YML047W-A_d

Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain
fixedexpanded
Profile for YML047W-A / YML047W-A

Click on Significant Values for Screen Details ID:SGTC_9|Compound:0092-0002|FD-Score:3.85|P-value:3.36E-5 ID:SGTC_17|Compound:0960-0276|FD-Score:3.16|P-value:5.48E-4 ID:SGTC_42|Compound:0133-0086|FD-Score:4.49|P-value:1.70E-6 ID:SGTC_92|Compound:0063-0024|FD-Score:3.44|P-value:1.90E-4 ID:SGTC_94|Compound:0334-0113|FD-Score:3.09|P-value:6.92E-4 ID:SGTC_115|Compound:0527-0192|FD-Score:3.09|P-value:6.91E-4 ID:SGTC_125|Compound:0133-0007|FD-Score:3.20|P-value:4.70E-4 ID:SGTC_126|Compound:0417-1624|FD-Score:3.16|P-value:5.49E-4 ID:SGTC_145|Compound:3737-0113|FD-Score:3.40|P-value:2.22E-4 ID:SGTC_471|Compound:1-acyl-paf|FD-Score:3.90|P-value:2.74E-5 ID:SGTC_531|Compound:3788-1495|FD-Score:-3.33|P-value:2.61E-4 ID:SGTC_857|Compound:0438-0306|FD-Score:3.21|P-value:4.47E-4 ID:SGTC_893|Compound:0958-0369|FD-Score:3.13|P-value:6.06E-4 ID:SGTC_979|Compound:1426-2828|FD-Score:3.20|P-value:4.76E-4 ID:SGTC_1059|Compound:3448-6867|FD-Score:3.08|P-value:7.23E-4 ID:SGTC_1074|Compound:carmofur|FD-Score:3.04|P-value:8.48E-4 ID:SGTC_1263|Compound:0774-1208|FD-Score:3.26|P-value:3.78E-4 ID:SGTC_1459|Compound:k035-0031|FD-Score:3.20|P-value:4.77E-4 ID:SGTC_1512|Compound:0259-0544|FD-Score:-3.09|P-value:6.20E-4 ID:SGTC_1643|Compound:st009866|FD-Score:-3.15|P-value:5.13E-4 ID:SGTC_1662|Compound:st014054|FD-Score:3.27|P-value:3.55E-4 ID:SGTC_1668|Compound:st014914|FD-Score:4.67|P-value:6.53E-7 ID:SGTC_1758|Compound:st042942|FD-Score:5.25|P-value:2.76E-8 ID:SGTC_1762|Compound:st045503|FD-Score:3.21|P-value:4.50E-4 ID:SGTC_1763|Compound:st044482|FD-Score:-5.37|P-value:1.14E-8 ID:SGTC_1764|Compound:st044502|FD-Score:4.51|P-value:1.52E-6 ID:SGTC_1791|Compound:st048313|FD-Score:3.25|P-value:3.92E-4 ID:SGTC_1878|Compound:temozolomide|FD-Score:3.14|P-value:5.76E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:3.92|P-value:2.45E-5 ID:SGTC_1967|Compound:st070177|FD-Score:3.08|P-value:7.20E-4 ID:SGTC_1988|Compound:st071872|FD-Score:3.38|P-value:2.38E-4 ID:SGTC_2016|Compound:5121758|FD-Score:-3.73|P-value:4.96E-5 ID:SGTC_2024|Compound:5144227|FD-Score:5.04|P-value:9.06E-8 ID:SGTC_2066|Compound:5222451|FD-Score:3.49|P-value:1.55E-4 ID:SGTC_2089|Compound:5281248|FD-Score:3.37|P-value:2.49E-4 ID:SGTC_2528|Compound:xanthyletin|FD-Score:-3.20|P-value:4.21E-4 ID:SGTC_2537|Compound:larixol|FD-Score:-3.40|P-value:1.96E-4 ID:SGTC_2585|Compound:alliin|FD-Score:-3.93|P-value:2.07E-5 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:3.21|P-value:4.50E-4 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:-5.32|P-value:1.50E-8 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:4.54|P-value:1.28E-6 ID:SGTC_2612|Compound:dictamnine|FD-Score:4.25|P-value:5.35E-6 ID:SGTC_2657|Compound:nystatin|FD-Score:3.44|P-value:1.89E-4 ID:SGTC_2789|Compound:5281112|FD-Score:4.76|P-value:4.16E-7 ID:SGTC_2945|Compound:9067681|FD-Score:-3.38|P-value:2.15E-4 ID:SGTC_2997|Compound:9067075|FD-Score:-4.12|P-value:8.77E-6 ID:SGTC_3043|Compound:9092303|FD-Score:-3.13|P-value:5.50E-4 ID:SGTC_3133|Compound:9127736|FD-Score:3.51|P-value:1.40E-4 ID:SGTC_3140|Compound:9094243|FD-Score:-3.45|P-value:1.58E-4 ID:SGTC_3178|Compound:9107506|FD-Score:3.20|P-value:4.75E-4 ID:SGTC_3324|Compound:9138759|FD-Score:-3.89|P-value:2.46E-5 ID:SGTC_3326|Compound:9140064|FD-Score:3.05|P-value:8.01E-4 ID:SGTC_3327|Compound:9140648|FD-Score:3.11|P-value:6.48E-4 ID:SGTC_9|Compound:0092-0002|FD-Score:3.85|P-value:3.36E-5 ID:SGTC_17|Compound:0960-0276|FD-Score:3.16|P-value:5.48E-4 ID:SGTC_42|Compound:0133-0086|FD-Score:4.49|P-value:1.70E-6 ID:SGTC_92|Compound:0063-0024|FD-Score:3.44|P-value:1.90E-4 ID:SGTC_94|Compound:0334-0113|FD-Score:3.09|P-value:6.92E-4 ID:SGTC_115|Compound:0527-0192|FD-Score:3.09|P-value:6.91E-4 ID:SGTC_125|Compound:0133-0007|FD-Score:3.20|P-value:4.70E-4 ID:SGTC_126|Compound:0417-1624|FD-Score:3.16|P-value:5.49E-4 ID:SGTC_145|Compound:3737-0113|FD-Score:3.40|P-value:2.22E-4 ID:SGTC_471|Compound:1-acyl-paf|FD-Score:3.90|P-value:2.74E-5 ID:SGTC_531|Compound:3788-1495|FD-Score:-3.33|P-value:2.61E-4 ID:SGTC_857|Compound:0438-0306|FD-Score:3.21|P-value:4.47E-4 ID:SGTC_893|Compound:0958-0369|FD-Score:3.13|P-value:6.06E-4 ID:SGTC_979|Compound:1426-2828|FD-Score:3.20|P-value:4.76E-4 ID:SGTC_1059|Compound:3448-6867|FD-Score:3.08|P-value:7.23E-4 ID:SGTC_1074|Compound:carmofur|FD-Score:3.04|P-value:8.48E-4 ID:SGTC_1263|Compound:0774-1208|FD-Score:3.26|P-value:3.78E-4 ID:SGTC_1459|Compound:k035-0031|FD-Score:3.20|P-value:4.77E-4 ID:SGTC_1512|Compound:0259-0544|FD-Score:-3.09|P-value:6.20E-4 ID:SGTC_1643|Compound:st009866|FD-Score:-3.15|P-value:5.13E-4 ID:SGTC_1662|Compound:st014054|FD-Score:3.27|P-value:3.55E-4 ID:SGTC_1668|Compound:st014914|FD-Score:4.67|P-value:6.53E-7 ID:SGTC_1758|Compound:st042942|FD-Score:5.25|P-value:2.76E-8 ID:SGTC_1762|Compound:st045503|FD-Score:3.21|P-value:4.50E-4 ID:SGTC_1763|Compound:st044482|FD-Score:-5.37|P-value:1.14E-8 ID:SGTC_1764|Compound:st044502|FD-Score:4.51|P-value:1.52E-6 ID:SGTC_1791|Compound:st048313|FD-Score:3.25|P-value:3.92E-4 ID:SGTC_1878|Compound:temozolomide|FD-Score:3.14|P-value:5.76E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:3.92|P-value:2.45E-5 ID:SGTC_1967|Compound:st070177|FD-Score:3.08|P-value:7.20E-4 ID:SGTC_1988|Compound:st071872|FD-Score:3.38|P-value:2.38E-4 ID:SGTC_2016|Compound:5121758|FD-Score:-3.73|P-value:4.96E-5 ID:SGTC_2024|Compound:5144227|FD-Score:5.04|P-value:9.06E-8 ID:SGTC_2066|Compound:5222451|FD-Score:3.49|P-value:1.55E-4 ID:SGTC_2089|Compound:5281248|FD-Score:3.37|P-value:2.49E-4 ID:SGTC_2528|Compound:xanthyletin|FD-Score:-3.20|P-value:4.21E-4 ID:SGTC_2537|Compound:larixol|FD-Score:-3.40|P-value:1.96E-4 ID:SGTC_2585|Compound:alliin|FD-Score:-3.93|P-value:2.07E-5 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:3.21|P-value:4.50E-4 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:-5.32|P-value:1.50E-8 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:4.54|P-value:1.28E-6 ID:SGTC_2612|Compound:dictamnine|FD-Score:4.25|P-value:5.35E-6 ID:SGTC_2657|Compound:nystatin|FD-Score:3.44|P-value:1.89E-4 ID:SGTC_2789|Compound:5281112|FD-Score:4.76|P-value:4.16E-7 ID:SGTC_2945|Compound:9067681|FD-Score:-3.38|P-value:2.15E-4 ID:SGTC_2997|Compound:9067075|FD-Score:-4.12|P-value:8.77E-6 ID:SGTC_3043|Compound:9092303|FD-Score:-3.13|P-value:5.50E-4 ID:SGTC_3133|Compound:9127736|FD-Score:3.51|P-value:1.40E-4 ID:SGTC_3140|Compound:9094243|FD-Score:-3.45|P-value:1.58E-4 ID:SGTC_3178|Compound:9107506|FD-Score:3.20|P-value:4.75E-4 ID:SGTC_3324|Compound:9138759|FD-Score:-3.89|P-value:2.46E-5 ID:SGTC_3326|Compound:9140064|FD-Score:3.05|P-value:8.01E-4 ID:SGTC_3327|Compound:9140648|FD-Score:3.11|P-value:6.48E-4

Top fitness defect scores for YML047W-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1758 st042942 5.25 75.2 µM 2.76E-8 7 7.76E-8
2 SGTC_2024 5144227 5.04 134.0 µM 9.06E-8 14 2.35E-7
3 SGTC_2789 5281112 4.76 71.4 µM 4.16E-7 16 9.71E-7
4 SGTC_1668 st014914 4.67 51.6 µM 6.53E-7 RPP1 & pyrimidine depletion 2 1.48E-6
5 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 4.54 70.0 µM 1.28E-6 redox potentiating 56 2.78E-6
6 SGTC_1764 st044502 4.51 93.5 µM 1.52E-6 23 3.25E-6
7 SGTC_42 0133-0086 4.49 60.6 µM 1.70E-6 14 3.62E-6
8 SGTC_2612 dictamnine 4.25 15.5 µM 5.35E-6 RNA pol III & RNase P/MRP 36 1.05E-5
9 SGTC_1926 methyl fluorone black 3.92 53.6 µM 2.45E-5 DNA intercalators 64 4.35E-5
10 SGTC_471 1-acyl-paf 3.90 4.0 µM 2.74E-5 DNA intercalators 32 4.83E-5
11 SGTC_9 0092-0002 3.85 10.4 µM 3.36E-5 30 5.84E-5
12 SGTC_3133 9127736 3.51 49.5 µM 1.40E-4 34 2.22E-4
13 SGTC_2066 5222451 3.49 176.0 µM 1.55E-4 heme biosynthesis & mitochondrial translocase 52 2.44E-4
14 SGTC_2657 nystatin 3.44 74.4 µM 1.89E-4 26 2.93E-4
15 SGTC_92 0063-0024 3.44 660.9 µM 1.90E-4 23 2.95E-4
16 SGTC_145 3737-0113 3.40 38.4 µM 2.22E-4 DNA intercalators 102 3.41E-4
17 SGTC_1988 st071872 3.38 53.4 µM 2.38E-4 17 3.64E-4
18 SGTC_2089 5281248 3.37 129.7 µM 2.49E-4 superoxide 45 3.80E-4
19 SGTC_1662 st014054 3.27 52.0 µM 3.55E-4 TSC3-RPN4 14 5.30E-4
20 SGTC_1263 0774-1208 3.26 64.8 µM 3.78E-4 86 5.61E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.212 2.77E-35 YGL002W ERP6 hom Member of the p24 family involved in ER to Golgi transport; similar to Emp24p and Erv25p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; ERP6 has a paralog, ERP1, that arose from the whole genome duplication
0.178 2.18E-25 YEL064C AVT2 hom Putative transporter, member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters
0.176 1.31E-24 YGR156W PTI1 het Essential protein that is a component of CPF (cleavage and polyadenylation factor); involved in 3' end formation of snoRNA and mRNA; interacts directly with Pta1p; has similarity to mammalian Cleavage-Stimulation Factor CstF-64
0.158 4.63E-20 YDR211W GCD6 het Catalytic epsilon subunit of the translation initiation factor eIF2B; eIF2B is the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression; forms cytoplasmic foci upon DNA replication stress
0.143 8.42E-17 YPR059C_d YPR059C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YMC1/YPR058W
0.137 1.56E-15 YMR194C-B CMC4 hom Protein that localizes to the mitochondrial intermembrane space via the Mia40p-Erv1p system; contains twin cysteine-x(9)-cysteine motifs
0.137 1.68E-15 YMR208W ERG12 het Mevalonate kinase, acts in the biosynthesis of isoprenoids and sterols, including ergosterol, from mevalonate
0.132 1.39E-14 YPL197C_d YPL197C_d hom Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the ribosomal gene RPB7B
0.131 2.85E-14 YIL144W TID3 het Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p); conserved coiled-coil protein involved in chromosome segregation, spindle checkpoint activity, kinetochore assembly and clustering
0.130 4.82E-14 YEL017C-A PMP2 hom Proteolipid associated with plasma membrane H(+)-ATPase (Pma1p); regulates plasma membrane H(+)-ATPase activity; protein abundance increases in response to DNA replication stress; PMP2 has a paralog, PMP1, that arose from the whole genome duplication
0.129 7.40E-14 YGR070W ROM1 hom GDP/GTP exchange protein (GEP) for Rho1p; mutations are synthetically lethal with mutations in rom2, which also encodes a GEP
0.128 1.06E-13 YKR079C TRZ1 het tRNA 3'-end processing endonuclease tRNase Z; also localized to mitochondria and interacts genetically with Rex2 exonuclease; homolog of the human candidate prostate cancer susceptibility gene ELAC2
0.125 3.95E-13 YOR278W HEM4 het Uroporphyrinogen III synthase, catalyzes the conversion of hydroxymethylbilane to uroporphyrinogen III, the fourth step in heme biosynthesis; deficiency in the human homolog can result in the disease congenital erythropoietic porphyria
0.124 6.24E-13 YKL137W CMC1 hom Evolutionarily conserved copper-binding protein of the mitochondrial intermembrane space, may be involved in delivering copper from the matrix to the cytochrome c oxidase complex; contains a twin CX9C motif
0.119 5.32E-12 YDR458C HEH2 hom Inner nuclear membrane (INM) protein; contains helix-extension-helix (HEH) motif, nuclear localization signal sequence; targeting to the INM requires the Srp1p-Kap95p karyopherins and the Ran cycle