GTP-binding protein of the ras superfamily involved in termination of M-phase; controls actomyosin and septin dynamics during cytokinesis
Zygosity: Heterozygous strain
fixedexpanded
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Top fitness defect scores for YML064C deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Correlation | pval | ORF | Gene | Zygosity | Description |
---|---|---|---|---|---|
0.183 | 8.93E-27 | YBL034C | STU1 | het | Component of the mitotic spindle that binds to interpolar microtubules via its association with beta-tubulin (Tub2p); required for interpolar microtubules to provide an outward force on the spindle poles |
0.176 | 1.07E-24 | YDR287W | INM2 | hom | Inositol monophosphatase, involved in biosynthesis of inositol; enzymatic activity requires magnesium ions and is inhibited by lithium and sodium ions; inm1 inm2 double mutant lacks inositol auxotrophy |
0.151 | 1.24E-18 | YKL154W | SRP102 | het | Signal recognition particle (SRP) receptor beta subunit; involved in SRP-dependent protein targeting; anchors the alpha subunit, Srp101p to the ER membrane |
0.131 | 2.67E-14 | YKL024C | URA6 | het | Uridylate kinase, catalyzes the seventh enzymatic step in the de novo biosynthesis of pyrimidines, converting uridine monophosphate (UMP) into uridine-5'-diphosphate (UDP) |
0.119 | 4.09E-12 | YMR301C | ATM1 | het | Mitochondrial inner membrane ATP-binding cassette (ABC) transporter, exports mitochondrially synthesized precursors of iron-sulfur (Fe/S) clusters to the cytosol |
0.118 | 5.68E-12 | YDL127W | PCL2 | hom | Cyclin, interacts with cyclin-dependent kinase Pho85p; member of the Pcl1,2-like subfamily, involved in the regulation of polarized growth and morphogenesis and progression through the cell cycle; localizes to sites of polarized cell growth |
0.118 | 7.43E-12 | YFL028C | CAF16 | hom | Part of evolutionarily-conserved CCR4-NOT regulatory complex; contains single ABC-type ATPase domain but no transmembrane domain; interacts with several subunits of Mediator |
0.116 | 1.55E-11 | YDR262W_p | YDR262W_p | hom | Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole and is induced in response to the DNA-damaging agent MMS; gene expression increases in response to Zymoliase treatment |
0.116 | 1.59E-11 | YHR028C | DAP2 | hom | Dipeptidyl aminopeptidase, synthesized as a glycosylated precursor; localizes to the vacuolar membrane; similar to Ste13p |
0.115 | 2.62E-11 | YGR142W | BTN2 | hom | v-SNARE binding protein; facilitates specific protein retrieval from a late endosome to the Golgi; modulates arginine uptake, possible role in mediating pH homeostasis between the vacuole and plasma membrane H(+)-ATPase; BTN2 has a paralog, CUR1, that arose from the whole genome duplication |
0.114 | 3.39E-11 | YHR063C | PAN5 | hom | 2-dehydropantoate 2-reductase, part of the pantothenic acid pathway, structurally homologous to E. coli panE |
0.110 | 1.88E-10 | YBL005W | PDR3 | hom | Transcriptional activator of the pleiotropic drug resistance network; regulates expression of ATP-binding cassette (ABC) transporters through binding to cis-acting sites known as PDREs (PDR responsive elements); post-translationally up-regulated in cells lacking a functional mitochondrial genome; PDR3 has a paralog, PDR1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress |
0.110 | 2.00E-10 | YCR095W-A_p | YCR095W-A_p | hom | Putative protein of unknown function |
0.107 | 6.04E-10 | YLR117C | CLF1 | het | Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; homolog of Drosophila crooked neck protein; interacts with U1 snRNP proteins |
0.105 | 9.22E-10 | YER013W | PRP22 | het | DEAH-box RNA-dependent ATPase/ATP-dependent RNA helicase, associates with lariat intermediates before the second catalytic step of splicing; mediates ATP-dependent mRNA release from the spliceosome and unwinds RNA duplexes |