YML063W / RPS1B

Ribosomal protein 10 (rp10) of the small (40S) subunit; homologous to mammalian ribosomal protein S3A, no bacterial homolog; RPS1B has a paralog, RPS1A, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YML063W / RPS1B

Click on Significant Values for Screen Details ID:SGTC_65|Compound:0798-0905|FD-Score:5.11|P-value:5.74E-7 ID:SGTC_69|Compound:0096-0274|FD-Score:4.83|P-value:2.23E-6 ID:SGTC_95|Compound:0471-0001|FD-Score:3.58|P-value:3.36E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:3.78|P-value:1.66E-4 ID:SGTC_164|Compound:4100-3994|FD-Score:-3.34|P-value:6.28E-4 ID:SGTC_304|Compound:1310-0298|FD-Score:-3.30|P-value:7.36E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-3.71|P-value:1.73E-4 ID:SGTC_341|Compound:1486-1430|FD-Score:4.73|P-value:3.46E-6 ID:SGTC_358|Compound:0075-0058|FD-Score:3.39|P-value:6.46E-4 ID:SGTC_387|Compound:norethindrone acetate|FD-Score:3.60|P-value:3.15E-4 ID:SGTC_462|Compound:ag-879|FD-Score:3.93|P-value:9.58E-5 ID:SGTC_517|Compound:1365-0151|FD-Score:3.49|P-value:4.60E-4 ID:SGTC_544|Compound:k015-0020|FD-Score:6.06|P-value:4.06E-9 ID:SGTC_691|Compound:1548-0686|FD-Score:3.54|P-value:3.99E-4 ID:SGTC_795|Compound:0685-0265|FD-Score:3.34|P-value:7.73E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:3.53|P-value:4.01E-4 ID:SGTC_831|Compound:k061-1017|FD-Score:3.62|P-value:2.95E-4 ID:SGTC_864|Compound:0469-0573|FD-Score:4.81|P-value:2.39E-6 ID:SGTC_974|Compound:1326-0144|FD-Score:-4.03|P-value:5.13E-5 ID:SGTC_1015|Compound:4130-4525|FD-Score:4.20|P-value:3.30E-5 ID:SGTC_1021|Compound:4476-0760|FD-Score:3.44|P-value:5.60E-4 ID:SGTC_1331|Compound:1472-0049|FD-Score:3.79|P-value:1.59E-4 ID:SGTC_1342|Compound:1486-1464|FD-Score:4.04|P-value:6.20E-5 ID:SGTC_1473|Compound:k844-0725|FD-Score:4.15|P-value:4.01E-5 ID:SGTC_1482|Compound:3346-2049|FD-Score:4.39|P-value:1.53E-5 ID:SGTC_1513|Compound:0337-0559|FD-Score:3.48|P-value:4.82E-4 ID:SGTC_1529|Compound:apigenin|FD-Score:3.91|P-value:1.02E-4 ID:SGTC_1725|Compound:st036284|FD-Score:3.69|P-value:2.31E-4 ID:SGTC_1743|Compound:st037606|FD-Score:4.26|P-value:2.64E-5 ID:SGTC_1781|Compound:st038725|FD-Score:5.82|P-value:1.56E-8 ID:SGTC_1891|Compound:st059073|FD-Score:4.16|P-value:3.88E-5 ID:SGTC_1920|Compound:st075728|FD-Score:3.88|P-value:1.15E-4 ID:SGTC_2055|Compound:5235184|FD-Score:3.40|P-value:6.41E-4 ID:SGTC_2057|Compound:5236571|FD-Score:-3.62|P-value:2.37E-4 ID:SGTC_2184|Compound:6075246|FD-Score:4.66|P-value:4.66E-6 ID:SGTC_2460|Compound:5552655|FD-Score:3.28|P-value:9.30E-4 ID:SGTC_2548|Compound:3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin|FD-Score:-3.64|P-value:2.24E-4 ID:SGTC_2551|Compound:apiole|FD-Score:-3.87|P-value:9.53E-5 ID:SGTC_2569|Compound:tetrandrine|FD-Score:4.09|P-value:5.07E-5 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:4.66|P-value:4.77E-6 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:5.81|P-value:1.57E-8 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:5.41|P-value:1.32E-7 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.34|P-value:7.65E-4 ID:SGTC_2700|Compound:st077718|FD-Score:-3.60|P-value:2.60E-4 ID:SGTC_2755|Compound:lomerizine|FD-Score:3.48|P-value:4.81E-4 ID:SGTC_2830|Compound:7992007|FD-Score:3.46|P-value:5.11E-4 ID:SGTC_3197|Compound:9113331|FD-Score:-3.40|P-value:5.26E-4 ID:SGTC_65|Compound:0798-0905|FD-Score:5.11|P-value:5.74E-7 ID:SGTC_69|Compound:0096-0274|FD-Score:4.83|P-value:2.23E-6 ID:SGTC_95|Compound:0471-0001|FD-Score:3.58|P-value:3.36E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:3.78|P-value:1.66E-4 ID:SGTC_164|Compound:4100-3994|FD-Score:-3.34|P-value:6.28E-4 ID:SGTC_304|Compound:1310-0298|FD-Score:-3.30|P-value:7.36E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-3.71|P-value:1.73E-4 ID:SGTC_341|Compound:1486-1430|FD-Score:4.73|P-value:3.46E-6 ID:SGTC_358|Compound:0075-0058|FD-Score:3.39|P-value:6.46E-4 ID:SGTC_387|Compound:norethindrone acetate|FD-Score:3.60|P-value:3.15E-4 ID:SGTC_462|Compound:ag-879|FD-Score:3.93|P-value:9.58E-5 ID:SGTC_517|Compound:1365-0151|FD-Score:3.49|P-value:4.60E-4 ID:SGTC_544|Compound:k015-0020|FD-Score:6.06|P-value:4.06E-9 ID:SGTC_691|Compound:1548-0686|FD-Score:3.54|P-value:3.99E-4 ID:SGTC_795|Compound:0685-0265|FD-Score:3.34|P-value:7.73E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:3.53|P-value:4.01E-4 ID:SGTC_831|Compound:k061-1017|FD-Score:3.62|P-value:2.95E-4 ID:SGTC_864|Compound:0469-0573|FD-Score:4.81|P-value:2.39E-6 ID:SGTC_974|Compound:1326-0144|FD-Score:-4.03|P-value:5.13E-5 ID:SGTC_1015|Compound:4130-4525|FD-Score:4.20|P-value:3.30E-5 ID:SGTC_1021|Compound:4476-0760|FD-Score:3.44|P-value:5.60E-4 ID:SGTC_1331|Compound:1472-0049|FD-Score:3.79|P-value:1.59E-4 ID:SGTC_1342|Compound:1486-1464|FD-Score:4.04|P-value:6.20E-5 ID:SGTC_1473|Compound:k844-0725|FD-Score:4.15|P-value:4.01E-5 ID:SGTC_1482|Compound:3346-2049|FD-Score:4.39|P-value:1.53E-5 ID:SGTC_1513|Compound:0337-0559|FD-Score:3.48|P-value:4.82E-4 ID:SGTC_1529|Compound:apigenin|FD-Score:3.91|P-value:1.02E-4 ID:SGTC_1725|Compound:st036284|FD-Score:3.69|P-value:2.31E-4 ID:SGTC_1743|Compound:st037606|FD-Score:4.26|P-value:2.64E-5 ID:SGTC_1781|Compound:st038725|FD-Score:5.82|P-value:1.56E-8 ID:SGTC_1891|Compound:st059073|FD-Score:4.16|P-value:3.88E-5 ID:SGTC_1920|Compound:st075728|FD-Score:3.88|P-value:1.15E-4 ID:SGTC_2055|Compound:5235184|FD-Score:3.40|P-value:6.41E-4 ID:SGTC_2057|Compound:5236571|FD-Score:-3.62|P-value:2.37E-4 ID:SGTC_2184|Compound:6075246|FD-Score:4.66|P-value:4.66E-6 ID:SGTC_2460|Compound:5552655|FD-Score:3.28|P-value:9.30E-4 ID:SGTC_2548|Compound:3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin|FD-Score:-3.64|P-value:2.24E-4 ID:SGTC_2551|Compound:apiole|FD-Score:-3.87|P-value:9.53E-5 ID:SGTC_2569|Compound:tetrandrine|FD-Score:4.09|P-value:5.07E-5 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:4.66|P-value:4.77E-6 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:5.81|P-value:1.57E-8 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:5.41|P-value:1.32E-7 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.34|P-value:7.65E-4 ID:SGTC_2700|Compound:st077718|FD-Score:-3.60|P-value:2.60E-4 ID:SGTC_2755|Compound:lomerizine|FD-Score:3.48|P-value:4.81E-4 ID:SGTC_2830|Compound:7992007|FD-Score:3.46|P-value:5.11E-4 ID:SGTC_3197|Compound:9113331|FD-Score:-3.40|P-value:5.26E-4

Top fitness defect scores for YML063W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_544 k015-0020 6.06 52.4 µM 4.06E-9 1 6.91E-10
2 SGTC_1781 st038725 5.82 66.3 µM 1.56E-8 NEO1 60 3.03E-9
3 SGTC_2572 astragaloside iv 5.81 100.0 µM 1.57E-8 4 3.05E-9
4 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 5.41 13.2 µM 1.32E-7 7 3.15E-8
5 SGTC_65 0798-0905 5.11 35.0 µM 5.74E-7 calcium & mitochondrial duress 50 1.57E-7
6 SGTC_69 0096-0274 4.83 206.7 µM 2.23E-6 mitochondrial processes 20 6.95E-7
7 SGTC_864 0469-0573 4.81 172.0 µM 2.39E-6 5 7.50E-7
8 SGTC_341 1486-1430 4.73 230.0 µM 3.46E-6 11 1.12E-6
9 SGTC_2184 6075246 4.66 200.0 µM 4.66E-6 12 1.56E-6
10 SGTC_2571 chrysanthemic acid 4.66 100.0 µM 4.77E-6 8 1.60E-6
11 SGTC_1482 3346-2049 4.39 8.5 µM 1.53E-5 22 5.74E-6
12 SGTC_1743 st037606 4.26 46.4 µM 2.64E-5 17 1.04E-5
13 SGTC_1015 4130-4525 4.20 82.0 µM 3.30E-5 60S ribosome export 16 1.33E-5
14 SGTC_1891 st059073 4.16 26.2 µM 3.88E-5 TSC3-RPN4 19 1.59E-5
15 SGTC_1473 k844-0725 4.15 134.0 µM 4.01E-5 8 1.64E-5
16 SGTC_2569 tetrandrine 4.09 100.0 µM 5.07E-5 18 2.13E-5
17 SGTC_1342 1486-1464 4.04 234.0 µM 6.20E-5 13 2.65E-5
18 SGTC_462 ag-879 3.93 158.0 µM 9.58E-5 31 4.27E-5
19 SGTC_1529 apigenin 3.91 74.0 µM 1.02E-4 35 4.58E-5
20 SGTC_1920 st075728 3.88 45.7 µM 1.15E-4 23 5.21E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.165 7.32E-22 YDR140W MTQ2 hom S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; subunit of complex with Trm112p that methylates translation release factor Sup45p (eRF1) in the ternary complex eRF1-eRF3-GTP; similar to E.coli PrmC
0.160 1.31E-20 YLR048W RPS0B hom Protein component of the small (40S) ribosomal subunit; RPS0B has a paralog, RPS0A, that arose from the whole genome duplication; required for maturation of 18S rRNA along with Rps0Ap; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal; homologous to human ribosomal protein SA and bacterial S2
0.147 1.09E-17 YBR169C SSE2 hom Member of the heat shock protein 70 (HSP70) family; may be involved in protein folding; localized to the cytoplasm; SSE2 has a paralog, SSE1, that arose from the whole genome duplication
0.140 2.99E-16 YJL136C RPS21B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S21, no bacterial homolog; RPS21B has a paralog, RPS21A, that arose from the whole genome duplication
0.135 4.57E-15 YBR189W RPS9B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S9 and bacterial S4; RPS9B has a paralog, RPS9A, that arose from the whole genome duplication
0.133 9.64E-15 YGR162W TIF4631 hom Translation initiation factor eIF4G; subunit of the mRNA cap-binding protein complex (eIF4F) that also contains eIF4E (Cdc33p); interacts with Pab1p and with eIF4A (Tif1p); also has a role in biogenesis of the large ribosomal subunit; TIF4631 has a paralog, TIF4632, that arose from the whole genome duplication
0.124 4.89E-13 YBR139W YBR139W hom Putative serine type carboxypeptidase with a role in phytochelatin synthesis; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; expression induced by nitrogen limitation in a GLN3, GAT1-independent manner
0.122 1.53E-12 YOR293W RPS10A hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S10, no bacterial homolog; RPS10A has a paralog, RPS10B, that arose from the whole genome duplication
0.121 2.07E-12 YLR062C_d BUD28_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene RPL22A; diploid mutant displays a weak budding pattern phenotype in a systematic assay
0.119 4.08E-12 YLR068W FYV7 hom Essential protein required for maturation of 18S rRNA; required for survival upon exposure to K1 killer toxin
0.119 4.50E-12 YDR500C RPL37B hom Ribosomal 60S subunit protein L37B; protein abundance increases in response to DNA replication stress; homologous to mammalian ribosomal protein L37, no bacterial homolog; RPL37B has a paralog, RPL37A, that arose from the whole genome duplication
0.117 1.13E-11 YOR295W UAF30 hom Subunit of UAF (upstream activation factor); UAF is an RNA polymerase I specific transcription stimulatory factor composed of Uaf30p, Rrn5p, Rrn9p, Rrn10p, histones H3 and H4; deletion decreases cellular growth rate; UAF30 has a paralog, TRI1, that arose from the whole genome duplication
0.113 4.81E-11 YIR026C YVH1 hom Protein phosphatase involved in vegetative growth at low temperatures, sporulation, and glycogen accumulation; mutants are defective in 60S ribosome assembly; member of the dual-specificity family of protein phosphatases
0.111 1.02E-10 YDL061C RPS29B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S29 and bacterial S14; RPS29B has a paralog, RPS29A, that arose from the whole genome duplication
0.111 1.11E-10 YJL189W RPL39 hom Ribosomal 60S subunit protein L39; required for ribosome biogenesis; loss of both Rpl31p and Rpl39p confers lethality; also exhibits genetic interactions with SIS1 and PAB1; homologous to mammalian ribosomal protein L39, no bacterial homolog