YML050W / AIM32

Putative protein of unknown function; null mutant is viable and displays elevated frequency of mitochondrial genome loss

Zygosity: Homozygous strain
fixedexpanded
Profile for YML050W / AIM32

Click on Significant Values for Screen Details ID:SGTC_52|Compound:0329-0193|FD-Score:-3.59|P-value:3.41E-4 ID:SGTC_108|Compound:0509-0257|FD-Score:-3.49|P-value:4.72E-4 ID:SGTC_115|Compound:0527-0192|FD-Score:-3.88|P-value:1.20E-4 ID:SGTC_571|Compound:k831-0106|FD-Score:-3.49|P-value:4.74E-4 ID:SGTC_691|Compound:1548-0686|FD-Score:-4.00|P-value:7.81E-5 ID:SGTC_757|Compound:1066-0008|FD-Score:3.40|P-value:7.33E-4 ID:SGTC_817|Compound:1391-0715|FD-Score:4.88|P-value:2.35E-6 ID:SGTC_823|Compound:0417-1665|FD-Score:5.10|P-value:8.72E-7 ID:SGTC_824|Compound:1304-0008|FD-Score:-4.99|P-value:1.20E-6 ID:SGTC_825|Compound:1988-2224|FD-Score:4.99|P-value:1.42E-6 ID:SGTC_826|Compound:1683-5028|FD-Score:-4.68|P-value:4.91E-6 ID:SGTC_832|Compound:4083-0019|FD-Score:-3.81|P-value:1.57E-4 ID:SGTC_917|Compound:harmaline|FD-Score:5.76|P-value:3.22E-8 ID:SGTC_983|Compound:1491-0821|FD-Score:3.34|P-value:8.90E-4 ID:SGTC_1012|Compound:4112-3522|FD-Score:-3.63|P-value:2.91E-4 ID:SGTC_1319|Compound:1306-0155|FD-Score:3.45|P-value:6.27E-4 ID:SGTC_1394|Compound:3474-0001|FD-Score:3.50|P-value:5.34E-4 ID:SGTC_1501|Compound:4491-0275|FD-Score:-3.29|P-value:9.05E-4 ID:SGTC_1602|Compound:st001878|FD-Score:3.70|P-value:2.71E-4 ID:SGTC_2000|Compound:st075254|FD-Score:3.52|P-value:4.93E-4 ID:SGTC_2077|Compound:5212015|FD-Score:-3.63|P-value:2.95E-4 ID:SGTC_2078|Compound:5212016|FD-Score:-3.59|P-value:3.44E-4 ID:SGTC_2080|Compound:5212524|FD-Score:-3.30|P-value:8.91E-4 ID:SGTC_2130|Compound:NSC 7|FD-Score:-4.70|P-value:4.52E-6 ID:SGTC_2357|Compound:9067248|FD-Score:3.60|P-value:3.76E-4 ID:SGTC_2362|Compound:9071156|FD-Score:-4.30|P-value:2.40E-5 ID:SGTC_2365|Compound:9042475|FD-Score:3.64|P-value:3.29E-4 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:-3.68|P-value:2.52E-4 ID:SGTC_2532|Compound:xanthone|FD-Score:-3.64|P-value:2.81E-4 ID:SGTC_2554|Compound:13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one|FD-Score:3.80|P-value:1.88E-4 ID:SGTC_2632|Compound:3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone|FD-Score:3.64|P-value:3.30E-4 ID:SGTC_2705|Compound:st078069|FD-Score:3.69|P-value:2.72E-4 ID:SGTC_2810|Compound:7959871|FD-Score:5.52|P-value:1.12E-7 ID:SGTC_2815|Compound:7968870|FD-Score:3.50|P-value:5.26E-4 ID:SGTC_2865|Compound:9030313|FD-Score:3.46|P-value:5.93E-4 ID:SGTC_2869|Compound:9037858|FD-Score:4.59|P-value:8.51E-6 ID:SGTC_2954|Compound:9074818|FD-Score:-3.55|P-value:3.90E-4 ID:SGTC_2964|Compound:9083345|FD-Score:6.16|P-value:3.79E-9 ID:SGTC_2983|Compound:9022671|FD-Score:-3.39|P-value:6.69E-4 ID:SGTC_3006|Compound:9075424|FD-Score:3.89|P-value:1.36E-4 ID:SGTC_3155|Compound:9099265|FD-Score:4.93|P-value:1.92E-6 ID:SGTC_3185|Compound:9108267|FD-Score:4.04|P-value:7.66E-5 ID:SGTC_3317|Compound:9138495|FD-Score:3.70|P-value:2.67E-4 ID:SGTC_52|Compound:0329-0193|FD-Score:-3.59|P-value:3.41E-4 ID:SGTC_108|Compound:0509-0257|FD-Score:-3.49|P-value:4.72E-4 ID:SGTC_115|Compound:0527-0192|FD-Score:-3.88|P-value:1.20E-4 ID:SGTC_571|Compound:k831-0106|FD-Score:-3.49|P-value:4.74E-4 ID:SGTC_691|Compound:1548-0686|FD-Score:-4.00|P-value:7.81E-5 ID:SGTC_757|Compound:1066-0008|FD-Score:3.40|P-value:7.33E-4 ID:SGTC_817|Compound:1391-0715|FD-Score:4.88|P-value:2.35E-6 ID:SGTC_823|Compound:0417-1665|FD-Score:5.10|P-value:8.72E-7 ID:SGTC_824|Compound:1304-0008|FD-Score:-4.99|P-value:1.20E-6 ID:SGTC_825|Compound:1988-2224|FD-Score:4.99|P-value:1.42E-6 ID:SGTC_826|Compound:1683-5028|FD-Score:-4.68|P-value:4.91E-6 ID:SGTC_832|Compound:4083-0019|FD-Score:-3.81|P-value:1.57E-4 ID:SGTC_917|Compound:harmaline|FD-Score:5.76|P-value:3.22E-8 ID:SGTC_983|Compound:1491-0821|FD-Score:3.34|P-value:8.90E-4 ID:SGTC_1012|Compound:4112-3522|FD-Score:-3.63|P-value:2.91E-4 ID:SGTC_1319|Compound:1306-0155|FD-Score:3.45|P-value:6.27E-4 ID:SGTC_1394|Compound:3474-0001|FD-Score:3.50|P-value:5.34E-4 ID:SGTC_1501|Compound:4491-0275|FD-Score:-3.29|P-value:9.05E-4 ID:SGTC_1602|Compound:st001878|FD-Score:3.70|P-value:2.71E-4 ID:SGTC_2000|Compound:st075254|FD-Score:3.52|P-value:4.93E-4 ID:SGTC_2077|Compound:5212015|FD-Score:-3.63|P-value:2.95E-4 ID:SGTC_2078|Compound:5212016|FD-Score:-3.59|P-value:3.44E-4 ID:SGTC_2080|Compound:5212524|FD-Score:-3.30|P-value:8.91E-4 ID:SGTC_2130|Compound:NSC 7|FD-Score:-4.70|P-value:4.52E-6 ID:SGTC_2357|Compound:9067248|FD-Score:3.60|P-value:3.76E-4 ID:SGTC_2362|Compound:9071156|FD-Score:-4.30|P-value:2.40E-5 ID:SGTC_2365|Compound:9042475|FD-Score:3.64|P-value:3.29E-4 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:-3.68|P-value:2.52E-4 ID:SGTC_2532|Compound:xanthone|FD-Score:-3.64|P-value:2.81E-4 ID:SGTC_2554|Compound:13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one|FD-Score:3.80|P-value:1.88E-4 ID:SGTC_2632|Compound:3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone|FD-Score:3.64|P-value:3.30E-4 ID:SGTC_2705|Compound:st078069|FD-Score:3.69|P-value:2.72E-4 ID:SGTC_2810|Compound:7959871|FD-Score:5.52|P-value:1.12E-7 ID:SGTC_2815|Compound:7968870|FD-Score:3.50|P-value:5.26E-4 ID:SGTC_2865|Compound:9030313|FD-Score:3.46|P-value:5.93E-4 ID:SGTC_2869|Compound:9037858|FD-Score:4.59|P-value:8.51E-6 ID:SGTC_2954|Compound:9074818|FD-Score:-3.55|P-value:3.90E-4 ID:SGTC_2964|Compound:9083345|FD-Score:6.16|P-value:3.79E-9 ID:SGTC_2983|Compound:9022671|FD-Score:-3.39|P-value:6.69E-4 ID:SGTC_3006|Compound:9075424|FD-Score:3.89|P-value:1.36E-4 ID:SGTC_3155|Compound:9099265|FD-Score:4.93|P-value:1.92E-6 ID:SGTC_3185|Compound:9108267|FD-Score:4.04|P-value:7.66E-5 ID:SGTC_3317|Compound:9138495|FD-Score:3.70|P-value:2.67E-4

Top fitness defect scores for YML050W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2964 9083345 6.16 53.4 µM 3.79E-9 4 3.68E-10
2 SGTC_917 harmaline 5.76 728.1 nM 3.22E-8 ergosterol biosynthesis 5 4.12E-9
3 SGTC_2810 7959871 5.52 45.5 µM 1.12E-7 copper-dependent oxidative stress 13 1.67E-8
4 SGTC_823 0417-1665 5.10 178.0 µM 8.72E-7 23 1.70E-7
5 SGTC_825 1988-2224 4.99 89.6 µM 1.42E-6 cell wall signaling 21 2.95E-7
6 SGTC_3155 9099265 4.93 49.5 µM 1.92E-6 11 4.15E-7
7 SGTC_817 1391-0715 4.88 46.0 µM 2.35E-6 7 5.22E-7
8 SGTC_2869 9037858 4.59 32.5 µM 8.51E-6 6 2.22E-6
9 SGTC_3185 9108267 4.04 49.5 µM 7.66E-5 60S ribosome export 16 2.65E-5
10 SGTC_3006 9075424 3.89 71.4 µM 1.36E-4 12 5.07E-5
11 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 3.80 66.7 µM 1.88E-4 30 7.27E-5
12 SGTC_3317 9138495 3.70 8.8 µM 2.67E-4 38 1.08E-4
13 SGTC_1602 st001878 3.70 87.6 µM 2.71E-4 22 1.10E-4
14 SGTC_2705 st078069 3.69 42.8 µM 2.72E-4 9 1.10E-4
15 SGTC_2365 9042475 3.64 200.0 µM 3.29E-4 50 1.37E-4
16 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 3.64 100.0 µM 3.30E-4 26 1.37E-4
17 SGTC_2357 9067248 3.60 200.0 µM 3.76E-4 31 1.59E-4
18 SGTC_2000 st075254 3.52 36.4 µM 4.93E-4 16 2.16E-4
19 SGTC_2815 7968870 3.50 71.4 µM 5.26E-4 42 2.32E-4
20 SGTC_1394 3474-0001 3.50 65.7 µM 5.34E-4 endomembrane recycling 53 2.36E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.107 4.82E-10 YEL065W SIT1 hom Ferrioxamine B transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; transcription is induced during iron deprivation and diauxic shift; potentially phosphorylated by Cdc28p
0.086 5.30E-7 YBL052C SAS3 hom Histone acetyltransferase catalytic subunit of NuA3 complex that acetylates histone H3, involved in transcriptional silencing; homolog of the mammalian MOZ proto-oncogene; mutant has aneuploidy tolerance; sas3gcn5 double mutation is lethal
0.082 1.81E-6 YOR214C_p YOR214C_p hom Putative protein of unknown function; YOR214C is not an essential gene
0.080 3.56E-6 YOR318C_d YOR318C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; transcript is predicted to be spliced but there is no evidence that it is spliced in vivo
0.078 5.58E-6 YHR072W ERG7 het Lanosterol synthase, an essential enzyme that catalyzes the cyclization of squalene 2,3-epoxide, a step in ergosterol biosynthesis
0.077 7.84E-6 YMR011W HXT2 hom High-affinity glucose transporter of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose
0.076 9.55E-6 YHR194W MDM31 hom Mitochondrial protein that may have a role in phospholipid metabolism; inner membrane protein with similarity to Mdm32p; required for normal mitochondrial morphology and inheritance; interacts genetically with MMM1, MMM2, MDM10, MDM12, and MDM34
0.074 1.65E-5 YJR135C MCM22 hom Outer kinetochore protein and component of the Ctf3 subcomplex; binds to centromeric DNA in a Ctf19p-dependent manner; involved in chromosome segregation and minichromosome maintenance; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-K and fission yeast sim4
0.071 3.93E-5 YHR039C MSC7 hom Protein of unknown function, green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; msc7 mutants are defective in directing meiotic recombination events to homologous chromatids
0.071 3.94E-5 YDR498C SEC20 het Membrane glycoprotein v-SNARE involved in retrograde transport from the Golgi to the ER; required for N- and O-glycosylation in the Golgi but not in the ER; interacts with the Dsl1p complex through Tip20p
0.070 4.94E-5 YPR112C MRD1 het Essential conserved small ribosomal subunit (40s) synthesis factor; component of the 90S preribosome; required for production of 18S rRNA and small ribosomal subunit; contains five consensus RNA-binding domains and binds to the pre-rRNA at two sites within the 18S region
0.069 6.94E-5 YOL130W ALR1 het Plasma membrane Mg(2+) transporter, expression and turnover are regulated by Mg(2+) concentration; overexpression confers increased tolerance to Al(3+) and Ga(3+) ions
0.068 8.81E-5 YBR120C CBP6 hom Mitochondrial protein required for translation of the COB mRNA; forms a complex with Cbp3p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.067 9.32E-5 YER009W NTF2 het Nuclear envelope protein, interacts with GDP-bound Gsp1p and with proteins of the nuclear pore to transport Gsp1p into the nucleus where it is an essential player in nucleocytoplasmic transport
0.066 1.16E-4 YOR005C DNL4 hom DNA ligase required for nonhomologous end-joining (NHEJ), forms stable heterodimer with required cofactor Lif1p, interacts with Nej1p; involved in meiosis, not essential for vegetative growth