YML078W / CPR3

Mitochondrial peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; involved in protein refolding after import into mitochondria

Zygosity: Homozygous strain
fixedexpanded
Profile for YML078W / CPR3

Click on Significant Values for Screen Details ID:SGTC_21|Compound:0849-0113|FD-Score:3.40|P-value:4.51E-4 ID:SGTC_73|Compound:0327-0325|FD-Score:3.28|P-value:6.94E-4 ID:SGTC_386|Compound:1509-0011|FD-Score:4.04|P-value:4.10E-5 ID:SGTC_485|Compound:niflumic acid|FD-Score:4.04|P-value:4.07E-5 ID:SGTC_513|Compound:4245-1575|FD-Score:-3.23|P-value:7.44E-4 ID:SGTC_701|Compound:4424-0219|FD-Score:-3.27|P-value:6.61E-4 ID:SGTC_935|Compound:2996-0153|FD-Score:3.69|P-value:1.57E-4 ID:SGTC_989|Compound:1501-0895|FD-Score:3.64|P-value:1.92E-4 ID:SGTC_1002|Compound:4049-0206|FD-Score:3.47|P-value:3.55E-4 ID:SGTC_1078|Compound:idebenone|FD-Score:3.18|P-value:9.59E-4 ID:SGTC_1216|Compound:1165-0504|FD-Score:-3.45|P-value:3.52E-4 ID:SGTC_1222|Compound:0366-0074|FD-Score:4.01|P-value:4.49E-5 ID:SGTC_1459|Compound:k035-0031|FD-Score:5.34|P-value:9.33E-8 ID:SGTC_1494|Compound:4358-1428|FD-Score:4.11|P-value:3.06E-5 ID:SGTC_1500|Compound:4488-1866|FD-Score:-3.92|P-value:5.91E-5 ID:SGTC_1501|Compound:4491-0275|FD-Score:-3.28|P-value:6.35E-4 ID:SGTC_1502|Compound:4534-4282|FD-Score:-3.99|P-value:4.43E-5 ID:SGTC_1626|Compound:st003712|FD-Score:6.34|P-value:2.99E-10 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:3.42|P-value:4.33E-4 ID:SGTC_1633|Compound:st005664|FD-Score:-4.64|P-value:2.64E-6 ID:SGTC_1634|Compound:st006576|FD-Score:5.29|P-value:1.19E-7 ID:SGTC_1712|Compound:st032288|FD-Score:3.36|P-value:5.24E-4 ID:SGTC_1922|Compound:5578187|FD-Score:-3.16|P-value:9.45E-4 ID:SGTC_1949|Compound:st076024|FD-Score:3.60|P-value:2.22E-4 ID:SGTC_1962|Compound:st076595|FD-Score:3.87|P-value:7.87E-5 ID:SGTC_1963|Compound:st076565|FD-Score:3.36|P-value:5.20E-4 ID:SGTC_1964|Compound:st076914|FD-Score:4.43|P-value:7.54E-6 ID:SGTC_1970|Compound:st070122|FD-Score:4.03|P-value:4.24E-5 ID:SGTC_1976|Compound:st070609|FD-Score:-4.45|P-value:6.21E-6 ID:SGTC_1978|Compound:st071761|FD-Score:4.10|P-value:3.18E-5 ID:SGTC_1979|Compound:st071809|FD-Score:4.59|P-value:3.69E-6 ID:SGTC_1987|Compound:st072290|FD-Score:-4.10|P-value:2.76E-5 ID:SGTC_2077|Compound:5212015|FD-Score:-3.20|P-value:8.13E-4 ID:SGTC_2157|Compound:5649910|FD-Score:3.51|P-value:3.06E-4 ID:SGTC_2166|Compound:5933061|FD-Score:3.94|P-value:6.06E-5 ID:SGTC_2269|Compound:7935389|FD-Score:4.47|P-value:6.30E-6 ID:SGTC_2272|Compound:7805186|FD-Score:-3.23|P-value:7.47E-4 ID:SGTC_2277|Compound:7947813|FD-Score:3.40|P-value:4.62E-4 ID:SGTC_2323|Compound:6148992|FD-Score:5.00|P-value:5.30E-7 ID:SGTC_2390|Compound:9097792|FD-Score:3.65|P-value:1.82E-4 ID:SGTC_2552|Compound:juarezic acid|FD-Score:3.36|P-value:5.33E-4 ID:SGTC_2587|Compound:piperic acid|FD-Score:3.25|P-value:7.70E-4 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:-3.17|P-value:9.09E-4 ID:SGTC_2795|Compound:7780010|FD-Score:3.37|P-value:5.13E-4 ID:SGTC_2797|Compound:7859098|FD-Score:-5.08|P-value:3.05E-7 ID:SGTC_2822|Compound:7994718|FD-Score:3.61|P-value:2.15E-4 ID:SGTC_3002|Compound:9075603|FD-Score:3.74|P-value:1.30E-4 ID:SGTC_3089|Compound:9117425|FD-Score:-3.31|P-value:5.59E-4 ID:SGTC_3268|Compound:9137683|FD-Score:5.19|P-value:2.01E-7 ID:SGTC_21|Compound:0849-0113|FD-Score:3.40|P-value:4.51E-4 ID:SGTC_73|Compound:0327-0325|FD-Score:3.28|P-value:6.94E-4 ID:SGTC_386|Compound:1509-0011|FD-Score:4.04|P-value:4.10E-5 ID:SGTC_485|Compound:niflumic acid|FD-Score:4.04|P-value:4.07E-5 ID:SGTC_513|Compound:4245-1575|FD-Score:-3.23|P-value:7.44E-4 ID:SGTC_701|Compound:4424-0219|FD-Score:-3.27|P-value:6.61E-4 ID:SGTC_935|Compound:2996-0153|FD-Score:3.69|P-value:1.57E-4 ID:SGTC_989|Compound:1501-0895|FD-Score:3.64|P-value:1.92E-4 ID:SGTC_1002|Compound:4049-0206|FD-Score:3.47|P-value:3.55E-4 ID:SGTC_1078|Compound:idebenone|FD-Score:3.18|P-value:9.59E-4 ID:SGTC_1216|Compound:1165-0504|FD-Score:-3.45|P-value:3.52E-4 ID:SGTC_1222|Compound:0366-0074|FD-Score:4.01|P-value:4.49E-5 ID:SGTC_1459|Compound:k035-0031|FD-Score:5.34|P-value:9.33E-8 ID:SGTC_1494|Compound:4358-1428|FD-Score:4.11|P-value:3.06E-5 ID:SGTC_1500|Compound:4488-1866|FD-Score:-3.92|P-value:5.91E-5 ID:SGTC_1501|Compound:4491-0275|FD-Score:-3.28|P-value:6.35E-4 ID:SGTC_1502|Compound:4534-4282|FD-Score:-3.99|P-value:4.43E-5 ID:SGTC_1626|Compound:st003712|FD-Score:6.34|P-value:2.99E-10 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:3.42|P-value:4.33E-4 ID:SGTC_1633|Compound:st005664|FD-Score:-4.64|P-value:2.64E-6 ID:SGTC_1634|Compound:st006576|FD-Score:5.29|P-value:1.19E-7 ID:SGTC_1712|Compound:st032288|FD-Score:3.36|P-value:5.24E-4 ID:SGTC_1922|Compound:5578187|FD-Score:-3.16|P-value:9.45E-4 ID:SGTC_1949|Compound:st076024|FD-Score:3.60|P-value:2.22E-4 ID:SGTC_1962|Compound:st076595|FD-Score:3.87|P-value:7.87E-5 ID:SGTC_1963|Compound:st076565|FD-Score:3.36|P-value:5.20E-4 ID:SGTC_1964|Compound:st076914|FD-Score:4.43|P-value:7.54E-6 ID:SGTC_1970|Compound:st070122|FD-Score:4.03|P-value:4.24E-5 ID:SGTC_1976|Compound:st070609|FD-Score:-4.45|P-value:6.21E-6 ID:SGTC_1978|Compound:st071761|FD-Score:4.10|P-value:3.18E-5 ID:SGTC_1979|Compound:st071809|FD-Score:4.59|P-value:3.69E-6 ID:SGTC_1987|Compound:st072290|FD-Score:-4.10|P-value:2.76E-5 ID:SGTC_2077|Compound:5212015|FD-Score:-3.20|P-value:8.13E-4 ID:SGTC_2157|Compound:5649910|FD-Score:3.51|P-value:3.06E-4 ID:SGTC_2166|Compound:5933061|FD-Score:3.94|P-value:6.06E-5 ID:SGTC_2269|Compound:7935389|FD-Score:4.47|P-value:6.30E-6 ID:SGTC_2272|Compound:7805186|FD-Score:-3.23|P-value:7.47E-4 ID:SGTC_2277|Compound:7947813|FD-Score:3.40|P-value:4.62E-4 ID:SGTC_2323|Compound:6148992|FD-Score:5.00|P-value:5.30E-7 ID:SGTC_2390|Compound:9097792|FD-Score:3.65|P-value:1.82E-4 ID:SGTC_2552|Compound:juarezic acid|FD-Score:3.36|P-value:5.33E-4 ID:SGTC_2587|Compound:piperic acid|FD-Score:3.25|P-value:7.70E-4 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:-3.17|P-value:9.09E-4 ID:SGTC_2795|Compound:7780010|FD-Score:3.37|P-value:5.13E-4 ID:SGTC_2797|Compound:7859098|FD-Score:-5.08|P-value:3.05E-7 ID:SGTC_2822|Compound:7994718|FD-Score:3.61|P-value:2.15E-4 ID:SGTC_3002|Compound:9075603|FD-Score:3.74|P-value:1.30E-4 ID:SGTC_3089|Compound:9117425|FD-Score:-3.31|P-value:5.59E-4 ID:SGTC_3268|Compound:9137683|FD-Score:5.19|P-value:2.01E-7

Top fitness defect scores for YML078W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1626 st003712 6.34 1.8 µM 2.99E-10 6 1.17E-10
2 SGTC_1459 k035-0031 5.34 35.7 µM 9.33E-8 DNA intercalators 7 4.72E-8
3 SGTC_1634 st006576 5.29 41.0 µM 1.19E-7 TSC3-RPN4 8 6.08E-8
4 SGTC_3268 9137683 5.19 49.5 µM 2.01E-7 2 1.05E-7
5 SGTC_2323 6148992 5.00 148.3 µM 5.30E-7 14 2.90E-7
6 SGTC_1979 st071809 4.59 45.3 µM 3.69E-6 RPP1 & pyrimidine depletion 4 2.20E-6
7 SGTC_2269 7935389 4.47 174.4 µM 6.30E-6 tubulin folding & SWR complex 19 3.84E-6
8 SGTC_1964 st076914 4.43 61.0 µM 7.54E-6 RPP1 & pyrimidine depletion 9 4.64E-6
9 SGTC_1494 4358-1428 4.11 177.0 µM 3.06E-5 18 2.00E-5
10 SGTC_1978 st071761 4.10 42.0 µM 3.18E-5 TSC3-RPN4 13 2.08E-5
11 SGTC_485 niflumic acid 4.04 177.0 µM 4.07E-5 8 2.70E-5
12 SGTC_386 1509-0011 4.04 3.1 µM 4.10E-5 142 2.71E-5
13 SGTC_1970 st070122 4.03 35.8 µM 4.24E-5 TSC3-RPN4 25 2.81E-5
14 SGTC_1222 0366-0074 4.01 1.2 µM 4.49E-5 TSC3-RPN4 13 2.99E-5
15 SGTC_2166 5933061 3.94 31.5 µM 6.06E-5 tubulin folding & SWR complex 45 4.08E-5
16 SGTC_1962 st076595 3.87 64.5 µM 7.87E-5 redox potentiating 26 5.36E-5
17 SGTC_3002 9075603 3.74 71.4 µM 1.30E-4 26 9.09E-5
18 SGTC_935 2996-0153 3.69 430.0 µM 1.57E-4 PDR1 25 1.10E-4
19 SGTC_2390 9097792 3.65 176.6 µM 1.82E-4 21 1.29E-4
20 SGTC_989 1501-0895 3.64 10.3 µM 1.92E-4 14 1.36E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.106 7.74E-10 YJL022W_d YJL022W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene PET130
0.102 2.93E-9 YJR047C ANB1 hom Translation elongation factor eIF-5A; previously thought to function in translation initiation; undergoes an essential hypusination modification; expressed under anaerobic conditions; ANB1 has a paralog, HYP2, that arose from the whole genome duplication
0.086 5.91E-7 YOR059C YOR059C hom Lipid particle protein of unknown function; contains a putative lipase serine active site; induced by transcription factor Rpn4p; protein abundance increases in response to DNA replication stress
0.085 9.25E-7 YKL051W SFK1 hom Plasma membrane protein that may act together with or upstream of Stt4p to generate normal levels of the essential phospholipid PI4P, at least partially mediates proper localization of Stt4p to the plasma membrane
0.083 1.38E-6 YHR116W COX23 hom Mitochondrial intermembrane space protein that functions in mitochondrial copper homeostasis, essential for functional cytochrome oxidase expression; homologous to Cox17p; contains twin cysteine-x9-cysteine motifs
0.082 1.94E-6 YBR062C_p YBR062C_p hom Protein of unknown function that interacts with Msb2p; may play a role in activation of the filamentous growth pathway.
0.082 1.91E-6 YJL158C CIS3 hom Mannose-containing glycoprotein constituent of the cell wall; member of the PIR (proteins with internal repeats) family
0.078 5.93E-6 YBR271W EFM2 hom S-adenosylmethionine-dependent methyltransferase; methylates translation elongation factors EF2 (Eft1p and Eft2p) and EF3A (Yef3p); belongs to the seven beta-strand family; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; predicted to be involved in ribosome biogenesis
0.077 8.09E-6 YDL178W DLD2 hom D-lactate dehydrogenase, located in the mitochondrial matrix
0.076 1.14E-5 YFR056C_d YFR056C_d hom Dubious open reading frame unlikely to encode a protein based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YFR055W
0.073 2.25E-5 YMR093W UTP15 het Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA
0.072 3.03E-5 YMR150C IMP1 hom Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p
0.070 4.57E-5 YCL044C MGR1 hom Subunit of the mitochondrial (mt) i-AAA protease supercomplex, which degrades misfolded mitochondrial proteins; forms a subcomplex with Mgr3p that binds to substrates to facilitate proteolysis; required for growth of cells lacking mtDNA
0.069 6.48E-5 YPL189C-A COA2 hom Cytochrome oxidase assembly factor; null mutation results in respiratory deficiency with specific loss of cytochrome oxidase activity; functions downstream of assembly factors Mss51p and Coa1p and interacts with assembly factor Shy1p
0.069 6.61E-5 YKL042W SPC42 het Central plaque component of spindle pole body (SPB); involved in SPB duplication, may facilitate attachment of the SPB to the nuclear membrane