YML082W_p

Putative protein predicted to have carbon-sulfur lyase activity; transcriptionally regulated by Upc2p via an upstream sterol response element; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and the cytoplasm; YML082W is not an essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YML082W / YML082W

Click on Significant Values for Screen Details ID:SGTC_78|Compound:0336-0123|FD-Score:3.49|P-value:8.05E-4 ID:SGTC_136|Compound:0097-0015|FD-Score:3.98|P-value:1.56E-4 ID:SGTC_309|Compound:k408-0051|FD-Score:3.57|P-value:6.12E-4 ID:SGTC_403|Compound:arphamenine a|FD-Score:-3.64|P-value:3.87E-4 ID:SGTC_765|Compound:1319-0117|FD-Score:3.86|P-value:2.36E-4 ID:SGTC_780|Compound:0109-0199|FD-Score:3.58|P-value:5.90E-4 ID:SGTC_816|Compound:0325-0417|FD-Score:4.04|P-value:1.25E-4 ID:SGTC_821|Compound:1114-0266|FD-Score:5.14|P-value:1.56E-6 ID:SGTC_826|Compound:1683-5028|FD-Score:4.24|P-value:6.07E-5 ID:SGTC_1064|Compound:honokiol|FD-Score:6.11|P-value:1.40E-8 ID:SGTC_1138|Compound:3761-0006|FD-Score:-4.02|P-value:1.06E-4 ID:SGTC_1403|Compound:3909-7815|FD-Score:4.10|P-value:1.02E-4 ID:SGTC_1419|Compound:3993-2473|FD-Score:3.49|P-value:7.88E-4 ID:SGTC_1663|Compound:st014140|FD-Score:3.60|P-value:5.67E-4 ID:SGTC_1670|Compound:st016595|FD-Score:3.80|P-value:2.92E-4 ID:SGTC_1671|Compound:st016596|FD-Score:5.20|P-value:1.15E-6 ID:SGTC_1674|Compound:st016616|FD-Score:4.38|P-value:3.62E-5 ID:SGTC_2236|Compound:dapsone|FD-Score:4.12|P-value:9.35E-5 ID:SGTC_2363|Compound:9053361|FD-Score:-3.54|P-value:5.40E-4 ID:SGTC_2369|Compound:9071472|FD-Score:4.27|P-value:5.39E-5 ID:SGTC_2462|Compound:5162487|FD-Score:-4.65|P-value:9.35E-6 ID:SGTC_2470|Compound:5664817|FD-Score:3.86|P-value:2.39E-4 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:-3.80|P-value:2.31E-4 ID:SGTC_2611|Compound:pyromycin|FD-Score:4.93|P-value:3.87E-6 ID:SGTC_2644|Compound:guaiazulene|FD-Score:3.50|P-value:7.70E-4 ID:SGTC_2767|Compound:sibutramine|FD-Score:-3.71|P-value:3.11E-4 ID:SGTC_2772|Compound:vinpocetine|FD-Score:-3.43|P-value:7.63E-4 ID:SGTC_2919|Compound:7978188|FD-Score:-4.67|P-value:8.59E-6 ID:SGTC_2920|Compound:7982904|FD-Score:4.96|P-value:3.36E-6 ID:SGTC_3144|Compound:9087057|FD-Score:4.49|P-value:2.37E-5 ID:SGTC_3263|Compound:9137018|FD-Score:4.07|P-value:1.12E-4 ID:SGTC_78|Compound:0336-0123|FD-Score:3.49|P-value:8.05E-4 ID:SGTC_136|Compound:0097-0015|FD-Score:3.98|P-value:1.56E-4 ID:SGTC_309|Compound:k408-0051|FD-Score:3.57|P-value:6.12E-4 ID:SGTC_403|Compound:arphamenine a|FD-Score:-3.64|P-value:3.87E-4 ID:SGTC_765|Compound:1319-0117|FD-Score:3.86|P-value:2.36E-4 ID:SGTC_780|Compound:0109-0199|FD-Score:3.58|P-value:5.90E-4 ID:SGTC_816|Compound:0325-0417|FD-Score:4.04|P-value:1.25E-4 ID:SGTC_821|Compound:1114-0266|FD-Score:5.14|P-value:1.56E-6 ID:SGTC_826|Compound:1683-5028|FD-Score:4.24|P-value:6.07E-5 ID:SGTC_1064|Compound:honokiol|FD-Score:6.11|P-value:1.40E-8 ID:SGTC_1138|Compound:3761-0006|FD-Score:-4.02|P-value:1.06E-4 ID:SGTC_1403|Compound:3909-7815|FD-Score:4.10|P-value:1.02E-4 ID:SGTC_1419|Compound:3993-2473|FD-Score:3.49|P-value:7.88E-4 ID:SGTC_1663|Compound:st014140|FD-Score:3.60|P-value:5.67E-4 ID:SGTC_1670|Compound:st016595|FD-Score:3.80|P-value:2.92E-4 ID:SGTC_1671|Compound:st016596|FD-Score:5.20|P-value:1.15E-6 ID:SGTC_1674|Compound:st016616|FD-Score:4.38|P-value:3.62E-5 ID:SGTC_2236|Compound:dapsone|FD-Score:4.12|P-value:9.35E-5 ID:SGTC_2363|Compound:9053361|FD-Score:-3.54|P-value:5.40E-4 ID:SGTC_2369|Compound:9071472|FD-Score:4.27|P-value:5.39E-5 ID:SGTC_2462|Compound:5162487|FD-Score:-4.65|P-value:9.35E-6 ID:SGTC_2470|Compound:5664817|FD-Score:3.86|P-value:2.39E-4 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:-3.80|P-value:2.31E-4 ID:SGTC_2611|Compound:pyromycin|FD-Score:4.93|P-value:3.87E-6 ID:SGTC_2644|Compound:guaiazulene|FD-Score:3.50|P-value:7.70E-4 ID:SGTC_2767|Compound:sibutramine|FD-Score:-3.71|P-value:3.11E-4 ID:SGTC_2772|Compound:vinpocetine|FD-Score:-3.43|P-value:7.63E-4 ID:SGTC_2919|Compound:7978188|FD-Score:-4.67|P-value:8.59E-6 ID:SGTC_2920|Compound:7982904|FD-Score:4.96|P-value:3.36E-6 ID:SGTC_3144|Compound:9087057|FD-Score:4.49|P-value:2.37E-5 ID:SGTC_3263|Compound:9137018|FD-Score:4.07|P-value:1.12E-4

Top fitness defect scores for YML082W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1064 honokiol 6.11 6.8 µM 1.40E-8 4 4.98E-10
2 SGTC_1671 st016596 5.20 74.5 µM 1.15E-6 11 9.72E-8
3 SGTC_821 1114-0266 5.14 29.2 µM 1.56E-6 6 1.41E-7
4 SGTC_2920 7982904 4.96 15.8 µM 3.36E-6 4 3.51E-7
5 SGTC_2611 pyromycin 4.93 23.9 µM 3.87E-6 10 4.16E-7
6 SGTC_3144 9087057 4.49 49.5 µM 2.37E-5 8 3.63E-6
7 SGTC_1674 st016616 4.38 23.6 µM 3.62E-5 21 6.04E-6
8 SGTC_2369 9071472 4.27 200.0 µM 5.39E-5 11 9.71E-6
9 SGTC_826 1683-5028 4.24 118.0 µM 6.07E-5 11 1.12E-5
10 SGTC_2236 dapsone 4.12 200.0 µM 9.35E-5 7 1.88E-5
11 SGTC_1403 3909-7815 4.10 62.9 µM 1.02E-4 15 2.07E-5
12 SGTC_3263 9137018 4.07 49.5 µM 1.12E-4 13 2.32E-5
13 SGTC_816 0325-0417 4.04 81.3 µM 1.25E-4 10 2.65E-5
14 SGTC_136 0097-0015 3.98 404.5 µM 1.56E-4 60S ribosome export 17 3.45E-5
15 SGTC_765 1319-0117 3.86 244.0 µM 2.36E-4 60S ribosome export 13 5.67E-5
16 SGTC_2470 5664817 3.86 21.7 µM 2.39E-4 11 5.75E-5
17 SGTC_1670 st016595 3.80 4.0 µM 2.92E-4 13 7.30E-5
18 SGTC_1663 st014140 3.60 55.4 µM 5.67E-4 60S ribosome export 23 1.62E-4
19 SGTC_780 0109-0199 3.58 192.0 µM 5.90E-4 26 1.69E-4
20 SGTC_309 k408-0051 3.57 1.5 µM 6.12E-4 75 1.77E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.104 1.66E-9 YJR046W TAH11 het DNA replication licensing factor, required for pre-replication complex assembly
0.086 5.89E-7 YOL053W AIM39 hom Putative protein of unknown function; null mutant displays elevated frequency of mitochondrial genome loss
0.082 1.78E-6 YNL031C HHT2 hom Histone H3, core histone protein required for chromatin assembly, part of heterochromatin-mediated telomeric and HM silencing; one of two identical histone H3 proteins (see HHT1); regulated by acetylation, methylation, and phosphorylation
0.081 2.30E-6 YKR084C HBS1 hom GTPase with similarity to translation release factors; together with binding partner Dom34p, facilitates ribosomal subunit dissociation and peptidyl-tRNA release when translation is stalled; genetically implicated in mRNA no-go decay
0.080 3.91E-6 YBR025C OLA1 hom P-loop ATPase with similarity to human OLA1 and bacterial YchF; identified as specifically interacting with the proteasome; protein abundance increases in response to hydrogen peroxide and to DNA replication stress
0.079 4.16E-6 YKR075C_p YKR075C_p hom Protein of unknown function; similar to YOR062Cp and Reg1p; expression regulated by glucose and Rgt1p; GFP-fusion protein is induced in response to the DNA-damaging agent MMS
0.078 5.91E-6 YNR058W BIO3 hom 7,8-diamino-pelargonic acid aminotransferase (DAPA), catalyzes the second step in the biotin biosynthesis pathway; BIO3 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis
0.077 6.97E-6 YBR089C-A NHP6B hom High-mobility group (HMG) protein, binds to and remodels nucleosomes; involved in recruiting FACT and other chromatin remodelling complexes to the chromosomes; functionally redundant with Nhp6Ap; homologous to mammalian HMGB1 and HMGB2; NHP6B has a paralog, NHP6A, that arose from the whole genome duplication
0.076 1.18E-5 YGR033C TIM21 hom Nonessential subunit of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); interacts with the Translocase of the Outer Mitochondrial membrane (TOM complex) and with respiratory enzymes; may regulate TIM23 complex activity
0.074 1.89E-5 YPR039W_d YPR039W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified non essential genes ERV2/YPR037C and TIP41/YPR040W
0.071 4.24E-5 YDL141W BPL1 het Biotin:apoprotein ligase, covalently modifies proteins with the addition of biotin, required for acetyl-CoA carboxylase (Acc1p) holoenzyme formation
0.070 4.49E-5 YGR103W NOP7 het Component of several different pre-ribosomal particles; forms a complex with Ytm1p and Erb1p that is required for maturation of the large ribosomal subunit; required for exit from G0 and the initiation of cell proliferation
0.067 1.02E-4 YLR247C IRC20 hom Putative helicase; localizes to the mitochondrion and the nucleus; YLR247C is not an essential gene; null mutant displays increased levels of spontaneous Rad52p foci
0.066 1.45E-4 YJL153C INO1 hom Inositol-3-phosphate synthase, involved in synthesis of inositol phosphates and inositol-containing phospholipids; transcription is coregulated with other phospholipid biosynthetic genes by Ino2p and Ino4p, which bind the UASINO DNA element
0.065 1.51E-4 YOR317W FAA1 hom Long chain fatty acyl-CoA synthetase; activates imported fatty acids with a preference for C12:0-C16:0 chain lengths; functions in long chain fatty acid import; accounts for most acyl-CoA synthetase activity; localized to lipid particles; involved in sphingolipid-to-glycerolipid metabolism; forms ER foci upon DNA replication stress; FAA1 has a paralog, FAA4, that arose from the whole genome duplication