YML077W / BET5

Component of the TRAPP (transport protein particle) complex, which plays an essential role in the vesicular transport from endoplasmic reticulum to Golgi

Zygosity: Heterozygous strain
fixedexpanded
Profile for YML077W / BET5

Click on Significant Values for Screen Details ID:SGTC_64|Compound:000l-0018|FD-Score:3.04|P-value:4.84E-4 ID:SGTC_175|Compound:3793-3120|FD-Score:2.93|P-value:7.54E-4 ID:SGTC_176|Compound:1486-1328|FD-Score:-4.04|P-value:5.74E-6 ID:SGTC_182|Compound:3448-4371|FD-Score:3.38|P-value:1.23E-4 ID:SGTC_191|Compound:3914-0123|FD-Score:-2.92|P-value:7.59E-4 ID:SGTC_306|Compound:1672-3436|FD-Score:3.23|P-value:2.30E-4 ID:SGTC_506|Compound:n9-isopropylolomoucine|FD-Score:3.09|P-value:3.97E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:-3.19|P-value:2.67E-4 ID:SGTC_600|Compound:1495-0418|FD-Score:3.09|P-value:4.02E-4 ID:SGTC_618|Compound:k072-0232|FD-Score:2.94|P-value:7.24E-4 ID:SGTC_643|Compound:k048-0106|FD-Score:3.21|P-value:2.52E-4 ID:SGTC_801|Compound:0866-0028|FD-Score:-3.14|P-value:3.28E-4 ID:SGTC_853|Compound:0419-0306|FD-Score:-2.90|P-value:8.19E-4 ID:SGTC_878|Compound:0828-0289|FD-Score:3.31|P-value:1.62E-4 ID:SGTC_1128|Compound:3448-9350|FD-Score:-3.38|P-value:1.24E-4 ID:SGTC_1137|Compound:ixabepilone|FD-Score:-4.43|P-value:7.54E-7 ID:SGTC_1224|Compound:0823-0416|FD-Score:2.86|P-value:9.45E-4 ID:SGTC_1300|Compound:1094-0077|FD-Score:3.26|P-value:2.04E-4 ID:SGTC_1414|Compound:3917-0015|FD-Score:2.92|P-value:7.73E-4 ID:SGTC_1531|Compound:st059297|FD-Score:4.50|P-value:5.17E-7 ID:SGTC_1534|Compound:6-azauridine|FD-Score:-3.73|P-value:2.52E-5 ID:SGTC_1545|Compound:lovastatin|FD-Score:-3.74|P-value:2.44E-5 ID:SGTC_1550|Compound:gossypolone|FD-Score:-4.32|P-value:1.38E-6 ID:SGTC_1553|Compound:gossypol|FD-Score:3.49|P-value:7.69E-5 ID:SGTC_1588|Compound:farnesol|FD-Score:2.88|P-value:9.02E-4 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:-3.29|P-value:1.78E-4 ID:SGTC_1638|Compound:st008370|FD-Score:-3.72|P-value:2.67E-5 ID:SGTC_1719|Compound:st032227|FD-Score:-2.89|P-value:8.45E-4 ID:SGTC_1728|Compound:st035614|FD-Score:4.62|P-value:2.72E-7 ID:SGTC_1729|Compound:st035615|FD-Score:-6.33|P-value:3.09E-12 ID:SGTC_1751|Compound:st044839|FD-Score:2.91|P-value:8.01E-4 ID:SGTC_1756|Compound:st041558|FD-Score:3.88|P-value:1.27E-5 ID:SGTC_1758|Compound:st042942|FD-Score:2.94|P-value:7.06E-4 ID:SGTC_1760|Compound:st045453|FD-Score:3.15|P-value:3.22E-4 ID:SGTC_1916|Compound:st067606|FD-Score:3.45|P-value:9.10E-5 ID:SGTC_2006|Compound:4011487|FD-Score:-4.87|P-value:6.34E-8 ID:SGTC_2008|Compound:4012253|FD-Score:-3.12|P-value:3.48E-4 ID:SGTC_2090|Compound:5301565|FD-Score:-3.16|P-value:3.03E-4 ID:SGTC_2119|Compound:5528445|FD-Score:2.99|P-value:5.94E-4 ID:SGTC_2301|Compound:7769476|FD-Score:-3.16|P-value:2.95E-4 ID:SGTC_2312|Compound:7706453|FD-Score:2.93|P-value:7.48E-4 ID:SGTC_2325|Compound:6158266|FD-Score:3.08|P-value:4.24E-4 ID:SGTC_2354|Compound:9060492|FD-Score:3.34|P-value:1.46E-4 ID:SGTC_2385|Compound:9074692|FD-Score:-4.04|P-value:5.66E-6 ID:SGTC_2437|Compound:5741531|FD-Score:3.12|P-value:3.57E-4 ID:SGTC_2453|Compound:5731132|FD-Score:3.20|P-value:2.59E-4 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:-3.67|P-value:3.35E-5 ID:SGTC_2640|Compound:pentamidine|FD-Score:2.90|P-value:8.34E-4 ID:SGTC_2650|Compound:prasterone|FD-Score:3.13|P-value:3.43E-4 ID:SGTC_2750|Compound:bromebric acid|FD-Score:3.94|P-value:9.38E-6 ID:SGTC_2752|Compound:diclazuril|FD-Score:-3.54|P-value:6.02E-5 ID:SGTC_2754|Compound:granisetron|FD-Score:2.92|P-value:7.67E-4 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:5.21|P-value:7.86E-9 ID:SGTC_2862|Compound:9027634|FD-Score:-2.94|P-value:7.07E-4 ID:SGTC_2881|Compound:9058953|FD-Score:-2.96|P-value:6.54E-4 ID:SGTC_2965|Compound:9082772|FD-Score:-6.49|P-value:9.15E-13 ID:SGTC_3030|Compound:9087619|FD-Score:-3.07|P-value:4.20E-4 ID:SGTC_3074|Compound:9116018|FD-Score:-3.87|P-value:1.33E-5 ID:SGTC_3078|Compound:9116413|FD-Score:-3.86|P-value:1.41E-5 ID:SGTC_3140|Compound:9094243|FD-Score:-3.58|P-value:5.16E-5 ID:SGTC_3148|Compound:9097893|FD-Score:-3.05|P-value:4.62E-4 ID:SGTC_3221|Compound:9128209|FD-Score:-2.90|P-value:8.15E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:3.04|P-value:4.84E-4 ID:SGTC_175|Compound:3793-3120|FD-Score:2.93|P-value:7.54E-4 ID:SGTC_176|Compound:1486-1328|FD-Score:-4.04|P-value:5.74E-6 ID:SGTC_182|Compound:3448-4371|FD-Score:3.38|P-value:1.23E-4 ID:SGTC_191|Compound:3914-0123|FD-Score:-2.92|P-value:7.59E-4 ID:SGTC_306|Compound:1672-3436|FD-Score:3.23|P-value:2.30E-4 ID:SGTC_506|Compound:n9-isopropylolomoucine|FD-Score:3.09|P-value:3.97E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:-3.19|P-value:2.67E-4 ID:SGTC_600|Compound:1495-0418|FD-Score:3.09|P-value:4.02E-4 ID:SGTC_618|Compound:k072-0232|FD-Score:2.94|P-value:7.24E-4 ID:SGTC_643|Compound:k048-0106|FD-Score:3.21|P-value:2.52E-4 ID:SGTC_801|Compound:0866-0028|FD-Score:-3.14|P-value:3.28E-4 ID:SGTC_853|Compound:0419-0306|FD-Score:-2.90|P-value:8.19E-4 ID:SGTC_878|Compound:0828-0289|FD-Score:3.31|P-value:1.62E-4 ID:SGTC_1128|Compound:3448-9350|FD-Score:-3.38|P-value:1.24E-4 ID:SGTC_1137|Compound:ixabepilone|FD-Score:-4.43|P-value:7.54E-7 ID:SGTC_1224|Compound:0823-0416|FD-Score:2.86|P-value:9.45E-4 ID:SGTC_1300|Compound:1094-0077|FD-Score:3.26|P-value:2.04E-4 ID:SGTC_1414|Compound:3917-0015|FD-Score:2.92|P-value:7.73E-4 ID:SGTC_1531|Compound:st059297|FD-Score:4.50|P-value:5.17E-7 ID:SGTC_1534|Compound:6-azauridine|FD-Score:-3.73|P-value:2.52E-5 ID:SGTC_1545|Compound:lovastatin|FD-Score:-3.74|P-value:2.44E-5 ID:SGTC_1550|Compound:gossypolone|FD-Score:-4.32|P-value:1.38E-6 ID:SGTC_1553|Compound:gossypol|FD-Score:3.49|P-value:7.69E-5 ID:SGTC_1588|Compound:farnesol|FD-Score:2.88|P-value:9.02E-4 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:-3.29|P-value:1.78E-4 ID:SGTC_1638|Compound:st008370|FD-Score:-3.72|P-value:2.67E-5 ID:SGTC_1719|Compound:st032227|FD-Score:-2.89|P-value:8.45E-4 ID:SGTC_1728|Compound:st035614|FD-Score:4.62|P-value:2.72E-7 ID:SGTC_1729|Compound:st035615|FD-Score:-6.33|P-value:3.09E-12 ID:SGTC_1751|Compound:st044839|FD-Score:2.91|P-value:8.01E-4 ID:SGTC_1756|Compound:st041558|FD-Score:3.88|P-value:1.27E-5 ID:SGTC_1758|Compound:st042942|FD-Score:2.94|P-value:7.06E-4 ID:SGTC_1760|Compound:st045453|FD-Score:3.15|P-value:3.22E-4 ID:SGTC_1916|Compound:st067606|FD-Score:3.45|P-value:9.10E-5 ID:SGTC_2006|Compound:4011487|FD-Score:-4.87|P-value:6.34E-8 ID:SGTC_2008|Compound:4012253|FD-Score:-3.12|P-value:3.48E-4 ID:SGTC_2090|Compound:5301565|FD-Score:-3.16|P-value:3.03E-4 ID:SGTC_2119|Compound:5528445|FD-Score:2.99|P-value:5.94E-4 ID:SGTC_2301|Compound:7769476|FD-Score:-3.16|P-value:2.95E-4 ID:SGTC_2312|Compound:7706453|FD-Score:2.93|P-value:7.48E-4 ID:SGTC_2325|Compound:6158266|FD-Score:3.08|P-value:4.24E-4 ID:SGTC_2354|Compound:9060492|FD-Score:3.34|P-value:1.46E-4 ID:SGTC_2385|Compound:9074692|FD-Score:-4.04|P-value:5.66E-6 ID:SGTC_2437|Compound:5741531|FD-Score:3.12|P-value:3.57E-4 ID:SGTC_2453|Compound:5731132|FD-Score:3.20|P-value:2.59E-4 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:-3.67|P-value:3.35E-5 ID:SGTC_2640|Compound:pentamidine|FD-Score:2.90|P-value:8.34E-4 ID:SGTC_2650|Compound:prasterone|FD-Score:3.13|P-value:3.43E-4 ID:SGTC_2750|Compound:bromebric acid|FD-Score:3.94|P-value:9.38E-6 ID:SGTC_2752|Compound:diclazuril|FD-Score:-3.54|P-value:6.02E-5 ID:SGTC_2754|Compound:granisetron|FD-Score:2.92|P-value:7.67E-4 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:5.21|P-value:7.86E-9 ID:SGTC_2862|Compound:9027634|FD-Score:-2.94|P-value:7.07E-4 ID:SGTC_2881|Compound:9058953|FD-Score:-2.96|P-value:6.54E-4 ID:SGTC_2965|Compound:9082772|FD-Score:-6.49|P-value:9.15E-13 ID:SGTC_3030|Compound:9087619|FD-Score:-3.07|P-value:4.20E-4 ID:SGTC_3074|Compound:9116018|FD-Score:-3.87|P-value:1.33E-5 ID:SGTC_3078|Compound:9116413|FD-Score:-3.86|P-value:1.41E-5 ID:SGTC_3140|Compound:9094243|FD-Score:-3.58|P-value:5.16E-5 ID:SGTC_3148|Compound:9097893|FD-Score:-3.05|P-value:4.62E-4 ID:SGTC_3221|Compound:9128209|FD-Score:-2.90|P-value:8.15E-4

Top fitness defect scores for YML077W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2758 dehydroepiandrosterone 5.21 69.3 µM 7.86E-9 3 9.39E-8 0.96
2 SGTC_1728 st035614 4.62 33.8 µM 2.72E-7 2 1.93E-6 0.30
3 SGTC_1531 st059297 4.50 52.4 µM 5.17E-7 1 3.35E-6 0.33
4 SGTC_2750 bromebric acid 3.94 70.2 µM 9.38E-6 4 4.00E-5 0.04
5 SGTC_1756 st041558 3.88 35.5 µM 1.27E-5 5 5.19E-5 0.41
6 SGTC_1553 gossypol 3.49 38.6 µM 7.69E-5 4 2.42E-4 0.58
7 SGTC_1916 st067606 3.45 49.2 µM 9.10E-5 12 2.80E-4 0.04
8 SGTC_182 3448-4371 3.38 550.5 µM 1.23E-4 5 3.62E-4 0.06
9 SGTC_2354 9060492 3.34 162.0 µM 1.46E-4 10 4.20E-4 0.05
10 SGTC_878 0828-0289 3.31 13.7 µM 1.62E-4 28 4.59E-4 0.18
11 SGTC_1300 1094-0077 3.26 113.0 µM 2.04E-4 8 5.60E-4 0.08
12 SGTC_306 1672-3436 3.23 11.6 µM 2.30E-4 Golgi 8 6.19E-4 0.01
13 SGTC_643 k048-0106 3.21 28.4 µM 2.52E-4 RSC & ERG11 22 6.70E-4 0.05
14 SGTC_2453 5731132 3.20 22.2 µM 2.59E-4 13 6.87E-4 0.03
15 SGTC_1760 st045453 3.15 10.4 µM 3.22E-4 NEO1-PIK1 7 8.28E-4 0.02
16 SGTC_2650 prasterone 3.13 100.0 µM 3.43E-4 4 8.74E-4 0.01
17 SGTC_2437 5741531 3.12 144.2 µM 3.57E-4 17 9.03E-4 0.00
18 SGTC_506 n9-isopropylolomoucine 3.09 153.0 µM 3.97E-4 8 9.90E-4 0.17
19 SGTC_600 1495-0418 3.09 41.6 µM 4.02E-4 RPP1 & pyrimidine depletion 14 0.00100 0.08
20 SGTC_2325 6158266 3.08 200.0 µM 4.24E-4 15 0.00105 0.03

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.142 1.47E-16 YDR416W SYF1 het Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; null mutant has splicing defect and arrests in G2/M; homologs in human and C. elegans
0.111 9.88E-11 YKL012W PRP40 het U1 snRNP protein involved in splicing, interacts with the branchpoint-binding protein during the formation of the second commitment complex
0.100 7.49E-9 YGL015C_p YGL015C_p hom Putative protein of unknown function; null mutants accumulate cargo in the Golgi
0.099 1.07E-8 YMR308C PSE1 het Karyopherin/importin that interacts with the nuclear pore complex; acts as the nuclear import receptor for specific proteins, including Pdr1p, Yap1p, Ste12p, and Aft1p
0.098 1.34E-8 YOL149W DCP1 het Subunit of the Dcp1p-Dcp2p decapping enzyme complex; decapping complex removes the 5' cap structure from mRNAs prior to their degradation; enhances the activity of catalytic subunit Dcp2p; regulated by DEAD box protein Dhh1p; forms cytoplasmic foci upon DNA replication stress
0.096 2.92E-8 YDR478W SNM1 het Subunit of RNase MRP, which cleaves pre-rRNA and has a role in cell cycle-regulated degradation of daughter cell-specific mRNAs; binds to the NME1 RNA subunit of RNase MRP
0.094 4.93E-8 YBL041W PRE7 het Beta 6 subunit of the 20S proteasome
0.094 5.42E-8 YGR036C CAX4 hom Dolichyl pyrophosphate (Dol-P-P) phosphatase with a luminally oriented active site in the ER, cleaves the anhydride linkage in Dol-P-P, required for Dol-P-P-linked oligosaccharide intermediate synthesis and protein N-glycosylation
0.093 5.89E-8 YDR499W LCD1 het Essential protein required for the DNA integrity checkpoint pathways; interacts physically with Mec1p; putative homolog of S. pombe Rad26 and human ATRIP; forms nuclear foci upon DNA replication stress
0.091 1.30E-7 YLR223C IFH1 het Coactivator that regulates transcription of ribosomal protein (RP) genes; recruited to RP gene promoters during optimal growth conditions via Fhl1p; subunit of CURI, a complex that coordinates RP production and pre-rRNA processing
0.088 3.62E-7 YER023W PRO3 het Delta 1-pyrroline-5-carboxylate reductase, catalyzes the last step in proline biosynthesis
0.087 5.11E-7 YOR335C ALA1 het Cytoplasmic and mitochondrial alanyl-tRNA synthetase, required for protein synthesis; point mutation (cdc64-1 allele) causes cell cycle arrest at G1; lethality of null mutation is functionally complemented by human homolog
0.086 6.29E-7 YDR021W FAL1 het Nucleolar protein required for maturation of 18S rRNA, member of the eIF4A subfamily of DEAD-box ATP-dependent RNA helicases
0.085 7.21E-7 YPL011C TAF3 het TFIID subunit (47 kDa), involved in promoter binding and RNA polymerase II transcription initiation
0.081 2.37E-6 YDL088C ASM4 hom FG-nucleoporin component of central core of nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport; induces membrane tubulation, which may contribute to nuclear pore assembly; ASM4 has a paralog, NUP53, that arose from the whole genome duplication