Putative protein of unknown function; null mutant is viable and displays elevated frequency of mitochondrial genome loss
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YML050W deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Correlation | pval | ORF | Gene | Zygosity | Description |
---|---|---|---|---|---|
0.107 | 4.82E-10 | YEL065W | SIT1 | hom | Ferrioxamine B transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; transcription is induced during iron deprivation and diauxic shift; potentially phosphorylated by Cdc28p |
0.086 | 5.30E-7 | YBL052C | SAS3 | hom | Histone acetyltransferase catalytic subunit of NuA3 complex that acetylates histone H3, involved in transcriptional silencing; homolog of the mammalian MOZ proto-oncogene; mutant has aneuploidy tolerance; sas3gcn5 double mutation is lethal |
0.082 | 1.81E-6 | YOR214C_p | YOR214C_p | hom | Putative protein of unknown function; YOR214C is not an essential gene |
0.080 | 3.56E-6 | YOR318C_d | YOR318C_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; transcript is predicted to be spliced but there is no evidence that it is spliced in vivo |
0.078 | 5.58E-6 | YHR072W | ERG7 | het | Lanosterol synthase, an essential enzyme that catalyzes the cyclization of squalene 2,3-epoxide, a step in ergosterol biosynthesis |
0.077 | 7.84E-6 | YMR011W | HXT2 | hom | High-affinity glucose transporter of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose |
0.076 | 9.55E-6 | YHR194W | MDM31 | hom | Mitochondrial protein that may have a role in phospholipid metabolism; inner membrane protein with similarity to Mdm32p; required for normal mitochondrial morphology and inheritance; interacts genetically with MMM1, MMM2, MDM10, MDM12, and MDM34 |
0.074 | 1.65E-5 | YJR135C | MCM22 | hom | Outer kinetochore protein and component of the Ctf3 subcomplex; binds to centromeric DNA in a Ctf19p-dependent manner; involved in chromosome segregation and minichromosome maintenance; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-K and fission yeast sim4 |
0.071 | 3.93E-5 | YHR039C | MSC7 | hom | Protein of unknown function, green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; msc7 mutants are defective in directing meiotic recombination events to homologous chromatids |
0.071 | 3.94E-5 | YDR498C | SEC20 | het | Membrane glycoprotein v-SNARE involved in retrograde transport from the Golgi to the ER; required for N- and O-glycosylation in the Golgi but not in the ER; interacts with the Dsl1p complex through Tip20p |
0.070 | 4.94E-5 | YPR112C | MRD1 | het | Essential conserved small ribosomal subunit (40s) synthesis factor; component of the 90S preribosome; required for production of 18S rRNA and small ribosomal subunit; contains five consensus RNA-binding domains and binds to the pre-rRNA at two sites within the 18S region |
0.069 | 6.94E-5 | YOL130W | ALR1 | het | Plasma membrane Mg(2+) transporter, expression and turnover are regulated by Mg(2+) concentration; overexpression confers increased tolerance to Al(3+) and Ga(3+) ions |
0.068 | 8.81E-5 | YBR120C | CBP6 | hom | Mitochondrial protein required for translation of the COB mRNA; forms a complex with Cbp3p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex |
0.067 | 9.32E-5 | YER009W | NTF2 | het | Nuclear envelope protein, interacts with GDP-bound Gsp1p and with proteins of the nuclear pore to transport Gsp1p into the nucleus where it is an essential player in nucleocytoplasmic transport |
0.066 | 1.16E-4 | YOR005C | DNL4 | hom | DNA ligase required for nonhomologous end-joining (NHEJ), forms stable heterodimer with required cofactor Lif1p, interacts with Nej1p; involved in meiosis, not essential for vegetative growth |