YML055W / SPC2

Subunit of signal peptidase complex (Spc1p, Spc2p, Spc3p, Sec11p), which catalyzes cleavage of N-terminal signal sequences of proteins targeted to the secretory pathway; homologous to mammalian SPC25

Zygosity: Homozygous strain
fixedexpanded
Profile for YML055W / SPC2

Click on Significant Values for Screen Details ID:SGTC_39|Compound:0986-0283|FD-Score:3.65|P-value:3.70E-4 ID:SGTC_121|Compound:0557-0495|FD-Score:3.91|P-value:1.48E-4 ID:SGTC_166|Compound:k072-0058|FD-Score:5.58|P-value:1.21E-7 ID:SGTC_167|Compound:3672-0051|FD-Score:6.72|P-value:2.32E-10 ID:SGTC_206|Compound:4546-0025|FD-Score:3.85|P-value:1.81E-4 ID:SGTC_294|Compound:k038-0071|FD-Score:3.39|P-value:8.64E-4 ID:SGTC_539|Compound:4859-0462|FD-Score:3.58|P-value:4.60E-4 ID:SGTC_615|Compound:k087-0205|FD-Score:-3.33|P-value:9.52E-4 ID:SGTC_625|Compound:k213-0058|FD-Score:9.00|P-value:3.63E-17 ID:SGTC_691|Compound:1548-0686|FD-Score:3.93|P-value:1.39E-4 ID:SGTC_695|Compound:3505-6186|FD-Score:3.91|P-value:1.49E-4 ID:SGTC_766|Compound:1391-0721|FD-Score:4.08|P-value:8.06E-5 ID:SGTC_772|Compound:k072-0172|FD-Score:3.48|P-value:6.51E-4 ID:SGTC_779|Compound:1360-0071|FD-Score:3.83|P-value:1.94E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:5.62|P-value:9.45E-8 ID:SGTC_1385|Compound:3091-4834|FD-Score:4.21|P-value:4.81E-5 ID:SGTC_1727|Compound:st034309|FD-Score:-4.27|P-value:3.47E-5 ID:SGTC_1770|Compound:st043884|FD-Score:4.72|P-value:6.29E-6 ID:SGTC_1791|Compound:st048313|FD-Score:3.54|P-value:5.38E-4 ID:SGTC_1893|Compound:st059353|FD-Score:4.33|P-value:3.10E-5 ID:SGTC_1917|Compound:st066507|FD-Score:3.77|P-value:2.40E-4 ID:SGTC_1940|Compound:st075990|FD-Score:-4.75|P-value:4.93E-6 ID:SGTC_1949|Compound:st076024|FD-Score:4.23|P-value:4.60E-5 ID:SGTC_1954|Compound:st077032|FD-Score:4.74|P-value:5.82E-6 ID:SGTC_1991|Compound:st073000|FD-Score:3.42|P-value:7.84E-4 ID:SGTC_2092|Compound:5303694|FD-Score:-4.79|P-value:4.16E-6 ID:SGTC_2103|Compound:5378138|FD-Score:-3.35|P-value:8.94E-4 ID:SGTC_2252|Compound:omeprazole|FD-Score:3.84|P-value:1.89E-4 ID:SGTC_2254|Compound:7938975|FD-Score:3.69|P-value:3.22E-4 ID:SGTC_2261|Compound:9010538|FD-Score:-3.33|P-value:9.59E-4 ID:SGTC_2271|Compound:7849410|FD-Score:-3.54|P-value:4.88E-4 ID:SGTC_2272|Compound:7805186|FD-Score:-3.35|P-value:8.94E-4 ID:SGTC_2276|Compound:7947513|FD-Score:-3.76|P-value:2.28E-4 ID:SGTC_2281|Compound:7943571|FD-Score:-3.43|P-value:7.00E-4 ID:SGTC_2306|Compound:7482397|FD-Score:-3.69|P-value:2.96E-4 ID:SGTC_2310|Compound:7668677|FD-Score:4.99|P-value:1.93E-6 ID:SGTC_2464|Compound:5717415|FD-Score:3.44|P-value:7.37E-4 ID:SGTC_2485|Compound:5633444|FD-Score:3.64|P-value:3.77E-4 ID:SGTC_2533|Compound:agelasine|FD-Score:-3.61|P-value:3.87E-4 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:5.30|P-value:4.60E-7 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:-3.48|P-value:5.94E-4 ID:SGTC_2803|Compound:7707263|FD-Score:4.09|P-value:7.81E-5 ID:SGTC_2906|Compound:7926292|FD-Score:-3.55|P-value:4.70E-4 ID:SGTC_3108|Compound:9121785|FD-Score:-4.12|P-value:6.08E-5 ID:SGTC_3198|Compound:9112019|FD-Score:3.77|P-value:2.42E-4 ID:SGTC_3228|Compound:9131799|FD-Score:3.67|P-value:3.45E-4 ID:SGTC_3332|Compound:9141069|FD-Score:3.42|P-value:7.74E-4 ID:SGTC_39|Compound:0986-0283|FD-Score:3.65|P-value:3.70E-4 ID:SGTC_121|Compound:0557-0495|FD-Score:3.91|P-value:1.48E-4 ID:SGTC_166|Compound:k072-0058|FD-Score:5.58|P-value:1.21E-7 ID:SGTC_167|Compound:3672-0051|FD-Score:6.72|P-value:2.32E-10 ID:SGTC_206|Compound:4546-0025|FD-Score:3.85|P-value:1.81E-4 ID:SGTC_294|Compound:k038-0071|FD-Score:3.39|P-value:8.64E-4 ID:SGTC_539|Compound:4859-0462|FD-Score:3.58|P-value:4.60E-4 ID:SGTC_615|Compound:k087-0205|FD-Score:-3.33|P-value:9.52E-4 ID:SGTC_625|Compound:k213-0058|FD-Score:9.00|P-value:3.63E-17 ID:SGTC_691|Compound:1548-0686|FD-Score:3.93|P-value:1.39E-4 ID:SGTC_695|Compound:3505-6186|FD-Score:3.91|P-value:1.49E-4 ID:SGTC_766|Compound:1391-0721|FD-Score:4.08|P-value:8.06E-5 ID:SGTC_772|Compound:k072-0172|FD-Score:3.48|P-value:6.51E-4 ID:SGTC_779|Compound:1360-0071|FD-Score:3.83|P-value:1.94E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:5.62|P-value:9.45E-8 ID:SGTC_1385|Compound:3091-4834|FD-Score:4.21|P-value:4.81E-5 ID:SGTC_1727|Compound:st034309|FD-Score:-4.27|P-value:3.47E-5 ID:SGTC_1770|Compound:st043884|FD-Score:4.72|P-value:6.29E-6 ID:SGTC_1791|Compound:st048313|FD-Score:3.54|P-value:5.38E-4 ID:SGTC_1893|Compound:st059353|FD-Score:4.33|P-value:3.10E-5 ID:SGTC_1917|Compound:st066507|FD-Score:3.77|P-value:2.40E-4 ID:SGTC_1940|Compound:st075990|FD-Score:-4.75|P-value:4.93E-6 ID:SGTC_1949|Compound:st076024|FD-Score:4.23|P-value:4.60E-5 ID:SGTC_1954|Compound:st077032|FD-Score:4.74|P-value:5.82E-6 ID:SGTC_1991|Compound:st073000|FD-Score:3.42|P-value:7.84E-4 ID:SGTC_2092|Compound:5303694|FD-Score:-4.79|P-value:4.16E-6 ID:SGTC_2103|Compound:5378138|FD-Score:-3.35|P-value:8.94E-4 ID:SGTC_2252|Compound:omeprazole|FD-Score:3.84|P-value:1.89E-4 ID:SGTC_2254|Compound:7938975|FD-Score:3.69|P-value:3.22E-4 ID:SGTC_2261|Compound:9010538|FD-Score:-3.33|P-value:9.59E-4 ID:SGTC_2271|Compound:7849410|FD-Score:-3.54|P-value:4.88E-4 ID:SGTC_2272|Compound:7805186|FD-Score:-3.35|P-value:8.94E-4 ID:SGTC_2276|Compound:7947513|FD-Score:-3.76|P-value:2.28E-4 ID:SGTC_2281|Compound:7943571|FD-Score:-3.43|P-value:7.00E-4 ID:SGTC_2306|Compound:7482397|FD-Score:-3.69|P-value:2.96E-4 ID:SGTC_2310|Compound:7668677|FD-Score:4.99|P-value:1.93E-6 ID:SGTC_2464|Compound:5717415|FD-Score:3.44|P-value:7.37E-4 ID:SGTC_2485|Compound:5633444|FD-Score:3.64|P-value:3.77E-4 ID:SGTC_2533|Compound:agelasine|FD-Score:-3.61|P-value:3.87E-4 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:5.30|P-value:4.60E-7 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:-3.48|P-value:5.94E-4 ID:SGTC_2803|Compound:7707263|FD-Score:4.09|P-value:7.81E-5 ID:SGTC_2906|Compound:7926292|FD-Score:-3.55|P-value:4.70E-4 ID:SGTC_3108|Compound:9121785|FD-Score:-4.12|P-value:6.08E-5 ID:SGTC_3198|Compound:9112019|FD-Score:3.77|P-value:2.42E-4 ID:SGTC_3228|Compound:9131799|FD-Score:3.67|P-value:3.45E-4 ID:SGTC_3332|Compound:9141069|FD-Score:3.42|P-value:7.74E-4

Top fitness defect scores for YML055W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_625 k213-0058 9.00 121.0 µM 3.63E-17 translation 7 1.14E-19
2 SGTC_167 3672-0051 6.72 66.2 µM 2.32E-10 10 8.82E-12
3 SGTC_800 3448-7362 5.62 155.0 µM 9.45E-8 translation 63 9.29E-9
4 SGTC_166 k072-0058 5.58 166.4 µM 1.21E-7 DNA intercalators 7 1.23E-8
5 SGTC_2539 epi(13)torulosol 5.30 80.0 µM 4.60E-7 8 5.80E-8
6 SGTC_2310 7668677 4.99 200.0 µM 1.93E-6 13 3.04E-7
7 SGTC_1954 st077032 4.74 68.9 µM 5.82E-6 8 1.09E-6
8 SGTC_1770 st043884 4.72 66.3 µM 6.29E-6 6 1.19E-6
9 SGTC_1893 st059353 4.33 36.1 µM 3.10E-5 13 7.53E-6
10 SGTC_1949 st076024 4.23 69.1 µM 4.60E-5 14 1.19E-5
11 SGTC_1385 3091-4834 4.21 14.1 µM 4.81E-5 RPP1 & pyrimidine depletion 15 1.25E-5
12 SGTC_2803 7707263 4.09 71.4 µM 7.81E-5 28 2.19E-5
13 SGTC_766 1391-0721 4.08 126.0 µM 8.06E-5 13 2.28E-5
14 SGTC_691 1548-0686 3.93 185.0 µM 1.39E-4 33 4.28E-5
15 SGTC_121 0557-0495 3.91 61.3 µM 1.48E-4 calcium & mitochondrial duress 57 4.59E-5
16 SGTC_695 3505-6186 3.91 243.0 µM 1.49E-4 24 4.62E-5
17 SGTC_206 4546-0025 3.85 72.0 µM 1.81E-4 NEO1 76 5.80E-5
18 SGTC_2252 omeprazole 3.84 400.0 µM 1.89E-4 12 6.08E-5
19 SGTC_779 1360-0071 3.83 233.0 µM 1.94E-4 fatty acid desaturase (OLE1) 31 6.28E-5
20 SGTC_1917 st066507 3.77 28.5 µM 2.40E-4 Golgi 44 8.02E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.126 2.56E-13 YIR021W-A_p YIR021W-A_p hom Putative protein of unknown function; identified by expression profiling and mass spectrometry
0.118 7.38E-12 YLR048W RPS0B hom Protein component of the small (40S) ribosomal subunit; RPS0B has a paralog, RPS0A, that arose from the whole genome duplication; required for maturation of 18S rRNA along with Rps0Ap; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal; homologous to human ribosomal protein SA and bacterial S2
0.117 8.81E-12 YJR145C RPS4A hom Protein component of the small (40S) ribosomal subunit; mutation affects 20S pre-rRNA processing; homologous to mammalian ribosomal protein S4, no bacterial homolog; RPS4A has a paralog, RPS4B, that arose from the whole genome duplication
0.116 1.36E-11 YMR315W YMR315W hom Protein with NADP(H) oxidoreductase activity; transcription is regulated by Stb5p in response to NADPH depletion induced by diamide; promoter contains a putative Stb5p binding site; protein abundance increases in response to DNA replication stress
0.109 2.26E-10 YOR085W OST3 hom Gamma subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins; Ost3p is important for N-glycosylation of a subset of proteins
0.104 1.50E-9 YBR191W RPL21A hom Ribosomal 60S subunit protein L21A; homologous to mammalian ribosomal protein L21, no bacterial homolog; RPL21A has a paralog, RPL21B, that arose from the whole genome duplication
0.104 1.66E-9 YAL058W CNE1 hom Calnexin; integral membrane ER chaperone involved in folding and quality control of glycoproteins; chaperone activity is inhibited by Mpd1p, with which Cne1p interacts; 24% identical to mammalian calnexin; Ca+ binding not yet shown in yeast
0.102 3.07E-9 YGR162W TIF4631 hom Translation initiation factor eIF4G; subunit of the mRNA cap-binding protein complex (eIF4F) that also contains eIF4E (Cdc33p); interacts with Pab1p and with eIF4A (Tif1p); also has a role in biogenesis of the large ribosomal subunit; TIF4631 has a paralog, TIF4632, that arose from the whole genome duplication
0.101 5.18E-9 YER016W BIM1 hom Microtubule-binding protein that together with Kar9p makes up the cortical microtubule capture site and delays the exit from mitosis when the spindle is oriented abnormally
0.095 3.26E-8 YJL069C UTP18 het Possible U3 snoRNP protein involved in maturation of pre-18S rRNA, based on computational analysis of large-scale protein-protein interaction data
0.094 5.72E-8 YBL071C-B_p YBL071C-B_p hom Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
0.093 6.42E-8 YGL167C PMR1 hom High affinity Ca2+/Mn2+ P-type ATPase required for Ca2+ and Mn2+ transport into Golgi; involved in Ca2+ dependent protein sorting and processing; mutations in human homolog ATP2C1 cause acantholytic skin condition Hailey-Hailey disease
0.093 7.59E-8 YOR216C RUD3 hom Golgi matrix protein involved in the structural organization of the cis-Golgi; interacts genetically with COG3 and USO1
0.093 7.82E-8 YDR281C PHM6 hom Protein of unknown function, expression is regulated by phosphate levels
0.091 1.16E-7 YPL062W_d YPL062W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YPL062W is not an essential gene; homozygous diploid mutant shows a decrease in glycogen accumulation