YML068W / ITT1

Protein that modulates the efficiency of translation termination, interacts with translation release factors eRF1 (Sup45p) and eRF3 (Sup35p) in vitro, contains a zinc finger domain characteristic of the TRIAD class of proteins

Zygosity: Homozygous strain
fixedexpanded
Profile for YML068W / ITT1

Click on Significant Values for Screen Details ID:SGTC_136|Compound:0097-0015|FD-Score:-3.12|P-value:2.62E-4 ID:SGTC_140|Compound:0062-0056|FD-Score:-2.90|P-value:6.38E-4 ID:SGTC_166|Compound:k072-0058|FD-Score:-4.00|P-value:4.43E-6 ID:SGTC_167|Compound:3672-0051|FD-Score:-3.05|P-value:3.56E-4 ID:SGTC_465|Compound:cgp-37157|FD-Score:2.84|P-value:7.71E-4 ID:SGTC_540|Compound:1187-0821|FD-Score:-2.87|P-value:7.09E-4 ID:SGTC_631|Compound:k072-0230|FD-Score:4.30|P-value:7.90E-7 ID:SGTC_632|Compound:0781-2353|FD-Score:3.10|P-value:2.72E-4 ID:SGTC_666|Compound:0272-0154|FD-Score:2.90|P-value:6.04E-4 ID:SGTC_787|Compound:4152-0075|FD-Score:2.78|P-value:9.57E-4 ID:SGTC_814|Compound:3342-0569|FD-Score:7.01|P-value:2.89E-15 ID:SGTC_815|Compound:1582-0027|FD-Score:5.84|P-value:3.78E-11 ID:SGTC_830|Compound:4076-0286|FD-Score:-3.16|P-value:2.22E-4 ID:SGTC_934|Compound:2950-0684|FD-Score:2.83|P-value:7.96E-4 ID:SGTC_965|Compound:1291-5240|FD-Score:3.84|P-value:9.38E-6 ID:SGTC_1243|Compound:0416-0003|FD-Score:-3.89|P-value:7.49E-6 ID:SGTC_1245|Compound:0418-0076|FD-Score:-4.26|P-value:1.10E-6 ID:SGTC_1260|Compound:0700-1617|FD-Score:2.80|P-value:9.02E-4 ID:SGTC_1344|Compound:1488-0097|FD-Score:-2.80|P-value:9.43E-4 ID:SGTC_1412|Compound:3909-8563|FD-Score:3.70|P-value:1.84E-5 ID:SGTC_1441|Compound:4106-0040|FD-Score:3.00|P-value:4.15E-4 ID:SGTC_1583|Compound:clindamycin|FD-Score:4.93|P-value:1.93E-8 ID:SGTC_1701|Compound:st028638|FD-Score:4.34|P-value:6.34E-7 ID:SGTC_1783|Compound:st039459|FD-Score:-4.13|P-value:2.20E-6 ID:SGTC_1797|Compound:st048695|FD-Score:3.58|P-value:3.28E-5 ID:SGTC_1849|Compound:st056239|FD-Score:-2.80|P-value:9.16E-4 ID:SGTC_2126|Compound:5251174|FD-Score:4.23|P-value:1.18E-6 ID:SGTC_2131|Compound:toluylene red|FD-Score:3.67|P-value:2.16E-5 ID:SGTC_2241|Compound:6772625|FD-Score:-3.00|P-value:4.30E-4 ID:SGTC_2244|Compound:6635614|FD-Score:2.79|P-value:9.11E-4 ID:SGTC_2245|Compound:6637752|FD-Score:3.21|P-value:1.72E-4 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:4.85|P-value:3.25E-8 ID:SGTC_2797|Compound:7859098|FD-Score:-3.42|P-value:7.05E-5 ID:SGTC_2831|Compound:7999036|FD-Score:-5.38|P-value:1.05E-9 ID:SGTC_2834|Compound:9001755|FD-Score:-3.52|P-value:4.57E-5 ID:SGTC_2843|Compound:9000894|FD-Score:5.78|P-value:5.99E-11 ID:SGTC_2845|Compound:9003024|FD-Score:3.91|P-value:6.55E-6 ID:SGTC_2846|Compound:9008642|FD-Score:-5.88|P-value:2.98E-11 ID:SGTC_2848|Compound:9016370|FD-Score:2.82|P-value:8.17E-4 ID:SGTC_2855|Compound:9016525|FD-Score:-3.06|P-value:3.37E-4 ID:SGTC_3065|Compound:9113888|FD-Score:5.61|P-value:2.04E-10 ID:SGTC_3068|Compound:9116768|FD-Score:2.80|P-value:8.74E-4 ID:SGTC_3140|Compound:9094243|FD-Score:-3.20|P-value:1.90E-4 ID:SGTC_3205|Compound:9113483|FD-Score:3.38|P-value:8.25E-5 ID:SGTC_3214|Compound:9129694|FD-Score:3.44|P-value:6.24E-5 ID:SGTC_3217|Compound:9129673|FD-Score:3.89|P-value:7.21E-6 ID:SGTC_3332|Compound:9141069|FD-Score:4.21|P-value:1.31E-6 ID:SGTC_136|Compound:0097-0015|FD-Score:-3.12|P-value:2.62E-4 ID:SGTC_140|Compound:0062-0056|FD-Score:-2.90|P-value:6.38E-4 ID:SGTC_166|Compound:k072-0058|FD-Score:-4.00|P-value:4.43E-6 ID:SGTC_167|Compound:3672-0051|FD-Score:-3.05|P-value:3.56E-4 ID:SGTC_465|Compound:cgp-37157|FD-Score:2.84|P-value:7.71E-4 ID:SGTC_540|Compound:1187-0821|FD-Score:-2.87|P-value:7.09E-4 ID:SGTC_631|Compound:k072-0230|FD-Score:4.30|P-value:7.90E-7 ID:SGTC_632|Compound:0781-2353|FD-Score:3.10|P-value:2.72E-4 ID:SGTC_666|Compound:0272-0154|FD-Score:2.90|P-value:6.04E-4 ID:SGTC_787|Compound:4152-0075|FD-Score:2.78|P-value:9.57E-4 ID:SGTC_814|Compound:3342-0569|FD-Score:7.01|P-value:2.89E-15 ID:SGTC_815|Compound:1582-0027|FD-Score:5.84|P-value:3.78E-11 ID:SGTC_830|Compound:4076-0286|FD-Score:-3.16|P-value:2.22E-4 ID:SGTC_934|Compound:2950-0684|FD-Score:2.83|P-value:7.96E-4 ID:SGTC_965|Compound:1291-5240|FD-Score:3.84|P-value:9.38E-6 ID:SGTC_1243|Compound:0416-0003|FD-Score:-3.89|P-value:7.49E-6 ID:SGTC_1245|Compound:0418-0076|FD-Score:-4.26|P-value:1.10E-6 ID:SGTC_1260|Compound:0700-1617|FD-Score:2.80|P-value:9.02E-4 ID:SGTC_1344|Compound:1488-0097|FD-Score:-2.80|P-value:9.43E-4 ID:SGTC_1412|Compound:3909-8563|FD-Score:3.70|P-value:1.84E-5 ID:SGTC_1441|Compound:4106-0040|FD-Score:3.00|P-value:4.15E-4 ID:SGTC_1583|Compound:clindamycin|FD-Score:4.93|P-value:1.93E-8 ID:SGTC_1701|Compound:st028638|FD-Score:4.34|P-value:6.34E-7 ID:SGTC_1783|Compound:st039459|FD-Score:-4.13|P-value:2.20E-6 ID:SGTC_1797|Compound:st048695|FD-Score:3.58|P-value:3.28E-5 ID:SGTC_1849|Compound:st056239|FD-Score:-2.80|P-value:9.16E-4 ID:SGTC_2126|Compound:5251174|FD-Score:4.23|P-value:1.18E-6 ID:SGTC_2131|Compound:toluylene red|FD-Score:3.67|P-value:2.16E-5 ID:SGTC_2241|Compound:6772625|FD-Score:-3.00|P-value:4.30E-4 ID:SGTC_2244|Compound:6635614|FD-Score:2.79|P-value:9.11E-4 ID:SGTC_2245|Compound:6637752|FD-Score:3.21|P-value:1.72E-4 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:4.85|P-value:3.25E-8 ID:SGTC_2797|Compound:7859098|FD-Score:-3.42|P-value:7.05E-5 ID:SGTC_2831|Compound:7999036|FD-Score:-5.38|P-value:1.05E-9 ID:SGTC_2834|Compound:9001755|FD-Score:-3.52|P-value:4.57E-5 ID:SGTC_2843|Compound:9000894|FD-Score:5.78|P-value:5.99E-11 ID:SGTC_2845|Compound:9003024|FD-Score:3.91|P-value:6.55E-6 ID:SGTC_2846|Compound:9008642|FD-Score:-5.88|P-value:2.98E-11 ID:SGTC_2848|Compound:9016370|FD-Score:2.82|P-value:8.17E-4 ID:SGTC_2855|Compound:9016525|FD-Score:-3.06|P-value:3.37E-4 ID:SGTC_3065|Compound:9113888|FD-Score:5.61|P-value:2.04E-10 ID:SGTC_3068|Compound:9116768|FD-Score:2.80|P-value:8.74E-4 ID:SGTC_3140|Compound:9094243|FD-Score:-3.20|P-value:1.90E-4 ID:SGTC_3205|Compound:9113483|FD-Score:3.38|P-value:8.25E-5 ID:SGTC_3214|Compound:9129694|FD-Score:3.44|P-value:6.24E-5 ID:SGTC_3217|Compound:9129673|FD-Score:3.89|P-value:7.21E-6 ID:SGTC_3332|Compound:9141069|FD-Score:4.21|P-value:1.31E-6

Top fitness defect scores for YML068W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_814 3342-0569 7.01 96.0 µM 2.89E-15 1 1.23E-12
2 SGTC_815 1582-0027 5.84 36.9 µM 3.78E-11 2 2.63E-9
3 SGTC_2843 9000894 5.78 45.5 µM 5.99E-11 1 3.83E-9
4 SGTC_3065 9113888 5.61 49.5 µM 2.04E-10 6 1.03E-8
5 SGTC_1583 clindamycin 4.93 39.6 µM 1.93E-8 mitochondrial processes 3 4.11E-7
6 SGTC_2565 isoliquiritigenin 4.85 100.0 µM 3.25E-8 19 6.28E-7
7 SGTC_1701 st028638 4.34 40.4 µM 6.34E-7 10 7.00E-6
8 SGTC_631 k072-0230 4.30 41.5 µM 7.90E-7 60S ribosome export 13 8.37E-6
9 SGTC_2126 5251174 4.23 33.9 µM 1.18E-6 22 1.16E-5
10 SGTC_3332 9141069 4.21 11.2 µM 1.31E-6 10 1.26E-5
11 SGTC_2845 9003024 3.91 43.0 µM 6.55E-6 amide catabolism 46 4.67E-5
12 SGTC_3217 9129673 3.89 49.5 µM 7.21E-6 42 5.04E-5
13 SGTC_965 1291-5240 3.84 308.0 µM 9.38E-6 32 6.25E-5
14 SGTC_1412 3909-8563 3.70 178.0 µM 1.84E-5 12 1.08E-4
15 SGTC_2131 toluylene red 3.67 5.3 µM 2.16E-5 60S ribosome export 30 1.23E-4
16 SGTC_1797 st048695 3.58 56.8 µM 3.28E-5 NEO1 82 1.73E-4
17 SGTC_3214 9129694 3.44 49.5 µM 6.24E-5 39 2.92E-4
18 SGTC_3205 9113483 3.38 49.5 µM 8.25E-5 57 3.67E-4
19 SGTC_2245 6637752 3.21 200.0 µM 1.72E-4 32 6.68E-4
20 SGTC_632 0781-2353 3.10 4.7 µM 2.72E-4 Golgi 84 9.71E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.126 2.07E-13 YEL001C IRC22 hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion localizes to the ER; YEL001C is non-essential; null mutant displays increased levels of spontaneous Rad52p foci
0.114 3.29E-11 YBR085C-A YBR085C-A hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to the nucleus; protein abundance increases in response to DNA replication stress
0.104 1.31E-9 YNL094W APP1 hom Phosphatidate phosphatase, converts phosphatidate to diacylglycerol; App1p, Pah1p, Dpp1p, and Lpp1p are responsible for all the phosphatidate phosphatase activity; component of cortical actin patches; interacts with components of endocytic pathway
0.102 2.94E-9 YGR210C_p YGR210C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.100 6.27E-9 YER181C_d YER181C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative data; extensively overlaps a Ty1 LTR; protein product is detected in highly purified mitochondria in high-throughput studies
0.096 2.21E-8 YKL202W_d YKL202W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.096 2.31E-8 YDR436W PPZ2 hom Serine/threonine protein phosphatase Z, isoform of Ppz1p; involved in regulation of potassium transport, which affects osmotic stability, cell cycle progression, and halotolerance
0.095 4.10E-8 YMR088C VBA1 hom Permease of basic amino acids in the vacuolar membrane
0.094 5.02E-8 YIL146C ATG32 hom Mitochondrial outer membrane protein required to initiate mitophagy; recruits the autophagy adaptor protein Atg11p and the ubiquitin-like protein Atg8p to the mitochondrial surface to initiate mitophagy, the selective vacuolar degradation of mitochondria in response to starvation; can promote pexophagy when placed ectopically in the peroxisomal membrane
0.094 5.67E-8 YKL006C-A SFT1 het Intra-Golgi v-SNARE, required for transport of proteins between an early and a later Golgi compartment
0.090 1.70E-7 YDR400W URH1 hom Uridine nucleosidase (uridine-cytidine N-ribohydrolase), cleaves N-glycosidic bonds in nucleosides; involved in the pyrimidine salvage and nicotinamide riboside salvage pathways
0.089 2.30E-7 YLR307C-A_p YLR307C-A_p hom Putative protein of unknown function
0.084 9.82E-7 YLR054C OSW2 hom Protein of unknown function proposed to be involved in the assembly of the spore wall
0.083 1.66E-6 YER067W RGI1 hom Protein of unknown function; involved in energy metabolism under respiratory conditions; protein abundance is increased upon intracellular iron depletion; protein abundance increases in response to DNA replication stress
0.082 1.76E-6 YGR292W MAL12 hom Maltase (alpha-D-glucosidase), inducible protein involved in maltose catabolism; encoded in the MAL1 complex locus; hydrolyzes the disaccharides maltose, turanose, maltotriose, and sucrose