YML080W / DUS1

Dihydrouridine synthase, member of a widespread family of conserved proteins including Smm1p, Dus3p, and Dus4p; modifies pre-tRNA(Phe) at U17

Zygosity: Homozygous strain
fixedexpanded
Profile for YML080W / DUS1

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:3.14|P-value:2.20E-4 ID:SGTC_73|Compound:0327-0325|FD-Score:3.12|P-value:2.34E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:3.73|P-value:1.57E-5 ID:SGTC_236|Compound:1509-0011|FD-Score:-3.54|P-value:8.00E-5 ID:SGTC_242|Compound:5hr heat shock (37°C) + 5-fluorouracil|FD-Score:3.02|P-value:3.48E-4 ID:SGTC_290|Compound:2043-6722|FD-Score:3.02|P-value:3.56E-4 ID:SGTC_348|Compound:k064-0012|FD-Score:2.76|P-value:9.64E-4 ID:SGTC_416|Compound:estradiol valerate|FD-Score:-3.12|P-value:4.58E-4 ID:SGTC_493|Compound:zm226600|FD-Score:-3.37|P-value:1.69E-4 ID:SGTC_907|Compound:3448-6986|FD-Score:2.83|P-value:7.34E-4 ID:SGTC_911|Compound:3456-4043|FD-Score:4.81|P-value:4.59E-8 ID:SGTC_1025|Compound:k007-0731|FD-Score:-3.59|P-value:6.38E-5 ID:SGTC_1046|Compound:2001-0062|FD-Score:-2.98|P-value:7.77E-4 ID:SGTC_1048|Compound:3161-0300|FD-Score:3.16|P-value:2.00E-4 ID:SGTC_1445|Compound:4239-0156|FD-Score:3.26|P-value:1.31E-4 ID:SGTC_1617|Compound:st002906|FD-Score:2.98|P-value:4.16E-4 ID:SGTC_1677|Compound:st019204|FD-Score:-3.43|P-value:1.33E-4 ID:SGTC_1681|Compound:tripelennamine|FD-Score:4.15|P-value:1.97E-6 ID:SGTC_1682|Compound:st012968|FD-Score:-3.23|P-value:2.92E-4 ID:SGTC_1684|Compound:st024538|FD-Score:3.43|P-value:6.44E-5 ID:SGTC_1694|Compound:st024011|FD-Score:2.83|P-value:7.47E-4 ID:SGTC_1726|Compound:st035556|FD-Score:-3.62|P-value:5.77E-5 ID:SGTC_1732|Compound:st034308|FD-Score:3.34|P-value:9.28E-5 ID:SGTC_1905|Compound:st060207|FD-Score:-3.48|P-value:1.07E-4 ID:SGTC_2129|Compound:girgensonine|FD-Score:3.00|P-value:3.89E-4 ID:SGTC_2263|Compound:7948595|FD-Score:3.10|P-value:2.55E-4 ID:SGTC_2271|Compound:7849410|FD-Score:-2.94|P-value:9.29E-4 ID:SGTC_2282|Compound:7944268|FD-Score:-4.12|P-value:5.28E-6 ID:SGTC_2288|Compound:7946289|FD-Score:4.42|P-value:4.34E-7 ID:SGTC_2290|Compound:7904846|FD-Score:3.02|P-value:3.49E-4 ID:SGTC_2382|Compound:9035899|FD-Score:2.82|P-value:7.76E-4 ID:SGTC_2421|Compound:5690543|FD-Score:2.84|P-value:6.99E-4 ID:SGTC_2434|Compound:5670830|FD-Score:-3.09|P-value:5.14E-4 ID:SGTC_2448|Compound:5185112|FD-Score:2.80|P-value:8.34E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:-5.41|P-value:3.08E-9 ID:SGTC_2497|Compound:7-hydroxyflavone|FD-Score:-3.58|P-value:6.77E-5 ID:SGTC_2504|Compound:purpurogallin|FD-Score:4.05|P-value:3.30E-6 ID:SGTC_2506|Compound:ethyl hematommate|FD-Score:5.03|P-value:1.18E-8 ID:SGTC_2630|Compound:antimycin a|FD-Score:3.18|P-value:1.81E-4 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:-3.83|P-value:2.15E-5 ID:SGTC_2638|Compound:epoxomicin|FD-Score:4.02|P-value:3.75E-6 ID:SGTC_2762|Compound:leflunomide|FD-Score:-3.01|P-value:7.04E-4 ID:SGTC_2763|Compound:lisinopril|FD-Score:5.34|P-value:1.59E-9 ID:SGTC_2764|Compound:methyldopa|FD-Score:3.68|P-value:1.97E-5 ID:SGTC_2766|Compound:oltipraz|FD-Score:4.02|P-value:3.69E-6 ID:SGTC_2770|Compound:toltrazuril|FD-Score:2.78|P-value:8.97E-4 ID:SGTC_3211|Compound:9128781|FD-Score:-3.56|P-value:7.28E-5 ID:SGTC_3267|Compound:9137951|FD-Score:-3.12|P-value:4.63E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:3.14|P-value:2.20E-4 ID:SGTC_73|Compound:0327-0325|FD-Score:3.12|P-value:2.34E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:3.73|P-value:1.57E-5 ID:SGTC_236|Compound:1509-0011|FD-Score:-3.54|P-value:8.00E-5 ID:SGTC_242|Compound:5hr heat shock (37°C) + 5-fluorouracil|FD-Score:3.02|P-value:3.48E-4 ID:SGTC_290|Compound:2043-6722|FD-Score:3.02|P-value:3.56E-4 ID:SGTC_348|Compound:k064-0012|FD-Score:2.76|P-value:9.64E-4 ID:SGTC_416|Compound:estradiol valerate|FD-Score:-3.12|P-value:4.58E-4 ID:SGTC_493|Compound:zm226600|FD-Score:-3.37|P-value:1.69E-4 ID:SGTC_907|Compound:3448-6986|FD-Score:2.83|P-value:7.34E-4 ID:SGTC_911|Compound:3456-4043|FD-Score:4.81|P-value:4.59E-8 ID:SGTC_1025|Compound:k007-0731|FD-Score:-3.59|P-value:6.38E-5 ID:SGTC_1046|Compound:2001-0062|FD-Score:-2.98|P-value:7.77E-4 ID:SGTC_1048|Compound:3161-0300|FD-Score:3.16|P-value:2.00E-4 ID:SGTC_1445|Compound:4239-0156|FD-Score:3.26|P-value:1.31E-4 ID:SGTC_1617|Compound:st002906|FD-Score:2.98|P-value:4.16E-4 ID:SGTC_1677|Compound:st019204|FD-Score:-3.43|P-value:1.33E-4 ID:SGTC_1681|Compound:tripelennamine|FD-Score:4.15|P-value:1.97E-6 ID:SGTC_1682|Compound:st012968|FD-Score:-3.23|P-value:2.92E-4 ID:SGTC_1684|Compound:st024538|FD-Score:3.43|P-value:6.44E-5 ID:SGTC_1694|Compound:st024011|FD-Score:2.83|P-value:7.47E-4 ID:SGTC_1726|Compound:st035556|FD-Score:-3.62|P-value:5.77E-5 ID:SGTC_1732|Compound:st034308|FD-Score:3.34|P-value:9.28E-5 ID:SGTC_1905|Compound:st060207|FD-Score:-3.48|P-value:1.07E-4 ID:SGTC_2129|Compound:girgensonine|FD-Score:3.00|P-value:3.89E-4 ID:SGTC_2263|Compound:7948595|FD-Score:3.10|P-value:2.55E-4 ID:SGTC_2271|Compound:7849410|FD-Score:-2.94|P-value:9.29E-4 ID:SGTC_2282|Compound:7944268|FD-Score:-4.12|P-value:5.28E-6 ID:SGTC_2288|Compound:7946289|FD-Score:4.42|P-value:4.34E-7 ID:SGTC_2290|Compound:7904846|FD-Score:3.02|P-value:3.49E-4 ID:SGTC_2382|Compound:9035899|FD-Score:2.82|P-value:7.76E-4 ID:SGTC_2421|Compound:5690543|FD-Score:2.84|P-value:6.99E-4 ID:SGTC_2434|Compound:5670830|FD-Score:-3.09|P-value:5.14E-4 ID:SGTC_2448|Compound:5185112|FD-Score:2.80|P-value:8.34E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:-5.41|P-value:3.08E-9 ID:SGTC_2497|Compound:7-hydroxyflavone|FD-Score:-3.58|P-value:6.77E-5 ID:SGTC_2504|Compound:purpurogallin|FD-Score:4.05|P-value:3.30E-6 ID:SGTC_2506|Compound:ethyl hematommate|FD-Score:5.03|P-value:1.18E-8 ID:SGTC_2630|Compound:antimycin a|FD-Score:3.18|P-value:1.81E-4 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:-3.83|P-value:2.15E-5 ID:SGTC_2638|Compound:epoxomicin|FD-Score:4.02|P-value:3.75E-6 ID:SGTC_2762|Compound:leflunomide|FD-Score:-3.01|P-value:7.04E-4 ID:SGTC_2763|Compound:lisinopril|FD-Score:5.34|P-value:1.59E-9 ID:SGTC_2764|Compound:methyldopa|FD-Score:3.68|P-value:1.97E-5 ID:SGTC_2766|Compound:oltipraz|FD-Score:4.02|P-value:3.69E-6 ID:SGTC_2770|Compound:toltrazuril|FD-Score:2.78|P-value:8.97E-4 ID:SGTC_3211|Compound:9128781|FD-Score:-3.56|P-value:7.28E-5 ID:SGTC_3267|Compound:9137951|FD-Score:-3.12|P-value:4.63E-4

Top fitness defect scores for YML080W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2763 lisinopril 5.34 49.3 µM 1.59E-9 1 4.56E-8
2 SGTC_2506 ethyl hematommate 5.03 54.2 µM 1.18E-8 RPP1 & pyrimidine depletion 4 2.41E-7
3 SGTC_911 3456-4043 4.81 236.0 µM 4.59E-8 mitochondrial processes 16 7.46E-7
4 SGTC_2288 7946289 4.42 167.3 µM 4.34E-7 18 4.82E-6
5 SGTC_1681 tripelennamine 4.15 100.0 µM 1.97E-6 17 1.70E-5
6 SGTC_2504 purpurogallin 4.05 52.3 µM 3.30E-6 RPP1 & pyrimidine depletion 20 2.60E-5
7 SGTC_2766 oltipraz 4.02 83.9 µM 3.69E-6 heme requiring 23 2.86E-5
8 SGTC_2638 epoxomicin 4.02 18.0 µM 3.75E-6 34 2.89E-5
9 SGTC_116 0155-0182 3.73 31.8 µM 1.57E-5 mitochondrial response to ROS 95 9.51E-5
10 SGTC_2764 methyldopa 3.68 94.7 µM 1.97E-5 21 1.15E-4
11 SGTC_1684 st024538 3.43 14.6 µM 6.44E-5 16 3.07E-4
12 SGTC_1732 st034308 3.34 51.8 µM 9.28E-5 48 4.16E-4
13 SGTC_1445 4239-0156 3.26 97.7 µM 1.31E-4 58 5.52E-4
14 SGTC_2630 antimycin a 3.18 100.0 µM 1.81E-4 mitochondrial processes 71 7.24E-4
15 SGTC_1048 3161-0300 3.16 24.5 µM 2.00E-4 48 7.87E-4
16 SGTC_58 0957-0393 3.14 9.0 µM 2.20E-4 cell wall 475 8.52E-4
17 SGTC_73 0327-0325 3.12 16.2 µM 2.34E-4 DNA damage response 95 8.95E-4
18 SGTC_2263 7948595 3.10 193.3 µM 2.55E-4 28 9.61E-4
19 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 3.02 4.6 µM 3.48E-4 heat shock/prefoldin 81 0.00125
20 SGTC_2290 7904846 3.02 200.0 µM 3.49E-4 75 0.00125

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.128 1.06E-13 YMR136W GAT2 hom Protein containing GATA family zinc finger motifs; similar to Gln3p and Dal80p; expression repressed by leucine
0.113 5.74E-11 YLR004C THI73 hom Putative plasma membrane permease proposed to be involved in carboxylic acid uptake and repressed by thiamine; substrate of Dbf2p/Mob1p kinase; transcription is altered if mitochondrial dysfunction occurs
0.112 9.47E-11 YHL028W WSC4 hom ER membrane protein involved in the translocation of soluble secretory proteins and insertion of membrane proteins into the ER membrane; may also have a role in the stress response but has only partial functional overlap with WSC1-3
0.106 6.99E-10 YBR296C PHO89 hom Na+/Pi cotransporter, active in early growth phase; similar to phosphate transporters of Neurospora crassa; transcription regulated by inorganic phosphate concentrations and Pho4p; mutations in related human transporter genes hPit1 and hPit2 are associated with hyperphosphatemia-induced calcification of vascular tissue and familial idiopathic basal ganglia calcification
0.101 3.94E-9 YAL015C NTG1 hom DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase; involved in base excision repair; acts in both nucleus and mitochondrion; creates a double-strand break at mtDNA origins that stimulates replication in response to oxidative stress; NTG1 has a paralog, NTG2, that arose from the whole genome duplication
0.099 9.19E-9 YDR205W MSC2 hom Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids
0.097 1.82E-8 YML116W-A_d YML116W-A_d hom Putative protein of unknown function
0.096 2.59E-8 YJR054W KCH1 hom Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family; potential Cdc28p substrate
0.090 1.56E-7 YGR203W YCH1 hom Phosphatase with sequence similarity to Cdc25p, Arr2p and Mih1p; member of the single-domain rhodanese homology superfamily; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus
0.088 2.82E-7 YMR193C-A_d YMR193C-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.088 3.69E-7 YJR044C VPS55 hom Late endosomal protein involved in late endosome to vacuole trafficking; functional homolog of human obesity receptor gene-related protein (OB-RGRP)
0.087 4.41E-7 YIL111W COX5B hom Subunit Vb of cytochrome c oxidase; cytochrome c oxidase is the terminal member of the mitochondrial inner membrane electron transport chain; Cox5Bp is predominantly expressed during anaerobic growth while its isoform Va (Cox5Ap) is expressed during aerobic growth; COX5B has a paralog, COX5A, that arose from the whole genome duplication
0.085 8.14E-7 YMR272C SCS7 hom Sphingolipid alpha-hydroxylase, functions in the alpha-hydroxylation of sphingolipid-associated very long chain fatty acids, has both cytochrome b5-like and hydroxylase/desaturase domains, not essential for growth
0.085 8.02E-7 YER048C CAJ1 hom Nuclear type II J heat shock protein of the E. coli dnaJ family, contains a leucine zipper-like motif, binds to non-native substrates for presentation to Ssa3p, may function during protein translocation, assembly and disassembly
0.085 9.37E-7 YJL083W TAX4 hom EH domain-containing protein; involved in regulating phosphatidylinositol 4,5-bisphosphate levels and autophagy; Irs4p and Tax4p bind and activate the PtdIns phosphatase Inp51p; Irs4p and Tax4p are involved in localizing Atg17p to the PAS; TAX4 has a paralog, IRS4, that arose from the whole genome duplication