YML043C / RRN11

Component of the core factor (CF) rDNA transcription factor complex; CF is required for transcription of 35S rRNA genes by RNA polymerase I and is composed of Rrn6p, Rrn7p, and Rrn11p

Zygosity: Heterozygous strain
fixedexpanded
Profile for YML043C / RRN11

Click on Significant Values for Screen Details ID:SGTC_2|Compound:0422-0095|FD-Score:3.19|P-value:2.03E-4 ID:SGTC_7|Compound:0192-1582|FD-Score:4.28|P-value:1.18E-6 ID:SGTC_57|Compound:miconazole|FD-Score:2.79|P-value:9.65E-4 ID:SGTC_135|Compound:0933-0004|FD-Score:3.51|P-value:5.11E-5 ID:SGTC_231|Compound:b-estradiol|FD-Score:-3.11|P-value:4.82E-4 ID:SGTC_294|Compound:k038-0071|FD-Score:2.97|P-value:4.93E-4 ID:SGTC_348|Compound:k064-0012|FD-Score:3.50|P-value:5.47E-5 ID:SGTC_395|Compound:anisomycin|FD-Score:3.35|P-value:1.04E-4 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:-2.92|P-value:9.54E-4 ID:SGTC_439|Compound:amiodarone|FD-Score:3.20|P-value:1.99E-4 ID:SGTC_500|Compound:h-89|FD-Score:2.97|P-value:4.98E-4 ID:SGTC_573|Compound:3702-0553|FD-Score:-3.04|P-value:6.25E-4 ID:SGTC_598|Compound:3937-0236|FD-Score:3.41|P-value:8.03E-5 ID:SGTC_734|Compound:2023-0417|FD-Score:3.01|P-value:4.19E-4 ID:SGTC_804|Compound:1595-0054|FD-Score:-3.93|P-value:1.37E-5 ID:SGTC_859|Compound:0439-0102|FD-Score:3.13|P-value:2.67E-4 ID:SGTC_960|Compound:1222-0186|FD-Score:-2.93|P-value:9.44E-4 ID:SGTC_1241|Compound:0364-0022|FD-Score:-3.53|P-value:8.31E-5 ID:SGTC_1243|Compound:0416-0003|FD-Score:-4.66|P-value:3.00E-7 ID:SGTC_1251|Compound:0490-5699|FD-Score:3.36|P-value:1.02E-4 ID:SGTC_1573|Compound:oleylamine|FD-Score:3.06|P-value:3.46E-4 ID:SGTC_1616|Compound:st002734|FD-Score:3.30|P-value:1.27E-4 ID:SGTC_1622|Compound:st003707|FD-Score:-3.60|P-value:6.28E-5 ID:SGTC_1633|Compound:st005664|FD-Score:-3.60|P-value:6.30E-5 ID:SGTC_1644|Compound:st010134|FD-Score:3.03|P-value:3.86E-4 ID:SGTC_1648|Compound:st011736|FD-Score:-3.27|P-value:2.47E-4 ID:SGTC_1667|Compound:st014849|FD-Score:3.54|P-value:4.60E-5 ID:SGTC_1740|Compound:st038286|FD-Score:-4.92|P-value:6.74E-8 ID:SGTC_1851|Compound:st056236|FD-Score:3.05|P-value:3.64E-4 ID:SGTC_1894|Compound:3',6'-dihydroxyflavone|FD-Score:3.00|P-value:4.39E-4 ID:SGTC_1904|Compound:st060225|FD-Score:-3.28|P-value:2.40E-4 ID:SGTC_2001|Compound:4023502|FD-Score:-3.48|P-value:1.04E-4 ID:SGTC_2350|Compound:9023895|FD-Score:4.39|P-value:6.76E-7 ID:SGTC_2352|Compound:9027995|FD-Score:-2.97|P-value:8.06E-4 ID:SGTC_2356|Compound:9061756|FD-Score:-4.17|P-value:4.18E-6 ID:SGTC_2358|Compound:9037157|FD-Score:3.98|P-value:5.72E-6 ID:SGTC_2362|Compound:9071156|FD-Score:4.01|P-value:4.94E-6 ID:SGTC_2363|Compound:9053361|FD-Score:3.61|P-value:3.38E-5 ID:SGTC_2364|Compound:9055074|FD-Score:-5.21|P-value:1.14E-8 ID:SGTC_2463|Compound:5473429|FD-Score:3.61|P-value:3.37E-5 ID:SGTC_2479|Compound:5617353|FD-Score:2.86|P-value:7.52E-4 ID:SGTC_2493|Compound:resveratrol|FD-Score:4.06|P-value:3.69E-6 ID:SGTC_2504|Compound:purpurogallin|FD-Score:2.95|P-value:5.32E-4 ID:SGTC_2507|Compound:purpurin|FD-Score:2.81|P-value:9.06E-4 ID:SGTC_2749|Compound:bexarotene|FD-Score:3.69|P-value:2.28E-5 ID:SGTC_2780|Compound:5215298|FD-Score:5.80|P-value:9.54E-11 ID:SGTC_2|Compound:0422-0095|FD-Score:3.19|P-value:2.03E-4 ID:SGTC_7|Compound:0192-1582|FD-Score:4.28|P-value:1.18E-6 ID:SGTC_57|Compound:miconazole|FD-Score:2.79|P-value:9.65E-4 ID:SGTC_135|Compound:0933-0004|FD-Score:3.51|P-value:5.11E-5 ID:SGTC_231|Compound:b-estradiol|FD-Score:-3.11|P-value:4.82E-4 ID:SGTC_294|Compound:k038-0071|FD-Score:2.97|P-value:4.93E-4 ID:SGTC_348|Compound:k064-0012|FD-Score:3.50|P-value:5.47E-5 ID:SGTC_395|Compound:anisomycin|FD-Score:3.35|P-value:1.04E-4 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:-2.92|P-value:9.54E-4 ID:SGTC_439|Compound:amiodarone|FD-Score:3.20|P-value:1.99E-4 ID:SGTC_500|Compound:h-89|FD-Score:2.97|P-value:4.98E-4 ID:SGTC_573|Compound:3702-0553|FD-Score:-3.04|P-value:6.25E-4 ID:SGTC_598|Compound:3937-0236|FD-Score:3.41|P-value:8.03E-5 ID:SGTC_734|Compound:2023-0417|FD-Score:3.01|P-value:4.19E-4 ID:SGTC_804|Compound:1595-0054|FD-Score:-3.93|P-value:1.37E-5 ID:SGTC_859|Compound:0439-0102|FD-Score:3.13|P-value:2.67E-4 ID:SGTC_960|Compound:1222-0186|FD-Score:-2.93|P-value:9.44E-4 ID:SGTC_1241|Compound:0364-0022|FD-Score:-3.53|P-value:8.31E-5 ID:SGTC_1243|Compound:0416-0003|FD-Score:-4.66|P-value:3.00E-7 ID:SGTC_1251|Compound:0490-5699|FD-Score:3.36|P-value:1.02E-4 ID:SGTC_1573|Compound:oleylamine|FD-Score:3.06|P-value:3.46E-4 ID:SGTC_1616|Compound:st002734|FD-Score:3.30|P-value:1.27E-4 ID:SGTC_1622|Compound:st003707|FD-Score:-3.60|P-value:6.28E-5 ID:SGTC_1633|Compound:st005664|FD-Score:-3.60|P-value:6.30E-5 ID:SGTC_1644|Compound:st010134|FD-Score:3.03|P-value:3.86E-4 ID:SGTC_1648|Compound:st011736|FD-Score:-3.27|P-value:2.47E-4 ID:SGTC_1667|Compound:st014849|FD-Score:3.54|P-value:4.60E-5 ID:SGTC_1740|Compound:st038286|FD-Score:-4.92|P-value:6.74E-8 ID:SGTC_1851|Compound:st056236|FD-Score:3.05|P-value:3.64E-4 ID:SGTC_1894|Compound:3',6'-dihydroxyflavone|FD-Score:3.00|P-value:4.39E-4 ID:SGTC_1904|Compound:st060225|FD-Score:-3.28|P-value:2.40E-4 ID:SGTC_2001|Compound:4023502|FD-Score:-3.48|P-value:1.04E-4 ID:SGTC_2350|Compound:9023895|FD-Score:4.39|P-value:6.76E-7 ID:SGTC_2352|Compound:9027995|FD-Score:-2.97|P-value:8.06E-4 ID:SGTC_2356|Compound:9061756|FD-Score:-4.17|P-value:4.18E-6 ID:SGTC_2358|Compound:9037157|FD-Score:3.98|P-value:5.72E-6 ID:SGTC_2362|Compound:9071156|FD-Score:4.01|P-value:4.94E-6 ID:SGTC_2363|Compound:9053361|FD-Score:3.61|P-value:3.38E-5 ID:SGTC_2364|Compound:9055074|FD-Score:-5.21|P-value:1.14E-8 ID:SGTC_2463|Compound:5473429|FD-Score:3.61|P-value:3.37E-5 ID:SGTC_2479|Compound:5617353|FD-Score:2.86|P-value:7.52E-4 ID:SGTC_2493|Compound:resveratrol|FD-Score:4.06|P-value:3.69E-6 ID:SGTC_2504|Compound:purpurogallin|FD-Score:2.95|P-value:5.32E-4 ID:SGTC_2507|Compound:purpurin|FD-Score:2.81|P-value:9.06E-4 ID:SGTC_2749|Compound:bexarotene|FD-Score:3.69|P-value:2.28E-5 ID:SGTC_2780|Compound:5215298|FD-Score:5.80|P-value:9.54E-11

Top fitness defect scores for YML043C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2780 5215298 5.80 71.4 µM 9.54E-11 6 3.28E-9 0.51
2 SGTC_2350 9023895 4.39 38.9 µM 6.76E-7 ergosterol biosynthesis 5 5.77E-6 0.24
3 SGTC_7 0192-1582 4.28 4.2 µM 1.18E-6 1 9.21E-6 0.30
4 SGTC_2493 resveratrol 4.06 26.1 µM 3.69E-6 2 2.41E-5 0.07
5 SGTC_2362 9071156 4.01 126.0 µM 4.94E-6 2 3.08E-5 0.28
6 SGTC_2358 9037157 3.98 4.0 µM 5.72E-6 13 3.49E-5 0.04
7 SGTC_2749 bexarotene 3.69 57.4 µM 2.28E-5 6 1.12E-4 0.01
8 SGTC_2463 5473429 3.61 200.0 µM 3.37E-5 ERG2 7 1.55E-4 0.21
9 SGTC_2363 9053361 3.61 176.0 µM 3.38E-5 Golgi 13 1.55E-4 0.02
10 SGTC_1667 st014849 3.54 34.6 µM 4.60E-5 Golgi 4 2.02E-4 0.05
11 SGTC_135 0933-0004 3.51 26.4 µM 5.11E-5 60S ribosome export 9 2.21E-4 0.03
12 SGTC_348 k064-0012 3.50 10.7 µM 5.47E-5 60S ribosome export 10 2.34E-4 0.01
13 SGTC_598 3937-0236 3.41 20.2 µM 8.03E-5 ERG2 8 3.23E-4 0.11
14 SGTC_1251 0490-5699 3.36 265.0 µM 1.02E-4 12 3.96E-4 0.04
15 SGTC_395 anisomycin 3.35 6.2 µM 1.04E-4 8 4.03E-4 0.12
16 SGTC_1616 st002734 3.30 56.1 µM 1.27E-4 13 4.76E-4 0.05
17 SGTC_439 amiodarone 3.20 34.4 µM 1.99E-4 NEO1-PIK1 16 6.92E-4 0.02
18 SGTC_2 0422-0095 3.19 29.0 µM 2.03E-4 redox potentiating 10 7.05E-4 0.04
19 SGTC_859 0439-0102 3.13 54.6 µM 2.67E-4 redox potentiating 21 8.88E-4 0.07
20 SGTC_1573 oleylamine 3.06 1.1 µM 3.46E-4 13 0.00110 0.04

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.119 4.28E-12 YLR449W FPR4 hom Peptidyl-prolyl cis-trans isomerase (PPIase) (proline isomerase) localized to the nucleus; catalyzes isomerization of proline residues in histones H3 and H4, which affects lysine methylation of those histones
0.118 7.01E-12 YER115C SPR6 hom Protein of unknown function, expressed during sporulation; not required for sporulation, but gene exhibits genetic interactions with other genes required for sporulation
0.107 4.61E-10 YEL026W SNU13 het RNA binding protein, part of U3 snoRNP involved in rRNA processing, part of U4/U6-U5 tri-snRNP involved in mRNA splicing, similar to human 15.5K protein
0.107 4.93E-10 YBR221C PDB1 hom E1 beta subunit of the pyruvate dehydrogenase (PDH) complex, which is an evolutionarily-conserved multi-protein complex found in mitochondria
0.104 1.46E-9 YCL039W GID7 hom Subunit of GID Complex that binds directly to central component Vid30p; GID complex is involved in proteasome-dependent catabolite inactivation of fructose-1,6-bisphosphatase; Gid7p contains six WD40 repeats; computational analysis suggests that Gid7p and Moh1p have similar functions
0.102 2.98E-9 YGR129W SYF2 hom Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; isy1 syf2 cells have defective spindles activiating cell cycle arrest
0.097 1.61E-8 YOR105W_p YOR105W_p hom Protein of unknown function; expressed at both mRNA and protein levels
0.094 5.38E-8 YER052C HOM3 hom Aspartate kinase (L-aspartate 4-P-transferase); cytoplasmic enzyme that catalyzes the first step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis
0.092 8.31E-8 YNL215W IES2 hom Protein that associates with the INO80 chromatin remodeling complex; associates with the INO80 complex under low-salt conditions; essential for growth under anaerobic conditions; protein abundance increases in response to DNA replication stress
0.092 9.58E-8 YBR258C SHG1 hom Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres
0.090 2.03E-7 YGL194C HOS2 hom Histone deacetylase and subunit of Set3 and Rpd3L complexes; required for gene activation via specific deacetylation of lysines in H3 and H4 histone tails; subunit of the Set3 complex, a meiotic-specific repressor of sporulation specific genes that contains deacetylase activity; co-localizes with Cmr1p in nuclear foci in response to DNA damage by MMS
0.088 3.56E-7 YGL262W_p YGL262W_p hom Putative protein of unknown function; null mutant displays elevated sensitivity to expression of a mutant huntingtin fragment or of alpha-synuclein; YGL262W is not an essential gene
0.084 1.14E-6 YCR073C SSK22 hom MAP kinase kinase kinase of the HOG1 mitogen-activated signaling pathway; functionally redundant with, and homologous to, Ssk2p; interacts with and is activated by Ssk1p; phosphorylates Pbs2p
0.082 1.78E-6 YDL149W ATG9 hom Transmembrane protein involved in forming Cvt and autophagic vesicles; cycles between the phagophore assembly site (PAS) and other cytosolic punctate structures, not found in autophagosomes; may be involved in membrane delivery to the PAS
0.081 2.72E-6 YDR044W HEM13 het Coproporphyrinogen III oxidase, an oxygen requiring enzyme that catalyzes the sixth step in the heme biosynthetic pathway; transcription is repressed by oxygen and heme (via Rox1p and Hap1p)