YML067C / ERV41

Protein localized to COPII-coated vesicles, forms a complex with Erv46p; involved in the membrane fusion stage of transport; has homology to human ERGIC2 (PTX1) protein

Zygosity: Homozygous strain
fixedexpanded
Profile for YML067C / ERV41

Click on Significant Values for Screen Details ID:SGTC_6|Compound:0844-0013|FD-Score:4.38|P-value:6.06E-6 ID:SGTC_597|Compound:k018-0003|FD-Score:3.13|P-value:8.88E-4 ID:SGTC_720|Compound:r052-1644|FD-Score:3.71|P-value:1.06E-4 ID:SGTC_752|Compound:1896-0090|FD-Score:3.50|P-value:2.36E-4 ID:SGTC_867|Compound:0518-0118|FD-Score:-4.30|P-value:8.05E-6 ID:SGTC_880|Compound:0833-0487|FD-Score:3.13|P-value:8.86E-4 ID:SGTC_892|Compound:0929-0076|FD-Score:-3.44|P-value:2.80E-4 ID:SGTC_935|Compound:2996-0153|FD-Score:3.40|P-value:3.35E-4 ID:SGTC_1101|Compound:ebselen|FD-Score:4.14|P-value:1.78E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.66|P-value:1.20E-4 ID:SGTC_1109|Compound:tnp00067|FD-Score:3.48|P-value:2.51E-4 ID:SGTC_1137|Compound:ixabepilone|FD-Score:3.35|P-value:4.13E-4 ID:SGTC_1175|Compound:0741-0056|FD-Score:3.94|P-value:4.14E-5 ID:SGTC_1220|Compound:1838-0075|FD-Score:-3.11|P-value:9.04E-4 ID:SGTC_1234|Compound:0326-0494|FD-Score:3.91|P-value:4.61E-5 ID:SGTC_1330|Compound:1469-0054|FD-Score:4.99|P-value:3.02E-7 ID:SGTC_1335|Compound:1486-0900|FD-Score:4.11|P-value:2.01E-5 ID:SGTC_1352|Compound:1496-0991|FD-Score:3.41|P-value:3.27E-4 ID:SGTC_1404|Compound:3909-7820|FD-Score:3.60|P-value:1.62E-4 ID:SGTC_1429|Compound:4049-0205|FD-Score:-3.63|P-value:1.35E-4 ID:SGTC_1433|Compound:4060-0023|FD-Score:-4.35|P-value:6.66E-6 ID:SGTC_1683|Compound:st010134|FD-Score:-4.18|P-value:1.39E-5 ID:SGTC_1703|Compound:st026983|FD-Score:3.33|P-value:4.41E-4 ID:SGTC_1735|Compound:st034310|FD-Score:3.23|P-value:6.15E-4 ID:SGTC_1755|Compound:st041960|FD-Score:6.62|P-value:1.76E-11 ID:SGTC_1793|Compound:st048256|FD-Score:3.24|P-value:5.94E-4 ID:SGTC_1826|Compound:st055655|FD-Score:3.68|P-value:1.17E-4 ID:SGTC_1835|Compound:st008666|FD-Score:-3.12|P-value:8.74E-4 ID:SGTC_2035|Compound:5154463|FD-Score:-3.71|P-value:9.86E-5 ID:SGTC_2144|Compound:5628481|FD-Score:3.73|P-value:9.69E-5 ID:SGTC_2150|Compound:5556613|FD-Score:3.21|P-value:6.81E-4 ID:SGTC_2425|Compound:5628681|FD-Score:3.49|P-value:2.44E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:5.10|P-value:1.69E-7 ID:SGTC_2688|Compound:kanamycin b|FD-Score:5.33|P-value:5.08E-8 ID:SGTC_2728|Compound:chlorpromazine|FD-Score:3.95|P-value:3.94E-5 ID:SGTC_2730|Compound:imipramine|FD-Score:3.97|P-value:3.57E-5 ID:SGTC_2941|Compound:9056145|FD-Score:3.12|P-value:9.18E-4 ID:SGTC_2981|Compound:9013952|FD-Score:-4.72|P-value:1.15E-6 ID:SGTC_2982|Compound:9019404|FD-Score:-3.60|P-value:1.52E-4 ID:SGTC_3139|Compound:9095020|FD-Score:4.02|P-value:3.00E-5 ID:SGTC_3149|Compound:9097855|FD-Score:3.41|P-value:3.28E-4 ID:SGTC_3153|Compound:9100258|FD-Score:-3.90|P-value:4.73E-5 ID:SGTC_3201|Compound:9113999|FD-Score:3.65|P-value:1.33E-4 ID:SGTC_3209|Compound:9113616|FD-Score:3.34|P-value:4.22E-4 ID:SGTC_6|Compound:0844-0013|FD-Score:4.38|P-value:6.06E-6 ID:SGTC_597|Compound:k018-0003|FD-Score:3.13|P-value:8.88E-4 ID:SGTC_720|Compound:r052-1644|FD-Score:3.71|P-value:1.06E-4 ID:SGTC_752|Compound:1896-0090|FD-Score:3.50|P-value:2.36E-4 ID:SGTC_867|Compound:0518-0118|FD-Score:-4.30|P-value:8.05E-6 ID:SGTC_880|Compound:0833-0487|FD-Score:3.13|P-value:8.86E-4 ID:SGTC_892|Compound:0929-0076|FD-Score:-3.44|P-value:2.80E-4 ID:SGTC_935|Compound:2996-0153|FD-Score:3.40|P-value:3.35E-4 ID:SGTC_1101|Compound:ebselen|FD-Score:4.14|P-value:1.78E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.66|P-value:1.20E-4 ID:SGTC_1109|Compound:tnp00067|FD-Score:3.48|P-value:2.51E-4 ID:SGTC_1137|Compound:ixabepilone|FD-Score:3.35|P-value:4.13E-4 ID:SGTC_1175|Compound:0741-0056|FD-Score:3.94|P-value:4.14E-5 ID:SGTC_1220|Compound:1838-0075|FD-Score:-3.11|P-value:9.04E-4 ID:SGTC_1234|Compound:0326-0494|FD-Score:3.91|P-value:4.61E-5 ID:SGTC_1330|Compound:1469-0054|FD-Score:4.99|P-value:3.02E-7 ID:SGTC_1335|Compound:1486-0900|FD-Score:4.11|P-value:2.01E-5 ID:SGTC_1352|Compound:1496-0991|FD-Score:3.41|P-value:3.27E-4 ID:SGTC_1404|Compound:3909-7820|FD-Score:3.60|P-value:1.62E-4 ID:SGTC_1429|Compound:4049-0205|FD-Score:-3.63|P-value:1.35E-4 ID:SGTC_1433|Compound:4060-0023|FD-Score:-4.35|P-value:6.66E-6 ID:SGTC_1683|Compound:st010134|FD-Score:-4.18|P-value:1.39E-5 ID:SGTC_1703|Compound:st026983|FD-Score:3.33|P-value:4.41E-4 ID:SGTC_1735|Compound:st034310|FD-Score:3.23|P-value:6.15E-4 ID:SGTC_1755|Compound:st041960|FD-Score:6.62|P-value:1.76E-11 ID:SGTC_1793|Compound:st048256|FD-Score:3.24|P-value:5.94E-4 ID:SGTC_1826|Compound:st055655|FD-Score:3.68|P-value:1.17E-4 ID:SGTC_1835|Compound:st008666|FD-Score:-3.12|P-value:8.74E-4 ID:SGTC_2035|Compound:5154463|FD-Score:-3.71|P-value:9.86E-5 ID:SGTC_2144|Compound:5628481|FD-Score:3.73|P-value:9.69E-5 ID:SGTC_2150|Compound:5556613|FD-Score:3.21|P-value:6.81E-4 ID:SGTC_2425|Compound:5628681|FD-Score:3.49|P-value:2.44E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:5.10|P-value:1.69E-7 ID:SGTC_2688|Compound:kanamycin b|FD-Score:5.33|P-value:5.08E-8 ID:SGTC_2728|Compound:chlorpromazine|FD-Score:3.95|P-value:3.94E-5 ID:SGTC_2730|Compound:imipramine|FD-Score:3.97|P-value:3.57E-5 ID:SGTC_2941|Compound:9056145|FD-Score:3.12|P-value:9.18E-4 ID:SGTC_2981|Compound:9013952|FD-Score:-4.72|P-value:1.15E-6 ID:SGTC_2982|Compound:9019404|FD-Score:-3.60|P-value:1.52E-4 ID:SGTC_3139|Compound:9095020|FD-Score:4.02|P-value:3.00E-5 ID:SGTC_3149|Compound:9097855|FD-Score:3.41|P-value:3.28E-4 ID:SGTC_3153|Compound:9100258|FD-Score:-3.90|P-value:4.73E-5 ID:SGTC_3201|Compound:9113999|FD-Score:3.65|P-value:1.33E-4 ID:SGTC_3209|Compound:9113616|FD-Score:3.34|P-value:4.22E-4

Top fitness defect scores for YML067C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1755 st041960 6.62 45.2 µM 1.76E-11 3 1.75E-11
2 SGTC_2688 kanamycin b 5.33 96.7 µM 5.08E-8 calcium & mitochondrial duress 219 5.04E-8
3 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 5.10 3.7 µM 1.69E-7 29 1.68E-7
4 SGTC_1330 1469-0054 4.99 61.8 µM 3.02E-7 iron homeostasis 3 3.00E-7
5 SGTC_6 0844-0013 4.38 19.8 µM 6.06E-6 56 6.00E-6
6 SGTC_1101 ebselen 4.14 5.3 µM 1.78E-5 19 1.76E-5
7 SGTC_1335 1486-0900 4.11 202.0 µM 2.01E-5 20 1.99E-5
8 SGTC_3139 9095020 4.02 49.5 µM 3.00E-5 7 2.97E-5
9 SGTC_2730 imipramine 3.97 71.3 µM 3.57E-5 23 3.54E-5
10 SGTC_2728 chlorpromazine 3.95 9.2 µM 3.94E-5 2 3.90E-5
11 SGTC_1175 0741-0056 3.94 27.6 µM 4.14E-5 16 4.10E-5
12 SGTC_1234 0326-0494 3.91 15.5 µM 4.61E-5 13 4.57E-5
13 SGTC_2144 5628481 3.73 200.0 µM 9.69E-5 ERG2 29 9.59E-5
14 SGTC_720 r052-1644 3.71 49.9 µM 1.06E-4 TSC3-RPN4 31 1.05E-4
15 SGTC_1826 st055655 3.68 41.6 µM 1.17E-4 ERG2 48 1.16E-4
16 SGTC_3201 9113999 3.65 49.5 µM 1.33E-4 46 1.31E-4
17 SGTC_1404 3909-7820 3.60 48.3 µM 1.62E-4 60S ribosome export 12 1.60E-4
18 SGTC_752 1896-0090 3.50 130.0 µM 2.36E-4 TSC3-RPN4 29 2.33E-4
19 SGTC_2425 5628681 3.49 7.8 µM 2.44E-4 43 2.41E-4
20 SGTC_1109 tnp00067 3.48 928.3 nM 2.51E-4 28 2.49E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.174 3.16E-24 YNL176C_p TDA7_p hom Cell cycle-regulated gene of unknown function, promoter bound by Fkh2p; null mutant is sensitive to expression of the top1-T722A allele
0.170 2.87E-23 YDL049C KNH1 hom Protein with similarity to Kre9p, which is involved in cell wall beta 1,6-glucan synthesis; overproduction suppresses growth defects of a kre9 null mutant; required for propionic acid resistance
0.166 5.06E-22 YKL061W_p BLI1_p hom Putative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; green fluorescent protein (GFP)-fusion protein localizes to the endosome
0.157 5.63E-20 YBR175W SWD3 hom Essential subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; WD40 beta propeller superfamily member and ortholog of mammalian WDR5
0.143 8.04E-17 YGL017W ATE1 hom Arginyl-tRNA-protein transferase, catalyzes post-translational conjugation of arginine to the amino termini of acceptor proteins which are then subject to degradation via the N-end rule pathway
0.139 6.25E-16 YDR051C DET1 hom Acid phosphatase involved in the non-vesicular transport of sterols in both directions between the endoplasmic reticulum and plasma membrane; deletion confers sensitivity to nickel
0.139 6.59E-16 YER067C-A_d YER067C-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YER067W
0.138 8.82E-16 YDL018C ERP3 hom Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport
0.138 1.13E-15 YMR173W DDR48 hom DNA damage-responsive protein; expression is increased in response to heat-shock stress or treatments that produce DNA lesions; contains multiple repeats of the amino acid sequence NNNDSYGS; protein abundance increases in response to DNA replication stress
0.136 2.53E-15 YER064C VHR2 hom Non-essential nuclear protein; null mutation has global effects on transcription; VHR2 has a paralog, VHR1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
0.133 1.24E-14 YLR288C MEC3 hom DNA damage and meiotic pachytene checkpoint protein; subunit of a heterotrimeric complex (Rad17p-Mec3p-Ddc1p) that forms a sliding clamp, loaded onto partial duplex DNA by a clamp loader complex; homolog of human and S. pombe Hus1
0.131 2.72E-14 YJR092W BUD4 hom Anillin-like protein involved in bud-site selection; required for the axial budding pattern; localizes with septins to the bud neck in mitosis and may constitute an axial landmark for the next round of budding; required for the formation and disassembly of the double septin ring structure, and generally for septin organization; in vivo substrate of Cdc28p/Clb2p
0.130 4.80E-14 YGR236C SPG1 hom Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.124 5.51E-13 YNL242W ATG2 hom Peripheral membrane protein required for autophagic vesicle formation; also required for vesicle formation during pexophagy and the cytoplasm-to-vaucole targeting (Cvt) pathway; involved in Atg9p cycling between the phagophore assembly site and mitochondria; forms cytoplasmic foci upon DNA replication stress
0.124 6.17E-13 YFL046W_p FMP32_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies