YML066C / SMA2

Meiosis-specific prospore membrane protein; required to produce bending force necessary for proper assembly of the prospore membrane during sporulation

Zygosity: Homozygous strain
fixedexpanded
Profile for YML066C / SMA2

Click on Significant Values for Screen Details ID:SGTC_11|Compound:0438-0307|FD-Score:3.15|P-value:3.54E-4 ID:SGTC_41|Compound:0478-0632|FD-Score:3.42|P-value:1.18E-4 ID:SGTC_44|Compound:0929-0055|FD-Score:-3.59|P-value:9.24E-5 ID:SGTC_252|Compound:miconazole|FD-Score:3.29|P-value:2.02E-4 ID:SGTC_307|Compound:1501-1223|FD-Score:-3.32|P-value:2.78E-4 ID:SGTC_344|Compound:k064-0035|FD-Score:3.86|P-value:1.77E-5 ID:SGTC_364|Compound:0083-0097|FD-Score:3.12|P-value:4.02E-4 ID:SGTC_381|Compound:3461-2219|FD-Score:3.95|P-value:1.13E-5 ID:SGTC_551|Compound:k048-0028|FD-Score:3.39|P-value:1.37E-4 ID:SGTC_556|Compound:4058-0063|FD-Score:3.88|P-value:1.56E-5 ID:SGTC_558|Compound:k064-0027|FD-Score:3.25|P-value:2.38E-4 ID:SGTC_739|Compound:1486-1183|FD-Score:3.13|P-value:3.86E-4 ID:SGTC_830|Compound:4076-0286|FD-Score:-4.17|P-value:6.78E-6 ID:SGTC_876|Compound:0720-0963|FD-Score:2.99|P-value:6.42E-4 ID:SGTC_931|Compound:2812-0076|FD-Score:-3.08|P-value:6.96E-4 ID:SGTC_1007|Compound:4101-0031|FD-Score:2.99|P-value:6.55E-4 ID:SGTC_1136|Compound:pergolide|FD-Score:3.07|P-value:4.75E-4 ID:SGTC_1219|Compound:1469-0211|FD-Score:3.70|P-value:3.63E-5 ID:SGTC_1275|Compound:0867-0008|FD-Score:3.02|P-value:5.68E-4 ID:SGTC_1506|Compound:4226-2149|FD-Score:3.17|P-value:3.29E-4 ID:SGTC_1540|Compound:guanosine|FD-Score:2.87|P-value:9.86E-4 ID:SGTC_1561|Compound:5-methoxyflavone|FD-Score:3.14|P-value:3.68E-4 ID:SGTC_1656|Compound:st012921|FD-Score:3.87|P-value:1.69E-5 ID:SGTC_1710|Compound:st031758|FD-Score:2.95|P-value:7.36E-4 ID:SGTC_1733|Compound:st037357|FD-Score:-3.20|P-value:4.44E-4 ID:SGTC_1742|Compound:st038235|FD-Score:2.96|P-value:7.31E-4 ID:SGTC_1746|Compound:st038117|FD-Score:6.03|P-value:6.33E-11 ID:SGTC_1787|Compound:fluconazole|FD-Score:2.98|P-value:6.67E-4 ID:SGTC_2121|Compound:5257820|FD-Score:3.51|P-value:8.15E-5 ID:SGTC_2155|Compound:5570423|FD-Score:3.37|P-value:1.48E-4 ID:SGTC_2313|Compound:7726885|FD-Score:3.00|P-value:6.30E-4 ID:SGTC_2380|Compound:9035439|FD-Score:3.99|P-value:9.47E-6 ID:SGTC_2384|Compound:9036245|FD-Score:3.96|P-value:1.08E-5 ID:SGTC_2398|Compound:5228213|FD-Score:3.07|P-value:4.71E-4 ID:SGTC_2400|Compound:5203494|FD-Score:-3.71|P-value:5.52E-5 ID:SGTC_2676|Compound:harmalol|FD-Score:3.14|P-value:3.64E-4 ID:SGTC_2693|Compound:st077581|FD-Score:3.73|P-value:3.23E-5 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:4.09|P-value:5.85E-6 ID:SGTC_2753|Compound:fluvastatin|FD-Score:3.17|P-value:3.31E-4 ID:SGTC_2764|Compound:methyldopa|FD-Score:4.16|P-value:4.17E-6 ID:SGTC_2766|Compound:oltipraz|FD-Score:3.04|P-value:5.30E-4 ID:SGTC_2770|Compound:toltrazuril|FD-Score:3.58|P-value:6.21E-5 ID:SGTC_2791|Compound:5663188|FD-Score:3.87|P-value:1.64E-5 ID:SGTC_2855|Compound:9016525|FD-Score:-3.08|P-value:6.91E-4 ID:SGTC_2928|Compound:9011484|FD-Score:3.05|P-value:5.22E-4 ID:SGTC_2990|Compound:9074105|FD-Score:-3.70|P-value:5.87E-5 ID:SGTC_2992|Compound:9074591|FD-Score:-3.19|P-value:4.61E-4 ID:SGTC_3193|Compound:9111931|FD-Score:-3.31|P-value:2.91E-4 ID:SGTC_3314|Compound:9135860|FD-Score:3.88|P-value:1.63E-5 ID:SGTC_3316|Compound:9136639|FD-Score:-3.80|P-value:3.78E-5 ID:SGTC_3317|Compound:9138495|FD-Score:-3.75|P-value:4.60E-5 ID:SGTC_3318|Compound:9139014|FD-Score:-3.40|P-value:2.03E-4 ID:SGTC_3325|Compound:9138760|FD-Score:-4.02|P-value:1.41E-5 ID:SGTC_3334|Compound:9142812|FD-Score:3.28|P-value:2.08E-4 ID:SGTC_11|Compound:0438-0307|FD-Score:3.15|P-value:3.54E-4 ID:SGTC_41|Compound:0478-0632|FD-Score:3.42|P-value:1.18E-4 ID:SGTC_44|Compound:0929-0055|FD-Score:-3.59|P-value:9.24E-5 ID:SGTC_252|Compound:miconazole|FD-Score:3.29|P-value:2.02E-4 ID:SGTC_307|Compound:1501-1223|FD-Score:-3.32|P-value:2.78E-4 ID:SGTC_344|Compound:k064-0035|FD-Score:3.86|P-value:1.77E-5 ID:SGTC_364|Compound:0083-0097|FD-Score:3.12|P-value:4.02E-4 ID:SGTC_381|Compound:3461-2219|FD-Score:3.95|P-value:1.13E-5 ID:SGTC_551|Compound:k048-0028|FD-Score:3.39|P-value:1.37E-4 ID:SGTC_556|Compound:4058-0063|FD-Score:3.88|P-value:1.56E-5 ID:SGTC_558|Compound:k064-0027|FD-Score:3.25|P-value:2.38E-4 ID:SGTC_739|Compound:1486-1183|FD-Score:3.13|P-value:3.86E-4 ID:SGTC_830|Compound:4076-0286|FD-Score:-4.17|P-value:6.78E-6 ID:SGTC_876|Compound:0720-0963|FD-Score:2.99|P-value:6.42E-4 ID:SGTC_931|Compound:2812-0076|FD-Score:-3.08|P-value:6.96E-4 ID:SGTC_1007|Compound:4101-0031|FD-Score:2.99|P-value:6.55E-4 ID:SGTC_1136|Compound:pergolide|FD-Score:3.07|P-value:4.75E-4 ID:SGTC_1219|Compound:1469-0211|FD-Score:3.70|P-value:3.63E-5 ID:SGTC_1275|Compound:0867-0008|FD-Score:3.02|P-value:5.68E-4 ID:SGTC_1506|Compound:4226-2149|FD-Score:3.17|P-value:3.29E-4 ID:SGTC_1540|Compound:guanosine|FD-Score:2.87|P-value:9.86E-4 ID:SGTC_1561|Compound:5-methoxyflavone|FD-Score:3.14|P-value:3.68E-4 ID:SGTC_1656|Compound:st012921|FD-Score:3.87|P-value:1.69E-5 ID:SGTC_1710|Compound:st031758|FD-Score:2.95|P-value:7.36E-4 ID:SGTC_1733|Compound:st037357|FD-Score:-3.20|P-value:4.44E-4 ID:SGTC_1742|Compound:st038235|FD-Score:2.96|P-value:7.31E-4 ID:SGTC_1746|Compound:st038117|FD-Score:6.03|P-value:6.33E-11 ID:SGTC_1787|Compound:fluconazole|FD-Score:2.98|P-value:6.67E-4 ID:SGTC_2121|Compound:5257820|FD-Score:3.51|P-value:8.15E-5 ID:SGTC_2155|Compound:5570423|FD-Score:3.37|P-value:1.48E-4 ID:SGTC_2313|Compound:7726885|FD-Score:3.00|P-value:6.30E-4 ID:SGTC_2380|Compound:9035439|FD-Score:3.99|P-value:9.47E-6 ID:SGTC_2384|Compound:9036245|FD-Score:3.96|P-value:1.08E-5 ID:SGTC_2398|Compound:5228213|FD-Score:3.07|P-value:4.71E-4 ID:SGTC_2400|Compound:5203494|FD-Score:-3.71|P-value:5.52E-5 ID:SGTC_2676|Compound:harmalol|FD-Score:3.14|P-value:3.64E-4 ID:SGTC_2693|Compound:st077581|FD-Score:3.73|P-value:3.23E-5 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:4.09|P-value:5.85E-6 ID:SGTC_2753|Compound:fluvastatin|FD-Score:3.17|P-value:3.31E-4 ID:SGTC_2764|Compound:methyldopa|FD-Score:4.16|P-value:4.17E-6 ID:SGTC_2766|Compound:oltipraz|FD-Score:3.04|P-value:5.30E-4 ID:SGTC_2770|Compound:toltrazuril|FD-Score:3.58|P-value:6.21E-5 ID:SGTC_2791|Compound:5663188|FD-Score:3.87|P-value:1.64E-5 ID:SGTC_2855|Compound:9016525|FD-Score:-3.08|P-value:6.91E-4 ID:SGTC_2928|Compound:9011484|FD-Score:3.05|P-value:5.22E-4 ID:SGTC_2990|Compound:9074105|FD-Score:-3.70|P-value:5.87E-5 ID:SGTC_2992|Compound:9074591|FD-Score:-3.19|P-value:4.61E-4 ID:SGTC_3193|Compound:9111931|FD-Score:-3.31|P-value:2.91E-4 ID:SGTC_3314|Compound:9135860|FD-Score:3.88|P-value:1.63E-5 ID:SGTC_3316|Compound:9136639|FD-Score:-3.80|P-value:3.78E-5 ID:SGTC_3317|Compound:9138495|FD-Score:-3.75|P-value:4.60E-5 ID:SGTC_3318|Compound:9139014|FD-Score:-3.40|P-value:2.03E-4 ID:SGTC_3325|Compound:9138760|FD-Score:-4.02|P-value:1.41E-5 ID:SGTC_3334|Compound:9142812|FD-Score:3.28|P-value:2.08E-4

Top fitness defect scores for YML066C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1746 st038117 6.03 42.0 µM 6.33E-11 7 8.26E-10
2 SGTC_2764 methyldopa 4.16 94.7 µM 4.17E-6 15 1.58E-5
3 SGTC_2751 anetholtrithion 4.09 17.2 µM 5.85E-6 24 2.14E-5
4 SGTC_2380 9035439 3.99 200.0 µM 9.47E-6 endomembrane recycling 20 3.29E-5
5 SGTC_2384 9036245 3.96 200.0 µM 1.08E-5 30 3.69E-5
6 SGTC_381 3461-2219 3.95 42.7 µM 1.13E-5 copper-dependent oxidative stress 17 3.85E-5
7 SGTC_556 4058-0063 3.88 51.5 µM 1.56E-5 29 5.12E-5
8 SGTC_3314 9135860 3.88 59.4 µM 1.63E-5 18 5.32E-5
9 SGTC_2791 5663188 3.87 71.4 µM 1.64E-5 RPP1 & pyrimidine depletion 22 5.35E-5
10 SGTC_1656 st012921 3.87 11.0 µM 1.69E-5 33 5.50E-5
11 SGTC_344 k064-0035 3.86 6.4 µM 1.77E-5 60S ribosome export 21 5.73E-5
12 SGTC_2693 st077581 3.73 40.7 µM 3.23E-5 44 9.76E-5
13 SGTC_1219 1469-0211 3.70 33.1 µM 3.63E-5 21 1.09E-4
14 SGTC_2770 toltrazuril 3.58 17.5 µM 6.21E-5 37 1.75E-4
15 SGTC_2121 5257820 3.51 149.6 µM 8.15E-5 17 2.22E-4
16 SGTC_41 0478-0632 3.42 82.6 µM 1.18E-4 49 3.08E-4
17 SGTC_551 k048-0028 3.39 34.9 µM 1.37E-4 37 3.52E-4
18 SGTC_2155 5570423 3.37 76.0 µM 1.48E-4 ergosterol biosynthesis 23 3.78E-4
19 SGTC_252 miconazole 3.29 1.3 nM 2.02E-4 ergosterol depletion effects on membrane 60 4.99E-4
20 SGTC_3334 9142812 3.28 21.9 µM 2.08E-4 55 5.10E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.123 7.42E-13 YDL171C GLT1 hom NAD(+)-dependent glutamate synthase (GOGAT), synthesizes glutamate from glutamine and alpha-ketoglutarate; with Gln1p, forms the secondary pathway for glutamate biosynthesis from ammonia; expression regulated by nitrogen source
0.121 2.17E-12 YGL090W LIF1 hom Component of the DNA ligase IV complex that mediates nonhomologous end joining in DNA double-strand break repair; physically interacts with Dnl4p and Nej1p; homologous to mammalian XRCC4 protein
0.112 6.78E-11 YBR050C REG2 hom Regulatory subunit of the Glc7p type-1 protein phosphatase; involved with Reg1p, Glc7p, and Snf1p in regulation of glucose-repressible genes, also involved in glucose-induced proteolysis of maltose permease
0.101 4.68E-9 YML116W ATR1 hom Multidrug efflux pump of the major facilitator superfamily; required for resistance to aminotriazole and 4-nitroquinoline-N-oxide; ATR1 has a paralog, YMR279C, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.093 6.62E-8 YMR133W REC114 hom Protein involved in early stages of meiotic recombination; possibly involved in the coordination of recombination and meiotic division; mutations lead to premature initiation of the first meiotic division
0.092 9.21E-8 YHL030W ECM29 hom Scaffold protein; assists in association of the proteasome core particle with the regulatory particle; degraded by the mature proteasome after assembly; contains HEAT-like repeats; protein increases in abundance and relocalizes from nucleus to cytoplasm upon DNA replication stress
0.091 1.26E-7 YJR038C_d YJR038C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.089 2.29E-7 YMR136W GAT2 hom Protein containing GATA family zinc finger motifs; similar to Gln3p and Dal80p; expression repressed by leucine
0.089 2.51E-7 YGR009C SEC9 het t-SNARE protein important for fusion of secretory vesicles with the plasma membrane; similar to but not functionally redundant with Spo20p; SNAP-25 homolog
0.089 2.55E-7 YIL108W YIL108W hom Putative metalloendopeptidase; forms cytoplasmic foci upon DNA replication stress
0.083 1.35E-6 YNL310C ZIM17 het Heat shock protein with a zinc finger motif; essential for protein import into mitochondria; may act with Pam18p to facilitate recognition and folding of imported proteins by Ssc1p (mtHSP70) in the mitochondrial matrix
0.082 1.78E-6 YML075C HMG1 hom HMG-CoA reductase; catalyzes the conversion of HMG-CoA to mevalonate, which is a rate-limiting step in sterol biosynthesis; one of two isozymes; localizes to the nuclear envelope; overproduction induces the formation of karmellae; forms foci at the nuclear periphery upon DNA replication stress
0.082 2.10E-6 YMR088C VBA1 hom Permease of basic amino acids in the vacuolar membrane
0.081 2.68E-6 YKL022C CDC16 het Subunit of the anaphase-promoting complex/cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; required for sporulation
0.079 4.10E-6 YNL187W SWT21 hom Protein involved in mRNA splicing; contains a consensus nuclear export signal (NES) sequence similar to the consensus sequence recognized by Crm1p; interacts genetically with Prp40p and Tgs1p; contains WD40 repeats