Mitochondrial glycosylase/lyase that specifically excises 7,8-dihydro-8-oxoguanine residues located opposite cytosine or thymine residues in DNA, repairs oxidative damage to mitochondrial DNA, contributes to UVA resistance
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YML060W deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Correlation | pval | ORF | Gene | Zygosity | Description |
---|---|---|---|---|---|
0.254 | 1.60E-50 | YNL244C | SUI1 | het | Translation initiation factor eIF1; component of a complex involved in recognition of the initiator codon; modulates translation accuracy at the initiation phase |
0.149 | 5.09E-18 | YBR092C | PHO3 | hom | Constitutively expressed acid phosphatase similar to Pho5p; brought to the cell surface by transport vesicles; hydrolyzes thiamin phosphates in the periplasmic space, increasing cellular thiamin uptake; expression is repressed by thiamin |
0.130 | 3.73E-14 | YOL034W | SMC5 | het | Component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; binds single-stranded DNA and has ATPase activity; S. pombe homolog forms a heterodimer with S. pombe Rad18p that is involved in DNA repair |
0.119 | 4.94E-12 | YPR067W | ISA2 | hom | Protein required for maturation of mitochondrial [4Fe-4S] proteins; functions in a complex with Isa1p and possibly Iba57p; localizes to the mitochondrial intermembrane space, overexpression of ISA2 suppresses grx5 mutations |
0.111 | 1.02E-10 | YCL001W-B_p | YCL001W-B_p | hom | Putative protein of unknown function; present in a region duplicated between chromosomes XIV and III; YCL001W-B has a paralog, DOM34, that arose from the whole genome duplication |
0.110 | 1.93E-10 | YEL057C_p | YEL057C_p | hom | Protein of unknown function involved in telomere maintenance; target of UME6 regulation |
0.105 | 1.18E-9 | YHR016C | YSC84 | hom | Actin-binding protein; involved in bundling of actin filaments and endocytosis of actin cortical patches; activity stimulated by Las17p; contains SH3 domain similar to Rvs167p; YSC84 has a paralog, LSB3, that arose from the whole genome duplication |
0.100 | 6.04E-9 | YML101C-A_d | YML101C-A_d | hom | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
0.097 | 1.53E-8 | YLR071C | RGR1 | het | Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for glucose repression, HO repression, RME1 repression and sporulation |
0.092 | 9.16E-8 | YJL202C_d | YJL202C_d | het | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps 3' end of essential PRP21 gene encoding a subunit of the SF3a splicing factor complex |
0.085 | 7.80E-7 | YOL152W | FRE7 | hom | Putative ferric reductase with similarity to Fre2p; expression induced by low copper levels |
0.085 | 8.67E-7 | YDR032C | PST2 | hom | Protein with similarity to a family of flavodoxin-like proteins; induced by oxidative stress in a Yap1p dependent manner; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress; PST2 has a paralog, RFS1, that arose from the whole genome duplication |
0.083 | 1.55E-6 | YJL205C | NCE101 | hom | Protein of unknown function, involved in secretion of proteins that lack classical secretory signal sequences |
0.080 | 3.42E-6 | YFL017W-A | SMX2 | het | Core Sm protein Sm G; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Sme1p, and Smx3p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm G |
0.080 | 3.58E-6 | YGR201C_p | YGR201C_p | hom | Putative protein of unknown function |