YML081W / TDA9

DNA-binding protein, putative transcription factor; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; null mutant is sensitive to expression of the top1-T722A allele; not an essential gene; TDA9 has a paralog, RSF2, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YML081W / TDA9

Click on Significant Values for Screen Details ID:SGTC_6|Compound:0844-0013|FD-Score:6.84|P-value:4.10E-12 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:6.69|P-value:1.13E-11 ID:SGTC_32|Compound:0928-0142|FD-Score:3.12|P-value:8.32E-4 ID:SGTC_130|Compound:0136-0219|FD-Score:4.09|P-value:1.95E-5 ID:SGTC_132|Compound:0417-1715|FD-Score:3.36|P-value:3.60E-4 ID:SGTC_177|Compound:1327-0068|FD-Score:6.02|P-value:8.34E-10 ID:SGTC_211|Compound:3455-0679|FD-Score:3.35|P-value:3.67E-4 ID:SGTC_227|Compound:fluconazole|FD-Score:3.89|P-value:4.50E-5 ID:SGTC_352|Compound:k048-0007|FD-Score:-4.03|P-value:3.98E-5 ID:SGTC_363|Compound:0455-0021|FD-Score:6.16|P-value:3.57E-10 ID:SGTC_421|Compound:streptovitacin|FD-Score:3.75|P-value:8.01E-5 ID:SGTC_451|Compound:chloral hydrate|FD-Score:6.40|P-value:7.46E-11 ID:SGTC_480|Compound:am 92016|FD-Score:3.45|P-value:2.54E-4 ID:SGTC_494|Compound:Boc-Gly-Val-Val-CHO|FD-Score:3.37|P-value:3.38E-4 ID:SGTC_525|Compound:k781-2675|FD-Score:3.77|P-value:7.48E-5 ID:SGTC_625|Compound:k213-0058|FD-Score:3.90|P-value:4.33E-5 ID:SGTC_694|Compound:1315-0438|FD-Score:-4.00|P-value:4.65E-5 ID:SGTC_696|Compound:1560-0013|FD-Score:3.90|P-value:4.35E-5 ID:SGTC_703|Compound:3875-0075|FD-Score:3.21|P-value:6.03E-4 ID:SGTC_707|Compound:0865-0008|FD-Score:3.36|P-value:3.59E-4 ID:SGTC_788|Compound:1182-0090|FD-Score:7.77|P-value:4.20E-15 ID:SGTC_862|Compound:0452-0056|FD-Score:3.26|P-value:5.10E-4 ID:SGTC_950|Compound:1165-0508|FD-Score:4.34|P-value:6.49E-6 ID:SGTC_989|Compound:1501-0895|FD-Score:3.09|P-value:9.21E-4 ID:SGTC_995|Compound:3931-2021|FD-Score:3.33|P-value:3.96E-4 ID:SGTC_1029|Compound:k015-0030|FD-Score:3.28|P-value:4.78E-4 ID:SGTC_1057|Compound:3448-5381|FD-Score:3.24|P-value:5.38E-4 ID:SGTC_1239|Compound:0337-0584|FD-Score:5.26|P-value:6.90E-8 ID:SGTC_1317|Compound:1273-0028|FD-Score:7.31|P-value:1.36E-13 ID:SGTC_1362|Compound:1611-0397|FD-Score:3.48|P-value:2.28E-4 ID:SGTC_1497|Compound:4476-2978|FD-Score:4.05|P-value:2.38E-5 ID:SGTC_1775|Compound:st081588|FD-Score:3.17|P-value:6.90E-4 ID:SGTC_1786|Compound:berberine|FD-Score:3.47|P-value:2.36E-4 ID:SGTC_1829|Compound:berberine|FD-Score:3.17|P-value:6.88E-4 ID:SGTC_2139|Compound:5578692|FD-Score:3.85|P-value:5.48E-5 ID:SGTC_2223|Compound:6903751|FD-Score:3.71|P-value:9.33E-5 ID:SGTC_2233|Compound:sulbentine|FD-Score:4.48|P-value:3.41E-6 ID:SGTC_2439|Compound:5492030|FD-Score:-3.39|P-value:4.71E-4 ID:SGTC_2443|Compound:5493264|FD-Score:-3.64|P-value:1.88E-4 ID:SGTC_2446|Compound:5162541|FD-Score:4.64|P-value:1.63E-6 ID:SGTC_2476|Compound:5806916|FD-Score:-4.57|P-value:3.84E-6 ID:SGTC_2484|Compound:5809818|FD-Score:3.08|P-value:9.28E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:3.83|P-value:5.86E-5 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:3.12|P-value:8.18E-4 ID:SGTC_2606|Compound:farnesol|FD-Score:3.20|P-value:6.16E-4 ID:SGTC_2760|Compound:etidronate|FD-Score:3.25|P-value:5.23E-4 ID:SGTC_2770|Compound:toltrazuril|FD-Score:-3.20|P-value:9.05E-4 ID:SGTC_2799|Compound:7812892|FD-Score:6.88|P-value:3.07E-12 ID:SGTC_2861|Compound:9024595|FD-Score:-4.30|P-value:1.25E-5 ID:SGTC_2863|Compound:9028737|FD-Score:-3.38|P-value:4.82E-4 ID:SGTC_2866|Compound:9034245|FD-Score:-4.21|P-value:1.89E-5 ID:SGTC_3329|Compound:9141233|FD-Score:-3.23|P-value:8.16E-4 ID:SGTC_6|Compound:0844-0013|FD-Score:6.84|P-value:4.10E-12 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:6.69|P-value:1.13E-11 ID:SGTC_32|Compound:0928-0142|FD-Score:3.12|P-value:8.32E-4 ID:SGTC_130|Compound:0136-0219|FD-Score:4.09|P-value:1.95E-5 ID:SGTC_132|Compound:0417-1715|FD-Score:3.36|P-value:3.60E-4 ID:SGTC_177|Compound:1327-0068|FD-Score:6.02|P-value:8.34E-10 ID:SGTC_211|Compound:3455-0679|FD-Score:3.35|P-value:3.67E-4 ID:SGTC_227|Compound:fluconazole|FD-Score:3.89|P-value:4.50E-5 ID:SGTC_352|Compound:k048-0007|FD-Score:-4.03|P-value:3.98E-5 ID:SGTC_363|Compound:0455-0021|FD-Score:6.16|P-value:3.57E-10 ID:SGTC_421|Compound:streptovitacin|FD-Score:3.75|P-value:8.01E-5 ID:SGTC_451|Compound:chloral hydrate|FD-Score:6.40|P-value:7.46E-11 ID:SGTC_480|Compound:am 92016|FD-Score:3.45|P-value:2.54E-4 ID:SGTC_494|Compound:Boc-Gly-Val-Val-CHO|FD-Score:3.37|P-value:3.38E-4 ID:SGTC_525|Compound:k781-2675|FD-Score:3.77|P-value:7.48E-5 ID:SGTC_625|Compound:k213-0058|FD-Score:3.90|P-value:4.33E-5 ID:SGTC_694|Compound:1315-0438|FD-Score:-4.00|P-value:4.65E-5 ID:SGTC_696|Compound:1560-0013|FD-Score:3.90|P-value:4.35E-5 ID:SGTC_703|Compound:3875-0075|FD-Score:3.21|P-value:6.03E-4 ID:SGTC_707|Compound:0865-0008|FD-Score:3.36|P-value:3.59E-4 ID:SGTC_788|Compound:1182-0090|FD-Score:7.77|P-value:4.20E-15 ID:SGTC_862|Compound:0452-0056|FD-Score:3.26|P-value:5.10E-4 ID:SGTC_950|Compound:1165-0508|FD-Score:4.34|P-value:6.49E-6 ID:SGTC_989|Compound:1501-0895|FD-Score:3.09|P-value:9.21E-4 ID:SGTC_995|Compound:3931-2021|FD-Score:3.33|P-value:3.96E-4 ID:SGTC_1029|Compound:k015-0030|FD-Score:3.28|P-value:4.78E-4 ID:SGTC_1057|Compound:3448-5381|FD-Score:3.24|P-value:5.38E-4 ID:SGTC_1239|Compound:0337-0584|FD-Score:5.26|P-value:6.90E-8 ID:SGTC_1317|Compound:1273-0028|FD-Score:7.31|P-value:1.36E-13 ID:SGTC_1362|Compound:1611-0397|FD-Score:3.48|P-value:2.28E-4 ID:SGTC_1497|Compound:4476-2978|FD-Score:4.05|P-value:2.38E-5 ID:SGTC_1775|Compound:st081588|FD-Score:3.17|P-value:6.90E-4 ID:SGTC_1786|Compound:berberine|FD-Score:3.47|P-value:2.36E-4 ID:SGTC_1829|Compound:berberine|FD-Score:3.17|P-value:6.88E-4 ID:SGTC_2139|Compound:5578692|FD-Score:3.85|P-value:5.48E-5 ID:SGTC_2223|Compound:6903751|FD-Score:3.71|P-value:9.33E-5 ID:SGTC_2233|Compound:sulbentine|FD-Score:4.48|P-value:3.41E-6 ID:SGTC_2439|Compound:5492030|FD-Score:-3.39|P-value:4.71E-4 ID:SGTC_2443|Compound:5493264|FD-Score:-3.64|P-value:1.88E-4 ID:SGTC_2446|Compound:5162541|FD-Score:4.64|P-value:1.63E-6 ID:SGTC_2476|Compound:5806916|FD-Score:-4.57|P-value:3.84E-6 ID:SGTC_2484|Compound:5809818|FD-Score:3.08|P-value:9.28E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:3.83|P-value:5.86E-5 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:3.12|P-value:8.18E-4 ID:SGTC_2606|Compound:farnesol|FD-Score:3.20|P-value:6.16E-4 ID:SGTC_2760|Compound:etidronate|FD-Score:3.25|P-value:5.23E-4 ID:SGTC_2770|Compound:toltrazuril|FD-Score:-3.20|P-value:9.05E-4 ID:SGTC_2799|Compound:7812892|FD-Score:6.88|P-value:3.07E-12 ID:SGTC_2861|Compound:9024595|FD-Score:-4.30|P-value:1.25E-5 ID:SGTC_2863|Compound:9028737|FD-Score:-3.38|P-value:4.82E-4 ID:SGTC_2866|Compound:9034245|FD-Score:-4.21|P-value:1.89E-5 ID:SGTC_3329|Compound:9141233|FD-Score:-3.23|P-value:8.16E-4

Top fitness defect scores for YML081W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_788 1182-0090 7.77 188.0 µM 4.20E-15 endomembrane recycling 22 3.89E-15
2 SGTC_1317 1273-0028 7.31 910.0 nM 1.36E-13 azole & statin 20 1.31E-13
3 SGTC_2799 7812892 6.88 81.8 µM 3.07E-12 superoxide 5 3.02E-12
4 SGTC_6 0844-0013 6.84 19.8 µM 4.10E-12 7 4.05E-12
5 SGTC_28 pentachloropyridine N-oxide 6.69 1.6 µM 1.13E-11 TSC3-RPN4 9 1.13E-11
6 SGTC_451 chloral hydrate 6.40 100.0 µM 7.46E-11 12 7.54E-11
7 SGTC_363 0455-0021 6.16 3.1 µM 3.57E-10 azole & statin 29 3.65E-10
8 SGTC_177 1327-0068 6.02 8.4 µM 8.34E-10 22 8.59E-10
9 SGTC_1239 0337-0584 5.26 35.4 µM 6.90E-8 unfolded protein response 23 7.33E-8
10 SGTC_2446 5162541 4.64 200.0 µM 1.63E-6 4 1.76E-6
11 SGTC_2233 sulbentine 4.48 40.4 µM 3.41E-6 41 3.70E-6
12 SGTC_950 1165-0508 4.34 94.1 µM 6.49E-6 19 7.07E-6
13 SGTC_130 0136-0219 4.09 337.7 µM 1.95E-5 17 2.13E-5
14 SGTC_1497 4476-2978 4.05 41.3 µM 2.38E-5 6 2.60E-5
15 SGTC_625 k213-0058 3.90 121.0 µM 4.33E-5 translation 108 4.74E-5
16 SGTC_696 1560-0013 3.90 611.0 µM 4.35E-5 24 4.77E-5
17 SGTC_227 fluconazole 3.89 33.5 µM 4.50E-5 azole & statin 86 4.93E-5
18 SGTC_2139 5578692 3.85 56.5 µM 5.48E-5 superoxide 18 6.01E-5
19 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.83 3.7 µM 5.86E-5 91 6.43E-5
20 SGTC_525 k781-2675 3.77 26.7 µM 7.48E-5 redox potentiating 57 8.21E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.305 5.19E-73 YJR049C UTR1 hom ATP-NADH kinase; phosphorylates both NAD and NADH; active as a hexamer; enhances the activity of ferric reductase (Fre1p); UTR1 has a paralog, YEF1, that arose from the whole genome duplication
0.218 1.59E-37 YPL061W ALD6 hom Cytosolic aldehyde dehydrogenase, activated by Mg2+ and utilizes NADP+ as the preferred coenzyme; required for conversion of acetaldehyde to acetate; constitutively expressed; locates to the mitochondrial outer surface upon oxidative stress
0.208 4.76E-34 YPR074C TKL1 hom Transketolase; catalyzes conversion of xylulose-5-phosphate and ribose-5-phosphate to sedoheptulose-7-phosphate and glyceraldehyde-3-phosphate in the pentose phosphate pathway; needed for synthesis of aromatic amino acids; TKL1 has a paralog, TKL2, that arose from the whole genome duplication
0.202 5.20E-32 YMR154C RIM13 hom Calpain-like cysteine protease; involved in proteolytic activation of Rim101p in response to alkaline pH; localizes to punctate structures in alkaline conditions and in vps4 mutant; has similarity to A. nidulans palB
0.186 1.29E-27 YPL062W_d YPL062W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YPL062W is not an essential gene; homozygous diploid mutant shows a decrease in glycogen accumulation
0.186 1.77E-27 YLR359W ADE13 het Adenylosuccinate lyase, catalyzes two steps in the 'de novo' purine nucleotide biosynthetic pathway; expression is repressed by adenine and activated by Bas1p and Pho2p; mutations in human ortholog ADSL cause adenylosuccinase deficiency
0.169 5.48E-23 YDR181C SAS4 hom Subunit of the SAS complex (Sas2p, Sas4p, Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing; required for the HAT activity of Sas2p
0.159 1.78E-20 YGR122W YGR122W hom Protein that may be involved in pH regulation; probable ortholog of A. nidulans PalC, which is involved in pH regulation and binds to the ESCRT-III complex; null mutant does not properly process Rim101p and has decreased resistance to rapamycin; GFP-fusion protein is cytoplasmic; relative distribution to cytoplasm increases upon DNA replication stress
0.157 6.64E-20 YOR275C RIM20 hom Protein involved in proteolytic activation of Rim101p in response to alkaline pH; PalA/AIP1/Alix family member; interaction with the ESCRT-III subunit Snf7p suggests a relationship between pH response and multivesicular body formation
0.153 3.80E-19 YNL294C RIM21 hom pH sensor molecule, component of the RIM101 pathway; has a role in cell wall construction and alkaline pH response; is glycosylated and phosphorylated; interacts with Dfg16p and Rim9p to form a pH-sensing complex; localization to the plasma membrane is dependent on Dfg16p and Rim9p; has similarity to A. nidulans PalH
0.151 1.37E-18 YGL045W RIM8 hom Protein involved in proteolytic activation of Rim101p in response to alkaline pH; interacts with ESCRT-1 subunits Stp22p and Vps28p; essential for anaerobic growth; member of the arrestin-related trafficking adaptor family
0.144 5.42E-17 YPR198W SGE1 hom Plasma membrane multidrug transporter of the major facilitator superfamily, acts as an extrusion permease; partial multicopy suppressor of gal11 mutations
0.143 7.63E-17 YJL121C RPE1 hom D-ribulose-5-phosphate 3-epimerase, catalyzes a reaction in the non-oxidative part of the pentose-phosphate pathway; mutants are sensitive to oxidative stress
0.131 2.15E-14 YNL242W ATG2 hom Peripheral membrane protein required for autophagic vesicle formation; also required for vesicle formation during pexophagy and the cytoplasm-to-vaucole targeting (Cvt) pathway; involved in Atg9p cycling between the phagophore assembly site and mitochondria; forms cytoplasmic foci upon DNA replication stress
0.130 5.04E-14 YMR127C SAS2 hom Histone acetyltransferase (HAT) catalytic subunit of the SAS complex (Sas2p-Sas4p-Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing; member of the MYSTacetyltransferase family