YML046W / PRP39

U1 snRNP protein involved in splicing, contains multiple tetriatricopeptide repeats

Zygosity: Heterozygous strain
fixedexpanded
Profile for YML046W / PRP39

Click on Significant Values for Screen Details ID:SGTC_44|Compound:0929-0055|FD-Score:-4.46|P-value:5.95E-8 ID:SGTC_164|Compound:4100-3994|FD-Score:3.67|P-value:6.60E-6 ID:SGTC_372|Compound:0155-0182|FD-Score:-5.53|P-value:2.53E-11 ID:SGTC_758|Compound:0868-0029|FD-Score:-5.63|P-value:1.17E-11 ID:SGTC_763|Compound:3453-1109|FD-Score:3.09|P-value:1.20E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:-3.18|P-value:7.73E-5 ID:SGTC_852|Compound:0418-0143|FD-Score:2.98|P-value:2.03E-4 ID:SGTC_874|Compound:0599-0792|FD-Score:2.68|P-value:7.28E-4 ID:SGTC_917|Compound:harmaline|FD-Score:3.01|P-value:1.79E-4 ID:SGTC_1004|Compound:4084-0029|FD-Score:2.71|P-value:6.40E-4 ID:SGTC_1273|Compound:0849-0096|FD-Score:2.73|P-value:5.97E-4 ID:SGTC_1338|Compound:1486-1223|FD-Score:3.66|P-value:7.08E-6 ID:SGTC_1573|Compound:oleylamine|FD-Score:-2.80|P-value:4.34E-4 ID:SGTC_1602|Compound:st001878|FD-Score:5.01|P-value:1.36E-9 ID:SGTC_1619|Compound:st003326|FD-Score:3.94|P-value:1.49E-6 ID:SGTC_1659|Compound:st012954|FD-Score:2.82|P-value:4.10E-4 ID:SGTC_1784|Compound:st039334|FD-Score:2.86|P-value:3.43E-4 ID:SGTC_1917|Compound:st066507|FD-Score:3.54|P-value:1.32E-5 ID:SGTC_2013|Compound:4024628|FD-Score:3.40|P-value:2.76E-5 ID:SGTC_2111|Compound:5486399|FD-Score:-2.69|P-value:6.83E-4 ID:SGTC_2265|Compound:7929201|FD-Score:-3.38|P-value:3.03E-5 ID:SGTC_2312|Compound:7706453|FD-Score:3.53|P-value:1.41E-5 ID:SGTC_2412|Compound:st077135|FD-Score:3.03|P-value:1.60E-4 ID:SGTC_2413|Compound:inermin|FD-Score:3.90|P-value:1.80E-6 ID:SGTC_2465|Compound:5809242|FD-Score:-3.15|P-value:9.00E-5 ID:SGTC_2580|Compound:diallyl disulphide|FD-Score:-2.85|P-value:3.57E-4 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:2.94|P-value:2.42E-4 ID:SGTC_2630|Compound:antimycin a|FD-Score:4.11|P-value:5.28E-7 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:4.35|P-value:1.24E-7 ID:SGTC_2688|Compound:kanamycin b|FD-Score:-4.62|P-value:2.07E-8 ID:SGTC_2689|Compound:tacrolimus|FD-Score:3.68|P-value:6.40E-6 ID:SGTC_2750|Compound:bromebric acid|FD-Score:2.80|P-value:4.44E-4 ID:SGTC_2760|Compound:etidronate|FD-Score:-2.64|P-value:8.66E-4 ID:SGTC_2766|Compound:oltipraz|FD-Score:3.14|P-value:9.49E-5 ID:SGTC_2775|Compound:cyproheptadine|FD-Score:-3.34|P-value:3.65E-5 ID:SGTC_2810|Compound:7959871|FD-Score:2.69|P-value:6.93E-4 ID:SGTC_2929|Compound:9013348|FD-Score:2.90|P-value:2.93E-4 ID:SGTC_2933|Compound:9026794|FD-Score:3.60|P-value:9.79E-6 ID:SGTC_2939|Compound:9044578|FD-Score:2.94|P-value:2.46E-4 ID:SGTC_3062|Compound:9077494|FD-Score:-6.28|P-value:4.23E-14 ID:SGTC_3140|Compound:9094243|FD-Score:-2.64|P-value:8.46E-4 ID:SGTC_3177|Compound:9107506|FD-Score:2.81|P-value:4.20E-4 ID:SGTC_3202|Compound:9113761|FD-Score:2.96|P-value:2.17E-4 ID:SGTC_3207|Compound:9114163|FD-Score:3.83|P-value:2.79E-6 ID:SGTC_3300|Compound:9124615|FD-Score:2.84|P-value:3.72E-4 ID:SGTC_44|Compound:0929-0055|FD-Score:-4.46|P-value:5.95E-8 ID:SGTC_164|Compound:4100-3994|FD-Score:3.67|P-value:6.60E-6 ID:SGTC_372|Compound:0155-0182|FD-Score:-5.53|P-value:2.53E-11 ID:SGTC_758|Compound:0868-0029|FD-Score:-5.63|P-value:1.17E-11 ID:SGTC_763|Compound:3453-1109|FD-Score:3.09|P-value:1.20E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:-3.18|P-value:7.73E-5 ID:SGTC_852|Compound:0418-0143|FD-Score:2.98|P-value:2.03E-4 ID:SGTC_874|Compound:0599-0792|FD-Score:2.68|P-value:7.28E-4 ID:SGTC_917|Compound:harmaline|FD-Score:3.01|P-value:1.79E-4 ID:SGTC_1004|Compound:4084-0029|FD-Score:2.71|P-value:6.40E-4 ID:SGTC_1273|Compound:0849-0096|FD-Score:2.73|P-value:5.97E-4 ID:SGTC_1338|Compound:1486-1223|FD-Score:3.66|P-value:7.08E-6 ID:SGTC_1573|Compound:oleylamine|FD-Score:-2.80|P-value:4.34E-4 ID:SGTC_1602|Compound:st001878|FD-Score:5.01|P-value:1.36E-9 ID:SGTC_1619|Compound:st003326|FD-Score:3.94|P-value:1.49E-6 ID:SGTC_1659|Compound:st012954|FD-Score:2.82|P-value:4.10E-4 ID:SGTC_1784|Compound:st039334|FD-Score:2.86|P-value:3.43E-4 ID:SGTC_1917|Compound:st066507|FD-Score:3.54|P-value:1.32E-5 ID:SGTC_2013|Compound:4024628|FD-Score:3.40|P-value:2.76E-5 ID:SGTC_2111|Compound:5486399|FD-Score:-2.69|P-value:6.83E-4 ID:SGTC_2265|Compound:7929201|FD-Score:-3.38|P-value:3.03E-5 ID:SGTC_2312|Compound:7706453|FD-Score:3.53|P-value:1.41E-5 ID:SGTC_2412|Compound:st077135|FD-Score:3.03|P-value:1.60E-4 ID:SGTC_2413|Compound:inermin|FD-Score:3.90|P-value:1.80E-6 ID:SGTC_2465|Compound:5809242|FD-Score:-3.15|P-value:9.00E-5 ID:SGTC_2580|Compound:diallyl disulphide|FD-Score:-2.85|P-value:3.57E-4 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:2.94|P-value:2.42E-4 ID:SGTC_2630|Compound:antimycin a|FD-Score:4.11|P-value:5.28E-7 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:4.35|P-value:1.24E-7 ID:SGTC_2688|Compound:kanamycin b|FD-Score:-4.62|P-value:2.07E-8 ID:SGTC_2689|Compound:tacrolimus|FD-Score:3.68|P-value:6.40E-6 ID:SGTC_2750|Compound:bromebric acid|FD-Score:2.80|P-value:4.44E-4 ID:SGTC_2760|Compound:etidronate|FD-Score:-2.64|P-value:8.66E-4 ID:SGTC_2766|Compound:oltipraz|FD-Score:3.14|P-value:9.49E-5 ID:SGTC_2775|Compound:cyproheptadine|FD-Score:-3.34|P-value:3.65E-5 ID:SGTC_2810|Compound:7959871|FD-Score:2.69|P-value:6.93E-4 ID:SGTC_2929|Compound:9013348|FD-Score:2.90|P-value:2.93E-4 ID:SGTC_2933|Compound:9026794|FD-Score:3.60|P-value:9.79E-6 ID:SGTC_2939|Compound:9044578|FD-Score:2.94|P-value:2.46E-4 ID:SGTC_3062|Compound:9077494|FD-Score:-6.28|P-value:4.23E-14 ID:SGTC_3140|Compound:9094243|FD-Score:-2.64|P-value:8.46E-4 ID:SGTC_3177|Compound:9107506|FD-Score:2.81|P-value:4.20E-4 ID:SGTC_3202|Compound:9113761|FD-Score:2.96|P-value:2.17E-4 ID:SGTC_3207|Compound:9114163|FD-Score:3.83|P-value:2.79E-6 ID:SGTC_3300|Compound:9124615|FD-Score:2.84|P-value:3.72E-4

Top fitness defect scores for YML046W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1602 st001878 5.01 87.6 µM 1.36E-9 2 2.72E-7 0.41
2 SGTC_2636 apigenin dimethyl ether 4.35 100.0 µM 1.24E-7 10 6.94E-6 0.39
3 SGTC_2630 antimycin a 4.11 100.0 µM 5.28E-7 mitochondrial processes 8 1.97E-5 0.10
4 SGTC_1619 st003326 3.94 88.7 µM 1.49E-6 60S ribosome export 3 4.14E-5 0.15
5 SGTC_2413 inermin 3.90 26.1 µM 1.80E-6 18 4.75E-5 0.01
6 SGTC_3207 9114163 3.83 49.5 µM 2.79E-6 11 6.52E-5 0.04
7 SGTC_2689 tacrolimus 3.68 100.0 µM 6.40E-6 15 1.19E-4 0.04
8 SGTC_164 4100-3994 3.67 89.6 µM 6.60E-6 9 1.21E-4 0.15
9 SGTC_1338 1486-1223 3.66 76.0 µM 7.08E-6 3 1.27E-4 0.10
10 SGTC_2933 9026794 3.60 32.5 µM 9.79E-6 6 1.61E-4 0.09
11 SGTC_1917 st066507 3.54 28.5 µM 1.32E-5 Golgi 13 2.00E-4 0.02
12 SGTC_2312 7706453 3.53 155.7 µM 1.41E-5 18 2.09E-4 0.14
13 SGTC_2013 4024628 3.40 200.0 µM 2.76E-5 12 3.41E-4 0.09
14 SGTC_2766 oltipraz 3.14 83.9 µM 9.49E-5 heme requiring 29 8.33E-4 0.20
15 SGTC_763 3453-1109 3.09 128.0 µM 1.20E-4 14 9.86E-4 0.11
16 SGTC_2412 st077135 3.03 33.4 µM 1.60E-4 15 0.00122 0.02
17 SGTC_917 harmaline 3.01 728.1 nM 1.79E-4 ergosterol biosynthesis 17 0.00132 0.08
18 SGTC_852 0418-0143 2.98 439.0 µM 2.03E-4 calcium & mitochondrial duress 26 0.00145 0.05
19 SGTC_3202 9113761 2.96 49.5 µM 2.17E-4 28 0.00151 0.02
20 SGTC_2588 indole-3-carbinol 2.94 100.0 µM 2.42E-4 23 0.00164 0.02

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.235 2.59E-43 YHL045W_d YHL045W_d hom Putative protein of unknown function; not an essential gene
0.214 4.56E-36 YER172C BRR2 het RNA-dependent ATPase RNA helicase (DEIH box); required for disruption of U4/U6 base-pairing in native snRNPs to activate the spliceosome for catalysis; homologous to human U5-200kD
0.199 2.49E-31 YPL246C RBD2 hom Possible rhomboid protease, has similarity to eukaryotic rhomboid proteases including Pcp1p
0.195 3.32E-30 YDL155W CLB3 hom B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the G2/M transition; may be involved in DNA replication and spindle assembly; accumulates during S phase and G2, then targeted for ubiquitin-mediated degradation; relative distribution to the nucleus increases upon DNA replication stress
0.188 3.70E-28 YML029W USA1 hom Scaffold subunit of the Hrd1p ubiquitin ligase that also promotes ligase oligomerization; involved in ER-associated protein degradation (ERAD); interacts with the U1 snRNP-specific protein, Snp1p
0.172 1.12E-23 YLR034C SMF3 hom Putative divalent metal ion transporter involved in iron homeostasis; transcriptionally regulated by metal ions; member of the Nramp family of metal transport proteins; protein abundance increases in response to DNA replication stress
0.171 1.54E-23 YLR040C_p YLR040C_p hom Protein of unknown function; localizes to the cell wall; predicted to be a GPI-attached protein; upregulated by Mcm1p-Alpha1p transcription factor; partially overlaps the dubious ORF YLR041W; mRNA identified as translated by ribosome profiling data; YLR040C is not essential
0.171 2.57E-23 YGL090W LIF1 hom Component of the DNA ligase IV complex that mediates nonhomologous end joining in DNA double-strand break repair; physically interacts with Dnl4p and Nej1p; homologous to mammalian XRCC4 protein
0.170 2.91E-23 YIL009W FAA3 hom Long chain fatty acyl-CoA synthetase, activates imported fatty acids; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
0.165 5.72E-22 YOR271C_p FSF1_p hom Putative protein, predicted to be an alpha-isopropylmalate carrier; belongs to the sideroblastic-associated protein family; non-tagged protein is detected in purified mitochondria; likely to play a role in iron homeostasis
0.160 1.09E-20 YDL022W GPD1 hom NAD-dependent glycerol-3-phosphate dehydrogenase; key enzyme of glycerol synthesis, essential for growth under osmotic stress; expression regulated by high-osmolarity glycerol response pathway; homolog of Gpd2p; protein abundance increases in response to DNA replication stress; constitutively inactivated via phosphorylation by the protein kinases YPK1 and YPK2, dephosphorylation increases catalytic activity
0.158 2.67E-20 YOR014W RTS1 hom B-type regulatory subunit of protein phosphatase 2A (PP2A); Rts1p and Cdc55p are alternative regulatory subunits for PP2A catalytic subunits, Pph21p and Pph22p; PP2A-Rts1p protects cohesin when recruited by Sgo1p to the pericentromere; highly enriched at centromeres in the absence of Cdc55p; required for maintenance of septin ring organization during cytokinesis, for ring disassembly in G1 and for dephosphorylation of septin, Shs1p; homolog of the mammalian B' subunit of PP2A
0.157 5.08E-20 YPL113C_p YPL113C_p hom Glyoxylate reductase; acts on glyoxylate and hydroxypyruvate substrates; YPL113C is not an essential gene
0.148 5.52E-18 YFL038C YPT1 het Rab family GTPase, involved in the ER-to-Golgi step of the secretory pathway; complex formation with the Rab escort protein Mrs6p is required for prenylation of Ypt1p by protein geranylgeranyltransferase type II (Bet2p-Bet4p)
0.144 4.50E-17 YML025C YML6 het Mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L4 ribosomal protein and human mitoribosomal MRP-L4 protein; essential for viability, unlike most other mitoribosomal proteins