HIPHOP chemogenomics database

YML050W / AIM32

Putative protein of unknown function; null mutant is viable and displays elevated frequency of mitochondrial genome loss

Zygosity: Homozygous strain

fixedexpanded
Profile for YML050W / AIM32

Click on Significant Values for Screen Details

Top fitness defect scores for YML050W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_2964	9083345	6.16	53.4 µM	3.79E-9		4	3.68E-10
2	SGTC_917	harmaline	5.76	728.1 nM	3.22E-8	ergosterol biosynthesis	5	4.12E-9
3	SGTC_2810	7959871	5.52	45.5 µM	1.12E-7	copper-dependent oxidative stress	13	1.67E-8
4	SGTC_823	0417-1665	5.10	178.0 µM	8.72E-7		23	1.70E-7
5	SGTC_825	1988-2224	4.99	89.6 µM	1.42E-6	cell wall signaling	21	2.95E-7
6	SGTC_3155	9099265	4.93	49.5 µM	1.92E-6		11	4.15E-7
7	SGTC_817	1391-0715	4.88	46.0 µM	2.35E-6		7	5.22E-7
8	SGTC_2869	9037858	4.59	32.5 µM	8.51E-6		6	2.22E-6
9	SGTC_3185	9108267	4.04	49.5 µM	7.66E-5	60S ribosome export	16	2.65E-5
10	SGTC_3006	9075424	3.89	71.4 µM	1.36E-4		12	5.07E-5
11	SGTC_2554	13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one	3.80	66.7 µM	1.88E-4		30	7.27E-5
12	SGTC_3317	9138495	3.70	8.8 µM	2.67E-4		38	1.08E-4
13	SGTC_1602	st001878	3.70	87.6 µM	2.71E-4		22	1.10E-4
14	SGTC_2705	st078069	3.69	42.8 µM	2.72E-4		9	1.10E-4
15	SGTC_2365	9042475	3.64	200.0 µM	3.29E-4		50	1.37E-4
16	SGTC_2632	3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone	3.64	100.0 µM	3.30E-4		26	1.37E-4
17	SGTC_2357	9067248	3.60	200.0 µM	3.76E-4		31	1.59E-4
18	SGTC_2000	st075254	3.52	36.4 µM	4.93E-4		16	2.16E-4
19	SGTC_2815	7968870	3.50	71.4 µM	5.26E-4		42	2.32E-4
20	SGTC_1394	3474-0001	3.50	65.7 µM	5.34E-4	endomembrane recycling	53	2.36E-4

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.107	4.82E-10	YEL065W	SIT1	hom	Ferrioxamine B transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; transcription is induced during iron deprivation and diauxic shift; potentially phosphorylated by Cdc28p
0.086	5.30E-7	YBL052C	SAS3	hom	Histone acetyltransferase catalytic subunit of NuA3 complex that acetylates histone H3, involved in transcriptional silencing; homolog of the mammalian MOZ proto-oncogene; mutant has aneuploidy tolerance; sas3gcn5 double mutation is lethal
0.082	1.81E-6	YOR214C_p	YOR214C_p	hom	Putative protein of unknown function; YOR214C is not an essential gene
0.080	3.56E-6	YOR318C_d	YOR318C_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; transcript is predicted to be spliced but there is no evidence that it is spliced in vivo
0.078	5.58E-6	YHR072W	ERG7	het	Lanosterol synthase, an essential enzyme that catalyzes the cyclization of squalene 2,3-epoxide, a step in ergosterol biosynthesis
0.077	7.84E-6	YMR011W	HXT2	hom	High-affinity glucose transporter of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose
0.076	9.55E-6	YHR194W	MDM31	hom	Mitochondrial protein that may have a role in phospholipid metabolism; inner membrane protein with similarity to Mdm32p; required for normal mitochondrial morphology and inheritance; interacts genetically with MMM1, MMM2, MDM10, MDM12, and MDM34
0.074	1.65E-5	YJR135C	MCM22	hom	Outer kinetochore protein and component of the Ctf3 subcomplex; binds to centromeric DNA in a Ctf19p-dependent manner; involved in chromosome segregation and minichromosome maintenance; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-K and fission yeast sim4
0.071	3.93E-5	YHR039C	MSC7	hom	Protein of unknown function, green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; msc7 mutants are defective in directing meiotic recombination events to homologous chromatids
0.071	3.94E-5	YDR498C	SEC20	het	Membrane glycoprotein v-SNARE involved in retrograde transport from the Golgi to the ER; required for N- and O-glycosylation in the Golgi but not in the ER; interacts with the Dsl1p complex through Tip20p
0.070	4.94E-5	YPR112C	MRD1	het	Essential conserved small ribosomal subunit (40s) synthesis factor; component of the 90S preribosome; required for production of 18S rRNA and small ribosomal subunit; contains five consensus RNA-binding domains and binds to the pre-rRNA at two sites within the 18S region
0.069	6.94E-5	YOL130W	ALR1	het	Plasma membrane Mg(2+) transporter, expression and turnover are regulated by Mg(2+) concentration; overexpression confers increased tolerance to Al(3+) and Ga(3+) ions
0.068	8.81E-5	YBR120C	CBP6	hom	Mitochondrial protein required for translation of the COB mRNA; forms a complex with Cbp3p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.067	9.32E-5	YER009W	NTF2	het	Nuclear envelope protein, interacts with GDP-bound Gsp1p and with proteins of the nuclear pore to transport Gsp1p into the nucleus where it is an essential player in nucleocytoplasmic transport
0.066	1.16E-4	YOR005C	DNL4	hom	DNA ligase required for nonhomologous end-joining (NHEJ), forms stable heterodimer with required cofactor Lif1p, interacts with Nej1p; involved in meiosis, not essential for vegetative growth