YML064C / TEM1

GTP-binding protein of the ras superfamily involved in termination of M-phase; controls actomyosin and septin dynamics during cytokinesis

Zygosity: Heterozygous strain
fixedexpanded
Profile for YML064C / TEM1

Click on Significant Values for Screen Details ID:SGTC_141|Compound:0443-0274|FD-Score:-5.71|P-value:1.36E-9 ID:SGTC_166|Compound:k072-0058|FD-Score:-3.29|P-value:3.09E-4 ID:SGTC_212|Compound:3807-4682|FD-Score:7.14|P-value:3.94E-14 ID:SGTC_349|Compound:k015-0014|FD-Score:3.70|P-value:5.26E-5 ID:SGTC_426|Compound:0988-0037|FD-Score:2.97|P-value:9.17E-4 ID:SGTC_433|Compound:pimozide|FD-Score:-3.43|P-value:1.77E-4 ID:SGTC_473|Compound:2-arachidonoylglycerol|FD-Score:3.30|P-value:2.69E-4 ID:SGTC_534|Compound:k292-0788|FD-Score:3.13|P-value:5.26E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:-3.91|P-value:2.39E-5 ID:SGTC_801|Compound:0866-0028|FD-Score:-3.11|P-value:6.08E-4 ID:SGTC_987|Compound:1497-1013|FD-Score:-3.37|P-value:2.25E-4 ID:SGTC_1170|Compound:0310-0127|FD-Score:5.35|P-value:1.09E-8 ID:SGTC_1173|Compound:0443-0020|FD-Score:-3.67|P-value:6.66E-5 ID:SGTC_1183|Compound:1254-0324|FD-Score:-3.73|P-value:5.13E-5 ID:SGTC_1459|Compound:k035-0031|FD-Score:-3.06|P-value:7.25E-4 ID:SGTC_1575|Compound:cyproterone acetate|FD-Score:3.25|P-value:3.31E-4 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:2.98|P-value:8.85E-4 ID:SGTC_1747|Compound:st037496|FD-Score:3.01|P-value:7.86E-4 ID:SGTC_1893|Compound:st059353|FD-Score:3.33|P-value:2.38E-4 ID:SGTC_1905|Compound:st060207|FD-Score:3.29|P-value:2.86E-4 ID:SGTC_2011|Compound:4012611|FD-Score:4.49|P-value:1.28E-6 ID:SGTC_2117|Compound:5521686|FD-Score:4.24|P-value:4.42E-6 ID:SGTC_2131|Compound:toluylene red|FD-Score:3.98|P-value:1.50E-5 ID:SGTC_2327|Compound:6189656|FD-Score:2.98|P-value:8.86E-4 ID:SGTC_2484|Compound:5809818|FD-Score:3.40|P-value:1.82E-4 ID:SGTC_2508|Compound:celastrol|FD-Score:-3.46|P-value:1.57E-4 ID:SGTC_2807|Compound:7945238|FD-Score:3.11|P-value:5.61E-4 ID:SGTC_2843|Compound:9000894|FD-Score:-3.43|P-value:1.81E-4 ID:SGTC_2866|Compound:9034245|FD-Score:-3.19|P-value:4.57E-4 ID:SGTC_2904|Compound:7225135|FD-Score:3.32|P-value:2.50E-4 ID:SGTC_2908|Compound:7930301|FD-Score:-3.00|P-value:9.07E-4 ID:SGTC_2909|Compound:7941780|FD-Score:-4.26|P-value:4.63E-6 ID:SGTC_2913|Compound:7966556|FD-Score:4.37|P-value:2.40E-6 ID:SGTC_2925|Compound:9010536|FD-Score:-3.03|P-value:8.26E-4 ID:SGTC_2990|Compound:9074105|FD-Score:6.90|P-value:2.65E-13 ID:SGTC_2991|Compound:9074669|FD-Score:3.72|P-value:4.89E-5 ID:SGTC_2992|Compound:9074591|FD-Score:4.80|P-value:2.50E-7 ID:SGTC_2996|Compound:9066192|FD-Score:-3.19|P-value:4.56E-4 ID:SGTC_3204|Compound:9114183|FD-Score:3.97|P-value:1.63E-5 ID:SGTC_3206|Compound:9114350|FD-Score:3.94|P-value:1.87E-5 ID:SGTC_3221|Compound:9128209|FD-Score:3.56|P-value:9.67E-5 ID:SGTC_3223|Compound:9129970|FD-Score:3.65|P-value:6.66E-5 ID:SGTC_3227|Compound:9130768|FD-Score:3.16|P-value:4.70E-4 ID:SGTC_3265|Compound:9137266|FD-Score:-2.98|P-value:9.72E-4 ID:SGTC_3298|Compound:9116858|FD-Score:3.22|P-value:3.66E-4 ID:SGTC_3299|Compound:9121982|FD-Score:-3.20|P-value:4.36E-4 ID:SGTC_141|Compound:0443-0274|FD-Score:-5.71|P-value:1.36E-9 ID:SGTC_166|Compound:k072-0058|FD-Score:-3.29|P-value:3.09E-4 ID:SGTC_212|Compound:3807-4682|FD-Score:7.14|P-value:3.94E-14 ID:SGTC_349|Compound:k015-0014|FD-Score:3.70|P-value:5.26E-5 ID:SGTC_426|Compound:0988-0037|FD-Score:2.97|P-value:9.17E-4 ID:SGTC_433|Compound:pimozide|FD-Score:-3.43|P-value:1.77E-4 ID:SGTC_473|Compound:2-arachidonoylglycerol|FD-Score:3.30|P-value:2.69E-4 ID:SGTC_534|Compound:k292-0788|FD-Score:3.13|P-value:5.26E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:-3.91|P-value:2.39E-5 ID:SGTC_801|Compound:0866-0028|FD-Score:-3.11|P-value:6.08E-4 ID:SGTC_987|Compound:1497-1013|FD-Score:-3.37|P-value:2.25E-4 ID:SGTC_1170|Compound:0310-0127|FD-Score:5.35|P-value:1.09E-8 ID:SGTC_1173|Compound:0443-0020|FD-Score:-3.67|P-value:6.66E-5 ID:SGTC_1183|Compound:1254-0324|FD-Score:-3.73|P-value:5.13E-5 ID:SGTC_1459|Compound:k035-0031|FD-Score:-3.06|P-value:7.25E-4 ID:SGTC_1575|Compound:cyproterone acetate|FD-Score:3.25|P-value:3.31E-4 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:2.98|P-value:8.85E-4 ID:SGTC_1747|Compound:st037496|FD-Score:3.01|P-value:7.86E-4 ID:SGTC_1893|Compound:st059353|FD-Score:3.33|P-value:2.38E-4 ID:SGTC_1905|Compound:st060207|FD-Score:3.29|P-value:2.86E-4 ID:SGTC_2011|Compound:4012611|FD-Score:4.49|P-value:1.28E-6 ID:SGTC_2117|Compound:5521686|FD-Score:4.24|P-value:4.42E-6 ID:SGTC_2131|Compound:toluylene red|FD-Score:3.98|P-value:1.50E-5 ID:SGTC_2327|Compound:6189656|FD-Score:2.98|P-value:8.86E-4 ID:SGTC_2484|Compound:5809818|FD-Score:3.40|P-value:1.82E-4 ID:SGTC_2508|Compound:celastrol|FD-Score:-3.46|P-value:1.57E-4 ID:SGTC_2807|Compound:7945238|FD-Score:3.11|P-value:5.61E-4 ID:SGTC_2843|Compound:9000894|FD-Score:-3.43|P-value:1.81E-4 ID:SGTC_2866|Compound:9034245|FD-Score:-3.19|P-value:4.57E-4 ID:SGTC_2904|Compound:7225135|FD-Score:3.32|P-value:2.50E-4 ID:SGTC_2908|Compound:7930301|FD-Score:-3.00|P-value:9.07E-4 ID:SGTC_2909|Compound:7941780|FD-Score:-4.26|P-value:4.63E-6 ID:SGTC_2913|Compound:7966556|FD-Score:4.37|P-value:2.40E-6 ID:SGTC_2925|Compound:9010536|FD-Score:-3.03|P-value:8.26E-4 ID:SGTC_2990|Compound:9074105|FD-Score:6.90|P-value:2.65E-13 ID:SGTC_2991|Compound:9074669|FD-Score:3.72|P-value:4.89E-5 ID:SGTC_2992|Compound:9074591|FD-Score:4.80|P-value:2.50E-7 ID:SGTC_2996|Compound:9066192|FD-Score:-3.19|P-value:4.56E-4 ID:SGTC_3204|Compound:9114183|FD-Score:3.97|P-value:1.63E-5 ID:SGTC_3206|Compound:9114350|FD-Score:3.94|P-value:1.87E-5 ID:SGTC_3221|Compound:9128209|FD-Score:3.56|P-value:9.67E-5 ID:SGTC_3223|Compound:9129970|FD-Score:3.65|P-value:6.66E-5 ID:SGTC_3227|Compound:9130768|FD-Score:3.16|P-value:4.70E-4 ID:SGTC_3265|Compound:9137266|FD-Score:-2.98|P-value:9.72E-4 ID:SGTC_3298|Compound:9116858|FD-Score:3.22|P-value:3.66E-4 ID:SGTC_3299|Compound:9121982|FD-Score:-3.20|P-value:4.36E-4

Top fitness defect scores for YML064C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_212 3807-4682 7.14 38.8 µM 3.94E-14 tubulin folding & SWR complex 9 4.54E-13 0.23
2 SGTC_2990 9074105 6.90 71.4 µM 2.65E-13 2 2.61E-12 1.58
3 SGTC_1170 0310-0127 5.35 64.8 µM 1.09E-8 3 4.47E-8 0.27
4 SGTC_2992 9074591 4.80 71.4 µM 2.50E-7 2 7.90E-7 0.50
5 SGTC_2011 4012611 4.49 177.0 µM 1.28E-6 mitochondrial processes 7 3.52E-6 0.18
6 SGTC_2913 7966556 4.37 36.6 µM 2.40E-6 60S ribosome export 5 6.30E-6 0.21
7 SGTC_2117 5521686 4.24 200.0 µM 4.42E-6 3 1.10E-5 0.10
8 SGTC_2131 toluylene red 3.98 5.3 µM 1.50E-5 60S ribosome export 15 3.39E-5 0.25
9 SGTC_3204 9114183 3.97 49.5 µM 1.63E-5 6 3.66E-5 0.11
10 SGTC_3206 9114350 3.94 49.5 µM 1.87E-5 4 4.14E-5 0.30
11 SGTC_2991 9074669 3.72 71.4 µM 4.89E-5 azole & statin 22 1.00E-4 0.04
12 SGTC_349 k015-0014 3.70 24.0 µM 5.26E-5 8 1.07E-4 0.07
13 SGTC_3223 9129970 3.65 49.5 µM 6.66E-5 8 1.33E-4 0.08
14 SGTC_3221 9128209 3.56 49.5 µM 9.67E-5 9 1.87E-4 0.11
15 SGTC_2484 5809818 3.40 12.0 µM 1.82E-4 6 3.35E-4 0.21
16 SGTC_1893 st059353 3.33 36.1 µM 2.38E-4 11 4.29E-4 0.17
17 SGTC_2904 7225135 3.32 42.0 µM 2.50E-4 5 4.49E-4 0.00
18 SGTC_473 2-arachidonoylglycerol 3.30 10.0 µM 2.69E-4 10 4.80E-4 0.07
19 SGTC_1905 st060207 3.29 84.5 µM 2.86E-4 6 5.08E-4 0.02
20 SGTC_1575 cyproterone acetate 3.25 48.0 µM 3.31E-4 16 5.81E-4 0.19

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.183 8.93E-27 YBL034C STU1 het Component of the mitotic spindle that binds to interpolar microtubules via its association with beta-tubulin (Tub2p); required for interpolar microtubules to provide an outward force on the spindle poles
0.176 1.07E-24 YDR287W INM2 hom Inositol monophosphatase, involved in biosynthesis of inositol; enzymatic activity requires magnesium ions and is inhibited by lithium and sodium ions; inm1 inm2 double mutant lacks inositol auxotrophy
0.151 1.24E-18 YKL154W SRP102 het Signal recognition particle (SRP) receptor beta subunit; involved in SRP-dependent protein targeting; anchors the alpha subunit, Srp101p to the ER membrane
0.131 2.67E-14 YKL024C URA6 het Uridylate kinase, catalyzes the seventh enzymatic step in the de novo biosynthesis of pyrimidines, converting uridine monophosphate (UMP) into uridine-5'-diphosphate (UDP)
0.119 4.09E-12 YMR301C ATM1 het Mitochondrial inner membrane ATP-binding cassette (ABC) transporter, exports mitochondrially synthesized precursors of iron-sulfur (Fe/S) clusters to the cytosol
0.118 5.68E-12 YDL127W PCL2 hom Cyclin, interacts with cyclin-dependent kinase Pho85p; member of the Pcl1,2-like subfamily, involved in the regulation of polarized growth and morphogenesis and progression through the cell cycle; localizes to sites of polarized cell growth
0.118 7.43E-12 YFL028C CAF16 hom Part of evolutionarily-conserved CCR4-NOT regulatory complex; contains single ABC-type ATPase domain but no transmembrane domain; interacts with several subunits of Mediator
0.116 1.55E-11 YDR262W_p YDR262W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole and is induced in response to the DNA-damaging agent MMS; gene expression increases in response to Zymoliase treatment
0.116 1.59E-11 YHR028C DAP2 hom Dipeptidyl aminopeptidase, synthesized as a glycosylated precursor; localizes to the vacuolar membrane; similar to Ste13p
0.115 2.62E-11 YGR142W BTN2 hom v-SNARE binding protein; facilitates specific protein retrieval from a late endosome to the Golgi; modulates arginine uptake, possible role in mediating pH homeostasis between the vacuole and plasma membrane H(+)-ATPase; BTN2 has a paralog, CUR1, that arose from the whole genome duplication
0.114 3.39E-11 YHR063C PAN5 hom 2-dehydropantoate 2-reductase, part of the pantothenic acid pathway, structurally homologous to E. coli panE
0.110 1.88E-10 YBL005W PDR3 hom Transcriptional activator of the pleiotropic drug resistance network; regulates expression of ATP-binding cassette (ABC) transporters through binding to cis-acting sites known as PDREs (PDR responsive elements); post-translationally up-regulated in cells lacking a functional mitochondrial genome; PDR3 has a paralog, PDR1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
0.110 2.00E-10 YCR095W-A_p YCR095W-A_p hom Putative protein of unknown function
0.107 6.04E-10 YLR117C CLF1 het Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; homolog of Drosophila crooked neck protein; interacts with U1 snRNP proteins
0.105 9.22E-10 YER013W PRP22 het DEAH-box RNA-dependent ATPase/ATP-dependent RNA helicase, associates with lariat intermediates before the second catalytic step of splicing; mediates ATP-dependent mRNA release from the spliceosome and unwinds RNA duplexes