0881|FD-Score:5.42|P-value:6.43E-6 ID:SGTC_375|Compound:3970-0961|FD-Score:3.89|P-value:8.28E-4 ID:SGTC_379|Compound:3970-0972|FD-Score:3.91|P-value:7.93E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:-5.11|P-value:2.76E-5 ID:SGTC_445|Compound:e6 berbamine|FD-Score:4.10|P-value:4.60E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:7.00|P-value:9.36E-9 ID:SGTC_528|Compound:3492-0019|FD-Score:4.23|P-value:3.21E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:-4.18|P-value:5.00E-4 ID:SGTC_589|Compound:1227-0070|FD-Score:8.89|P-value:5.00E-13 ID:SGTC_635|Compound:k038-0028|FD-Score:4.70|P-value:7.49E-5 ID:SGTC_642|Compound:0335-0876|FD-Score:4.62|P-value:9.72E-5 ID:SGTC_666|Compound:0272-0154|FD-Score:4.14|P-value:4.15E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:19.10|P-value:6.64E-53 ID:SGTC_779|Compound:1360-0071|FD-Score:-4.78|P-value:8.26E-5 ID:SGTC_794|Compound:k038-0031|FD-Score:5.25|P-value:1.17E-5 ID:SGTC_825|Compound:1988-2224|FD-Score:11.70|P-value:4.90E-21 ID:SGTC_846|Compound:0335-0850|FD-Score:5.22|P-value:1.29E-5 ID:SGTC_871|Compound:0574-0004|FD-Score:4.20|P-value:3.50E-4 ID:SGTC_897|Compound:1000-0139|FD-Score:5.13|P-value:1.78E-5 ID:SGTC_916|Compound:4466-0038|FD-Score:4.07|P-value:5.07E-4 ID:SGTC_974|Compound:1326-0144|FD-Score:5.54|P-value:4.15E-6 ID:SGTC_975|Compound:1335-0046|FD-Score:5.90|P-value:1.02E-6 ID:SGTC_1179|Compound:1021-1431|FD-Score:4.78|P-value:5.81E-5 ID:SGTC_1260|Compound:0700-1617|FD-Score:4.26|P-value:2.88E-4 ID:SGTC_1317|Compound:1273-0028|FD-Score:4.18|P-value:3.64E-4 ID:SGTC_1326|Compound:1431-2094|FD-Score:21.50|P-value:1.40E-66 ID:SGTC_1374|Compound:2889-5571|FD-Score:8.36|P-value:9.65E-12 ID:SGTC_1401|Compound:3807-4679|FD-Score:12.60|P-value:2.85E-24 ID:SGTC_1433|Compound:4060-0023|FD-Score:15.10|P-value:4.27E-34 ID:SGTC_1437|Compound:4092-1038|FD-Score:4.37|P-value:2.08E-4 ID:SGTC_1493|Compound:4348-0038|FD-Score:4.78|P-value:5.77E-5 ID:SGTC_1566|Compound:6,7-dimethoxy-4-ethylcoumarin|FD-Score:5.93|P-value:9.01E-7 ID:SGTC_1576|Compound:erythromycin ethylsuccinate|FD-Score:4.93|P-value:3.52E-5 ID:SGTC_1643|Compound:st009866|FD-Score:13.50|P-value:1.32E-27 ID:SGTC_1661|Compound:st013063|FD-Score:6.67|P-value:4.08E-8 ID:SGTC_1687|Compound:st020778|FD-Score:5.45|P-value:5.67E-6 ID:SGTC_1712|Compound:st032288|FD-Score:4.81|P-value:5.19E-5 ID:SGTC_1741|Compound:st038134|FD-Score:5.56|P-value:3.80E-6 ID:SGTC_1745|Compound:st081495|FD-Score:4.11|P-value:4.45E-4 ID:SGTC_1754|Compound:st042065|FD-Score:9.88|P-value:1.17E-15 ID:SGTC_1760|Compound:st045453|FD-Score:4.37|P-value:2.11E-4 ID:SGTC_1800|Compound:st050079|FD-Score:4.34|P-value:2.29E-4 ID:SGTC_1803|Compound:st050068|FD-Score:8.24|P-value:1.90E-11 ID:SGTC_1831|Compound:st055328|FD-Score:10.30|P-value:9.10E-17 ID:SGTC_1837|Compound:st055472|FD-Score:-4.36|P-value:3.01E-4 ID:SGTC_1875|Compound:nocodazole|FD-Score:11.40|P-value:2.83E-20 ID:SGTC_1965|Compound:Pectolinarigenin|FD-Score:5.33|P-value:8.94E-6 ID:SGTC_1994|Compound:st072947|FD-Score:4.23|P-value:3.15E-4 ID:SGTC_2004|Compound:4023728|FD-Score:4.10|P-value:4.62E-4 ID:SGTC_2061|Compound:5245884|FD-Score:6.08|P-value:4.99E-7 ID:SGTC_2090|Compound:5301565|FD-Score:4.28|P-value:2.76E-4 ID:SGTC_2125|Compound:5246583|FD-Score:6.30|P-value:2.00E-7 ID:SGTC_2141|Compound:5621638|FD-Score:13.90|P-value:3.95E-29 ID:SGTC_2166|Compound:5933061|FD-Score:7.88|P-value:1.27E-10 ID:SGTC_2173|Compound:5763948|FD-Score:6.15|P-value:3.75E-7 ID:SGTC_2174|Compound:5790901|FD-Score:29.60|P-value:4.85E-124 ID:SGTC_2186|Compound:6124449|FD-Score:6.85|P-value:1.87E-8 ID:SGTC_2188|Compound:6126565|FD-Score:7.15|P-value:4.64E-9 ID:SGTC_2200|Compound:6600604|FD-Score:20.00|P-value:4.13E-58 ID:SGTC_2202|Compound:7226349|FD-Score:6.39|P-value:1.39E-7 ID:SGTC_2233|Compound:sulbentine|FD-Score:5.23|P-value:1.27E-5 ID:SGTC_2254|Compound:7938975|FD-Score:5.02|P-value:2.61E-5 ID:SGTC_2255|Compound:7941087|FD-Score:4.40|P-value:1.93E-4 ID:SGTC_2269|Compound:7935389|FD-Score:7.06|P-value:7.07E-9 ID:SGTC_2277|Compound:7947813|FD-Score:5.09|P-value:2.02E-5 ID:SGTC_2304|Compound:7443016|FD-Score:4.79|P-value:5.68E-5 ID:SGTC_2319|Compound:6033012|FD-Score:28.90|P-value:8.41E-118 ID:SGTC_2352|Compound:9027995|FD-Score:18.10|P-value:1.08E-47 ID:SGTC_2368|Compound:9071271|FD-Score:5.83|P-value:1.34E-6 ID:SGTC_2398|Compound:5228213|FD-Score:-4.12|P-value:5.99E-4 ID:SGTC_2408|Compound:sulbentine|FD-Score:4.42|P-value:1.79E-4 ID:SGTC_2461|Compound:5755302|FD-Score:4.33|P-value:2.38E-4 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:-4.21|P-value:4.64E-4 ID:SGTC_2534|Compound:helenine|FD-Score:7.21|P-value:3.52E-9 ID:SGTC_2556|Compound:citropten|FD-Score:4.15|P-value:4.00E-4 ID:SGTC_2561|Compound:acetosyringone|FD-Score:4.51|P-value:1.35E-4 ID:SGTC_2619|Compound:obliquin|FD-Score:4.49|P-value:1.44E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:6.35|P-value:1.65E-7 ID:SGTC_2696|Compound:st077691|FD-Score:7.25|P-value:2.92E-9 ID:SGTC_2749|Compound:bexarotene|FD-Score:-4.23|P-value:4.39E-4 ID:SGTC_2912|Compound:7964298|FD-Score:7.76|P-value:2.29E-10 ID:SGTC_2947|Compound:9072639|FD-Score:4.09|P-value:4.72E-4 ID:SGTC_2997|Compound:9067075|FD-Score:13.30|P-value:7.67E-27 ID:SGTC_3037|Compound:9091026|FD-Score:4.97|P-value:3.04E-5 ID:SGTC_3142|Compound:9086498|FD-Score:-6.38|P-value:2.31E-7 ID:SGTC_3202|Compound:9113761|FD-Score:-4.00|P-value:8.37E-4 ID:SGTC_3210|Compound:9128157|FD-Score:8.53|P-value:3.82E-12 ID:SGTC_3253|Compound:9135987|FD-Score:4.15|P-value:4.04E-4 ID:SGTC_3282|Compound:9108498|FD-Score:4.77|P-value:5.96E-5 ID:SGTC_3294|Compound:9122953|FD-Score:8.18|P-value:2.64E-11 ID:SGTC_3304|Compound:9125678|FD-Score:5.44|P-value:5.91E-6 ID:SGTC_3311|Compound:9131146|FD-Score:4.99|P-value:2.91E-5 ID:SGTC_3317|Compound:9138495|FD-Score:6.21|P-value:2.98E-7 ID:SGTC_3322|Compound:9139058|FD-Score:5.41|P-value:6.65E-6 ID:SGTC_23|Compound:0213-0011|FD-Score:-4.06|P-value:6.99E-4 ID:SGTC_36|Compound:0335-0881|FD-Score:14.40|P-value:3.35E-31 ID:SGTC_58|Compound:0957-0393|FD-Score:4.89|P-value:4.02E-5 ID:SGTC_64|Compound:000l-0018|FD-Score:5.61|P-value:3.18E-6 ID:SGTC_67|Compound:0335-0847|FD-Score:10.60|P-value:9.62E-18 ID:SGTC_137|Compound:0438-0332|FD-Score:15.20|P-value:3.76E-34 ID:SGTC_138|Compound:0850-0259|FD-Score:6.98|P-value:1.02E-8 ID:SGTC_142|Compound:0335-0849|FD-Score:10.20|P-value:1.43E-16 ID:SGTC_158|Compound:k038-0087|FD-Score:8.31|P-value:1.30E-11 ID:SGTC_161|Compound:4065-0411|FD-Score:8.55|P-value:3.50E-12 ID:SGTC_163|Compound:1327-0036|FD-Score:4.71|P-value:7.28E-5 ID:SGTC_165|Compound:k038-0023|FD-Score:16.80|P-value:1.87E-41 ID:SGTC_200|Compound:k038-0079|FD-Score:11.70|P-value:4.67E-21 ID:SGTC_210|Compound:3551-0445|FD-Score:16.10|P-value:2.74E-38 ID:SGTC_212|Compound:3807-4682|FD-Score:9.83|P-value:1.63E-15 ID:SGTC_216|Compound:k038-0035|FD-Score:10.40|P-value:3.86E-17 ID:SGTC_221|Compound:trifluoperazine|FD-Score:27.00|P-value:1.70E-103 ID:SGTC_229|Compound:benomyl|FD-Score:20.70|P-value:1.52E-61 ID:SGTC_256|Compound:clotrimazole|FD-Score:4.97|P-value:3.13E-5 ID:SGTC_286|Compound:k060-0067|FD-Score:10.40|P-value:3.47E-17 ID:SGTC_294|Compound:k038-0071|FD-Score:4.93|P-value:3.55E-5 ID:SGTC_340|Compound:k038-0059|FD-Score:7.94|P-value:9.32E-11 ID:SGTC_367|Compound:0335-0881|FD-Score:5.42|P-value:6.43E-6 ID:SGTC_375|Compound:3970-0961|FD-Score:3.89|P-value:8.28E-4 ID:SGTC_379|Compound:3970-0972|FD-Score:3.91|P-value:7.93E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:-5.11|P-value:2.76E-5 ID:SGTC_445|Compound:e6 berbamine|FD-Score:4.10|P-value:4.60E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:7.00|P-value:9.36E-9 ID:SGTC_528|Compound:3492-0019|FD-Score:4.23|P-value:3.21E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:-4.18|P-value:5.00E-4 ID:SGTC_589|Compound:1227-0070|FD-Score:8.89|P-value:5.00E-13 ID:SGTC_635|Compound:k038-0028|FD-Score:4.70|P-value:7.49E-5 ID:SGTC_642|Compound:0335-0876|FD-Score:4.62|P-value:9.72E-5 ID:SGTC_666|Compound:0272-0154|FD-Score:4.14|P-value:4.15E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:19.10|P-value:6.64E-53 ID:SGTC_779|Compound:1360-0071|FD-Score:-4.78|P-value:8.26E-5 ID:SGTC_794|Compound:k038-0031|FD-Score:5.25|P-value:1.17E-5 ID:SGTC_825|Compound:1988-2224|FD-Score:11.70|P-value:4.90E-21 ID:SGTC_846|Compound:0335-0850|FD-Score:5.22|P-value:1.29E-5 ID:SGTC_871|Compound:0574-0004|FD-Score:4.20|P-value:3.50E-4 ID:SGTC_897|Compound:1000-0139|FD-Score:5.13|P-value:1.78E-5 ID:SGTC_916|Compound:4466-0038|FD-Score:4.07|P-value:5.07E-4 ID:SGTC_974|Compound:1326-0144|FD-Score:5.54|P-value:4.15E-6 ID:SGTC_975|Compound:1335-0046|FD-Score:5.90|P-value:1.02E-6 ID:SGTC_1179|Compound:1021-1431|FD-Score:4.78|P-value:5.81E-5 ID:SGTC_1260|Compound:0700-1617|FD-Score:4.26|P-value:2.88E-4 ID:SGTC_1317|Compound:1273-0028|FD-Score:4.18|P-value:3.64E-4 ID:SGTC_1326|Compound:1431-2094|FD-Score:21.50|P-value:1.40E-66 ID:SGTC_1374|Compound:2889-5571|FD-Score:8.36|P-value:9.65E-12 ID:SGTC_1401|Compound:3807-4679|FD-Score:12.60|P-value:2.85E-24 ID:SGTC_1433|Compound:4060-0023|FD-Score:15.10|P-value:4.27E-34 ID:SGTC_1437|Compound:4092-1038|FD-Score:4.37|P-value:2.08E-4 ID:SGTC_1493|Compound:4348-0038|FD-Score:4.78|P-value:5.77E-5 ID:SGTC_1566|Compound:6,7-dimethoxy-4-ethylcoumarin|FD-Score:5.93|P-value:9.01E-7 ID:SGTC_1576|Compound:erythromycin ethylsuccinate|FD-Score:4.93|P-value:3.52E-5 ID:SGTC_1643|Compound:st009866|FD-Score:13.50|P-value:1.32E-27 ID:SGTC_1661|Compound:st013063|FD-Score:6.67|P-value:4.08E-8 ID:SGTC_1687|Compound:st020778|FD-Score:5.45|P-value:5.67E-6 ID:SGTC_1712|Compound:st032288|FD-Score:4.81|P-value:5.19E-5 ID:SGTC_1741|Compound:st038134|FD-Score:5.56|P-value:3.80E-6 ID:SGTC_1745|Compound:st081495|FD-Score:4.11|P-value:4.45E-4 ID:SGTC_1754|Compound:st042065|FD-Score:9.88|P-value:1.17E-15 ID:SGTC_1760|Compound:st045453|FD-Score:4.37|P-value:2.11E-4 ID:SGTC_1800|Compound:st050079|FD-Score:4.34|P-value:2.29E-4 ID:SGTC_1803|Compound:st050068|FD-Score:8.24|P-value:1.90E-11 ID:SGTC_1831|Compound:st055328|FD-Score:10.30|P-value:9.10E-17 ID:SGTC_1837|Compound:st055472|FD-Score:-4.36|P-value:3.01E-4 ID:SGTC_1875|Compound:nocodazole|FD-Score:11.40|P-value:2.83E-20 ID:SGTC_1965|Compound:Pectolinarigenin|FD-Score:5.33|P-value:8.94E-6 ID:SGTC_1994|Compound:st072947|FD-Score:4.23|P-value:3.15E-4 ID:SGTC_2004|Compound:4023728|FD-Score:4.10|P-value:4.62E-4 ID:SGTC_2061|Compound:5245884|FD-Score:6.08|P-value:4.99E-7 ID:SGTC_2090|Compound:5301565|FD-Score:4.28|P-value:2.76E-4 ID:SGTC_2125|Compound:5246583|FD-Score:6.30|P-value:2.00E-7 ID:SGTC_2141|Compound:5621638|FD-Score:13.90|P-value:3.95E-29 ID:SGTC_2166|Compound:5933061|FD-Score:7.88|P-value:1.27E-10 ID:SGTC_2173|Compound:5763948|FD-Score:6.15|P-value:3.75E-7 ID:SGTC_2174|Compound:5790901|FD-Score:29.60|P-value:4.85E-124 ID:SGTC_2186|Compound:6124449|FD-Score:6.85|P-value:1.87E-8 ID:SGTC_2188|Compound:6126565|FD-Score:7.15|P-value:4.64E-9 ID:SGTC_2200|Compound:6600604|FD-Score:20.00|P-value:4.13E-58 ID:SGTC_2202|Compound:7226349|FD-Score:6.39|P-value:1.39E-7 ID:SGTC_2233|Compound:sulbentine|FD-Score:5.23|P-value:1.27E-5 ID:SGTC_2254|Compound:7938975|FD-Score:5.02|P-value:2.61E-5 ID:SGTC_2255|Compound:7941087|FD-Score:4.40|P-value:1.93E-4 ID:SGTC_2269|Compound:7935389|FD-Score:7.06|P-value:7.07E-9 ID:SGTC_2277|Compound:7947813|FD-Score:5.09|P-value:2.02E-5 ID:SGTC_2304|Compound:7443016|FD-Score:4.79|P-value:5.68E-5 ID:SGTC_2319|Compound:6033012|FD-Score:28.90|P-value:8.41E-118 ID:SGTC_2352|Compound:9027995|FD-Score:18.10|P-value:1.08E-47 ID:SGTC_2368|Compound:9071271|FD-Score:5.83|P-value:1.34E-6 ID:SGTC_2398|Compound:5228213|FD-Score:-4.12|P-value:5.99E-4 ID:SGTC_2408|Compound:sulbentine|FD-Score:4.42|P-value:1.79E-4 ID:SGTC_2461|Compound:5755302|FD-Score:4.33|P-value:2.38E-4 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:-4.21|P-value:4.64E-4 ID:SGTC_2534|Compound:helenine|FD-Score:7.21|P-value:3.52E-9 ID:SGTC_2556|Compound:citropten|FD-Score:4.15|P-value:4.00E-4 ID:SGTC_2561|Compound:acetosyringone|FD-Score:4.51|P-value:1.35E-4 ID:SGTC_2619|Compound:obliquin|FD-Score:4.49|P-value:1.44E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:6.35|P-value:1.65E-7 ID:SGTC_2696|Compound:st077691|FD-Score:7.25|P-value:2.92E-9 ID:SGTC_2749|Compound:bexarotene|FD-Score:-4.23|P-value:4.39E-4 ID:SGTC_2912|Compound:7964298|FD-Score:7.76|P-value:2.29E-10 ID:SGTC_2947|Compound:9072639|FD-Score:4.09|P-value:4.72E-4 ID:SGTC_2997|Compound:9067075|FD-Score:13.30|P-value:7.67E-27 ID:SGTC_3037|Compound:9091026|FD-Score:4.97|P-value:3.04E-5 ID:SGTC_3142|Compound:9086498|FD-Score:-6.38|P-value:2.31E-7 ID:SGTC_3202|Compound:9113761|FD-Score:-4.00|P-value:8.37E-4 ID:SGTC_3210|Compound:9128157|FD-Score:8.53|P-value:3.82E-12 ID:SGTC_3253|Compound:9135987|FD-Score:4.15|P-value:4.04E-4 ID:SGTC_3282|Compound:9108498|FD-Score:4.77|P-value:5.96E-5 ID:SGTC_3294|Compound:9122953|FD-Score:8.18|P-value:2.64E-11 ID:SGTC_3304|Compound:9125678|FD-Score:5.44|P-value:5.91E-6 ID:SGTC_3311|Compound:9131146|FD-Score:4.99|P-value:2.91E-5 ID:SGTC_3317|Compound:9138495|FD-Score:6.21|P-value:2.98E-7 ID:SGTC_3322|Compound:9139058|FD-Score:5.41|P-value:6.65E-6

Top fitness defect scores for YML041C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2174 5790901 29.60 200.0 µM 4.85E-124 tubulin folding & SWR complex 1 3.74E-193
2 SGTC_2319 6033012 28.90 152.6 µM 8.41E-118 tubulin folding & SWR complex 1 2.33E-183
3 SGTC_221 trifluoperazine 27.00 10.3 µM 1.70E-103 NEO1-PIK1 3 6.57E-161
4 SGTC_1326 1431-2094 21.50 10.8 µM 1.40E-66 tubulin folding & SWR complex 1 5.36E-103
5 SGTC_229 benomyl 20.70 22.9 µM 1.52E-61 tubulin folding & SWR complex 3 4.17E-95
6 SGTC_2200 6600604 20.00 21.9 µM 4.13E-58 tubulin folding & SWR complex 1 1.01E-89
7 SGTC_673 1082-0474 19.10 110.0 µM 6.64E-53 RSC complex & mRNA processing 1 1.45E-81
8 SGTC_2352 9027995 18.10 87.8 µM 1.08E-47 tubulin folding & SWR complex 1 2.11E-73
9 SGTC_165 k038-0023 16.80 64.4 µM 1.87E-41 ubiquinone biosynthesis & proteasome 1 1.24E-63
10 SGTC_210 3551-0445 16.10 56.8 µM 2.74E-38 7 1.12E-58
11 SGTC_137 0438-0332 15.20 85.4 µM 3.76E-34 ubiquinone biosynthesis & proteasome 14 3.33E-52
12 SGTC_1433 4060-0023 15.10 7.6 µM 4.27E-34 tubulin folding & SWR complex 1 4.06E-52
13 SGTC_36 0335-0881 14.40 14.2 µM 3.35E-31 ubiquinone biosynthesis & proteasome 12 1.37E-47
14 SGTC_2141 5621638 13.90 7.7 µM 3.95E-29 tubulin folding & SWR complex 3 2.37E-44
15 SGTC_1643 st009866 13.50 20.2 µM 1.32E-27 6 5.68E-42
16 SGTC_2997 9067075 13.30 71.4 µM 7.67E-27 unfolded protein response 4 8.92E-41
17 SGTC_1401 3807-4679 12.60 7.6 µM 2.85E-24 tubulin folding & SWR complex 2 9.22E-37
18 SGTC_200 k038-0079 11.70 37.5 µM 4.67E-21 ubiquinone biosynthesis & proteasome 3 9.59E-32
19 SGTC_825 1988-2224 11.70 89.6 µM 4.90E-21 cell wall signaling 3 1.03E-31
20 SGTC_1875 nocodazole 11.40 6.0 µM 2.83E-20 tubulin folding & SWR complex 11 1.60E-30

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.717 0 YLR085C ARP6 hom Actin-related protein that binds nucleosomes; a component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A
0.680 0 YAL011W SWC3 hom Protein of unknown function, component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for formation of nuclear-associated array of smooth endoplasmic reticulum known as karmellae
0.663 0 YDR334W SWR1 hom Swi2/Snf2-related ATPase that is the structural component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A
0.633 0 YDR485C VPS72 hom Htz1p-binding component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for vacuolar protein sorting
0.592 3.56E-316 YBR231C SWC5 hom Component of the SWR1 complex; complex exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; protein abundance increases in response to DNA replication stress
0.517 1.09E-228 YER007W PAC2 hom Microtubule effector required for tubulin heterodimer formation, binds alpha-tubulin, required for normal microtubule function, null mutant exhibits cold-sensitive microtubules and sensitivity to benomyl
0.494 4.56E-205 YML124C TUB3 hom Alpha-tubulin; associates with beta-tubulin (Tub2p) to form tubulin dimer, which polymerizes to form microtubules; expressed at lower level than Tub1p; TUB3 has a paralog, TUB1, that arose from the whole genome duplication
0.437 1.89E-156 YOR349W CIN1 hom Tubulin folding factor D involved in beta-tubulin (Tub2p) folding; isolated as mutant with increased chromosome loss and sensitivity to benomyl
0.408 2.13E-134 YOL012C HTZ1 hom Histone variant H2AZ, exchanged for histone H2A in nucleosomes by the SWR1 complex; involved in transcriptional regulation through prevention of the spread of silent heterochromatin
0.390 2.76E-122 YPL241C CIN2 hom GTPase-activating protein (GAP) for Cin4p; tubulin folding factor C involved in beta-tubulin (Tub2p) folding; mutants display increased chromosome loss and benomyl sensitivity; deletion complemented by human GAP, retinitis pigmentosa 2
0.321 2.72E-81 YJL168C SET2 hom Histone methyltransferase with a role in transcriptional elongation; methylates H3 lysine 36, which suppresses incorporation of acetylated histones and signals for the deacetylation of these histones within transcribed genes; associates with the C-terminal domain of Rpo21p; histone methylation activity is regulated by phosphorylation status of Rpo21p
0.311 3.68E-76 YNL107W YAF9 hom Subunit of both the NuA4 histone H4 acetyltransferase complex and the SWR1 complex, may function to antagonize silencing near telomeres; interacts directly with Swc4p, has homology to human leukemogenic protein AF9, contains a YEATS domain
0.303 4.80E-72 YKL025C PAN3 hom Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex, which acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes
0.287 1.14E-64 YGL094C PAN2 hom Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex, which acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes
0.277 6.99E-60 YOR254C SEC63 het Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER