YML062C / MFT1

Subunit of the THO complex, which is a nuclear complex comprised of Hpr1p, Mft1p, Rlr1p, and Thp2p, that is involved in transcription elongation and mitotic recombination; involved in telomere maintenance

Zygosity: Homozygous strain
fixedexpanded
Profile for YML062C / MFT1

Click on Significant Values for Screen Details ID:SGTC_5|Compound:0352-0601|FD-Score:9.23|P-value:1.92E-18 ID:SGTC_8|Compound:0354-0001|FD-Score:6.36|P-value:1.10E-9 ID:SGTC_14|Compound:0354-0009|FD-Score:7.36|P-value:2.17E-12 ID:SGTC_22|Compound:0964-0034|FD-Score:3.48|P-value:5.26E-4 ID:SGTC_31|Compound:0508-1974|FD-Score:3.61|P-value:3.43E-4 ID:SGTC_35|Compound:0133-0054|FD-Score:4.31|P-value:2.49E-5 ID:SGTC_43|Compound:0570-0105|FD-Score:14.20|P-value:7.60E-41 ID:SGTC_58|Compound:0957-0393|FD-Score:-6.10|P-value:4.78E-9 ID:SGTC_101|Compound:0490-5701|FD-Score:4.62|P-value:6.95E-6 ID:SGTC_144|Compound:4161-2749|FD-Score:4.53|P-value:9.98E-6 ID:SGTC_146|Compound:3448-8650|FD-Score:35.60|P-value:8.50E-247 ID:SGTC_147|Compound:4466-0538|FD-Score:3.50|P-value:4.98E-4 ID:SGTC_161|Compound:4065-0411|FD-Score:3.97|P-value:9.17E-5 ID:SGTC_178|Compound:4092-0806|FD-Score:4.46|P-value:1.33E-5 ID:SGTC_207|Compound:4185-0010|FD-Score:10.60|P-value:9.73E-24 ID:SGTC_265|Compound:mycophenolic acid|FD-Score:3.61|P-value:3.37E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-5.75|P-value:3.15E-8 ID:SGTC_329|Compound:k048-0121|FD-Score:4.74|P-value:4.03E-6 ID:SGTC_350|Compound:k064-0020|FD-Score:4.26|P-value:2.98E-5 ID:SGTC_376|Compound:3970-0862|FD-Score:4.45|P-value:1.38E-5 ID:SGTC_377|Compound:3970-0964|FD-Score:8.87|P-value:3.46E-17 ID:SGTC_391|Compound:gliotoxin|FD-Score:4.96|P-value:1.54E-6 ID:SGTC_439|Compound:amiodarone|FD-Score:7.89|P-value:5.58E-14 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-5.97|P-value:9.89E-9 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-4.31|P-value:2.53E-5 ID:SGTC_488|Compound:nitrendipine|FD-Score:3.96|P-value:9.59E-5 ID:SGTC_528|Compound:3492-0019|FD-Score:12.40|P-value:1.14E-31 ID:SGTC_542|Compound:3381-0244|FD-Score:4.80|P-value:3.09E-6 ID:SGTC_543|Compound:3844-1095|FD-Score:5.05|P-value:9.97E-7 ID:SGTC_562|Compound:3772-2733|FD-Score:7.47|P-value:1.04E-12 ID:SGTC_617|Compound:3770-0098|FD-Score:4.70|P-value:4.77E-6 ID:SGTC_649|Compound:1123-0311|FD-Score:4.83|P-value:2.76E-6 ID:SGTC_658|Compound:3253-0951|FD-Score:5.23|P-value:4.23E-7 ID:SGTC_669|Compound:0108-0021|FD-Score:4.09|P-value:5.95E-5 ID:SGTC_805|Compound:3852-0218|FD-Score:5.04|P-value:1.06E-6 ID:SGTC_817|Compound:1391-0715|FD-Score:-3.50|P-value:5.05E-4 ID:SGTC_823|Compound:0417-1665|FD-Score:5.15|P-value:6.38E-7 ID:SGTC_887|Compound:0885-0007|FD-Score:5.25|P-value:3.91E-7 ID:SGTC_919|Compound:tnp00227|FD-Score:6.54|P-value:3.69E-10 ID:SGTC_996|Compound:3970-0799|FD-Score:5.74|P-value:3.34E-8 ID:SGTC_1073|Compound:triclabendazole|FD-Score:-3.56|P-value:4.15E-4 ID:SGTC_1089|Compound:terbinafine|FD-Score:3.89|P-value:1.27E-4 ID:SGTC_1155|Compound:4088-0394|FD-Score:4.11|P-value:5.39E-5 ID:SGTC_1198|Compound:1612-1005|FD-Score:4.56|P-value:8.80E-6 ID:SGTC_1209|Compound:2323-2347|FD-Score:5.19|P-value:5.26E-7 ID:SGTC_1269|Compound:0831-0796|FD-Score:3.71|P-value:2.37E-4 ID:SGTC_1304|Compound:1165-0502|FD-Score:3.87|P-value:1.36E-4 ID:SGTC_1350|Compound:1495-0454|FD-Score:3.37|P-value:7.55E-4 ID:SGTC_1411|Compound:3909-8223|FD-Score:4.08|P-value:6.16E-5 ID:SGTC_1505|Compound:k297-0037|FD-Score:-3.82|P-value:1.65E-4 ID:SGTC_1519|Compound:esterone|FD-Score:3.84|P-value:1.48E-4 ID:SGTC_1521|Compound:st012942|FD-Score:-5.13|P-value:6.94E-7 ID:SGTC_1570|Compound:verbenone|FD-Score:-3.92|P-value:1.16E-4 ID:SGTC_1687|Compound:st020778|FD-Score:4.45|P-value:1.42E-5 ID:SGTC_1712|Compound:st032288|FD-Score:11.40|P-value:5.52E-27 ID:SGTC_1754|Compound:st042065|FD-Score:6.70|P-value:1.43E-10 ID:SGTC_1768|Compound:st044301|FD-Score:3.32|P-value:8.89E-4 ID:SGTC_1786|Compound:berberine|FD-Score:5.23|P-value:4.32E-7 ID:SGTC_1904|Compound:st060225|FD-Score:3.64|P-value:3.02E-4 ID:SGTC_1909|Compound:st060837|FD-Score:8.91|P-value:2.53E-17 ID:SGTC_1911|Compound:st060208|FD-Score:4.06|P-value:6.54E-5 ID:SGTC_1941|Compound:st076221|FD-Score:3.75|P-value:2.07E-4 ID:SGTC_2021|Compound:4019055|FD-Score:5.00|P-value:1.26E-6 ID:SGTC_2306|Compound:7482397|FD-Score:3.59|P-value:3.62E-4 ID:SGTC_2419|Compound:paclitaxel|FD-Score:3.56|P-value:3.97E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:4.36|P-value:2.03E-5 ID:SGTC_2503|Compound:beta-caryophyllene alcohol|FD-Score:4.10|P-value:5.76E-5 ID:SGTC_2546|Compound:rhodinyl acetate|FD-Score:3.54|P-value:4.27E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:-7.69|P-value:2.38E-13 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:4.16|P-value:4.57E-5 ID:SGTC_2679|Compound:rapamycin|FD-Score:5.48|P-value:1.26E-7 ID:SGTC_2814|Compound:7977482|FD-Score:5.25|P-value:3.85E-7 ID:SGTC_2830|Compound:7992007|FD-Score:4.88|P-value:2.22E-6 ID:SGTC_2834|Compound:9001755|FD-Score:-3.89|P-value:1.29E-4 ID:SGTC_2980|Compound:9014342|FD-Score:3.88|P-value:1.30E-4 ID:SGTC_3143|Compound:9086658|FD-Score:3.59|P-value:3.61E-4 ID:SGTC_3148|Compound:9097893|FD-Score:4.43|P-value:1.52E-5 ID:SGTC_3269|Compound:9137823|FD-Score:4.24|P-value:3.35E-5 ID:SGTC_3337|Compound:9144342|FD-Score:10.00|P-value:2.08E-21 ID:SGTC_5|Compound:0352-0601|FD-Score:9.23|P-value:1.92E-18 ID:SGTC_8|Compound:0354-0001|FD-Score:6.36|P-value:1.10E-9 ID:SGTC_14|Compound:0354-0009|FD-Score:7.36|P-value:2.17E-12 ID:SGTC_22|Compound:0964-0034|FD-Score:3.48|P-value:5.26E-4 ID:SGTC_31|Compound:0508-1974|FD-Score:3.61|P-value:3.43E-4 ID:SGTC_35|Compound:0133-0054|FD-Score:4.31|P-value:2.49E-5 ID:SGTC_43|Compound:0570-0105|FD-Score:14.20|P-value:7.60E-41 ID:SGTC_58|Compound:0957-0393|FD-Score:-6.10|P-value:4.78E-9 ID:SGTC_101|Compound:0490-5701|FD-Score:4.62|P-value:6.95E-6 ID:SGTC_144|Compound:4161-2749|FD-Score:4.53|P-value:9.98E-6 ID:SGTC_146|Compound:3448-8650|FD-Score:35.60|P-value:8.50E-247 ID:SGTC_147|Compound:4466-0538|FD-Score:3.50|P-value:4.98E-4 ID:SGTC_161|Compound:4065-0411|FD-Score:3.97|P-value:9.17E-5 ID:SGTC_178|Compound:4092-0806|FD-Score:4.46|P-value:1.33E-5 ID:SGTC_207|Compound:4185-0010|FD-Score:10.60|P-value:9.73E-24 ID:SGTC_265|Compound:mycophenolic acid|FD-Score:3.61|P-value:3.37E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-5.75|P-value:3.15E-8 ID:SGTC_329|Compound:k048-0121|FD-Score:4.74|P-value:4.03E-6 ID:SGTC_350|Compound:k064-0020|FD-Score:4.26|P-value:2.98E-5 ID:SGTC_376|Compound:3970-0862|FD-Score:4.45|P-value:1.38E-5 ID:SGTC_377|Compound:3970-0964|FD-Score:8.87|P-value:3.46E-17 ID:SGTC_391|Compound:gliotoxin|FD-Score:4.96|P-value:1.54E-6 ID:SGTC_439|Compound:amiodarone|FD-Score:7.89|P-value:5.58E-14 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-5.97|P-value:9.89E-9 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-4.31|P-value:2.53E-5 ID:SGTC_488|Compound:nitrendipine|FD-Score:3.96|P-value:9.59E-5 ID:SGTC_528|Compound:3492-0019|FD-Score:12.40|P-value:1.14E-31 ID:SGTC_542|Compound:3381-0244|FD-Score:4.80|P-value:3.09E-6 ID:SGTC_543|Compound:3844-1095|FD-Score:5.05|P-value:9.97E-7 ID:SGTC_562|Compound:3772-2733|FD-Score:7.47|P-value:1.04E-12 ID:SGTC_617|Compound:3770-0098|FD-Score:4.70|P-value:4.77E-6 ID:SGTC_649|Compound:1123-0311|FD-Score:4.83|P-value:2.76E-6 ID:SGTC_658|Compound:3253-0951|FD-Score:5.23|P-value:4.23E-7 ID:SGTC_669|Compound:0108-0021|FD-Score:4.09|P-value:5.95E-5 ID:SGTC_805|Compound:3852-0218|FD-Score:5.04|P-value:1.06E-6 ID:SGTC_817|Compound:1391-0715|FD-Score:-3.50|P-value:5.05E-4 ID:SGTC_823|Compound:0417-1665|FD-Score:5.15|P-value:6.38E-7 ID:SGTC_887|Compound:0885-0007|FD-Score:5.25|P-value:3.91E-7 ID:SGTC_919|Compound:tnp00227|FD-Score:6.54|P-value:3.69E-10 ID:SGTC_996|Compound:3970-0799|FD-Score:5.74|P-value:3.34E-8 ID:SGTC_1073|Compound:triclabendazole|FD-Score:-3.56|P-value:4.15E-4 ID:SGTC_1089|Compound:terbinafine|FD-Score:3.89|P-value:1.27E-4 ID:SGTC_1155|Compound:4088-0394|FD-Score:4.11|P-value:5.39E-5 ID:SGTC_1198|Compound:1612-1005|FD-Score:4.56|P-value:8.80E-6 ID:SGTC_1209|Compound:2323-2347|FD-Score:5.19|P-value:5.26E-7 ID:SGTC_1269|Compound:0831-0796|FD-Score:3.71|P-value:2.37E-4 ID:SGTC_1304|Compound:1165-0502|FD-Score:3.87|P-value:1.36E-4 ID:SGTC_1350|Compound:1495-0454|FD-Score:3.37|P-value:7.55E-4 ID:SGTC_1411|Compound:3909-8223|FD-Score:4.08|P-value:6.16E-5 ID:SGTC_1505|Compound:k297-0037|FD-Score:-3.82|P-value:1.65E-4 ID:SGTC_1519|Compound:esterone|FD-Score:3.84|P-value:1.48E-4 ID:SGTC_1521|Compound:st012942|FD-Score:-5.13|P-value:6.94E-7 ID:SGTC_1570|Compound:verbenone|FD-Score:-3.92|P-value:1.16E-4 ID:SGTC_1687|Compound:st020778|FD-Score:4.45|P-value:1.42E-5 ID:SGTC_1712|Compound:st032288|FD-Score:11.40|P-value:5.52E-27 ID:SGTC_1754|Compound:st042065|FD-Score:6.70|P-value:1.43E-10 ID:SGTC_1768|Compound:st044301|FD-Score:3.32|P-value:8.89E-4 ID:SGTC_1786|Compound:berberine|FD-Score:5.23|P-value:4.32E-7 ID:SGTC_1904|Compound:st060225|FD-Score:3.64|P-value:3.02E-4 ID:SGTC_1909|Compound:st060837|FD-Score:8.91|P-value:2.53E-17 ID:SGTC_1911|Compound:st060208|FD-Score:4.06|P-value:6.54E-5 ID:SGTC_1941|Compound:st076221|FD-Score:3.75|P-value:2.07E-4 ID:SGTC_2021|Compound:4019055|FD-Score:5.00|P-value:1.26E-6 ID:SGTC_2306|Compound:7482397|FD-Score:3.59|P-value:3.62E-4 ID:SGTC_2419|Compound:paclitaxel|FD-Score:3.56|P-value:3.97E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:4.36|P-value:2.03E-5 ID:SGTC_2503|Compound:beta-caryophyllene alcohol|FD-Score:4.10|P-value:5.76E-5 ID:SGTC_2546|Compound:rhodinyl acetate|FD-Score:3.54|P-value:4.27E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:-7.69|P-value:2.38E-13 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:4.16|P-value:4.57E-5 ID:SGTC_2679|Compound:rapamycin|FD-Score:5.48|P-value:1.26E-7 ID:SGTC_2814|Compound:7977482|FD-Score:5.25|P-value:3.85E-7 ID:SGTC_2830|Compound:7992007|FD-Score:4.88|P-value:2.22E-6 ID:SGTC_2834|Compound:9001755|FD-Score:-3.89|P-value:1.29E-4 ID:SGTC_2980|Compound:9014342|FD-Score:3.88|P-value:1.30E-4 ID:SGTC_3143|Compound:9086658|FD-Score:3.59|P-value:3.61E-4 ID:SGTC_3148|Compound:9097893|FD-Score:4.43|P-value:1.52E-5 ID:SGTC_3269|Compound:9137823|FD-Score:4.24|P-value:3.35E-5 ID:SGTC_3337|Compound:9144342|FD-Score:10.00|P-value:2.08E-21

Top fitness defect scores for YML062C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_146 3448-8650 35.60 53.1 µM 8.50E-247 NEO1-PIK1 1 1.59E-278
2 SGTC_43 0570-0105 14.20 72.5 µM 7.60E-41 ERG2 2 7.16E-46
3 SGTC_528 3492-0019 12.40 172.0 µM 1.14E-31 calcium & mitochondrial duress 29 1.64E-35
4 SGTC_1712 st032288 11.40 53.4 µM 5.52E-27 calcium & mitochondrial duress 15 3.18E-30
5 SGTC_207 4185-0010 10.60 4.5 µM 9.73E-24 endomembrane recycling 18 1.47E-26
6 SGTC_3337 9144342 10.00 33.5 µM 2.08E-21 2 6.23E-24
7 SGTC_5 0352-0601 9.23 109.9 µM 1.92E-18 ERG2 1 1.38E-20
8 SGTC_1909 st060837 8.91 51.5 µM 2.53E-17 6 2.54E-19
9 SGTC_377 3970-0964 8.87 33.1 µM 3.46E-17 2 3.61E-19
10 SGTC_439 amiodarone 7.89 34.4 µM 5.58E-14 NEO1-PIK1 24 1.49E-15
11 SGTC_562 3772-2733 7.47 112.0 µM 1.04E-12 ERG2 21 4.04E-14
12 SGTC_14 0354-0009 7.36 295.0 µM 2.17E-12 4 9.25E-14
13 SGTC_1754 st042065 6.70 16.1 µM 1.43E-10 NEO1-PIK1 80 1.04E-11
14 SGTC_919 tnp00227 6.54 403.6 nM 3.69E-10 RNA pol III & RNase P/MRP 5 3.02E-11
15 SGTC_8 0354-0001 6.36 70.0 µM 1.10E-9 24 1.03E-10
16 SGTC_996 3970-0799 5.74 1.8 µM 3.34E-8 40 4.83E-9
17 SGTC_2679 rapamycin 5.48 1.0 nM 1.26E-7 88 2.15E-8
18 SGTC_2814 7977482 5.25 43.0 µM 3.85E-7 13 7.56E-8
19 SGTC_887 0885-0007 5.25 9.6 µM 3.91E-7 endomembrane recycling 19 7.67E-8
20 SGTC_658 3253-0951 5.23 102.0 µM 4.23E-7 calcium & mitochondrial duress 26 8.39E-8

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.351 6.45E-98 YHR167W THP2 hom Subunit of the THO complex, which connects transcription elongation and mitotic recombination, and of the TREX complex, which is recruited to activated genes and couples transcription to mRNA export; involved in telomere maintenance
0.336 5.22E-89 YIL170W HXT12 hom Possible pseudogene in strain S288C; YIL170W/HXT12 and the adjacent ORF, YIL171W, together encode a non-functional member of the hexose transporter family
0.311 5.62E-76 YKR095W MLP1 hom Myosin-like protein associated with the nuclear envelope, connects the nuclear pore complex with the nuclear interior; involved with Tel1p in telomere length control; involved with Pml1p and Pml39p in nuclear retention of unspliced mRNAs
0.309 4.47E-75 YNL140C_p YNL140C_p hom Protein of unknown function; expressed at both mRNA and protein levels; partially overlaps THO2/YNL139C
0.302 1.14E-71 YOL072W THP1 hom Nuclear pore-associated protein; component of TREX-2 complex (Sac3p-Thp1p-Sus1p-Cdc31p) involved in transcription elongation and mRNA export from the nucleus; involved in post-transcriptional tethering of active genes to the nuclear periphery and to non-nascent mRNP; contains a PAM domain implicated in protein-protein binding
0.302 2.02E-71 YPL145C KES1 hom One of seven members of the yeast oxysterol binding protein family; involved in negative regulation of Sec14p-dependent Golgi complex secretory functions, peripheral membrane protein that localizes to the Golgi complex; KES1 has a paralog, HES1, that arose from the whole genome duplication
0.285 1.25E-63 YJR088C EMC2 hom Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; homologous to worm Y57G7A.10/EMC-2, fly CG17556, human TTC35
0.272 4.79E-58 YJL124C LSM1 hom Lsm (Like Sm) protein; forms heteroheptameric complex (with Lsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p) involved in degradation of cytoplasmic mRNAs; unlike most Sm-like proteins, Lsm1p requires both its SM-domain and C-terminal domain for RNA-binding; forms cytoplasmic foci upon DNA replication stress
0.272 7.36E-58 YDR372C VPS74 hom Golgi phosphatidylinositol-4-kinase effector and PtdIns4P sensor; interacts with the cytosolic domains of cis and medial glycosyltransferases, and in the PtdIns4P-bound state mediates the targeting of these enzymes to the Golgi; interacts with the catalytic domain of Sac1p, the major cellular PtdIns4P phosphatase, to direct dephosphosphorylation of the Golgi pool of PtdIns4P; tetramerization required for function; ortholog of human GOLPH3/GPP34/GMx33
0.266 1.74E-55 YDR093W DNF2 hom Aminophospholipid translocase (flippase) that localizes primarily to the plasma membrane; contributes to endocytosis, protein transport and cell polarity; type 4 P-type ATPase
0.254 1.49E-50 YNL246W VPS75 hom NAP family histone chaperone; binds to histones and Rtt109p, stimulating histone acetyltransferase activity; possesses nucleosome assembly activity in vitro; proposed role in vacuolar protein sorting and in double-strand break repair; protein abundance increases in response to DNA replication stress
0.251 2.69E-49 YDL019C OSH2 hom Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability
0.231 7.06E-42 YPR091C NVJ2 hom Lipid-binding ER protein, enriched at nucleus-vacuolar junctions (NVJ); may be involved in sterol metabolism or signaling at the NVJ; contains a synaptotagmin-like-mitochondrial- lipid binding protein (SMP) domain; binds phosphatidylinositols and other lipids in a large-scale study; may interact with ribosomes, based on co-purification experiments
0.230 2.45E-41 YDR467C_d YDR467C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.226 6.31E-40 YGR178C PBP1 hom Component of glucose deprivation induced stress granules; involved in P-body-dependent granule assembly; similar to human ataxin-2; interacts with Pab1p to regulate mRNA polyadenylation; interacts with Mkt1p to regulate HO translation; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress