YML060W / OGG1

Mitochondrial glycosylase/lyase that specifically excises 7,8-dihydro-8-oxoguanine residues located opposite cytosine or thymine residues in DNA, repairs oxidative damage to mitochondrial DNA, contributes to UVA resistance

Zygosity: Homozygous strain
fixedexpanded
Profile for YML060W / OGG1

Click on Significant Values for Screen Details ID:SGTC_20|Compound:0481-0013|FD-Score:3.30|P-value:3.97E-4 ID:SGTC_450|Compound:aminopyrene|FD-Score:3.59|P-value:1.28E-4 ID:SGTC_452|Compound:diindolylmethane|FD-Score:3.41|P-value:2.63E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:3.41|P-value:2.61E-4 ID:SGTC_615|Compound:k087-0205|FD-Score:-3.87|P-value:4.04E-5 ID:SGTC_908|Compound:3448-7491|FD-Score:-4.00|P-value:2.30E-5 ID:SGTC_974|Compound:1326-0144|FD-Score:-3.14|P-value:6.86E-4 ID:SGTC_981|Compound:1488-1094|FD-Score:3.82|P-value:5.11E-5 ID:SGTC_987|Compound:1497-1013|FD-Score:4.24|P-value:7.92E-6 ID:SGTC_1045|Compound:1348-1485|FD-Score:3.72|P-value:7.69E-5 ID:SGTC_1137|Compound:ixabepilone|FD-Score:-3.18|P-value:5.88E-4 ID:SGTC_1145|Compound:3546-0597|FD-Score:3.31|P-value:3.83E-4 ID:SGTC_1153|Compound:4055-0057|FD-Score:-3.56|P-value:1.43E-4 ID:SGTC_1238|Compound:0333-0287|FD-Score:3.20|P-value:5.59E-4 ID:SGTC_1240|Compound:0356-0016|FD-Score:3.39|P-value:2.78E-4 ID:SGTC_1248|Compound:0469-0687|FD-Score:3.50|P-value:1.87E-4 ID:SGTC_1260|Compound:0700-1617|FD-Score:9.27|P-value:2.00E-21 ID:SGTC_1264|Compound:0783-0040|FD-Score:3.11|P-value:7.68E-4 ID:SGTC_1283|Compound:0922-0125|FD-Score:-3.36|P-value:3.15E-4 ID:SGTC_1316|Compound:1272-0050|FD-Score:3.64|P-value:1.06E-4 ID:SGTC_1370|Compound:2001-0092|FD-Score:3.53|P-value:1.66E-4 ID:SGTC_1409|Compound:3909-8004|FD-Score:3.12|P-value:7.58E-4 ID:SGTC_1523|Compound:st012844|FD-Score:4.01|P-value:2.29E-5 ID:SGTC_1524|Compound:corynanthine|FD-Score:-3.93|P-value:3.10E-5 ID:SGTC_1526|Compound:st051518|FD-Score:5.24|P-value:4.75E-8 ID:SGTC_1563|Compound:conessine|FD-Score:3.50|P-value:1.83E-4 ID:SGTC_1726|Compound:st035556|FD-Score:-3.75|P-value:6.64E-5 ID:SGTC_1727|Compound:st034309|FD-Score:3.19|P-value:5.96E-4 ID:SGTC_1822|Compound:st052468|FD-Score:3.20|P-value:5.75E-4 ID:SGTC_1880|Compound:MG-132|FD-Score:3.04|P-value:9.99E-4 ID:SGTC_2009|Compound:4012297|FD-Score:3.80|P-value:5.45E-5 ID:SGTC_2240|Compound:6690706|FD-Score:3.24|P-value:4.92E-4 ID:SGTC_2247|Compound:cerulenin|FD-Score:4.09|P-value:1.56E-5 ID:SGTC_2318|Compound:6029776|FD-Score:-3.45|P-value:2.23E-4 ID:SGTC_2325|Compound:6158266|FD-Score:-3.82|P-value:4.87E-5 ID:SGTC_2478|Compound:5763493|FD-Score:4.79|P-value:5.37E-7 ID:SGTC_2484|Compound:5809818|FD-Score:3.90|P-value:3.63E-5 ID:SGTC_2561|Compound:acetosyringone|FD-Score:3.58|P-value:1.36E-4 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:3.17|P-value:6.26E-4 ID:SGTC_2868|Compound:9035608|FD-Score:3.22|P-value:5.29E-4 ID:SGTC_2972|Compound:9093619|FD-Score:3.05|P-value:9.55E-4 ID:SGTC_2975|Compound:9084847|FD-Score:3.71|P-value:8.18E-5 ID:SGTC_2978|Compound:9011784|FD-Score:5.80|P-value:1.85E-9 ID:SGTC_2982|Compound:9019404|FD-Score:3.49|P-value:1.94E-4 ID:SGTC_3006|Compound:9075424|FD-Score:3.23|P-value:5.10E-4 ID:SGTC_3050|Compound:9093513|FD-Score:-3.87|P-value:4.05E-5 ID:SGTC_3069|Compound:9117009|FD-Score:-3.15|P-value:6.67E-4 ID:SGTC_3075|Compound:9116269|FD-Score:10.50|P-value:8.28E-27 ID:SGTC_3076|Compound:9116187|FD-Score:-3.14|P-value:6.81E-4 ID:SGTC_3078|Compound:9116413|FD-Score:4.90|P-value:3.03E-7 ID:SGTC_3121|Compound:9125696|FD-Score:3.24|P-value:4.86E-4 ID:SGTC_20|Compound:0481-0013|FD-Score:3.30|P-value:3.97E-4 ID:SGTC_450|Compound:aminopyrene|FD-Score:3.59|P-value:1.28E-4 ID:SGTC_452|Compound:diindolylmethane|FD-Score:3.41|P-value:2.63E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:3.41|P-value:2.61E-4 ID:SGTC_615|Compound:k087-0205|FD-Score:-3.87|P-value:4.04E-5 ID:SGTC_908|Compound:3448-7491|FD-Score:-4.00|P-value:2.30E-5 ID:SGTC_974|Compound:1326-0144|FD-Score:-3.14|P-value:6.86E-4 ID:SGTC_981|Compound:1488-1094|FD-Score:3.82|P-value:5.11E-5 ID:SGTC_987|Compound:1497-1013|FD-Score:4.24|P-value:7.92E-6 ID:SGTC_1045|Compound:1348-1485|FD-Score:3.72|P-value:7.69E-5 ID:SGTC_1137|Compound:ixabepilone|FD-Score:-3.18|P-value:5.88E-4 ID:SGTC_1145|Compound:3546-0597|FD-Score:3.31|P-value:3.83E-4 ID:SGTC_1153|Compound:4055-0057|FD-Score:-3.56|P-value:1.43E-4 ID:SGTC_1238|Compound:0333-0287|FD-Score:3.20|P-value:5.59E-4 ID:SGTC_1240|Compound:0356-0016|FD-Score:3.39|P-value:2.78E-4 ID:SGTC_1248|Compound:0469-0687|FD-Score:3.50|P-value:1.87E-4 ID:SGTC_1260|Compound:0700-1617|FD-Score:9.27|P-value:2.00E-21 ID:SGTC_1264|Compound:0783-0040|FD-Score:3.11|P-value:7.68E-4 ID:SGTC_1283|Compound:0922-0125|FD-Score:-3.36|P-value:3.15E-4 ID:SGTC_1316|Compound:1272-0050|FD-Score:3.64|P-value:1.06E-4 ID:SGTC_1370|Compound:2001-0092|FD-Score:3.53|P-value:1.66E-4 ID:SGTC_1409|Compound:3909-8004|FD-Score:3.12|P-value:7.58E-4 ID:SGTC_1523|Compound:st012844|FD-Score:4.01|P-value:2.29E-5 ID:SGTC_1524|Compound:corynanthine|FD-Score:-3.93|P-value:3.10E-5 ID:SGTC_1526|Compound:st051518|FD-Score:5.24|P-value:4.75E-8 ID:SGTC_1563|Compound:conessine|FD-Score:3.50|P-value:1.83E-4 ID:SGTC_1726|Compound:st035556|FD-Score:-3.75|P-value:6.64E-5 ID:SGTC_1727|Compound:st034309|FD-Score:3.19|P-value:5.96E-4 ID:SGTC_1822|Compound:st052468|FD-Score:3.20|P-value:5.75E-4 ID:SGTC_1880|Compound:MG-132|FD-Score:3.04|P-value:9.99E-4 ID:SGTC_2009|Compound:4012297|FD-Score:3.80|P-value:5.45E-5 ID:SGTC_2240|Compound:6690706|FD-Score:3.24|P-value:4.92E-4 ID:SGTC_2247|Compound:cerulenin|FD-Score:4.09|P-value:1.56E-5 ID:SGTC_2318|Compound:6029776|FD-Score:-3.45|P-value:2.23E-4 ID:SGTC_2325|Compound:6158266|FD-Score:-3.82|P-value:4.87E-5 ID:SGTC_2478|Compound:5763493|FD-Score:4.79|P-value:5.37E-7 ID:SGTC_2484|Compound:5809818|FD-Score:3.90|P-value:3.63E-5 ID:SGTC_2561|Compound:acetosyringone|FD-Score:3.58|P-value:1.36E-4 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:3.17|P-value:6.26E-4 ID:SGTC_2868|Compound:9035608|FD-Score:3.22|P-value:5.29E-4 ID:SGTC_2972|Compound:9093619|FD-Score:3.05|P-value:9.55E-4 ID:SGTC_2975|Compound:9084847|FD-Score:3.71|P-value:8.18E-5 ID:SGTC_2978|Compound:9011784|FD-Score:5.80|P-value:1.85E-9 ID:SGTC_2982|Compound:9019404|FD-Score:3.49|P-value:1.94E-4 ID:SGTC_3006|Compound:9075424|FD-Score:3.23|P-value:5.10E-4 ID:SGTC_3050|Compound:9093513|FD-Score:-3.87|P-value:4.05E-5 ID:SGTC_3069|Compound:9117009|FD-Score:-3.15|P-value:6.67E-4 ID:SGTC_3075|Compound:9116269|FD-Score:10.50|P-value:8.28E-27 ID:SGTC_3076|Compound:9116187|FD-Score:-3.14|P-value:6.81E-4 ID:SGTC_3078|Compound:9116413|FD-Score:4.90|P-value:3.03E-7 ID:SGTC_3121|Compound:9125696|FD-Score:3.24|P-value:4.86E-4

Top fitness defect scores for YML060W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature		Screen
Rank
Screen
P-value
1 SGTC_3075 9116269 10.50 49.5 µM 8.28E-27 1 5.97E-26
2 SGTC_1260 0700-1617 9.27 7.8 µM 2.00E-21 calcium & mitochondrial duress 3 9.41E-21
3 SGTC_2978 9011784 5.80 43.0 µM 1.85E-9 7 3.39E-9
4 SGTC_1526 st051518 5.24 75.0 µM 4.75E-8 4 7.82E-8
5 SGTC_3078 9116413 4.90 49.5 µM 3.03E-7 unfolded protein response 19 4.70E-7
6 SGTC_2478 5763493 4.79 32.3 µM 5.37E-7 12 8.15E-7
7 SGTC_987 1497-1013 4.24 404.0 µM 7.92E-6 10 1.10E-5
8 SGTC_2247 cerulenin 4.09 830.0 nM 1.56E-5 14 2.13E-5
9 SGTC_1523 st012844 4.01 44.7 µM 2.29E-5 60S ribosome export 19 3.08E-5
10 SGTC_2484 5809818 3.90 12.0 µM 3.63E-5 17 4.80E-5
11 SGTC_981 1488-1094 3.82 54.9 µM 5.11E-5 27 6.68E-5
12 SGTC_2009 4012297 3.80 12.1 µM 5.45E-5 cell wall signaling 65 7.11E-5
13 SGTC_1045 1348-1485 3.72 165.0 µM 7.69E-5 40 9.92E-5
14 SGTC_2975 9084847 3.71 53.7 µM 8.18E-5 29 1.05E-4
15 SGTC_1316 1272-0050 3.64 65.9 µM 1.06E-4 15 1.36E-4
16 SGTC_450 aminopyrene 3.59 156.0 nM 1.28E-4 43 1.63E-4
17 SGTC_2561 acetosyringone 3.58 100.0 µM 1.36E-4 40 1.73E-4
18 SGTC_1370 2001-0092 3.53 44.6 µM 1.66E-4 50 2.09E-4
19 SGTC_1563 conessine 3.50 56.1 µM 1.83E-4 30 2.30E-4
20 SGTC_1248 0469-0687 3.50 58.6 µM 1.87E-4 47 2.35E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.254 1.60E-50 YNL244C SUI1 het Translation initiation factor eIF1; component of a complex involved in recognition of the initiator codon; modulates translation accuracy at the initiation phase
0.149 5.09E-18 YBR092C PHO3 hom Constitutively expressed acid phosphatase similar to Pho5p; brought to the cell surface by transport vesicles; hydrolyzes thiamin phosphates in the periplasmic space, increasing cellular thiamin uptake; expression is repressed by thiamin
0.130 3.73E-14 YOL034W SMC5 het Component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; binds single-stranded DNA and has ATPase activity; S. pombe homolog forms a heterodimer with S. pombe Rad18p that is involved in DNA repair
0.119 4.94E-12 YPR067W ISA2 hom Protein required for maturation of mitochondrial [4Fe-4S] proteins; functions in a complex with Isa1p and possibly Iba57p; localizes to the mitochondrial intermembrane space, overexpression of ISA2 suppresses grx5 mutations
0.111 1.02E-10 YCL001W-B_p YCL001W-B_p hom Putative protein of unknown function; present in a region duplicated between chromosomes XIV and III; YCL001W-B has a paralog, DOM34, that arose from the whole genome duplication
0.110 1.93E-10 YEL057C_p YEL057C_p hom Protein of unknown function involved in telomere maintenance; target of UME6 regulation
0.105 1.18E-9 YHR016C YSC84 hom Actin-binding protein; involved in bundling of actin filaments and endocytosis of actin cortical patches; activity stimulated by Las17p; contains SH3 domain similar to Rvs167p; YSC84 has a paralog, LSB3, that arose from the whole genome duplication
0.100 6.04E-9 YML101C-A_d YML101C-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.097 1.53E-8 YLR071C RGR1 het Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for glucose repression, HO repression, RME1 repression and sporulation
0.092 9.16E-8 YJL202C_d YJL202C_d het Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps 3' end of essential PRP21 gene encoding a subunit of the SF3a splicing factor complex
0.085 7.80E-7 YOL152W FRE7 hom Putative ferric reductase with similarity to Fre2p; expression induced by low copper levels
0.085 8.67E-7 YDR032C PST2 hom Protein with similarity to a family of flavodoxin-like proteins; induced by oxidative stress in a Yap1p dependent manner; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress; PST2 has a paralog, RFS1, that arose from the whole genome duplication
0.083 1.55E-6 YJL205C NCE101 hom Protein of unknown function, involved in secretion of proteins that lack classical secretory signal sequences
0.080 3.42E-6 YFL017W-A SMX2 het Core Sm protein Sm G; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Sme1p, and Smx3p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm G
0.080 3.58E-6 YGR201C_p YGR201C_p hom Putative protein of unknown function